白蛋白/肌酸比率、B12、叶酸和衰弱指数之间的关系
胃肠道恶性肿瘤手术患者白蛋白/肌酸比、B12、叶酸和衰弱指数之间的关系
In the literature, the relationship between frailty and various blood tests such as beta-2 microglobulin, CRP, procalcitonin, vitamin D, IL-1, and IL-6 has been investigated (2). In our study, the investigators aim to investigate the relationship between frailty status assessed using frailty scale forms (Frailty Scale Version 9) and preoperative levels of Albumin/Creatinine, B12, Folate, Ferritin, hemogram, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery. By identifying the relationship among these parameters, the investigators believe that modifiable factors contributing to frailty in patients at risk can be addressed through appropriate interventions.
研究概览
详细说明
Frailty is a condition associated with a decline in physiological performance. Patients are categorized as healthy, pre-frail, or frail based on physiological and functional characteristics. Frailty is known to be influenced by various lifestyle factors such as socioeconomic status, psychological factors, diet, exercise, and genetic predisposition. With aging, there is an increase in cognitive and physical dysfunction, which correlates with an increase in frailty. Along with frailty, geriatric symptoms, mortality, and other negative health outcomes also increase in the elderly population. Therefore, early detection of frailty is crucial to implementing lifestyle changes aimed at improving cognitive and physical status. Various assessment scales are used to evaluate frailty, such as the Frailty Scale Version 9.
In the literature, the relationship between frailty and various blood tests such as beta-2 microglobulin, CRP, procalcitonin, vitamin D, IL-1, and IL-6 has been investigated (2). In our study, the investigators aim to investigate the relationship between frailty status assessed using frailty scale form (Frailty Scale Version 9) and preoperative levels of Albumin/Creatinine, B12, Folate, Ferritin,hemogram, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery. By identifying the relationship among these parameters, the investigators believe that modifiable factors contributing to frailty in patients at risk can be addressed through appropriate interventions.
研究类型
注册 (估计的)
联系人和位置
学习联系方式
- 姓名：Yusuf Ozguner
- 电话号码：05427150725
- 邮箱：y.ozguner@hotmail.com
学习地点
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Ankara
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Çankaya、Ankara、土耳其（türkiye）
- 招聘中
- Yusuf
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接触：
- Yusuf Ozguner
- 电话号码：05427150725
- 邮箱：y.ozguner@hotmail.com
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Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle
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Ankara、Varlık Mahallesi, Halil Sezai Erkut Caddesi Yenimahalle、土耳其（türkiye）、06170
- 招聘中
- Ankara Etlik City Hospital
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接触：
- Yusuf Ozguner
- 电话号码：+903127970000
- 邮箱：etliksh.iletisim@saglik.gov.tr
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
In our study, we aim to investigate the relationship between frailty status assessed using frailty scale form (Frailty Scale Version 9) and preoperative levels of Albumin/Creatine, B12, Folate, Ferritin, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery.
描述
Inclusion Criteria:
- Patients who are over 65 years old.
- Patients classified under ASA (American Society of Anesthesiologists) risk groups I, II, and III.
- Patients with gastrointestinal malignancy undergoing surgery
Exclusion Criteria:
- Patients who are under 65 years old.
- Patients with an ASA score of IV or higher.
- Patients who refuse to participate in the study.
- Patients undergoing emergency surgeries will be excluded from the study
学习计划
研究是如何设计的？
设计细节
- 观测模型：CASE_ONLY
- 时间观点：PROSPECTIVE
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
Undergoing gastrointestinal malignancy surgery
In our study, we aim to investigate the relationship between frailty status assessed using frailty scale form (Frailty Scale Version 9) and preoperative levels of Albumin/Creatinine, B12, Folate, Hemogram in patients undergoing gastrointestinal malignancy surgery.Patients' frailty status will be assessed using the Frailty Scale Version 9.There are scores between 1 and 9 on this scale. Patients with a score of 4 or above are defined as fraile. |
In our study, we aim to investigate the relationship between frailty status assessed using frailty scale form (Frailty Scale Version 9) and preoperative levels of Albumin/Creatinine, B12, Folate, Ferritin, Sedimentation Rate, and CRP in patients undergoing gastrointestinal malignancy surgery. |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Association between preoperative Clinical Frailty Scale (CFS) score and serum albumin-to-creatinine ratio
大体时间：one day before surgery
|
Patients' frailty status will be assessed using the Frailty Scale Version 9.There are scores between 1 and 9 on this scale. Patients with a score of 4 or above are defined as fraile.(Association between preoperative Clinical Frailty Scale (CFS) score and serum albumin-to-creatinine ratio.) |
one day before surgery
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Association between preoperative Clinical Frailty Scale (CFS) score and B12 levels
大体时间：one day before surgery
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B12 concentration will be measured |
one day before surgery
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Association between preoperative Clinical Frailty Scale (CFS) score and Folate levels
大体时间：one day before surgery
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Folate concentration will be measured |
one day before surgery
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Association between preoperative Clinical Frailty Scale (CFS) score and iron levels
大体时间：one day before surgery
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Serum iron concentration will be measured. |
one day before surgery
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Association between preoperative Clinical Frailty Scale (CFS) score and Hemoglobin/RDW ratio.
大体时间：one day before surgery
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Hemoglobin/RDW ratio will be measured. |
one day before surgery
|
合作者和调查者
调查人员
- 首席研究员：Yusuf Ozguner、Ankara Etlik City Hospital
出版物和有用的链接
一般刊物
- Kim M, Suzuki T, Kojima N, Yoshida H, Yoshida Y, Hirano H, Won CW, Kim H. Association Between Serum beta2 -Microglobulin Levels and Prevalent and Incident Physical Frailty in Community-Dwelling Older Women. J Am Geriatr Soc. 2017 Apr;65(4):e83-e88. doi: 10.1111/jgs.14733. Epub 2017 Jan 31.
- Shamliyan T, Talley KM, Ramakrishnan R, Kane RL. Association of frailty with survival: a systematic literature review. Ageing Res Rev. 2013 Mar;12(2):719-36. doi: 10.1016/j.arr.2012.03.001. Epub 2012 Mar 12.
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (估计的)
研究完成 (估计的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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