French Military Firefighters to Assess Relationships Between Exposome and Health. (COMITEX-BSPP)

November 26, 2025 updated by: Direction Centrale du Service de Santé des Armées

Cohorte Militaire et Son Exposome : étude Pilote rétrospective au Sein de la Population Des Sapeurs-pompiers (Actuellement en Exercice et Anciens Sapeurs-pompiers) de la Brigade Des Sapeurs Pompiers de Paris

The aim of the study is to describe professional exposures and health events among French military firefighters (both active-duty personnel and veterans) and identify potential relationships between the exposome (the total history of occupational and personal exposures) and health status in these populations. The study is based on a self-administered questionnaire that collects retrospective and present information about exposures and health conditions.

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

This group of military personnel is professionally exposed, in the diversity of its activities (rescue of victims but also firefighting, protection of property, technological risks, traffic accidents, assistance to individuals, etc.), to multiple health risks, as specified in a report by ANSES (ANSES 2019):

  • chemical and particulate substances (polycyclic aromatic hydrocarbons (PAHs) present in fire smoke in particular, asbestos, diesel emissions);
  • biological agents (viruses, bacteria, mold, etc.) or physical agents (noise, ionizing or non-ionizing radiation such as electromagnetic fields, optical radiation, radioactivity, extreme temperatures and pressures, vibrations, etc.);
  • organizational constraints (time constraints, intensity and pace of work) and psychosocial constraints, including exposure to violence.

Furthermore, in 2007, the International Agency for Research on Cancer (IARC) classified firefighting as "probably carcinogenic to humans" based on limited evidence of cancer in humans, particularly non-Hodgkin's lymphoma, prostate cancer, and testicular cancer (IARC 2007). In 2022, occupational exposure of firefighters was considered "carcinogenic to humans" based on sufficient evidence for mesothelioma and bladder cancer and limited evidence for colon, prostate, and testicular cancers, melanoma, and non-Hodgkin's lymphoma (IARC 2022, Senate 2024).

A study conducted within the BSPP would not only provide better documentation of the impact of the military firefighting profession on health, but also estimate the feasibility of such a study: participation and adherence rates to the cohort, acceptability of the inclusion questionnaire and the questions asked with feedback. The data collected in the questionnaires that accompany nationwide cohort studies are indeed substantial, with a wide variety of questions requiring memory recall. Consequently, the choice and structure of the questions asked are essential in order to minimize the amount of missing data (non-response bias) and maintain a satisfactory quality of data collection, thereby ensuring the internal and external validity of the results obtained. The study among active and former firefighters will thus validate the method chosen to include participants in the future general military cohort, as well as the initial questionnaire. At the end of the questionnaire, questions about the participants' experience will be asked in order to assess the acceptance and feasibility of a future study.

Study Type

Observational

Enrollment (Estimated)

15000

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Active-duty personnel from Paris firefighters brigade as a whole. Veterans from Paris firefighters brigade with known email address.

Description

Inclusion Criteria:

  • Active-duty or veteran military personnel from French Paris firefighter brigade.
  • Aged at least 18.
  • Not opposed to participate to the study

Exclusion Criteria:

  • Opposition to participate
  • veterans under legal protection

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Active-duty firefighters (military)
Active-duty firefighters who will be considered several subgroups according exposure studied.
Veteran firesoldiers
Veteran firesoldiers who will partitioned in several subgroups according exposure studied.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
To identify associations between occupational and environnment exposures and the health status reported by current and former military firefighters,
Time Frame: Period at enrollment in the study (from January 2026 to March 2026) of Health outcome (with retrospective assessment of exposure in the past as firefighter).
To identify associations between occupational and environnment exposures and the health status reported by current and former military firefighters, through difference in prevalence of the health events (muscoskelatal, psychologic, cardiovascular... ) studied between those exposed to one or more risk factors (chemical/ physical/ psychological) and those not exposed to these factors.
Period at enrollment in the study (from January 2026 to March 2026) of Health outcome (with retrospective assessment of exposure in the past as firefighter).

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Direction Centrale du Service de Santé des Armées

Collaborators

Institut National de la Santé Et de la Recherche Médicale, France

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

January 1, 2026

Primary Completion (Estimated)

March 31, 2026

Study Completion (Estimated)

December 1, 2026

Study Registration Dates

First Submitted

September 10, 2025

First Submitted That Met QC Criteria

November 26, 2025

First Posted (Actual)

December 8, 2025

Study Record Updates

Last Update Posted (Actual)

December 8, 2025

Last Update Submitted That Met QC Criteria

November 26, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2023PBMD02

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

(security and regulation)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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