Predictors and Outcome of Rupture HCC in AU Hospitals

December 5, 2025 updated by: Mokhtar Omar Khaled, Assiut University

Predictors and Outcome of Rupture Hepatocellular Carcinoma in Assuit Unversity Hospitals

The aime of the study is To identify the Prevalence of rupture of HCC among patients diagnosed with HCC at Assiut University Hospitals in the last five years.

,detect the Risk factors and predictors of rupture HCC. and identify the survival rate in 1 year post rupture HCC patients.

Study Overview

Status

Not yet recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

All adult patients (≥18 years) with a confirmed diagnosis of HCC and evidence of spontaneous tumor rupture will be included. Rupture will be defined radiologically (via CT scan or ultrasound showing hemoperitoneum and liver lesion discontinuity) or confirmed intraoperatively

Description

Inclusion Criteria:

  • *Age ≥18 years

    • Diagnosed with HCC (radiologically or histopathologically)
    • Evidence of spontaneous rupture confirmed by imaging or surgical exploration
    • Admitted to the hospital during the study period

Exclusion Criteria:

  • * Traumatic liver rupture

    • Non-HCC liver malignancies
    • Incomplete medical records or missing imaging data

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Detect Prevalence of rupture of HCC among patients diagnosed with HCC at Assiut University hospitals in the last five years.
Time Frame: Baseline

The following variables will be extracted:

  1. Demographic data (age, gender, residence)
  2. Liver disease history (HBV/HCV status, Child-Pugh score, MELD score)
  3. Tumor characteristics (size, number, location, vascular invasion)
  4. Clinical presentation (abdominal pain, hypotension, hemoglobin level)
  5. Diagnostic imaging findings (CT, ultrasound)
  6. Management approach (conservative, transarterial embolization [TAE], surgical resection)
Baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Investigators

  • Principal Investigator: Mokhtar Qaleed, Assiut University
  • Study Director: Mahmoud Ashri, Assiut University
  • Study Director: Bahaa Osman Taha, Assiut University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

January 1, 2026

Primary Completion (Estimated)

August 1, 2026

Study Completion (Estimated)

August 1, 2027

Study Registration Dates

First Submitted

September 28, 2025

First Submitted That Met QC Criteria

December 5, 2025

First Posted (Actual)

December 18, 2025

Study Record Updates

Last Update Posted (Actual)

December 18, 2025

Last Update Submitted That Met QC Criteria

December 5, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • Rupture HCC in AU hospitals

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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