Non-acute Coronary occlusIon Treated By Everolimus ELuting Stent (CIBELES)

Inclusion Criteria:

• Patients ≥ 18 year-old.
• A total occlusion (TIMI 0-1) with an estimated time of occlusion > 2 weeks.
• Symptomatic or silent ischaemia, or viable myocardium.
• The occlusion is suitable for percutaneous coronary intervention.
• The guidewire has crossed the occlusion, and the occlusion has been dilated with balloon or other device.

Exclusion Criteria:

• Acute myocardial infarction in the myocardial area supplied by the target vessel within 2 weeks before the inclusion in the study.
• The lesion can not be crossed with the guidewire and balloon angioplasty.
• The vessel has been previously treated percutaneously.
• The lesion is not suitable for a 2.25-3.5 coronary stent implantation.
• The patient is not willing to undergo an angiographic follow-up.
• The patient has contraindications for prolonged double (aspirin plus clopidogrel) anti-platelet therapy (e.g. allergy to aspirin, need for chronic oral anti-coagulation, or scheduled surgical intervention within 12 months.
• Pregnancy or absence of pregnancy test in women of childbearing age.
• Chronic renal failure (creatinine plasmatic values > 3.0 mg/dl).
• Plasmatic platelet count < 100.000 mm-3 or > 700.000 mm-3.
• The patient has a severe non-cardiac disease that limits his/her life expectancy to < 1 year.
• The patient is currently included in other randomized trial.