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Ketamin og neuropatisk smerte (KETAPAIN)

5. november 2026 opdateret af: University Hospital, Clermont-Ferrand

The primary outcome is to compare the analgesic efficacy of intravenous ketamine treatment to that of a placebo in patients with refractory neuropathic pain.

The secondary outcomes are:

  1. - To compare the additive analgesic efficacy of prior administration of magnesium sulfate to that of placebo and ketamine only, on the effectiveness of intravenous ketamine treatment,
  2. - To study the evolution time of pain and analgesia after the intravenous administration of ketamine and placebo,
  3. - To study the correlation of the analgesic response to administered products respectively ketamine, ketamine and magnesium sulfate, placebo.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Description of the study:

Single-center clinical trial, controlled, randomized, double-blind, crossover design, against inactive placebo.

Each patient will receive successively the 3 products (ketamine / placebo, ketamine / magnesium sulfate, placebo / placebo) follows a predeter randomization list, with a wash-out period between each administration.

Visit 1

-Inclusion visit, signature of informed consent form, clinical examination and fill questionnaires.

For women of childbearing age a pregnancy test will be performed.The pain will be measured by a numerical scale.

The pain will be evaluated by scoring on a numerical scale. A booklet for monitoring analgesic concomitant medication and overall pain on a numerical scale will be given to the patient 14 days before the programmed infusion.

Visit 2 : Period 1 Day 0

Clinical examination, return of booklet completed by patient and fill questionnaires.

The pain will be evaluated by scoring on a numerical scale before and after the infusion.

For women of childbearing age a pregnancy test will be performed. Treatment allocation period follows a predeter randomization list. At the end of the infusion, a booklet for monitoring will be given to patients for the following weeks in order to score their overall pain until the next study period.

The output of the hospital patient (CPC / CETD) after each treatment will be authorized by the investigator.

Wash-out period: 5 weeks.

Phone call 1 (Day 1):

Patients will be called by phone to collect adverse events and concomitant medications. If necessary, the patients should return to consult the CPC / CETD for a clinical examination.

Patients will be called the week before their scheduled visit, if at that time their spontaneous pain is still low, according to the opinion of the investigator, the infusion visit will be shifted to allow the pain level back its basal level.

Visit 3 : Period 2 : Day 36 +/- 3 days

Same of period 1.

Phone call 2 J 37 +/- 3 days:

Same of phone call 1.

Visit 4 : Period 3 : Day 72 +/- 3 days

Same of period 1

Phone call 3 J 73 +/- 3 days:

Same of phone call 1.

Visit 5 : Day 108 +/- 3 days

Clinical examination, return of booklet completed by patient and fill questionnaires.

The pain will be evaluated by scoring on a numerical scale For women of childbearing age a pregnancy test will be performed. This visit is the end of the study.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

23

Fase

  • Fase 2

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Frankrig
      • Clermont-Ferrand, Frankrig, 63003
        • CHU de Clermont-Ferrand

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • Patient (s) are at least18 years old, with chronic pain (for more than 3 months), having the characteristics of a peripheral or central neuropathy, follow (s) at the Pain Clinic CHU Clermont-Ferrand and justifying the establishment of a therapeutic program including intravenous infusion of ketamine (as therapeutic test);
  • Patient (s) who had never received ketamine infusion under the care of their neuropathic pain;
  • History of illness compatible with an injury or disease of the somatosensory system;
  • Localized pain in an anatomical neuro territory;
  • Neurological examination shows sensory abnormalities,
  • The patients of childbearing potential must use effective contraception throughout the study;
  • For womens of childbearing age, they will be enrolled in the study after a negative urine pregnancy test; in case of suspicion of pregnancy, a blood pregnancy test should be performed;
  • Cooperation and willing to follow the study;
  • Acceptance to give written consent;
  • Affiliated to the French social security;
  • Inscription or acceptation of inscription in the national register of volunteers involved in trials.

Exclusion Criteria:

  • Patient (s) who have received intravenous ketamine infusion;
  • Patients with one or many contraindication to ketamine administration: known hypersensitivity to ketamine in which one of the constituents of the product, uncontrolled high blood pressure, severe cardiac insufficiency;
  • Patients with one or many contraindication of magnesium sulfate administration: Patients with severe renal impairment;
  • Patients with one or many contraindication to administration of sodium chloride: water inflation, fluid retention;
  • Patients with a medical history and / or surgical judged by the investigator to be not consistent with the clinical trial;
  • Patients with drug treatments judged by the investigator to be not consistent with the clinical trial;
  • Pregnancy or lactation women;
  • Patient who participated in another clinical trial, located in exclusion period or received benefits > 4500 euros during 12 months before the beginning of trial;
  • Patients with cooperation and understanding not to adhere strictly to the conditions provided in the clinical trial;
  • Patients receiving a measure of legal protection (guardianship…);
  • Patients are not affiliated to the System of the French Social Security

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Crossover opgave
  • Maskning: Dobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: INTRAVENØS KETAMINE
Medicin: Ketamin
Medicin: Magnesiumsulfat
Medicin: placebo: natriumchlorid

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Tidsramme
Numerisk vurderingsskala (NRS)
Tidsramme: på dag 1 og i en periode på 5 uger (35 dage).
på dag 1 og i en periode på 5 uger (35 dage).

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Intensity of the average
Tidsramme: at day 1

Intensity of the average daily pain evaluated by a numerical rating scale (NRS) assessed using a booklet
at day 1
Intensity of maximum daily pain
Tidsramme: at day 1

Intensity of maximum daily pain evaluated by a numerical rating scale (NRS) assessed using a booklet,
at day 1
Impact on quality of life
Tidsramme: at day 1

Impact on quality of life, mood and sleep assessed by questionnaires.
at day 1
Impact on mood
Tidsramme: at day 1

Impact on quality of life, mood and sleep assessed by questionnaires.
at day 1
Impact on sleep
Tidsramme: at day 1

Impact on quality of life, mood and sleep assessed by questionnaires.
at day 1

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

University Hospital, Clermont-Ferrand

Efterforskere

  • Ledende efterforsker: Gisèle PICKERING, University Hospital, Clermont-Ferrand

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

10. november 2015

Primær færdiggørelse (Faktiske)

13. maj 2018

Studieafslutning (Faktiske)

13. november 2018

Datoer for studieregistrering

Først indsendt

29. maj 2015

Først indsendt, der opfyldte QC-kriterier

5. juni 2015

Først opslået (Anslået)

10. juni 2015

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

9. november 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

5. november 2026

Sidst verificeret

1. juli 2016

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • CHU-0235

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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