Singing Training vs Usual Care 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC) (Sing-a-Lung 2)

Effects and Mechanisms of Online Delivered Singing Training vs Usual Care in Patients With Persistent Symptoms 6-18 Months After Surgical Resection for Non-small Cell Lung Cancer (NSCLC) - a Multi-centre RCT

People who have undergone curative surgery for non-small cell lung cancer (NSCLC) often experience reduced quality of life (QoL), a high burden of symptoms, and physical deconditioning. Current Danish rehabilitation offers are heterogeneous and inconsistent and not tailored to the specific needs of this population. Additionally, some patients continue to suffer from persistent physical symptoms months or even years after surgery, yet no targeted support is currently available for them. Singing - delivered as a structured form of training - has shown benefits in improving both physical and psychological outcomes in individuals with chronic obstructive pulmonary disease (COPD). Although singing has not yet been studied in NSCLC patients, the two conditions share overlapping symptoms and characteristics. Therefore, the present study aims to explore whether a singing-based intervention can help reduce symptom burden and improve physical function and QoL in NSCLC patients 6 to 18 months post-surgery. To test this, a multi-centre randomised controlled trial (RCT) will be conducted, comparing a singing intervention to usual care. Given that travel and distance often pose significant barriers to participation, the intervention will be delivered online.

Study Overview

• Status: Recruiting
• Conditions: Non-Small Cell Lung Cancer; Chronic Obstructive Lung Disease
• Intervention / Treatment: Behavioral: Control group: Usual care; Behavioral: Singing training (Singing for Lung Health (SLH))

Detailed Description

Post-surgical rehabilitation should include combined aerobic training and strength training, alone or combined with respiratory muscle training. A Cochrane review (Cavalheri, et al., 2019) concluded that rehabilitation with exercise training improved physical capacity and physical fitness and suggested improved Health-Related QoL and dyspnoea. Additionally, a Core Outcomes Set (Edbrooke, et al., 2025) defined critical outcomes as: physical function, HRQoL, breathlessness, activities of daily living, emotional and mental well-being, pain.

In a recent Danish mapping study (Kaasgaard, et al., 2024), a large proportion experiences physiological-oriented symptoms: Fatigue (78%), hyper-vigilance (74%), dyspnoea (65%), and pain (47%); besides psychological-oriented symptoms: Worry about the future (40%), depression (35%), and anxiety (29%). In addition, 27%, experienced having vocal problems. This was confirmed in a subsequent Danish cross-sectional study, which specifically found impaired QoL (physical functioning) and symptoms (dyspnoea) 6-12 months after NSCLC surgery. This aligns with other recent Danish studies demonstrating persistent symptoms long-term after NSCLC surgery. In addition, a systematic review found poor mental health-related QoL, dyspnoea, and pain up to one year after surgery. Taken together, this implies signs of a neglected population with persistent symptoms, yet without a standard offer available to support them.

Singing has become increasingly popular in respiratory diseases, comprising elements of both physiological training and psychosocial aspects, therefore, likely to address the unmet needs in lung cancer. Previous studies have suggested physiological training effects and increased respiratory control, less dyspnoea, improved QoL, and reduced anxiety and depression. Moreover, singing is suggested to confer physiological training effects with work load equivalent to brisk walk pace. Furthermore, singing is perceived as a relevant and beneficial activity that builds joy, meaning, and social cohesion. However, studies have overall mostly been small and heterogenous, and with contradictory findings and a lack of knowledge about the underpinning mechanisms. Moreover, there are different approaches to singing, although a conventional choir approach is mainly adapted. The currently most well-documented, best-practice disease-specific approach is Singing for Lung Health (SLH), developed within a multidisciplinary healthcare setting in the UK since 2008. SLH aims to provide health-promoting benefits, uses exercises and songs as tools for purpose, and, further, includes movement and dancing while singing. In a recent multicentre-RCT in COPD - Sing-a-Lung 1.0 -, the study investigators demonstrated that PR with SLH improved functional capacity and QoL in a dose-response manner and was non-inferior to PR with usual care delivery of physical exercise. Furthermore, SLH was related to improved respiratory strength and dyspnoea control. This RCT was conducted within a real-life community-based setting, was the largest study so far, had sufficient power to detect change (n=270), and, thus, represents a proof-of-concept study.

