Chlorhexidine Gluconate and Alcohol Hand Rubbing on Healthcare-associated Infection

February 12, 2026 updated by: Marwa Mohamed Farag, Alexandria University

a Comparison Between Effect of Chlorhexidine Gluconate and Alcohol Hand Rubbing on Healthcare-associated Infection

This study aims to compare of effect of chlorhexidine gluconate and alcohol hand rubbing on healthcare-associated infection (HCAI) in neonatal intensive care unit at Alexandria University Children Hospital.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

100

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

Neonates <37 weeks gestational age admitted to NICU of Alexandria University Children's Hospitals

Exclusion Criteria:

  • Patients with any of the following will be excluded:

    1. Obvious major congenital abnormalities, immunodeficiency and inborn error of metabolism.
    2. Early onset sepsis (before the third day).
    3. Infants more than 72 hours of age at the time of randomization.
    4. Parental consent lacking/refusal.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Alcohol hand rub
Medical staff used chlorhexidine in hand rubs before contacting the neonates during their hospital stay.
Drug: Alcohol hand rub group
Medical staff used alcohol in hand rubs before contacting the neonates during their hospital stay.
Active Comparator: chlorohexidine hand rub
Medical staff used alcohol in hand rubs before contacting the neonates during their hospital stay.
Drug: Chlorhexidine hand rub
Medical staff used Chlorhexidine in hand rubs before contacting the neonates during their hospital stay.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
blood culture
Time Frame: first month of life
having blood culture from studied groups on day 7, 14, and 28 after birth.
first month of life

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Alexandria University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 1, 2025

Primary Completion (Estimated)

March 1, 2026

Study Completion (Estimated)

April 1, 2026

Study Registration Dates

First Submitted

February 12, 2026

First Submitted That Met QC Criteria

February 12, 2026

First Posted (Actual)

February 19, 2026

Study Record Updates

Last Update Posted (Actual)

February 19, 2026

Last Update Submitted That Met QC Criteria

February 12, 2026

Last Verified

August 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 010820

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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