Analysis of NfL and GFAP in Different Dietary Patterns

December 17, 2025 updated by: Tobias Moser, Salzburger Landeskliniken

Vegan, Vegeratian, or Omnivore: Dietary Effects on the Brain Tissue Biomarkers

This observational study aims to investigate the impact of different dietary patterns on brain tissue biomarkers in healthy young adults by measuring blood levels of NfL and GFAP.

The primary research question is: Do vegan, vegetarian, or omnivorous diets influence NfL and GFAP levels?

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

300

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Tobias Moser, Prof.
  • Phone Number: +435725534720
  • Email: t.moser@salk.at

Study Locations

  • Austria
    • Salzburg
      • Salzburg, Salzburg, Austria, 5020
        • Recruiting
        • Christian-Doppler-Klinik
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Young and healthy individuals aged between 18 and 40 years

Description

Inclusion Criteria:

  • Healthy individuals who have followed a vegan, vegetarian, or omnivorous diet for at least one consecutive year
  • Aged between 18 and 40 years
  • Provision of written informed consent

Exclusion Criteria:

  • Diagnose neurological disorders (e.g. neurodegenerative, inflammatory, autoimmune, infectious, vascular)
  • Eating disorders
  • Excessive alcohol consumption
  • Pregnancy
  • Recent moderate to severe infection (within the past 12 weeks) , including SARS-CoV-2
  • Recent trauma, injury, or surgery (within the past 12 weeks)
  • Significant BMI fluctuations (>5 points) within the last year
  • Patients who have been using Proton pump inhibitors (PPIs) for an extended period (e.g., 1 month).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Omnivore
Vegan
Vegetarian

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Blood levels of the following biomarkers: neurofilament light chain (NfL) in pg/mL, glial fibrillary acidic protein (GFAP) in pg/mL.
Time Frame: Once at baseline
Once at baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Salzburger Landeskliniken

Collaborators

Medizinische Einrichtungen der Universität Düsseldorf
Universitätsklinkum Münster - Medizinische Klinik und Poliklinik B
Medizinische Fakultät der Universität zu Köln

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 18, 2025

Primary Completion (Estimated)

April 1, 2026

Study Completion (Estimated)

September 1, 2026

Study Registration Dates

First Submitted

December 9, 2025

First Submitted That Met QC Criteria

December 17, 2025

First Posted (Actual)

December 31, 2025

Study Record Updates

Last Update Posted (Actual)

December 31, 2025

Last Update Submitted That Met QC Criteria

December 17, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 1119/2025

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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