摂食障害における急性運動への反応
2026年7月31日 更新者：University of Wisconsin, Madison
制限性摂食障害における急性運動反応の特徴付け
摂食障害（ED）を持つ人は、精神疾患の中でも死亡率が最も高く、優先度の高い臨床集団を代表しており、強制的な運動（DEx）は、ED患者の最大80％に認められる症状であり、機能障害を増大させ、悪影響を及ぼします。治療結果に影響を与えます。
この研究では、EDを患う青年期および若年成人女性の運動に対する認知的、感情的、生物学的反応を特徴づけるタスクを開発し、急性の運動反応が自由生活活動およびDExと関連しているかどうかを判断します。
この R21 プロジェクトは、運動による症状をより正確にターゲットとした治療法の研究開発を導き、最終的に ED に関連する臨床転帰を改善するための基礎データを提供します。
調査の概要
詳細な説明
摂食障害 (ED) は、すべての精神疾患の中で最も致死性の高いものの 1 つです。
しかし、ED の第一選択治療は、思春期患者のおよそ 40% にしか効果がありません。
治療効果に対する障壁の 1 つは、駆動型運動 (DEx; 体重をコントロールしたり感情を調節したりするために強迫的に運動すること) の持続であり、これは拘束性 ED と診断された多くの青少年 (59 ～ 73%) の間で報告されている特徴的な症状です。
他の負の後遺症の中でも、DEx は、自殺行動、治療成績の低下、併発する精神病理の増加、および再発のリスクと関連しています。
さらに、ED 患者と健康な集団を区別する複数の食事関連タスクが検証されていますが、現時点では ED 集団の運動に対する感受性と反応性を直接評価する、十分に検証されたタスクはありません。
DEx は ED の維持に重要な役割を果たしている、あまり理解されていない症状であるため、その生体行動の基礎を調査することは非常に重要です。
既存の研究は、運動の報酬機能と脅威機能の両方を指摘しており、それがED患者のDExを促進し永続させる可能性があるとしている。
ED を持つ人々における運動の報酬機能と脅威機能の両方を評価することにより、この ED 機能のメカニズムの理解が深まります。最終的には、DEx についての理解が深まり、治療目標の情報が得られるでしょう。
提案されたプロジェクトでは、急性運動反応の包括的な評価に参加するために、ED を有する (n = 67) および持たない (n = 33) 青年期および若年成人女性 (16 ～ 22 歳) を 2 つの施設から募集します。
現在のプロジェクトでは、1) ED の有無における中強度の運動への実験室曝露に対する生体行動反応の変動を特徴づけます。 2) 運動中の報酬と脅威に関連するシステムの関与を捉えるタスクを作成し、改良する。 3) 急性運動反応は ED 患者の間でより顕著であり、急性運動反応は ED 症状の重症度、DEx、および自由生活活動に関連しているという仮説を検証します。
管理された環境下での ED 患者の急性運動効果の詳細な説明は、特に (i) DEx リスクと機能の評価を改善する (ii) DEx リスクのテスト可能なモデルを解明する、および (iii) ED の実証研究に大きな影響を与えるだろう。 ) DEx 介入のターゲットを提案します。
このプロジェクトで検証された方法は、治療抵抗性の ED の特徴である DEx についての理解を深めます。
これらの方法は、ED 治療における DEx の最適なターゲットを明らかにする大規模な臨床研究の基礎も築くでしょう。
研究の種類
介入
入学 (実際)
74
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
-
-
California
-
San Francisco、California、アメリカ、94158
- University of California San Francisco
-
-
Wisconsin
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Madison、Wisconsin、アメリカ、53719
- University of Wisconsin-Madison
-
-
参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
- 子
- 大人
健康ボランティアの受け入れ
はい
説明
包含基準:
- 16～22歳
- ED参加者は、体重と体型への懸念を特徴とするDSM-5制限型摂食障害、すなわち神経性食欲不振（AN）の基準を完全に満たさなければなりません。軽度、中等度、または部分寛解状態）、非定型 AN、および OSFED -AN タイプのみ）
- ED 参加者は医学的に安定しており、外来治療に適している必要があります。
- 生物学的女性、出生時に女性として割り当てられる
- 英語を話す
除外基準:
運動を妨げる病状（重度の喘息など）を持つ人は、禁忌から除外されます。
- 生物学的男性、出生時に割り当てられた男性
- BMI 16 未満 (18 歳以上)、または予想体重の 75% 未満 (18 歳未満)
- 摂食障害検査で報告された摂取量が1日1000kcal未満
- 電流パージ > 1 日あたり 1 回
- 現在、客観的な過食行為が定期的に発生している（週に 1 回以上）
- 摂食障害検査の面接による、現在のコントロール不能な食事の自己申告
- 過去 1 か月以内に ED 関連の入院、部分入院、または宿泊施設での治療があった
- 身体活動に関連する医学的懸念が裏付けられている場合（心血管疾患、肺疾患、または代謝性疾患に関する電話スクリーニングの質問で詳しく調査されています）。
- 主要な医学的障害 (例: がん、エイズ)
- 身体的な不快感または採血の困難
- 精神障害
- 知的障害
- 発達障害
- 活性物質使用障害
- 「Ask Suicide Screening Questionnaire」に基づく現在の自殺リスク
- 妊娠
- 少なくとも 4 週間安定していない精神科薬
- 急性の鎮静剤/鎮痛剤 (例: ベンゾジアゼピン、オピオイド) および処方興奮剤 (例: メチルフェニデート、アンフェタミン) は、検査前の 1 日間は許可されません。 記載された短期投薬保留は、ADHD またはその他の精神疾患の治療に使用される場合に記載された薬剤を服用している被験者にのみ適用されます。
- 安静時心拍数 <50 拍/分 (スクリーニング来院時に評価)
- 低血圧（<90/60）、（スクリーニング来院時に評価）
- 毎日の大麻使用
- 採血中または身体活動中にふらつきまたは失神の病歴がある
- 身体活動中の胸痛の病歴
- 身体活動によって悪化する可能性のある骨、関節、心臓、肺、代謝、またはその他の病状（COPD、糖尿病、高血圧など）で、現在投薬やライフスタイルの変更では対処されていないもの。
- 作業遂行を妨げる身体障害（視覚障害や聴覚障害など）
- 研究者が参加者を否定的な結果の危険にさらす可能性があると考えるその他の状態
- 体重や体形への懸念（ARFID）を含まない制限型摂食障害、または原発性過食症（神経性過食症）を患っている人
- 身体活動準備アンケートにおける運動に関連する健康リスクの指摘
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：他の
- 割り当て：非ランダム化
- 介入モデル：並列代入
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Healthy Controls
Study participants undergo Prescribed Exercise, Self-Paced Exercise, and Rest conditions over the course of 3 study days
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ED severity, biological and affective markers of physical activity response, and both exercise-specific and general positive (reward) and negative (avoidance/escape) valence sensitivities associate with physical activity will be comprehensively examined. During three different days, participants will:
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実験的：Participants with Eating Disorders
