Hjertesvigt-USB: Forudsigelse og progression (HF-USB)
This retrospective cohort study is to identify triggers of heart failure (HF) development and drivers of HF progression as well as the underlying cardiac disease (phenotype) to identify patients at risk and predict the clinical course of the disease. Data of patients who were hospitalized during the years 2010-2023 with acute coronary syndrome (ACS) and/ or with acute heart failure (AHF) will be collected and analyzed. In a subgroup cohort efficacy and safety of digoxin in patients with acute heart failure triggered by tachyarrhythmia will be evaluated.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Undersøgelsestype
Tilmelding (Anslået)
Kontakter og lokationer
Studiekontakt
- Navn: Christian Müller, Prof. Dr.
- Telefonnummer: 0041 6132 86 549
- E-mail: Christian.mueller@usb.ch
Undersøgelse Kontakt Backup
- Navn: Fiona Nafaa, MD
- Telefonnummer: +41 61 32 87747
- E-mail: fiona.nafaa@usb.ch
Studiesteder
-
-
-
Basel, Schweiz, 4031
- Rekruttering
- Cardiology, University Hospital Basel
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Kontakt:
- Christian Mueller, Prof. Dr.
- Telefonnummer: +41 61 32 86 549
- E-mail: Christian.mueller@usb.ch
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Patients that were hospitalized at the Universitätsspital Basel/ Switzerland with the diagnosis of ACS or AHF during the years 2010 - 2023
Beskrivelse
Inclusion Criteria:
- Patients hospitalized with a primary diagnosis of ACS
- Patients hospitalized with a primary or secondary diagnosis of AHF
Exclusion Criteria:
- Existence of a documented statement of the patient against the scientific use of clinical data
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: COHORT
- Tidsperspektiver: RETROSPECTIVE
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
|
acute coronary syndrome (ACS)
Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary diagnosis of ACS is analyzed. |
data generated by medical review include Medical history, Medications at presentation, during hospitalization and at discharge, New York Heart Association (NYHA) class, Killip class, Electrocardiographic (ECG) data, echocardiographic data, Interventions (Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft (CABG), Implantable Cardioverter Defibrillator (ICD) implantation, Cardiac Resynchronization Therapy (CRT) Implantation), Outcome Information: all-cause death, HF hospitalizations data generated by direct IT export include Anthropometric data (age, sex, height, weight), Vital signs, Laboratory data |
|
acute heart failure (AHF)
Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary or secondary diagnosis of AHF is analyzed. |
data generated by medical review include Medical history, Medications at presentation, during hospitalization and at discharge, New York Heart Association (NYHA) class, Killip class, Electrocardiographic (ECG) data, echocardiographic data, Interventions (Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft (CABG), Implantable Cardioverter Defibrillator (ICD) implantation, Cardiac Resynchronization Therapy (CRT) Implantation), Outcome Information: all-cause death, HF hospitalizations data generated by direct IT export include Anthropometric data (age, sex, height, weight), Vital signs, Laboratory data |
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
number of all-cause death
Tidsramme: 1 to 8 years after hospitalization
|
number of all-cause death in patients hospitalized with ACS and AHF during the years 2010-2023. |
1 to 8 years after hospitalization
|
|
number of HF hospitalizations
Tidsramme: 1 to 8 years after hospitalization
|
number of new HF hospitalizations in patients hospitalized with ACS and AHF during the years 2010-2023 |
1 to 8 years after hospitalization
|
|
number of cardiovascular death
Tidsramme: 1 to 8 years after hospitalization
|
number of cardiovascular death in patients hospitalized with ACS and AHF |
1 to 8 years after hospitalization
|
|
number of cardiovascular hospitalizations
Tidsramme: 1 to 8 years after hospitalization
|
number of cardiovascular hospitalizations |
1 to 8 years after hospitalization
|
Samarbejdspartnere og efterforskere
Efterforskere
- Ledende efterforsker: Christian Müller, Prof. Dr., Cardiology University Hospital Basel
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- 2019-00956
- 2019 (U.S. NIH-bevilling/kontrakt)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Studerer et amerikansk FDA-reguleret enhedsprodukt
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