Singing has not yet been investigated in lung cancer, but a qualitative study exploring singing for patients with breast or colorectal cancer suggests that singing may improve resilience, confidence, and mood, and builds social support. However, given that several epidemiological and common pathogenetic factors are shared between chronic obstructive pulmonary disease (COPD) and NSCLC patients, results from Sing-a-Lung 1.0 are likely to be transferrable specifically to people with lung cancer, and may address important needs of this overlooked group. However, the limited number of lung cancer patients in each municipality and the heterogeneity of current rehabilitation compromise the feasibility of an RCT equally to the one of Sing-a-Lung 1.0. Therefore, as it is expected that the patients will benefit from a singing intervention, singing will be compared with usual care. The singing intervention will be delivered online across all study sites, using video conferencing application, and delivered by three specialised singing teachers. Specifically, the study aims to investigate whether 10 weeks' online singing training (delivered as SLH) improves key physiological and psychosocial outcomes, and reduces symptom burden compared to usual care 6-18 months after curative intended NSCLC surgery, hypothesising that 1) SLH provides relevant and beneficial improvements in both physiological and psychological parameters (superior to usual care alone), and 2) SLH relieves symptom burden (superior to usual care alone). In an exploratory study of a sub-cohort, the study aims to investigate the underpinning mechanisms of singing compared to usual care, hypothesising that 3) SLH improves physical fitness, oxygenation, and inflammation. The overall project will run between Q3 2025 and Q4 2028. Intervention phase: Q1 2026 to Q3 2027. Recruitment and data collection at the following sites: Site 1) Dept. of Medicine, Zealand University Hospital, Roskilde and Næstved, Næstved Hospital, Ringstedgade 61, DK-4700 Naestved, Denmark; Site 2) Dept. of Respiratory Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400, København NV, Denmark; Site 3) Dept. of Respiratory Medicine, Lillebaelt Hospital, Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark; Site 4) Dept. of Respiratory Medicine, Odense University Hospital, J. B. Winsløws Vej 4, DK-5000 Odense, Denmark. Specifically, recruitment at Site 2 (or from Site 1 if living close to Copenhagen): Data collection (both for the main study and exploratory sub-study) at site 5) August Krogh Sect. for Molecular and Human Physiology, Dept. of Nutrition, Exercise University of Copenhagen, and Sports, Faculty of Health and Medical Sciences, Universitetsparken 3, DK-2100 København Ø, Denmark. Participants will be recruited using the following methods: 1) Retrospectively: Participants from the recent cross-sectional study, conducted at Site 1 and 2 (Kaasgaard, et al., in peer-review) who indicated to be interested in being part of the study; 2) Retrospectively: Patient lists from the Danish Lung Cancer Registry (DLCR); 3) Prospectively: Ongoing identification in follow-up consultation. Included study participants will be block randomised to either: Group 1: 10 weeks' online SLH, or Group 2: 10 weeks' usual care (followed by an offer of 10 weeks' online SLH). Study participants will be assessed at the following time points: Group 1: 1) T0: Baseline (at randomisation); 2) T1: Follow-up 11-14 weeks later). Group 2: 1) T0: Baseline (at randomisation); 2) T1: Follow-up 11-14 weeks later); 3) T2: Follow-up: Withing three weeks after the SLH intervention (appr. 11-14 weeks after T1). Primary study outcome: Change in physical capacity, assessed with the Six Minute Walking Test (6MWT). An a priori statistical power analysis calculation showed that the needed sample size is n=78 study participants and including an expected drop-out-rate of 20%, an overall total sample of n=100 study participants is needed. In the power analysis, the investigators considered data from previous studies on the primary study outcome, 6MWT distance, with a minimal important difference of ≥ 30 m, with the final calculation based on findings from our previous RCT on singing for COPD with a pre-post difference of mean 13.1±36.3 m after 10 weeks of singing in PR for COPD. Statistical power analysis calculations (primary study outcome: 6MWD): Estimated sample size for two-sample comparison of means: Test H0: n1 = n2, where n1 is the mean in population 1 and n2 is the mean in population 2. Assumptions: α (two-tailed) 0.05, β 0.2; Effect size Group 1: 15 m; Group 2: 5 m (SD 15). Estimated required sample sizes (based on power: 80 %): n1 = 52; n2 = 26

