Indvirkningen af oral cannabisadministration og co-administration af alkohol på svækkelse
29. juli 2026 opdateret af: Johns Hopkins University
Denne undersøgelse vil evaluere de individuelle og interaktive virkninger af oral cannabis og alkohol på subjektive og adfærdsmæssige mål for svækkelse.
Studieoversigt
Status
Status
Afsluttet
Betingelser
Betingelser
Intervention / Behandling
Intervention / Behandling
Detaljeret beskrivelse
Dette kliniske laboratoriestudie vil være dobbeltblindt, placebokontrolleret og vil anvende et eksperimentelt design inden for fagene.
Deltagerne vil gennemføre 7 ambulante lægemiddeladministrationssessioner, der vil bestå af selvadministration af oral cannabis (0, 10 eller 25 mg THC) og alkohol (enten placebo eller aktiv; BAC på 0,05 procent); deltagerne vil altid modtage både en alkoholdrik (aktiv eller placebo) og dosis cannabis (aktiv eller placebo).
Deltagerne vil også fuldføre en tilstand, hvor de administrerer alkohol (BAC: 0,08 procent) med placebo cannabis, som en positiv kontrol.
Primære resultater inkluderer præstationer på feltædruelighedstest, kognitiv og psykomotorisk svækkelse, subjektive lægemiddeleffekter og simuleret kørepræstation.
Blodkoncentrationer af THC og THC-metabolitter vil også blive bestemt.
Undersøgelsestype
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
Tilmelding
70
Fase
Fase
- Fase 1
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
Studiekontakt
- Navn: Tory Spindle, PhD
- Telefonnummer: 410-550-0529
- E-mail: tspindle@jhmi.edu
Studiesteder
-
-
Maryland
-
Baltimore, Maryland, Forenede Stater, 21224
- Johns Hopkins Behavioral Pharmacology Research Unit
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
21 år til 55 år (Voksen)
Tager imod sunde frivillige
Ja
Beskrivelse
Inklusionskriterier:
- Har givet skriftligt informeret samtykke
- Være mellem 21 og 50 år
- Være ved et godt generelt helbred baseret på en fysisk undersøgelse, sygehistorie, vitale tegn og screening af urin- og blodprøver
- Ikke være gravid eller ammende (hvis kvinde). Alle kvinder skal have en negativ serumgraviditetstest ved screeningsbesøget og en negativ uringraviditetstest ved hvert studiebesøg.
- Har et kropsmasseindeks (BMI) i intervallet 19 til 36 kg/m2
- Blodtrykket ved screeningsbesøg overstiger ikke et systolisk blodtryk (SBP) på 150 mmHg eller et diastolisk blodtryk (DBP) på 90 mmHg
- Har ikke doneret blod i de foregående 30 dage.
- Rapportér mindst 2 dages overspisning inden for de seneste 90 dage (flere end 4 eller 5 drinks ved en enkelt lejlighed for henholdsvis kvinder og mænd)
- Rapporter ≥ 5 brug af hash det seneste år
- Giv negativ urintest for ulovligt stofbrug (undtagen THC) og negativ alkoholtest (0 % BAC) ved screening og før studiesessioner
- Rapportér mindst 1 tilfælde af samtidig alkohol og brug inden for det seneste år.
Ekskluderingskriterier:
- Psykoaktivt stofbrug (bortset fra cannabis, nikotin, alkohol eller koffein) i den seneste måned
- Nuværende brug af håndkøbslægemidler (OTC), kosttilskud/vitaminer eller receptpligtig medicin, som efter efterforskerens eller det medicinske personales mening vil påvirke deltagerens sikkerhed
- Historie om eller aktuelle beviser for betydelig medicinsk tilstand
- Bevis på nuværende psykiatrisk tilstand [(MINI for Diagnostic and Statistical Manual (DSM)-V)]
- Opfyld kriterierne for alvorlig alkoholmisbrug (MINI for DSM-V)
- Clinical Institute Abtraction Assessment for Alcohol scale (CIWA-Ar) score > 9
- Har tidligere været i behandling for misbrug af alkohol eller cannabis
- Brug af cannabis i gennemsnit mere end 2 gange om ugen over de seneste 3 måneder
- Leverfunktionsprøver mere end 2x normalområdet
- Tilmelding til et andet klinisk forsøg eller modtagelse af et hvilket som helst lægemiddel som en del af forskning inden for de seneste 30 dage
- Shipley ordforrådsscore <18 (svarer til 5. klasses læseniveau).
