Metabolic Regeneration Registry for Periodontal Health (20-Patient Cohort).

April 22, 2026 updated by: Amar h Zireg

Retrospective Longitudinal Observation of a Proprietary Metabolic Protocol for Rapid Gingival Tissue Repair and Periodontal Pocket Stabilization.

This observational study documents the clinical outcomes of a proprietary, safe-to-swallow metabolic protocol for chronic gum disease. Based on 21 years of research and a focused 20-patient cohort, the study records visible clinical improvements in gingival inflammation and tissue color within 7 to 14 days. The protocol focuses on restoring the metabolic environment to achieve non-surgical periodontal pocket stabilization and natural tissue re-attachment.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

20

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Algeria
    • Wilaya de Bordj Bou Arréridj
      • Bordj Bou Arreridj, Wilaya de Bordj Bou Arréridj, Algeria, 34000
        • Zireg

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients aged 18 to 75 years diagnosed with chronic periodontitis, characterized by gingival inflammation, bleeding on probing, and periodontal pocket depths of 4mm or greater. The population includes individuals seeking non-surgical alternatives for gum tissue recovery.

Description

Inclusion Criteria:

  • Patients (18-75) with documented chronic periodontitis and pocket depths >4mm.

Exclusion Criteria:

  • Active oral malignancy or pregnancy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Visible reduction in gingival inflammation and erythema (redness) observed within 7 to 14 days
Time Frame: 7 to 14 days
7 to 14 days

Secondary Outcome Measures

Outcome Measure
Time Frame
Measurement of periodontal pocket depth reduction and tissue stability at 6 weeks
Time Frame: 6 weeks
6 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Amar h Zireg

Collaborators

Self funded

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 3, 2026

Primary Completion (Actual)

February 20, 2026

Study Completion (Actual)

February 26, 2026

Study Registration Dates

First Submitted

April 13, 2026

First Submitted That Met QC Criteria

April 13, 2026

First Posted (Actual)

April 20, 2026

Study Record Updates

Last Update Posted (Actual)

April 28, 2026

Last Update Submitted That Met QC Criteria

April 22, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • ZIREG-ORAL-2026

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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