• Study Type: Interventional
• Enrollment (Estimated): 100
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Mette Kaasgaard, PhD; Phone Number: 4528940238; Email: mkaasgaard@health.sdu.dk
• Study Contact Backup: Name: Uffe Bødtger, PhD; Phone Number: 4526791426; Email: ubt@regionsjaelland.dk

Study Locations

• Denmark
  • Copenhagen, Denmark, 2100
    • Recruiting
    • August Krogh Section for Molecular and Human Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Health and Medical Sciences, University of Copenhagen
    • Contact: Morten Hostrup, Associate Professor, PhD, MSc, MD; Phone Number: +4524474785; Email: mhostrup@nexs.ku.dk
  • Copenhagen, Denmark, 2400
    • Recruiting
    • Department of Respiratory Medicine, Bispebjerg Hospital
    • Contact: Anne Orholm Nielsen, PhD, MD; Phone Number: +4521547350; Email: anne.orholm.nielsen@regionh.dk
  • Næstved, Denmark, 4700
    • Recruiting
    • Department of Medicine Roskilde and Næstved, Zealand University Hospital
    • Contact: Uffe Bødtger, Professor, PhD, MD; Phone Number: 24791426; Email: ubt@regionsjaelland.dk
  • Odense, Denmark, 5000
    • Recruiting
    • Department of Respiratory Medicine, Odense University Hospital
    • Contact: Christian Borbjerg Laursen, Professor, PhD, MD; Phone Number: +4540383944; Email: christian.b.laursen@rsyd.dk
  • Vejle, Denmark, 7100
    • Recruiting
    • Department of Respiratory Medicine, Lillebaelt Hospital
    • Contact: Ole Hilberg, Professor, DMSc; Phone Number: +4520878694; Email: ole.hilberg@rsyd.dk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

Patients who display persistent symptoms 6-18 months (+/- one month) after surgical resection of localised lung cancer with video-assisted thoracoscopy (VATS) will be invited to participate in the study.

Inclusion criteria for the study include:

1. Persistent symptoms, i.e., an EORTC-QLQ-C30 symptom domain score (in any item) of ≥2 (="clinically relevant symptom or problem that should have healthcare professional attention"),
2. Surgery for stage I lung cancer 6-18 months (+/- one month) earlier,
3. Motivated for participating in the project (and acceptance of randomisation procedure),
4. Access to a computer or a tablet with internet access,
5. Ability to speak and understand Danish,
6. Acceptance of the scheduled times of the singing intervention twice a week.

Exclusion Criteria:

Exclusion criteria include:

1. Unstable coronary diseases,
2. Severe cognitive disabilities (e.g., dementia),
3. Indication for adjuvant chemotherapy or other antineoplastic therapy,
4. Signs of lung cancer recurrence at regular follow-up CT scan.

