Effects of Resistance-Based Multicomponent Training Incorporating Respiratory Exercise on Diaphragm Thickness, Hepatic Attenuation, and Quality of Life in Healthy Older Men: A Randomized Controlled Trial (RT-DIA-OLDER)
This randomized controlled trial investigated the effects of a four-week moderate-intensity resistance training program on diaphragm thickness, hepatic fat density, and health-related quality of life in healthy community-dwelling older men aged 60-75 years. Thirty participants were randomly assigned to a resistance training group or control group. Diaphragm thickness and hepatic attenuation were assessed using non-contrast computed tomography, and quality of life was evaluated using the SF-12 questionnaire. The primary outcome was change in diaphragm thickness. Secondary exploratory outcomes included hepatic fat density and SF-12 physical and mental health scores.
연구 개요
상태
상태
정황
정황
개입 / 치료
개입 / 치료
상세 설명
Aging is associated with progressive decline in respiratory muscle morphology, metabolic health, and perceived quality of life. While resistance training is well established for peripheral muscle adaptation, its short-term effects on diaphragm morphology and hepatic tissue density remain insufficiently investigated.
This randomized controlled pre-test-post-test trial enrolled 30 healthy men aged 60-75 years. Participants were randomly allocated (1:1) to:
Resistance Training Group (RT) Control Group (CON) The RT group completed a supervised moderate-intensity resistance training program three times per week for four weeks (30-40 minutes/session, RPE 12-15). The control group maintained usual daily activities.
Primary Outcome:
Change in diaphragm thickness (mm) assessed by non-contrast CT
Secondary Outcomes (Exploratory):
Hepatic attenuation (Hounsfield Units) via CT SF-12 Physical Health Score SF-12 Mental Health Score The study was approved by the Hitit University Scientific Research Ethics Committee (2025/0464) and conducted according to the Declaration of Helsinki.
연구 유형
연구 유형
등록 (실제)
등록
단계
단계
- 해당 없음
연락처 및 위치
연구 장소
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Trabzon, Ordu, Giresun, Rize, Artvin, Gümüşhane
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Gümüşhane, Trabzon, Ordu, Giresun, Rize, Artvin, Gümüşhane, 터키 (Türkiye), 29600
- Gumushane Univetsity
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참여기준
자격 기준
자격 기준
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건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Male
- Age 60-75 years
- Community-dwelling and functionally independent
- No structured exercise program in past 6 months
- No musculoskeletal injury in past 6 months
- Ability to provide written informed consent
- Stable neuropsychological status
Exclusion Criteria:
- Chronic liver disease
- Uncontrolled cardiovascular or pulmonary disease
- Recent respiratory infection
- Use of medications affecting muscle or liver metabolism (e.g., systemic corticosteroids, anabolic agents, hepatotoxic drugs)
- Participation in structured exercise or respiratory training within past 6 months
- Unstable thyroid hormone replacement therapy
공부 계획
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디자인 세부사항
- 주 목적: 다른
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 하나의
팔의 수
무기와 개입
참가자 그룹 / 팔참가자 그룹 / 팔 |
개입 / 치료개입 / 치료 |
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실험적: Resistance Training Group (RT)
Participants performed supervised resistance training three times per week for four weeks. Each session lasted 30-40 minutes and included: Lower body exercises (sit-to-stand, step-ups, glute bridge) Upper body exercises (wall push-ups, resistance band row, biceps curl) Core exercises Breathing exercises (diaphragmatic breathing, pursed-lip breathing) Warm-up protocol (10 minutes dynamic mobility) Intensity: Borg RPE 12-15 Rest interval: 60 seconds between sets |
Structured Moderate-Intensity Resistance Training Participants maintained their usual daily routines without structured exercise intervention. |
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간섭 없음: CONTROL
Participants maintained their usual daily routines without structured exercise intervention. |
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주요 결과 측정
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Diaphragm Thickness
기간: 4 weeks
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Diaphragm thickness measured in millimeters using non-contrast computed tomography at full inspiration. |
4 weeks
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2차 결과 측정
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Hepatic Fat Density
기간: 4 weeks
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Measurement: CT attenuation (Hounsfield Units) Single ROI in segment VIII |
4 weeks
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SF-12 Physical Health Score
기간: 4 weeks
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Instrument: Short Form-12 Health Survey The physical and mental health scores of the SF-12 subdimensions range from 0 to 100, with higher scores representing better health. |
4 weeks
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SF-12 Mental Health Score
기간: 4 weeks
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Instrument: Short Form-12 Health Survey The physical and mental health scores of the SF-12 subdimensions range from 0 to 100, with higher scores representing better health. |
4 weeks
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Six-minute walk test (6MWT)
기간: 4 WEEK
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Functional exercise capacity was assessed using the 6-Minute Walk Test (6MWT) according to a standardised protocol based on established 6MWT recommendations. The test was performed on a flat, straight 30-m indoor corridor, with the course clearly marked at both ends. Participants were instructed to walk back and forth along the corridor for 6 min at a self-selected walking pace, with the objective of covering the greatest possible distance within the allotted time. |
4 WEEK
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연구 시작 (실제)
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기본 완료 (실제)
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연구 완료
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최초 제출
최초 제출
QC 기준을 충족하는 최초 제출
QC 기준을 충족하는 최초 제출
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QC 기준을 충족하는 마지막 업데이트 제출
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개별 참가자 데이터(IPD) 계획
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IPD 계획 설명
Individual participant data will not be shared due to the absence of prior consent for data sharing and the potential risk of re-identification in a small, single-center sample. Only aggregate results will be disseminated.
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