A Study of HGS1036 in Combination With Chemotherapy in Subjects With Advanced Solid Malignancies

Inclusion Criteria:

• Have a histological or cytological diagnosis of malignant solid neoplasm requiring systemic chemotherapy.
• Age ≥18 years.
• ECOG performance status 0-1.
• Adequate organ function.
• Adequate hematological function.
• Have the ability to understand the requirements of the study, provide written informed consent, and comply with the study protocol procedures.
• Consent to collection of previously obtained, archival biopsy or surgical specimens of the currently treated malignancy when available.

Exclusion Criteria:

• Significant cardiac disease.
• Eye trauma or disease.
• Ocular surgery or blunt force trauma to the eye requiring treatment within 3 months prior to first dose of HGS1036.
• Presence or history of ≥ Grade 2 hemoptysis within 2 weeks of the first dose of HGS1036.
• Major surgery within 4 weeks of the first dose of HGS1036.
• Prior organ or allogeneic stem cell transplant.
• Non-healing or chronic wounds.
• Receipt of any anti-cancer therapy within 4 weeks prior to first dose of HGS1036.
• Receipt of any biological therapy (such as monoclonal antibodies) within 6 weeks of the first dose of HGS1036.
• Active CNS involvement by primary or metastatic tumor.
• Documented active infection requiring the use of systemic antibiotics.
• Pregnancy or lactation.
• Known HIV-positive serology, AIDS, or an AIDS-related illness.
• Conditions likely to increase the potential for abdominal perforation or fistula formation.