No previous singing experience or musical competence is required. Participants will be informed that they are allowed to participate in additional offer of structured or unstructured offer physical exercise training and/or singing along with the project.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Intervention: Singing training (Singing for Lung Health (SLH)); 10 weeks of singing training (conducted according to the Singing for Lung Health (SLH) approach). The singing training will be delivered online (1 1/2 hour twice a week) by professional singing teachers specifically trained and experienced within SLH. Sessions include physical, vocal, and breathing exercises and musical repertoire. Besides, movement, dancing, and artefacts for playful games are included along with singing. Each session consists of 20 min physical warm-ups, 20 min vocal warm-up with rhythm and pitch games, 40 min singing (incl. break), and 10 min cool-down. Participants are allowed to participate in additional offer of structured or unstructured offer physical exercise training and/or singing along with the project.	Behavioral: Singing training (Singing for Lung Health (SLH)); 10 weeks of singing training (conducted according to the Singing for Lung Health (SLH) approach). The singing training will be delivered online (1 1/2 hour twice a week) by professional singing teachers specifically trained and experienced within SLH. Sessions include physical, vocal, and breathing exercises and musical repertoire. Besides, movement, dancing, and artefacts for playful games are included along with singing. Each session consists of 20 min physical warm-ups, 20 min vocal warm-up with rhythm and pitch games, 40 min singing (incl. break), and 10 min cool-down.
Other: Control group: 1) Usual care, followed by Singing training (Singing for Lung Health (SLH)); 10 weeks of usual care (i.e., no specific additional intervention above those which the person usually engages with), followed by 10 weeks of singing training (conducted according to the Singing for Lung Health (SLH) approach). The singing training will be delivered online (1 1/2 hour twice a week) by professional singing teachers specifically trained and experienced within SLH. Sessions include physical, vocal, and breathing exercises and musical repertoire. Besides, movement, dancing, and artefacts for playful games are included along with singing. Each session consists of 20 min physical warm-ups, 20 min vocal warm-up with rhythm and pitch games, 40 min singing (incl. break), and 10 min cool-down. Participants are allowed to participate in additional offer of structured or unstructured offer physical exercise training and/or singing along with the project.	Behavioral: Control group: Usual care; The control group will receive usual care, i.e., no specific additional intervention above those which the person usually engages with.; Behavioral: Singing training (Singing for Lung Health (SLH)); 10 weeks of singing training (conducted according to the Singing for Lung Health (SLH) approach). The singing training will be delivered online (1 1/2 hour twice a week) by professional singing teachers specifically trained and experienced within SLH. Sessions include physical, vocal, and breathing exercises and musical repertoire. Besides, movement, dancing, and artefacts for playful games are included along with singing. Each session consists of 20 min physical warm-ups, 20 min vocal warm-up with rhythm and pitch games, 40 min singing (incl. break), and 10 min cool-down.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Physical capacity	Assessed with the Six Minute Walking Test (6MWT) (assessor-collected) , measured in meters walked in 6 minutes. Minimal important difference: >30 m.	Changes pre-post 10 weeks (measured at all assessment points).
Perceived exertion	Measured using BORG CR-10 dyspnoea scale (self-reported). The scale ranges from 0 to 10 points, where 0 represents no exertion/dyspnoea and 10 represents maximal exertion/dyspnoea. Minimal important difference: 1 point.	Changes measured before and after performance of 6MWT; Changes pre-post 10 weeks (measured at all assessment points).
Change in Health-related quality of life (HRQoL)	St. George's Respiratory Questionnaire (SGRQ) (self-reported questionnaire). SGRQ has 50 items with 76 weighted responses and four scores: Total, Symptom, Activity, Impact. Each score ranges from 0 to 100, with 100 representing worst possible health status and 0 best possible. Minimal important differnence: -4 units.	Changes pre-post 10 weeks (measured at all assessment points).

