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饮食失调对急性运动的反应

2026年7月31日 更新者：University of Wisconsin, Madison

限制性饮食失调的急性运动反应特征

饮食失调 (ED) 患者是临床重点关注的人群，其死亡率是所有精神疾病中最高的，而高达 80% 的 ED 患者中，强迫运动 (DEx) 是一种症状，会增加损害并产生负面影响影响治疗效果。 这项研究将开发任务来描述患有 ED 的青少年和年轻成年女性对运动的认知、情感和生物反应，并确定急性运动反应是否与自由生活活动和 DEx 相关。 该 R21 项目将提供基础数据，以指导更精确地针对强迫运动症状的治疗方法的研究和开发，并最终改善与 ED 相关的临床结果。

研究概览

地位

完全的

条件

干预/治疗

详细说明

饮食失调（ED）是所有精神疾病中最致命的一种。 然而，ED 的一线治疗仅对大约 40% 的青少年患者有效。 影响治疗效果的一个障碍是持续进行驱动性运动（DEx；以强迫性方式进行运动以控制体重和/或调节情绪），这是许多诊断为限制性 ED 的青少年 (59-73%) 中报告的一种标志性症状。 在其他负面后遗症中，DEx 与自杀行为、较差的治疗结果、共病精神病理学增加以及复发风险有关。 此外，虽然多项与饮食相关的任务已被验证可以区分 ED 患者和健康人群，但目前还没有经过充分验证的任务可以直接评估 ED 人群对运动的敏感性和反应性。 由于 DEx 是一种人们知之甚少的症状，但它在 ED 维持中发挥着关键作用，因此研究其生物行为基础至关重要。 现有的研究指出运动的奖励和威胁功能，这可能会推动并维持 ED 患者的 DEx。 对 ED 患者运动的奖励函数和威胁函数进行评估将提高对 ED 特征的机制理解；最终，加深对 DEx 的了解将为治疗目标提供信息。 拟议项目将从两个地点招募有（n = 67）和没有（n = 33）ED 的青少年和年轻成年女性（16-22 岁）参与急性运动反应的综合评估。 当前的项目将 1) 描述患有和未患有 ED 的人对实验室内中等强度运动的生物行为反应的变异性； 2）创建和完善任务，捕捉演习期间奖励和威胁相关系统的参与情况； 3) 测试假设，即急性运动反应在 ED 患者中更为明显，并且急性运动反应与 ED 症状严重程度、DEx 和自由生活活动有关。 在受控环境中详细解释 ED 患者的急性运动效应将对 ED 的实证研究产生重大影响，特别是 (i) 改进 DEx 风险和功能的评估 (ii) 阐明 DEx 风险的可测试模型以及 (iii) ）建议 DEx 干预的目标。 该项目中验证的方法将增进对 DEx（一种难治性 ED 特征）的理解。 这些方法还将为更大规模的临床研究奠定基础，从而阐明 DEx 在 ED 治疗中的最佳目标。

研究类型

介入性

注册 (实际的)

74

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 美国
    • California
      • San Francisco、California、美国、94158
        • University of California San Francisco
    • Wisconsin
      • Madison、Wisconsin、美国、53719
        • University of Wisconsin-Madison

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

  • 孩子
  • 成人

接受健康志愿者

是的

描述

纳入标准：

  • 16-22岁
  • ED 参与者必须符合 DSM-5 限制性饮食失调的全部标准，其特征是体重和体形问题，即神经性厌食症 (AN)；轻度、中度或部分缓解）、非典型 AN 和仅限 OSFED -AN 型）
  • 急诊科参与者必须身体状况稳定，并且适合门诊治疗
  • 生物学上的女性，出生时指定为女性
  • 英语会话