Study participants undergo Prescribed Exercise, Self-Paced Exercise, and Rest conditions over the course of 3 study days
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ED severity, biological and affective markers of physical activity response, and both exercise-specific and general positive (reward) and negative (avoidance/escape) valence sensitivities associate with physical activity will be comprehensively examined. During three different days, participants will:
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Body Image State Scale (BISS) Score: Average of All BISS 6-items
時間枠：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
Response to body image was measured using the BISS which is a 6-item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction).
Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"].
Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
|
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
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Appearance-Item Score From Body Image State Scale (BISS)
時間枠：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
Response to body image was measured using the BISS which is a 6-item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale(1-9, higher scores, higher satisfaction).
Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"].
Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
|
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
|
Average Person-Item Score From Body Image State Scale (BISS)
時間枠：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
Response to body image was measured using the BISS which is a 6 item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction).
The Average Person item asks participants to rate how they feel like they look compared to the average person from a great deal worse (1) to a great deal better (9).
Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
|
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
|
Looks-Item Score From Body Image State Scale (BISS)
時間枠：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
Response to body image was measured using the BISS which is a 6 item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction).
Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"].
Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
|
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
|
Physical Attraction-Item Score From Body Image State Scale (BISS)
時間枠：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
Response to body image was measured using the BISS which is a 6 item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction).
Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"].
Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
|
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
|
Shape-Item Score From Body Image State Scale (BISS)
時間枠：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
Response to body image was measured using the BISS which is a 6 item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction).
Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"].
Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
|
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
|
Weight-Item Score From Body Image State Scale (BISS)
時間枠：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
Response to body image was measured using the BISS which is a 6 item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction).
Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"].
Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
|
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
|
|
Physical Activity Affect Scale (PAAS): Anxious-Item Score
時間枠：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
Participants self-report items representing the highest loading items from the Physical Activity Affect Scale (PAAS) every 5 minutes during exercise.