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Quality of life	EORTC 30 item Quality of Life Questionnaire (QLQ-C30), v. 3.0 (self-reported questionnaire). Functional domains: Physical function, role functioning, emotional function, cognitive function, social function. QLQ-C30 has 30 items: 1-28 completed on a 4-point Likert scale (1=not at all, 2=a little, 3=quite a bit, and 4=very much); 29-30 completed on a 7-point scale defined by extremes (1=very poor, 7=excellent). Raw and transformed scores are calculated, based on instructions in the QLQ-C30 scoring manual. Calculated scores range: 0-100. For the Functional scale, 100 = highest possible level of functioning. Cutoffs for clinically important problems: based on EORTC Quality of Life Group (Physical functioning (≤83), role functioning (≤58), emotional functioning (≤71), cognitive functioning (≤75), social functioning (≤58))	Pre-post 10 weeks
Change in Symptoms burden	EORTC 30 item Quality of Life Questionnaire (QLQ-C30), v. 3.0 (self-reported). Symptom domains: Fatigue, nausea/vomiting, pain, sleep disturbances, dyspnoea, appetite loss, constipation, diarrhea, financial concerns. QLQ-C30 has 30 items: For 1-28: 4-point Likert scale (1=not at all, 2=a little, 3=quite a bit, 4=very much); for 29-30: 7-point scale defined by extremes (1=very poor, 7=excellent). Raw and transformed scores are calculated, based on the QLQ-C30 scoring manual. Calculated scores range: 0-100. For the Symptom scale, 100 = highest possible symptom burden. Cutoffs for clinically important problems: EORTC Quality of Life Group: Fatigue (≥39), nausea/vomiting (≥8), pain (≥25), insomnia (≥50), dyspnoea (≥17), appetite loss (≥50), constipation (≥50), diarrhea (≥17), financial concerns (≥17). Danish Multi-disciplinary Cancer Groups: ≥2 = "clinically relevant symptom"; ≥3 = "severe/serious symptom" (pain, dyspnoea, nausea/vomiting: ≥2 = "severe/serious symptom").	Changes pre-post 10 weeks (measured at all assessment points).
Change in symptoms burden	EORTC Quality of Life Lung Cancer Module Questionnaire (QLQ-LC13) is a supplementary lung cancer-specific questionnaire to be used in conjunction with the QLQ-C30. Both questionnaires developed and validated in patients with lung cancer (self-reported). The module consists of 13 items and comprises multi- and single-item measures of lung cancer-associated symptoms (i.e. coughing, haemoptysis, dyspnoea and pain). Scaling of items: 1 (Not at all) to 4 (Very much). Scoring: 0 to 100. (higher scores = increasing symptom levels. Minimal important difference not defined.	Changes pre-post 10 weeks (measured at all assessment points).
Change in symptoms burden: Dyspnoea	mMRC (Modified Medical Research Council Dyspnoea Scale) (self-reported). The scale includes scores from 0-4, with grade 0 corresponding to "Dyspnoea only when strenuous exercise" and grade 4 corresponding to "Too dyspneic to leave house or breathless when dressing. Minimal important difference: 1 point.	Changes pre-post 10 weeks (measured at all assessment points).
Change in symptoms burden: Breathing vigilance	The Breathing Vigilance Questionnaire (Breathe-VQ) quantifies breathing vigilance in individuals with respiratory diseases and dysfunctional breathing (self-reported). The questionnaire utilises a 5 point Likert scale (1 = "never" to 5 = "always"), with a brief introductory text followed by instructions for scoring 1. Respondents select the response that best describes their typical breathing perceptions, and higher scores indicates higher levels of breathing vigilance. Minimal important difference has not yet been defined.	Changes pre-post 10 weeks (measured at all assessment points).
Change in symptoms of anxiety and depression	Assessed with Hospital Anxiety and Depression Scale (HADS) (self-reported). HADS comprises 14 items, seven related to anxiety and seven related to depression. Minimal important difference: 1.32 (anxiety component) and 1.40 (depression component).	Changes pre-post 10 weeks (measured at all assessment points).
Change in airway physiology	Reversibility test using a spirometer (assessor-collected): FEV1 in litres and % predicted, FVC in litres and % predicted, FEV1%/FVC%. Values will be categorised according to Global Initiative for Chronic Obstructive Lung Disease (GOLD): FEV1% > 80 = GOLD 1 (mild); 50 ≤ FEV1% < 80 = GOLD 2 (moderate); 30 ≤ FEV1% < 50 = GOLD 3 (severe); FEV1% < 30 = GOLD 4 (very severe). Reference values: height, age, sex and ethnicity. Minimal important difference for FEV1 is considered to be 120 ml.	Changes pre-post 10 weeks (measured at all assessment points).
Change in aerobic fitness/Maximal oxygen uptake	VO2-max (test for VO2 max estimate; 70% of maximum heart rate for 20 minutes continuously). Women: 4-minute warm-up at 10 W, followed by an incremental ramp test with a workload increase of 10 W·min-¹. Men: 4-minute warm-up at 15 W, followed by an incremental ramp test with a workload increase of 15 W·min-¹. Criteria for Exhaustion: Respiratory exchange ratio (RER) ≥ 1.10; Cadence < 70 rpm despite verbal encouragement. Analysis: VO₂peak defined as the highest 30-second averaged VO₂ value obtained during the test; Incremental peak power output (iPPO) defined as the peak workload attained during the ramp test. Units of measure: Absolute VO₂peak: ml O2/min; Relative VO₂peak: ml O2/min/kg; iPPO: W.	Changes pre-post 10 weeks (measured at all assessment points).
Change in Heart rate	Maximum pulse and recovery after 6MTW. Minimal important difference is considered as a 10% change.	Changes pre-post 10 weeks (measured at all assessment points).
Adherence and drop-out	Continuously registered by the singing teachers and study nurses. Adherence rate will be divided into four categories (quartiles) with high adherence = ≥75% of all sessions.	Registred during and after 10 weeks (at all assessment points).
Adverse events	Any adverse events (adverse events (AE) and serious adverse events (SAE)).	Post 10 weeks (registered at assessment point 2 (and 3 for Group 2).
Change in inspiratory and expiratory pressure	Maximal inspiratory and expiratory pressure (MIP and MEP), measured in cm H2O.	Pre-post VO2 max test; pre-post 10 weeks (at all assessment points)