排除标准：

  • 患有无法运动的健康状况（例如严重哮喘）的人将因任何禁忌症而被排除在外

    • 生物学上的男性，出生时指定为男性
    • BMI 低于 16（18 岁以上）或低于预期体重的 75%（18 岁以下）
    • 饮食失调检查报告摄入量每日<1000kcal
    • 当前清除 >1x 每天
    • 当前客观暴食的定期发作（> 1 次/周）
    • 目前根据饮食失调检查访谈自我报告的饮食失控情况
    • 过去一个月因 ED 相关住院、部分住院或住院治疗
    • 任何经认可的与身体活动相关的医疗问题（如有关心血管、肺部或代谢疾病的电话筛查问题中所探讨的）。
    • 重大疾病（例如癌症、艾滋病）
    • 身体不适或抽血困难
    • 精神障碍
    • 智力障碍
    • 发育障碍
    • 活性物质使用障碍
    • 根据自杀筛查问卷当前的自杀风险
    • 怀孕
    • 至少 4 周不稳定的精神科药物
    • 实验室会议前一整天不允许使用急性镇静剂/止痛药（例如苯二氮卓类药物、阿片类药物）和处方兴奋剂（例如哌醋甲酯、安非他明）。 上述短期药物保留仅适用于在用于治疗多动症或其他精神疾病的情况下服用上述药物的受试者
    • 静息心率 <50 次/分钟（筛选访视时评估）
    • 低血压 (<90/60)，（在筛选访视时评估）
    • 每日吸食大麻
    • 抽血或体力活动期间有头晕或昏厥史
    • 体力活动时有胸痛史
    • 骨骼、关节、心脏、肺部、代谢或其他可能因体力活动而恶化的医疗状况（例如慢性阻塞性肺病、糖尿病、高血压），目前无法通过药物或生活方式的改变来解决。
    • 妨碍任务执行的身体残疾（例如失明或耳聋）
    • 研究者认为可能使参与者面临负面结果风险的任何其他情况
    • 患有限制性饮食失调症的个体，不包括体重和体形问题 (ARFID) 或有原发性暴食症 (神经性贪食症)
    • 身体活动准备问卷中与运动相关的健康风险指示

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：其他
  • 分配：非随机化
  • 介入模型：并行分配
  • 屏蔽：无（打开标签）

武器和干预

参与者组/臂
干预/治疗
实验性的：Healthy Controls
Study participants undergo Prescribed Exercise, Self-Paced Exercise, and Rest conditions over the course of 3 study days
其他：Biobehavioral Response to in-lab exposure to physical activity

ED severity, biological and affective markers of physical activity response, and both exercise-specific and general positive (reward) and negative (avoidance/escape) valence sensitivities associate with physical activity will be comprehensively examined.

During three different days, participants will:

  • A: Complete 2 different tasks, a reward task (prescribed rest condition) with self-report measures and two blood draws before and after completing the 30 minute rest condition, and a threat task (self-paced exercise condition) with self-report measures, a food challenge (to drink a milkshake) and 30 minutes of exercise.
  • B: Complete a reward task (prescribe exercise condition) where participants will earn points for exercise and have 2 blood draws before and after completing 30 minutes of exercise
  • C: Complete a threat task (self-paced rest condition) with self-report measures, a food challenge, and 30 minutes of rest.
实验性的：Participants with Eating Disorders
Study participants undergo Prescribed Exercise, Self-Paced Exercise, and Rest conditions over the course of 3 study days
其他：Biobehavioral Response to in-lab exposure to physical activity

ED severity, biological and affective markers of physical activity response, and both exercise-specific and general positive (reward) and negative (avoidance/escape) valence sensitivities associate with physical activity will be comprehensively examined.

During three different days, participants will:

