Prognostic Nutritional Index for Predicting Outcomes Following Coronary Artery Bypass Grafting (CABG) Surgery

January 11, 2026 updated by: Mohammed El Gazzar, Benha University

The Merits of the Prognostic Nutritional Index for Prediction of the Outcome of Coronary Artery Bypass Grafting Surgery: A Retrospective Observational Study

Coronary artery bypass grafting (CABG) is a major cardiac surgery associated with risks of serious perioperative complications and mortality. Malnutrition and inflammation are known independent risk factors for poor outcomes in patients with coronary artery disease. This retrospective observational study evaluates the Prognostic Nutritional Index (PNI)-a simple score derived from serum albumin and lymphocyte counts-as an objective measure of nutritional and inflammatory status. The research aims to determine how well preoperative PNI and its postoperative changes can predict complications such as acute kidney injury, myocardial infarction, and sternal wound infections in patients undergoing CABG.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

117

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Al Qalyoubia
      • Banhā, Al Qalyoubia, Egypt, 13511
        • Benha University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

The study population consists of adult patients (both male and female) who underwent major coronary artery bypass grafting surgery at the Cardiothoracic Surgery Department of Benha University Hospital within a recent five-year period.

Description

Inclusion Criteria:

  • Patients who underwent CABG surgery.
  • Availability of a signed informed consent form before surgery.

Exclusion Criteria:

  • Other concurrent cardiac surgeries.
  • Presence of malignancy or systemic inflammatory disorders.
  • Active infection or autoimmune disorders.
  • Maintenance on immunosuppressants.
  • Liver disease.
  • Files with missing data.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
CABG Patient Cohort.
Patients who underwent Coronary Artery Bypass Grafting surgery at Benha University Hospital over the preceding five years.
Diagnostic test: Prognostic Nutritional Index (PNI)
Calculated using serum albumin (g/L) and total peripheral lymphocyte count.
Diagnostic test: Neutrophil-to-Lymphocyte Ratio (NLR)
Calculated from peripheral blood counts.
Diagnostic test: Body Mass Index (BMI)
Calculated from preoperative weight and height.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Diagnostic Accuracy of the Prognostic Nutritional Index (PNI) in Predicting Post-CABG Complications.
Time Frame: Approximately 30 days (From surgery through the duration of the hospital/ICU stay.)
The Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) used to determine the performance of the PNI score in predicting the occurrence of major postoperative complications.
Approximately 30 days (From surgery through the duration of the hospital/ICU stay.)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Benha University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 15, 2025

Primary Completion (Actual)

January 11, 2026

Study Completion (Estimated)

January 20, 2026

Study Registration Dates

First Submitted

January 11, 2026

First Submitted That Met QC Criteria

January 11, 2026

First Posted (Actual)

January 21, 2026

Study Record Updates

Last Update Posted (Actual)

January 21, 2026

Last Update Submitted That Met QC Criteria

January 11, 2026

Last Verified

January 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • RC 6.11.2025

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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