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Resting blood samples	Blood Cells: Hemoglobin (Hb) (mmol/L); Hematrocrit (Hct) (L/L or %); Thrombocytes (x109/L); Leukocyte differential count: (x109/L). Kidney function: eGFR (mL/min/1,73m2). Liver function: ASAT (U/L); ALAT (U/L); ALB (U/L); ALP (g/L). Metabolic function: Lactate dehydrogenase (LDH), mmol/L. Stress response: Epinephrine (Adrenaline) (nmol/L); Norepinephrine (Noradrenaline) (nmol/L); Dopamin (nmol/L). Inflammation and inflammatory drivers: C-reactive protein (CRP) (mg/L); Inflammatory cytokines (TNF-α, IL-1β, IL-6) (pg/mL); JAK2V617F mutation.	Changes pre-post 10 weeks (measured at all assessment points).
Acute physiological response to maximal exercise (VO2max)	Metabolic markers: Lactate (mmol/L). Acid-base markers: pH; Partial pressure of carbon dioxide (pCO2) (mmHg); Bicarbonate (HCO3)(mmol/L). Oxygenation: Partial pressure of oxygen (pO2) (mmHg); Oxygen saturation (SaO2/SpO2) (%). Electrolyte and Ion Home: Potassium (mmol/L).	Changes pre-post 10 weeks (measured at all assessment points).
Peripheral oxygenation	Peripheral oxygenation (SpO2) (pulse oximeter).	Changes pre-post 10 weeks (measured at all assessment points).

Collaborators and Investigators

• Sponsor: Zealand University Hospital

Publications and helpful links

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Helpful Links

• Dansk Lunge Cancer Gruppe. DLCG. Lungecancer - kirurgisk behandling. 2020. KLINISKE RETNINGSLINJER | KRÆFT.
• Danske Multidisciplinære Cancer Grupper (DMCG). KLINISKE RETNINGSLINJER | KRÆFT: Opfølgning efter behandling for Lungekræft, Version 1.0
• Dansk Lunge Cancer Gruppe. Lungecancer - Visitation, Diagnose, Stadie. Klinisk Retningslinje│ Kræft. Version 2.0. 2020 Dec.
• Sundhedsstyrelsen. Pakkeforløb for lungekræft. For fagfolk. 2018. Elektronisk ISBN-nr.: 978- 87-7014-022-5
• Bjerno Nielsen, D.M., Bilde, L., et al. Temarapport om viden om kvalitet i kræftpatientforløb. Rehabilitering og palliative indsatser i forbindelse med kræft (report in Danish). Kræftens Bekæmpelse (Danish Cancer Society); 2021 Mar.
• Dansk Lunge Cancer Gruppe (DLCG). KLINISKE RETNINGSLINJER | KRÆFT | Lungekræft - Fysisk træning til patienter med lungekræft, Version 1.0. 2024 Dec.
• European Organisation for Research and Treatment of Cancer - EORTC Quality of Life, Manuals for EORTC QLQ-C30
• DMCG-PAL/Sekretariatet for Kliniske Retningslinjer på Kræftområdet. Klinisk relevante EORTC-scorer for behandling af patienter med kræft i specialiseret palliativ indsats

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2026
• Primary Completion (Estimated): April 1, 2027
• Study Completion (Estimated): October 1, 2027

Study Registration Dates

• First Submitted: January 20, 2026
• First Submitted That Met QC Criteria: March 4, 2026
• First Posted (Actual): March 10, 2026

Study Record Updates

• Last Update Posted (Actual): April 2, 2026
• Last Update Submitted That Met QC Criteria: March 27, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: rehabilitation; quality of life; lung cancer; physiology; physical capacity; symptom burden; singing; online training; airway physiology; six-minute walk test
• Additional Relevant MeSH Terms: Pathologic Processes; Neoplasms by Site; Neoplasms; Chronic Disease; Disease Attributes; Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Respiratory Tract Neoplasms; Thoracic Neoplasms; Carcinoma, Bronchogenic; Bronchial Neoplasms; Pathological Conditions, Signs and Symptoms; Pulmonary Disease, Chronic Obstructive; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Circulatory and Respiratory Physiological Phenomena; Respiratory Physiological Phenomena; Phonation; Singing
• Other Study ID Numbers: SJ-1027

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Anonymised datasets will be shared upon reasonable request.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No