  • A: Complete 2 different tasks, a reward task (prescribed rest condition) with self-report measures and two blood draws before and after completing the 30 minute rest condition, and a threat task (self-paced exercise condition) with self-report measures, a food challenge (to drink a milkshake) and 30 minutes of exercise.
  • B: Complete a reward task (prescribe exercise condition) where participants will earn points for exercise and have 2 blood draws before and after completing 30 minutes of exercise
  • C: Complete a threat task (self-paced rest condition) with self-report measures, a food challenge, and 30 minutes of rest.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Body Image State Scale (BISS) Score: Average of All BISS 6-items
大体时间：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Response to body image was measured using the BISS which is a 6-item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction). Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"]. Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Appearance-Item Score From Body Image State Scale (BISS)
大体时间：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Response to body image was measured using the BISS which is a 6-item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale(1-9, higher scores, higher satisfaction). Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"]. Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Average Person-Item Score From Body Image State Scale (BISS)
大体时间：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Response to body image was measured using the BISS which is a 6 item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction). The Average Person item asks participants to rate how they feel like they look compared to the average person from a great deal worse (1) to a great deal better (9). Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Looks-Item Score From Body Image State Scale (BISS)
大体时间：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Response to body image was measured using the BISS which is a 6 item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction). Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"]. Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Physical Attraction-Item Score From Body Image State Scale (BISS)
大体时间：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Response to body image was measured using the BISS which is a 6 item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction). Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"]. Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Shape-Item Score From Body Image State Scale (BISS)
大体时间：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Response to body image was measured using the BISS which is a 6 item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction). Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"]. Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Weight-Item Score From Body Image State Scale (BISS)
大体时间：Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Response to body image was measured using the BISS which is a 6 item scale that asks participants to report on their momentary body satisfaction on a 9-point Likert scale (1-9, higher scores, higher satisfaction). Each item begins with the sentence "Right now, I feel" [for instance: "Right now, I feel (Extremely dissatisfied to Extremely satisfied)"]. Participants are asked to rate their momentary body satisfaction every five minutes during each of 4 conditions: Prescribed Exercise (Reward Task), Self-Paced Exercise (Threat Task), Prescribed Rest (Reward Task), or Self-Paced Rest (Threat Task).
Every 5 minutes during 30 minute bout of activity . There is no follow up beyond the study day itself.
Physical Activity Affect Scale (PAAS): Anxious-Item Score
大体时间：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Participants self-report items representing the highest loading items from the Physical Activity Affect Scale (PAAS) every 5 minutes during exercise. These items include feeling 'Anxious', 'Crummy', 'Enthusiastic', 'Fatigued' and 'Calm'. Participants rate each item using a 5-point scale (0=do not feel-4=feel very strongly).
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Physical Activity Affect Scale (PAAS): Calm-Item Score
大体时间：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Participants self-report items representing the highest loading items from the Physical Activity Affect Scale (PAAS) every 5 minutes during exercise. These items include feeling 'Anxious', 'Crummy', 'Enthusiastic', 'Fatigued' and 'Calm'. Participants rate each item using a 5-point scale (0=do not feel-4=feel very strongly).
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Physical Activity Affect Scale (PAAS): Crummy-Item Score
大体时间：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Participants self-report items representing the highest loading items from the Physical Activity Affect Scale (PAAS) every 5 minutes during exercise. These items include feeling 'Anxious', 'Crummy', 'Enthusiastic', 'Fatigued' and 'Calm'. Participants rate each item using a 5-point scale (0=do not feel-4=feel very strongly).
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Physical Activity Affect Scale (PAAS): Enthusiastic-Item Score
大体时间：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Participants self-report items representing the highest loading items from the Physical Activity Affect Scale (PAAS) every 5 minutes during exercise. These items include feeling 'Anxious', 'Crummy', 'Enthusiastic', 'Fatigued' and 'Calm'. Participants rate each item using a 5-point scale (0=do not feel-4=feel very strongly).
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Physical Activity Affect Scale (PAAS): Fatigued-Item Score
大体时间：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Participants self-report items representing the highest loading items from the Physical Activity Affect Scale (PAAS) every 5 minutes during exercise. These items include feeling 'Anxious', 'Crummy', 'Enthusiastic', 'Fatigued' and 'Calm'. Participants rate each item using a 5-point scale (0=do not feel-4=feel very strongly).
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Borg Rating of Perceived Exertion (RPE) Score
大体时间：Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Participants were surveyed for their perceived exertion throughout the exercise conditions only. The Borg Rating of Perceived Exertion (RPE) scale was used to measure perceived exertion, rated 6 to 20 (no exertion to maximal exertion).
Every 5 minutes during a 30 minute bout of activity. There is no follow up beyond the study day itself.
Response to In-lab Exercise - Biomarkers: Circulating BDNF (ng/mL)
大体时间：pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.

