Intervento di esercizi Gerofit per anziani con anemia falciforme (studio SICKLE-FIT) (SICKLE-FIT)

Sperimentale: Esercizio

Ogni gruppo di 5-8 partecipanti si eserciterà 3 giorni a settimana per un massimo di 12 settimane. Le sessioni di allenamento saranno virtuali

Comportamentale: Programma di esercizi Gerofit

L'intervento di esercizi tele-Gerofit ha una formazione focalizzata sul rispetto delle linee guida sull'attività fisica e sull'incorporazione di allenamento cardiovascolare, di forza e di equilibrio. Le sessioni includeranno anche una componente di consapevolezza, riscaldamento, defaticamento e controlli di sicurezza. Gli esercizi sono personalizzati in base allo stato funzionale di ogni persona. L'intensità degli esercizi sarà determinata dai partecipanti fornendo una valutazione dello sforzo percepito (RPE) su una scala da 0 (facile) a 10 (molto difficile) per tutta la sessione. Le sessioni di allenamento iniziali inizieranno a bassa intensità e aumenteranno gradualmente la durata e l'intensità per consentire a ogni persona di raggiungere i livelli di esercizio raccomandati al proprio ritmo. Gli esercizi vengono svolti virtualmente tramite Zoom. Ogni coorte avrà 5-8 partecipanti. Il programma di esercizi sarà ottimizzato dopo ogni coorte con modifiche basate sul feedback dei partecipanti e degli esperti degli esercizi.

Feasibility, as Measured by Number of Participants Completing at Least 50% of the Exercise Sessions

Safety, as Measured by Number of Participants With Moderate or Severe Adverse Events

Number of participants with one or more moderate or severe adverse events within 48 hours after each exercise session.

Acceptability, as Measured by the Number of Participants Reporting the Intervention as Acceptable

Acceptability of the exercise program was measured on a scale of 1-10, where 1= severe dislike and 10 = absolute enjoyment. Reported as the number of participants with scores of 8-10.

Percent of Participants With Clinically Meaningful Change in Mobility as Measured by Usual Gait Speed

Reported as the percent change in usual walking speed on a 4.57 meter (15 feet) walking course.

Percent of Participants With Clinically Meaningful Change in Balance as Measured by Timed Up and Go

Performance test of physical mobility. This measures the number of seconds it takes to stand up from a standard chair (46cm), walk a distance of 10 ft (3 meters), turn back to the chair, and sit down again.

Percent of Participants With Clinically Meaningful Change in Aerobic Endurance as Measured by Six-Minute Walk Test (6MWT)

Measure of aerobic endurance. The participant walks as fast and as safely as possible for 6 minutes with prompts given every minute. Distance traveled in 6 minutes is recorded.

Percent of Participants With Clinically Meaningful Change in Upper Body Strength as Measured by Grip Strength

Measure of upper body strength. Jamar hydraulic hand dynamometer (Jamar Technologies) was used to measure grip strength in triplicate for both hands while subject remains seated. The greatest value was used in analysis.

Percent of Participants With Clinically Meaningful Change in Lower Body Strength as Measured by 30-second Chair Stand

30-second chair stand is a measure lower body strength. The participant sits in a folding chair without arms with chair pressed against the wall and stands up and sits back down with arms across their chest as many times as possible in 30 seconds.

Percent of Participants With Improved Quality of Movement Measured by Functional Movement Screen

Includes deep squat and mobility test of upper and lower extremities. This is measure of squat quality/form.