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Grundvidenskab
- Tildeling: Randomiseret
- Interventionel model: Crossover opgave
- Maskning: Dobbelt
Antal våben
7
Våben og indgreb
Deltagergruppe / ArmDeltagergruppe / Arm |
Intervention / BehandlingIntervention / Behandling |
|---|---|
|
Placebo komparator: Placebo cannabis + placebo alkohol
Deltagerne administrerer oral cannabis indeholdende 0 mg THC i kombination med en placebo alkoholdrik.
|
Cannabis vil blive indtaget oralt via en brownie
Alkohol indtages oralt via en drink med smag
|
|
Eksperimentel: lav dosis cannabis med placebo alkohol
Deltagerne administrerer oral cannabis indeholdende 10 mg THC i kombination med en placebo alkoholdrik.
|
Cannabis vil blive indtaget oralt via en brownie
Alkohol indtages oralt via en drink med smag
|
|
Eksperimentel: høj dosis cannabis med placebo alkohol
Deltagerne administrerer oral cannabis indeholdende 25 mg THC i kombination med en placebo alkoholdrik.
|
Cannabis vil blive indtaget oralt via en brownie
Alkohol indtages oralt via en drink med smag
|
|
Eksperimentel: lav dosis cannabis med lav dosis alkohol
Deltagerne administrerer oral cannabis indeholdende 10 mg THC i kombination med en alkoholdrik (0,05 procent BAC).
|
Cannabis vil blive indtaget oralt via en brownie
Alkohol indtages oralt via en drink med smag
|
|
Eksperimentel: høj dosis cannabis med lav dosis alkohol
Deltagerne administrerer oral cannabis indeholdende 25 mg THC i kombination med en alkoholdrik (0,05 procent BAC).
|
Cannabis vil blive indtaget oralt via en brownie
Alkohol indtages oralt via en drink med smag
|
|
Eksperimentel: Placebo cannabis + lav dosis alkohol
Deltagerne administrerer oral cannabis indeholdende 0 mg THC i kombination med en alkoholdrik (0,05 procent BAC).
|
Cannabis vil blive indtaget oralt via en brownie
Alkohol indtages oralt via en drink med smag
|
|
Eksperimentel: Placebo cannabis + høj dosis alkohol
Deltagerne administrerer oral cannabis indeholdende 0 mg THC i kombination med en alkoholdrik (0,08 procent BAC).
|
Cannabis vil blive indtaget oralt via en brownie
Alkohol indtages oralt via en drink med smag
|
Hvad måler undersøgelsen?
Primære resultatmål
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Mean Peak Change From Baseline DRUID Application Global Impairment Score
Tidsramme: 7.5 hours, assessed at baseline (prior to drug administration) and again 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours after oral cannabis ingestion.
|
Acute cognitive and behavioral impairment will be assessed with global impairment score (range 0-100) on the DRUID app (higher scores indicate greater impairment).
Results are mean change from baseline.
|
7.5 hours, assessed at baseline (prior to drug administration) and again 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours after oral cannabis ingestion.
|
|
Cumulative Score on Field Sobriety Tests
Tidsramme: 7.5 hours
|
Impairment will be assessed using a battery of standard field sobriety tests including: the Horizontal Gaze Nystagmus Test (HGN), the Walk and Turn, the One Leg Stand, and the Modified Romberg Balance.
We will report the cumulative amount of clues observed across these tasks (out of a possible 0-22 clues).
Higher scores indicate greater/worse impairment.
These assessments were completed once after 7.5 hours.
|
7.5 hours
|
|
Mean Peak Change From Baseline Scores on the Drug Effect Questionnaire (DEQ) - Feel Drug Effect
Tidsramme: 7.5 hours, assessed at baseline (prior to drug administration) and again 0.5, 1, 1.25, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours after oral cannabis ingestion
|
The DEQ will be used to obtain subjective ratings of "feel drug effects".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Results are mean change from baseline and a higher score indicates a more extreme/worse drug effect.
|
7.5 hours, assessed at baseline (prior to drug administration) and again 0.5, 1, 1.25, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours after oral cannabis ingestion
|
|
Drug Effect Questionnaire - Feel High
Tidsramme: 7.5 hours
|
The DEQ will be used to obtain subjective ratings of "feel high".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Higher score greater "feel high" rating.
|
7.5 hours
|
|
Drug Effect Questionnaire - Confidence to Drive (Change From Baseline)
Tidsramme: 7.5 hours
|
The DEQ will be used to obtain subjective ratings of "confidence to drive".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Higher scores indicate higher confidence to drive.
