Photobiomodulation Therapy on Nerve Repair Using Red and Infra-red Diode Lasers

February 10, 2026 updated by: mona oraby

Comparison Between Photobiomodulation Therapy on Nerve Repair Using Red and Infra-red Diode Lasers in Maxillofacial Region (A Randomized Clinical Trial)

Peripheral nerve injury is a major concern that drastically affects the patient's quality of life. Nowadays, several treatment options are available, including medical treatments, surgical intervention, and others. However, the trending photobiomodulation effect of laser therapy is attracting many dental professionals due to its promising results on nerve rehabilitation.

The study is intended to assess and compare laser photobiomodulation using red and infra-red diode lasers on the repair of nerve injury in the maxillofacial region.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Alexandria, Egypt
        • Alexandria University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  1. Patient aged range from 20-50 years old
  2. Patient suffering from nerve injury in the maxillofacial region for a period of 6 months or more without improvement.

Exclusion Criteria:

  • 1- Patient had undergone micro-neurosurgery to correct neurosensory deficit.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: 635 wavelength
Device: 635 wavelength
635 wavelength laser
Active Comparator: 980 wavelength
Device: 980 wavelength
980 wavelength laser

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
visual analogue scale
Time Frame: 1,2,4,8,12 weeks

from 1- 10

1 means no pain 10 means worst pain
1,2,4,8,12 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
clinical neurosensory test
Time Frame: 2,4,8,12 weeks
from S0 to S4 S0 means worst neurosensory function S4 full recovery for neurosensory function
2,4,8,12 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

mona oraby

Investigators

  • Principal Investigator: Mona S Oraby, Alexandria University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 18, 2025

Primary Completion (Actual)

January 18, 2026

Study Completion (Actual)

January 18, 2026

Study Registration Dates

First Submitted

February 5, 2026

First Submitted That Met QC Criteria

February 5, 2026

First Posted (Actual)

February 11, 2026

Study Record Updates

Last Update Posted (Actual)

February 12, 2026

Last Update Submitted That Met QC Criteria

February 10, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 00010556- 0008839

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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