Biomarkers will be collected via blood samples taken before and after exercise and rest and measured via Enzyme-linked immunosorbent assay (ELISA) kits:

  • circulating leptin (leptin immunoassay)
  • circulating endocannabinoids (2-arachidonoylglycerol (2-AG) and anandamide (AEA) plasma-based immunoassays)
  • circulating brain-derived neurotrophic factor (BDNF immunoassay)
  • circulating cortisol (Cortisol immunoassay)
pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
Response to In-lab Exercise - Biomarkers: Circulating Leptin (ng/mL)
大体时间：pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.

Biomarkers will be collected via blood samples taken before and after exercise and rest and measured via Enzyme-linked immunosorbent assay (ELISA) kits:

  • circulating leptin (leptin immunoassay)
  • circulating endocannabinoids (2-arachidonoylglycerol (2-AG) and anandamide (AEA) plasma-based immunoassays)
  • circulating brain-derived neurotrophic factor (BDNF immunoassay)
  • circulating cortisol (Cortisol immunoassay)
pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
Response to In-lab Exercise - Biomarkers: Circulating Cortisol (μg/dL)
大体时间：pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.

Biomarkers will be collected via blood samples taken before and after exercise and rest and measured via Enzyme-linked immunosorbent assay (ELISA) kits:

  • circulating leptin (leptin immunoassay)
  • circulating endocannabinoids (2-arachidonoylglycerol (2-AG) and anandamide (AEA) plasma-based immunoassays)
  • circulating brain-derived neurotrophic factor (BDNF immunoassay)
  • circulating cortisol (Cortisol immunoassay)
pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
Response to In-lab Exercise - Biomarkers: Circulating Anandamide (AEA) (ng/mL)
大体时间：pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.

Biomarkers will be collected via blood samples taken before and after exercise and rest and measured via Enzyme-linked immunosorbent assay (ELISA) kits:

  • circulating leptin (leptin immunoassay)
  • circulating endocannabinoids (2-arachidonoylglycerol (2-AG) and anandamide (AEA) plasma-based immunoassays)
  • circulating brain-derived neurotrophic factor (BDNF immunoassay)
  • circulating cortisol (Cortisol immunoassay)
pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.
Response to In-lab Exercise - Biomarkers: Circulating 2-arachidonoylglycerol (2-AG) (ng/mL)
大体时间：pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.

Biomarkers will be collected via blood samples taken before and after exercise and rest and measured via Enzyme-linked immunosorbent assay (ELISA) kits:

  • circulating leptin (leptin immunoassay)
  • circulating endocannabinoids (2-arachidonoylglycerol (2-AG) and anandamide (AEA) plasma-based immunoassays)
  • circulating brain-derived neurotrophic factor (BDNF immunoassay)
  • circulating cortisol (Cortisol immunoassay)
pre-exercise (Baseline), post-exercise (30 minutes), pre-rest (Baseline), post-rest (30 minutes). There is no follow up beyond the study day itself.

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

University of Wisconsin, Madison

合作者

National Institute of Mental Health (NIMH)

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2023年11月2日

初级完成 (实际的)

2025年7月31日

研究完成 (实际的)

2025年7月31日

研究注册日期

首次提交

2024年1月9日

首先提交符合 QC 标准的

2024年1月18日

首次发布 (实际的)

2024年1月19日

研究记录更新

最后更新发布 (实际的)

2026年8月25日

上次提交的符合 QC 标准的更新

2026年7月31日

最后验证

2026年7月1日

更多信息

与本研究相关的术语

关键字

其他相关的 MeSH 术语

其他研究编号

  • 2019-1585
  • 1R21MH131787-01A1 (美国 NIH 拨款/合同)

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

是的

IPD 计划说明

项目出版物将提供有关程序和分析的完整信息，以实现复制。 我们将在机构网页上共享数据和代码，以实现可重复性。

IPD 共享时间框架

研究结论时

IPD 共享支持信息类型

  • 研究方案
  • 树液
  • 分析代码

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

在美国制造并从美国出口的产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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