These items include feeling 'Anxious', 'Crummy', 'Enthusiastic', 'Fatigued' and 'Calm'.
Participants rate each item using a 5-point scale (0=do not feel-4=feel very strongly).
|
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
|
Physical Activity Affect Scale (PAAS): Calm-Item Score
時間枠：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
Participants self-report items representing the highest loading items from the Physical Activity Affect Scale (PAAS) every 5 minutes during exercise.
These items include feeling 'Anxious', 'Crummy', 'Enthusiastic', 'Fatigued' and 'Calm'.
Participants rate each item using a 5-point scale (0=do not feel-4=feel very strongly).
|
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
|
Physical Activity Affect Scale (PAAS): Crummy-Item Score
時間枠：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
Participants self-report items representing the highest loading items from the Physical Activity Affect Scale (PAAS) every 5 minutes during exercise.
These items include feeling 'Anxious', 'Crummy', 'Enthusiastic', 'Fatigued' and 'Calm'.
Participants rate each item using a 5-point scale (0=do not feel-4=feel very strongly).
|
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
|
Physical Activity Affect Scale (PAAS): Enthusiastic-Item Score
時間枠：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
Participants self-report items representing the highest loading items from the Physical Activity Affect Scale (PAAS) every 5 minutes during exercise.
These items include feeling 'Anxious', 'Crummy', 'Enthusiastic', 'Fatigued' and 'Calm'.
Participants rate each item using a 5-point scale (0=do not feel-4=feel very strongly).
|
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
|
Physical Activity Affect Scale (PAAS): Fatigued-Item Score
時間枠：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
Participants self-report items representing the highest loading items from the Physical Activity Affect Scale (PAAS) every 5 minutes during exercise.
These items include feeling 'Anxious', 'Crummy', 'Enthusiastic', 'Fatigued' and 'Calm'.
Participants rate each item using a 5-point scale (0=do not feel-4=feel very strongly).
|
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
|
Borg Rating of Perceived Exertion (RPE) Score
時間枠：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
Participants were surveyed for their perceived exertion throughout the exercise conditions only.
The Borg Rating of Perceived Exertion (RPE) scale was used to measure perceived exertion, rated 6 to 20 (no exertion to maximal exertion).
|
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
|
|
Response to In-lab Exercise - Biomarkers: Circulating BDNF (ng/mL)
時間枠：pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
|
Biomarkers will be collected via blood samples taken before and after exercise and rest and measured via Enzyme-linked immunosorbent assay (ELISA) kits:
|
pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
|
|
Response to In-lab Exercise - Biomarkers: Circulating Leptin (ng/mL)
時間枠：pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
|
Biomarkers will be collected via blood samples taken before and after exercise and rest and measured via Enzyme-linked immunosorbent assay (ELISA) kits:
|
pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
|
|
Response to In-lab Exercise - Biomarkers: Circulating Cortisol (μg/dL)
時間枠：pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
|
Biomarkers will be collected via blood samples taken before and after exercise and rest and measured via Enzyme-linked immunosorbent assay (ELISA) kits:
|
pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
|
|
Response to In-lab Exercise - Biomarkers: Circulating Anandamide (AEA) (ng/mL)
時間枠：pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
|
Biomarkers will be collected via blood samples taken before and after exercise and rest and measured via Enzyme-linked immunosorbent assay (ELISA) kits:
|
pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
|
|
Response to In-lab Exercise - Biomarkers: Circulating 2-arachidonoylglycerol (2-AG) (ng/mL)
時間枠：pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
|
Biomarkers will be collected via blood samples taken before and after exercise and rest and measured via Enzyme-linked immunosorbent assay (ELISA) kits:
|
pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
|
協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
出版物と役立つリンク
研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。
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研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (実際)
2023年11月2日
一次修了 (実際)
2025年7月31日
研究の完了 (実際)
2025年7月31日
試験登録日
最初に提出
2024年1月9日
QC基準を満たした最初の提出物
2024年1月18日
最初の投稿 (実際)
2024年1月19日
学習記録の更新
投稿された最後の更新 (実際)
2026年8月25日
QC基準を満たした最後の更新が送信されました
2026年7月31日
最終確認日
2026年7月1日
詳しくは
本研究に関する用語
その他の研究ID番号
- 2019-1585
- 1R21MH131787-01A1 (米国 NIH グラント/契約)
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