- ICH GCP
- Registro de ensayos clínicos de EE. UU.
- Ensayo clínico NCT03359122
Association of COPD Maintenance Medication Adherence With Resource Use and Cost Among COPD Patients (MARU)
Association of COPD Maintenance Medication Adherence With Resource Use and Cost Among COPD Patients-Retrospective Observational Cohort Study
Descripción general del estudio
Estado
Condiciones
Descripción detallada
Objectives: The primary objective of this study is to examine the association of COPD maintenance inhalation medication (Inhaled Corticosteroid or ICS) adherence with COPD exacerbation healthcare resource utilization among COPD patients with exacerbation history.
Study design: This study is a retrospective database analysis using 2014-2016 Guangzhou City health insurance database.
Data Source(s): Guangzhou city health insurance database will be used for this study. All outpatient and inpatient visits for one patient during 2014-2016 were available.
Study Population: This study will include patients with a physician COPD diagnosis in Guangzhou city health insurance database during 2015 and with complete treatment data during 1 year before and 1 year after the index date. The rough sample size of the study population was 49,000.
Outcome(s):
- Indicators of COPD control: exacerbations;
- Health resource utilization: annual number of inpatient days, inpatient visit number, emergency department (ED) visit number;
- Costs: COPD exacerbation hospitalization expenditures, all-cause hospitalization expenditure.
Statistical Analysis:
Descriptive statistics will be used for all variables, as appropriate. Continuous variables will be summarized by the number of observations, mean, standard deviation, median, minimum, maximum, first quartile and third quartile. Categorical variables will be summarized by frequency counts and percentages at each category. Number of patients and number of missing for each variable will be summarized.
Logistic regression will be used to estimate the risk of any hospitalization. Generalized Linear Models (GLMs) with a gamma distribution and log link will be used to approximate the highly right-skewed distribution of medical expenditure.
For exploratory objectives, Propensity Score Matching (PSM) will be used to explore the association of medication class and health resource utilization if applicable. The interaction of medication class * adherence or subgroup analysis (by medication class) will be considered when conducting the regression model.
Tipo de estudio
Inscripción (Actual)
Contactos y Ubicaciones
Ubicaciones de estudio
-
-
-
Beijing, Porcelana, 100000
- Research Site
-
-
Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
- Niño
- Adulto
- Adulto Mayor
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Método de muestreo
Población de estudio
Descripción
Inclusion Criteria:
- Patients diagnosed with COPD in 2015;
- Patients had complete hospital visit data available during pre-index 1 year period and post 1 year follow-up;
- Patients had at least one COPD exacerbation during 1 year prior to the index date;
- Patients had at least 2 COPD maintenance medication claims during post index 1 year period, as 2 claims are recommended to calculate adherence.
Exclusion Criteria:
- Inability to determine diagnoses from claims;
- Individuals with other chronic respiratory conditions such as respiratory cancer, pulmonary fibrosis, asthma.
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
---|---|---|
Indicators of COPD control
Periodo de tiempo: 2015.01-2016.12
|
Number of exacerbations
|
2015.01-2016.12
|
Health resource utilization
Periodo de tiempo: 2015.01-2016.12
|
Annual number of inpatient days
|
2015.01-2016.12
|
Costs of inpatient treatment
Periodo de tiempo: 2015.01-2016.12
|
Cost of COPD exacerbation inpatient treatment
|
2015.01-2016.12
|
Health resource utilization
Periodo de tiempo: 2015.01-2016.12
|
Inpatient visit number
|
2015.01-2016.12
|
Health resource utilization
Periodo de tiempo: 2015.01-2016.12
|
Emergency department (ED) visit number
|
2015.01-2016.12
|
Costs of inpatient treatment
Periodo de tiempo: 2015.01-2016.12
|
Cost of all-cause inpatient treatment
|
2015.01-2016.12
|
Colaboradores e Investigadores
Patrocinador
Publicaciones y enlaces útiles
Enlaces Útiles
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Actual)
Finalización del estudio (Actual)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Términos MeSH relevantes adicionales
Otros números de identificación del estudio
- D2287R00123
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .