アルブミン/クレアチン比、B12、葉酸、虚弱指数の関係
消化器悪性腫瘍の手術を受ける患者におけるアルブミン/クレアチン比、ビタミンB12、葉酸塩、虚弱指数の関係
In the literature, the relationship between frailty and various blood tests such as beta-2 microglobulin, CRP, procalcitonin, vitamin D, IL-1, and IL-6 has been investigated (2). In our study, the investigators aim to investigate the relationship between frailty status assessed using frailty scale forms (Frailty Scale Version 9) and preoperative levels of Albumin/Creatinine, B12, Folate, Ferritin, hemogram, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery. By identifying the relationship among these parameters, the investigators believe that modifiable factors contributing to frailty in patients at risk can be addressed through appropriate interventions.
調査の概要
詳細な説明
Frailty is a condition associated with a decline in physiological performance. Patients are categorized as healthy, pre-frail, or frail based on physiological and functional characteristics. Frailty is known to be influenced by various lifestyle factors such as socioeconomic status, psychological factors, diet, exercise, and genetic predisposition. With aging, there is an increase in cognitive and physical dysfunction, which correlates with an increase in frailty. Along with frailty, geriatric symptoms, mortality, and other negative health outcomes also increase in the elderly population. Therefore, early detection of frailty is crucial to implementing lifestyle changes aimed at improving cognitive and physical status. Various assessment scales are used to evaluate frailty, such as the Frailty Scale Version 9.
In the literature, the relationship between frailty and various blood tests such as beta-2 microglobulin, CRP, procalcitonin, vitamin D, IL-1, and IL-6 has been investigated (2). In our study, the investigators aim to investigate the relationship between frailty status assessed using frailty scale form (Frailty Scale Version 9) and preoperative levels of Albumin/Creatinine, B12, Folate, Ferritin,hemogram, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery. By identifying the relationship among these parameters, the investigators believe that modifiable factors contributing to frailty in patients at risk can be addressed through appropriate interventions.
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：Yusuf Ozguner
- 電話番号：05427150725
- メール：y.ozguner@hotmail.com
研究場所
-
-
Ankara
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Çankaya、Ankara、トルコ（Türkiye）
- 募集
- Yusuf
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コンタクト：
- Yusuf Ozguner
- 電話番号：05427150725
- メール：y.ozguner@hotmail.com
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-
Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle
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Ankara、Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle、トルコ（Türkiye）、06170
- 募集
- Ankara Etlik City Hospital
-
コンタクト：
- Yusuf Ozguner
- 電話番号：+903127970000
- メール：etliksh.iletisim@saglik.gov.tr
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-
参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
In our study, we aim to investigate the relationship between frailty status assessed using frailty scale form (Frailty Scale Version 9) and preoperative levels of Albumin/Creatine, B12, Folate, Ferritin, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery.
説明
Inclusion Criteria:
- Patients who are over 65 years old.
- Patients classified under ASA (American Society of Anesthesiologists) risk groups I, II, and III.
- Patients with gastrointestinal malignancy undergoing surgery
Exclusion Criteria:
- Patients who are under 65 years old.
- Patients with an ASA score of IV or higher.
- Patients who refuse to participate in the study.
- Patients undergoing emergency surgeries will be excluded from the study
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 観測モデル：CASE_ONLY
- 時間の展望：PROSPECTIVE
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
|
Undergoing gastrointestinal malignancy surgery
In our study, we aim to investigate the relationship between frailty status assessed using frailty scale form (Frailty Scale Version 9) and preoperative levels of Albumin/Creatinine, B12, Folate, Hemogram in patients undergoing gastrointestinal malignancy surgery.Patients' frailty status will be assessed using the Frailty Scale Version 9.There are scores between 1 and 9 on this scale. Patients with a score of 4 or above are defined as fraile. |
In our study, we aim to investigate the relationship between frailty status assessed using frailty scale form (Frailty Scale Version 9) and preoperative levels of Albumin/Creatinine, B12, Folate, Ferritin, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery. |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Association between preoperative Clinical Frailty Scale (CFS) score and serum albumin-to-creatinine ratio
時間枠：one day before surgery
|
Patients' frailty status will be assessed using the Frailty Scale Version 9.There are scores between 1 and 9 on this scale. Patients with a score of 4 or above are defined as fraile.(Association between preoperative Clinical Frailty Scale (CFS) score and serum albumin-to-creatinine ratio.) |
one day before surgery
|
二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Association between preoperative Clinical Frailty Scale (CFS) score and B12 levels
時間枠：one day before surgery
|
B12 concentration will be measured |
one day before surgery
|
|
Association between preoperative Clinical Frailty Scale (CFS) score and Folate levels
時間枠：one day before surgery
|
Folate concentration will be measured |
one day before surgery
|
|
Association between preoperative Clinical Frailty Scale (CFS) score and iron levels
時間枠：one day before surgery
|
Serum iron concentration will be measured. |
one day before surgery
|
|
Association between preoperative Clinical Frailty Scale (CFS) score and Hemoglobin/RDW ratio.
時間枠：one day before surgery
|
Hemoglobin/RDW ratio will be measured. |
one day before surgery
|
協力者と研究者
捜査官
- 主任研究者：Yusuf Ozguner、Ankara Etlik City Hospital
出版物と役立つリンク
一般刊行物
- Kim M, Suzuki T, Kojima N, Yoshida H, Yoshida Y, Hirano H, Won CW, Kim H. Association Between Serum beta2 -Microglobulin Levels and Prevalent and Incident Physical Frailty in Community-Dwelling Older Women. J Am Geriatr Soc. 2017 Apr;65(4):e83-e88. doi: 10.1111/jgs.14733. Epub 2017 Jan 31.
- Shamliyan T, Talley KM, Ramakrishnan R, Kane RL. Association of frailty with survival: a systematic literature review. Ageing Res Rev. 2013 Mar;12(2):719-36. doi: 10.1016/j.arr.2012.03.001. Epub 2012 Mar 12.
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
キーワード
追加の関連 MeSH 用語
その他の研究ID番号
- AnkaraEtlikYusufOzguner007
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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