Results expressed as change from baseline
|
7.5 hours
|
|
Drug Effect Questionnaire - Willingness to Drive
Tidsramme: 7.5 hours
|
The DEQ will be used to obtain subjective ratings of "willingness to drive".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Higher score indicates higher willingness to drive.
|
7.5 hours
|
|
Biphasic Alcohol Effects Scale (BAES) - Sedative Score
Tidsramme: Baseline, 7.5 hours
|
The BAES is used to assess sedative and stimulant subjective effects of alcohol.
There are 7 sedative-related questionnaire items, each presented on a scale of 0 (not at all) to 10 (extremely), which are integrated to produce an overall sedative score (0-70).
Higher scores indicating greater sedative effects of alcohol.
Scores presented show the change from baseline to 7.5 hours.
|
Baseline, 7.5 hours
|
|
Biphasic Alcohol Effects Scale (BAES) - Stimulant Score
Tidsramme: 7.5 hours
|
The BAES is used to assess sedative and stimulant subjective effects of alcohol.
There are 7 stimulant-related questionnaire items, each presented on a scale of 0 (not at all) to 10 (extremely), which are integrated to produce an overall stimulant score (0-70).
Higher scores indicating greater stimulant effects of alcohol.
|
7.5 hours
|
|
Subjective High Assessment Scale (SHAS)
Tidsramme: 7.5 hours
|
For the SHAS, participants are presented with 13 questionnaire items, displayed on a visual analog scale anchored from 0 (normal) to 10 (extremely), which assess subjective effects of alcohol.
These items are integrated to produce an overall SHAS score (0-130).
Higher score indicates greater effects of alcohol.
|
7.5 hours
|
|
Driving Performance as Assessed by Standard Deviation of Lateral Position (SDLP)
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
SDLP (measured in cm) was calculated across all drives to get a composite index of lateral control and reported as peak change from baseline.
SDLP is the gold standard of quantifying the magnitude of driving impairment from drugs and alcohol and has excellent predictive validity to actual driving.
Scores range from 0 to no upper limit.
Higher scores represent higher magnitude of driving impairment.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Driving Performance as Assessed by Composite Drive Score
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Driving impairment will be assessed via a composite drive score.
The composite drive score is derived by integrating various driving outcomes (see primary and secondary driving outcomes).
Higher z-score indicates worse performance.
The score is on a z-score scale, meaning a score of 1 equates to 1 standard deviation outside of the participants' mean baseline performance and a Z-score of 0 represents the mean baseline performance.
This was calculated across all drives and reported as peak change from baseline.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Sekundære resultatmål
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Driving Performance as Assessed by Standard Deviation of Speed (SDSP)
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
SDSP will be calculated across all drives to get a composite index of the variability in speed (measured in MPH) and is reported as peak change from baseline.
Scores range from 0 to no upper limit.
Higher scores represent higher magnitude of driving impairment.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Total Run Length
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
Total run length will be calculated across all drives and measured as peak change from baseline score (in seconds).
Higher scores represent higher magnitude of driving impairment.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Driving Performance (Number of Speed Exceedances)
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
Driving performance will be calculated across all drives to get a cumulative number of times participants exceed the allowable speed limit and reported as peak change from baseline.
Scores range from 0 to no upper limit.
Higher scores represent higher numbers of speed exceedances.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Driving Performance (Number of Accidents)
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
Driving performance will be calculated across all drives to get a cumulative number of accidents (including car collisions, pedestrians hit, etc.) and reported as peak change from baseline.
Scores range from 0 to no upper limit.
Higher scores represent higher numbers of accidents.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Driving Performance (Total Rule Violations)
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
Driving performance will be calculated across all drives to get a cumulative number of total rule violations (including number of missed stop signs, illegal turns, speed exceedances, etc.) and reported as peak change from baseline.
Scores range from 0 to no upper limit.
Higher scores represent higher numbers of rule violations.
All scores reported are relative to baseline, thus negative values represent a lower number of rule violations than at baseline.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Driving Performance (Distance to Lead Vehicles)
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
The STISIM Drive® M4000-R Console system will be used to assess driving performance, a state-of-the-art technology that has been independently validated to reflect real-world driving conditions.
Driving performance will be calculated across all drives to get the mean distance (in meters) maintained to lead vehicles during car-following segments and reported as peak change from baseline.
Scores range from 0 to no upper limit.
Higher scores represent greater distance maintained to lead vehicles.
All scores reported are relative to baseline, thus negative values represent a shorter distance maintained than at baseline.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Change in Field Sobriety Test - Score on Horizontal Gaze Nystagmus Test
Tidsramme: Baseline, 7.5 hours
|
Impairment will be assessed using performance on the Horizontal Gaze Nystagmus Test (HGN).
