FACBC Positron Emission Tomography/Computed Tomography(PET/CT) Used in the Diagnosis of Primary Prostate Cancer
Anti-[18F]FACBC PET-CT for the Characterization of Primary Prostate Cancer
The purpose of this research project is to test if a compound (chemical substance) has a natural tendency to go to prostate cancer. This compound has a small amount of radioactivity attached to it and is called a radiotracer. The name of the radiotracer is FACBC and can be detected on a special imaging device called a PET scanner (positron emission tomography). The radiotracer is treated in the body much like an amino acid which is a nutrient required for normal functioning. Tumors also use these nutrients. Earlier studies have shown that this radiotracer may be able to detect prostate cancer.
The investigators will perform a study with 20 patients in whom they know have prostate cancer after a biopsy and who are scheduled for an operation in which the prostate is removed and the nearby lymph nodes are examined. This operation is called prostatectomy. The investigators think that this radiotracer can help us determine where exactly the prostate cancer is present in the prostate or if it has spread. This information may be useful in the future to help with other non-surgical therapy such as radiation beam therapy.
The investigators will compare the results of the FACBC PET scan to the results of the pathology analysis of the removed prostate. In this way the investigators can determine how good a test FACBC PET is for finding out where and if prostate cancer is located in the prostate or nearby lymph nodes. The investigators will also do more advanced analysis on the biopsy samples to see if they can tell why FACBC goes into prostate cancer cells.
This radiotracer has been tested in over 100 human subjects without incident. It has also been chosen by the National Institutes of Health (NIH) as a promising radiotracer. The NIH is funding this study.
調査の概要
研究の種類
入学 (実際)
段階
- フェーズ2
連絡先と場所
研究場所
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Georgia
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Atlanta、Georgia、アメリカ、30322
- Emory University Hospital
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Patients must be 18 years of age or older.
- Patients will be scheduled for prostatectomy based on a diagnosis of primary prostate cancer.
- Ability to lie still for PET scanning
- Patients must be able to provide written informed consent.
Exclusion Criteria:
- Age less than 18
- Inability to lie still for PET scanning
- Cannot provide written informed consent.
- Less than 4 weeks since any prior prostate biopsy (to decrease false positive uptake from inflammation).
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：診断
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：FACBC Imaging
Dynamic FACBC PET of primary prostate carcinoma.
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Anti[18F]FACBC (10mci) will be given intravenously over 1-2 minutes prior to obtaining PET-CT images At 4 minutes, 10 consecutive/4minutes images will be obtained of the pelvis to include the prostate.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Diagnostic Performance Per Sextant at Each Time Point by Visual Analysis
時間枠：At 4, 16, 28 and 40 minutes post-injection of FACBC
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Each of 12 sextants per prostate (for a total of 120 sextants for the 10 patients) were analyzed separately at 4, 16, 28 and 40 min post-injection for the presence or absence of focal activity suspicious for tumor. Sensitivity: Proportion of people with a disease who have a positive test result Specificity: The proportion of people without disease who have a negative test result Positive Predictive Value (PPV):The probability that a person who has a positive test result has the disease for which the test was conducted. Negative Predictive Value (NPV): The probability that a person who has a negative test result does not have the disease for which the test was conducted Accuracy: Ability of the test to differentiate between disease and non-disease. Note: 'n=' is the denominator used to compute each parameter. |
At 4, 16, 28 and 40 minutes post-injection of FACBC
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Mean SUVmax of Low Versus High Gleason Groups
時間枠：4 minutes,16 minutes,28 minutes and 40 minutes
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To determine id radiotracer uptake correlates with gleason score
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4 minutes,16 minutes,28 minutes and 40 minutes
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協力者と研究者
スポンサー
捜査官
- 主任研究者：David M Schuster, MD、Emory University
出版物と役立つリンク
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。
anti [18F]FACBCの臨床試験
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Blue Earth DiagnosticsAmerican College of Radiology; Syne Qua Non Limited; IND 2 Results LLC完了
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Bital Savir-BaruchBlue Earth Diagnosticsわからない
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St. Olavs HospitalNorwegian University of Science and Technology; Norwegian Cancer Society完了
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Baptist Health South FloridaBlue Earth Diagnostics募集
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OHSU Knight Cancer InstituteOregon Health and Science University; Blue Earth Diagnostics積極的、募集していない
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Blue Earth DiagnosticsSyne Qua Non Limited; Innovate UK; IND 2 Results LLC完了