Cognitive Impairment in Older Adults With Hematologic Malignancies
Prevalence of Cognitive Impairment and Its Association With Activities of Daily Living Among Older Adults With Hematologic Malignancies Receiving Chemotherapy
This cross-sectional study aims to determine the prevalence of cognitive impairment and evaluate its relationship with activities of daily living among older adults with hematologic malignancies receiving chemotherapy.
Studieoversigt
Status
Detaljeret beskrivelse
Cognitive impairment is common among older adults with cancer and may affect treatment adherence and independence. This observational study will include adults aged 65 years or older with confirmed hematologic malignancies who are currently receiving chemotherapy.
Participants will undergo cognitive assessment using the Montreal Cognitive Assessment (MoCA) and functional assessment using the Katz Index of Activities of Daily Living (ADL) and Lawton Instrumental Activities of Daily Living (IADL).
Undersøgelsestype
Tilmelding (Anslået)
Kontakter og lokationer
Studiekontakt
- Navn: Kholoud K Fawzy, Resident
- Telefonnummer: 01009850621
- E-mail: khloud.18313604@med.aun.edu.eg
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Older adults aged 65 years or older with confirmed hematologic malignancies receiving chemotherapy at Assiut University Hospitals.
Beskrivelse
Inclusion Criteria:
- - Age 65 years or older
- Confirmed diagnosis of hematologic malignancy
- Currently receiving chemotherapy
- Able to communicate and participate in cognitive assessment
- Written informed consent
Exclusion Criteria:
- - Previously diagnosed dementia before the diagnosis of malignancy
- Delirium at the time of assessment
- Severe visual or hearing impairment interfering with cognitive testing
- History of major neurological disorders affecting cognition
- Severe psychiatric illness affecting cognitive assessment
- Critically ill patients unable to complete study assessment
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Observationsmodeller: CASE_ONLY
- Tidsperspektiver: CROSS_SECTIONAL
Kohorter og interventioner
Gruppe / kohorte |
|---|
|
Single cohort: Older adults with hematologic malignancies
Adults aged 65 years or older with hematologic malignancies receiving chemotherapy who will undergo cognitive and functional assessment. |
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Prevalence of cognitive impairment
Tidsramme: Baseline
|
Proportion of participants with cognitive impairment defined as a Montreal Cognitive Assessment (MoCA) score less than 26. |
Baseline
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Mean MoCA score
Tidsramme: Baseline
|
Mean Montreal Cognitive Assessment (MoCA) score (range 0-30, higher scores indicate better cognition).. |
Baseline
|
|
Mean Katz ADL score
Tidsramme: Baseline
|
Mean Katz Index of Independence in Activities of Daily Living score (range 0-6, higher scores indicate greater independence). |
Baseline
|
|
Mean Lawton IADL score
Tidsramme: Baseline
|
Mean Lawton Instrumental Activities of Daily Living score (range 0-8, higher scores indicate greater independence) |
Baseline
|
|
Proportion with impaired activities of daily living
Tidsramme: Baseline
|
Proportion of participants with impaired Katz ADL score. |
Baseline
|
|
Proportion with impaired instrumental activities of daily living
Tidsramme: Baseline
|
Proportion of participants with impaired Lawton IADL score. |
Baseline
|
Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Studiestol: Soher M kasem, prof, Internal Medicine Department, Assiut University Hospitals
Datoer for undersøgelser
Studer store datoer
Studiestart (Anslået)
Primær færdiggørelse (Anslået)
Studieafslutning (Anslået)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- Cognitive-Hematology-Assiut-20
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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