Total score will be recorded (out of possible 0-6 clues) with higher scores indicating higher impairment.
Assessed at baseline and 7.5 hours, change from baseline to 7.5 hours reported
|
Baseline, 7.5 hours
|
|
Change in Field Sobriety Test - Score on Walk and Turn Test
Tidsramme: Baseline, 7.5 hours
|
Impairment will be assessed using performance on the the Walk and Turn.
Total score will be recorded (out of a possible 0-8 clues) with higher scores indicating higher impairment.
Assessed at baseline and 7.5 hours, change from baseline to 7.5 hours reported
|
Baseline, 7.5 hours
|
|
Change in Field Sobriety Test - Score on One Leg Stand
Tidsramme: Baseline, 7.5 hours
|
Impairment will be assessed using performance on the One Leg Stand test.
Total score will be recorded (out of a possible 0-4 clues) with higher scores indicating higher impairment.
Assessed at baseline and 7.5 hours, change from baseline to 7.5 hours reported
|
Baseline, 7.5 hours
|
|
Change in Field Sobriety Test - Score on Modified Romberg Balance
Tidsramme: Baseline, 7.5 hours
|
Impairment will be assessed using performance on the Modified Romberg Balance test.
Total score will be recorded (out of a possible 0-4 clues) with higher scores indicating higher impairment.
Assessed at baseline and 7.5 hours, change from baseline to 7.5 hours reported
|
Baseline, 7.5 hours
|
|
Drug Effect Questionnaire - Like Drug Effect
Tidsramme: 7.5 hours
|
The DEQ will be used to obtain subjective ratings of "like drug effect".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Higher score indicating greater "liked drug effect" rating.
|
7.5 hours
|
|
Drug Effect Questionnaire - Dislike Drug Effect
Tidsramme: 7.5 hours
|
The DEQ will be used to obtain subjective ratings of "dislike drug effect".
Score range from 0 (none) to 100 (extreme) using a 100mm line anchored with none/extreme designation.
Higher score indicating greater "dislike drug effect" rating.
|
7.5 hours
|
|
Pharmacokinetics - CMax for THC and THC Metabolites
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Whole blood concentrations of THC, 11-OH-THC, and THCCOOH will be measured using quantitative liquid chromatography-tandem mass spectrometry (LC-MS-MS) analysis.
The maximum concentration (Cmax) is determined as the highest concentration reached for each individual (ng/mL) across all timepoints.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Pharmacokinetics - AUC for THC and THC Metabolites
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Whole blood concentrations of THC, 11-OH-THC, and THCCOOH will be measured using quantitative liquid chromatography-tandem mass spectrometry (LC-MS-MS) analysis.
The area under the curve (AUC) is calculated cumulative across all timepoints.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Pharmacokinetics - CMax for Alcohol
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
BAC will be measured using the Alco-Sensor IV.
Measuring BAC is needed to confirm that participants reached the targeted BAC for a given session and to confirm adherence to pre-session alcohol abstinence requirements (g/210L).
The maximum concentration (Cmax) is determined as the highest concentration reached for each individual (ng/mL) across all timepoints.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
|
Pharmacokinetics - AUC for Alcohol
Tidsramme: Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Whole blood concentrations of Alcohol will be measured using quantitative liquid chromatography-tandem mass spectrometry (LC-MS-MS) analysis.
The area under the curve (AUC) is calculated cumulative across all timepoints.
|
Baseline, 1, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, and 7.5 hours
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Sponsor
Samarbejdspartnere
Samarbejdspartnere
Efterforskere
Efterforskere
- Ledende efterforsker: Tory Spindle, PhD, Johns Hopkins University
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
Studiestart
17. februar 2022
Primær færdiggørelse (Faktiske)
Primær færdiggørelse
15. august 2025
Studieafslutning (Faktiske)
Studieafslutning
15. august 2025
Datoer for studieregistrering
Først indsendt
Først indsendt
11. juni 2021
Først indsendt, der opfyldte QC-kriterier
Først indsendt, der opfyldte QC-kriterier
11. juni 2021
Først opslået (Faktiske)
Først opslået
18. juni 2021
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering sendt
3. august 2026
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
29. juli 2026
Sidst verificeret
Sidst verificeret
1. juli 2026
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
Andre undersøgelses-id-numre
- IRB00290015
- 1R01DA052295-01 (U.S. NIH-bevilling/kontrakt)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
INGEN
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ja
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
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