기능적 운동 장애에서 배외측 전두엽 피질의 비침습적 간헐적 세타 파열 자극

가짜 비교기: 제어

가짜 코일을 이용한 가짜 TMS 자극

다른: 가짜 비교기

가짜 코일을 이용한 가짜 TMS 자극

실험적: 치료

활성 TMS 코일을 사용한 활성 TMS 자극

장치: MagStim

인터 버스트 간격이 200ms인 50Hz에서 3개의 버스트가 190초 동안 주어질 것이며 이 세션은 하루에 각 세션 사이에 20분씩 3번 반복됩니다. 연속 5일 동안 3회 세트를 5회 반복합니다.

Change in S-FMDRS at 1 Month After Real iTBS vs Sham iTBS

The Simplified Functional Movement Disorders Rating Scale (S-FMDRS) measures abnormal movements in 7 body regions as well as gait and speech. Symptom severity in each body region is rated from 0 to 3 (0=none, 1=mild, 2=moderate, 3=severe) and duration from 0 to 3 (0=none; 1=occasionally, 2=frequent, 3= constant). All severity and duration scores are added to yield a total score. The total score ranges from minimum 0 to maximum 68, high score representing worse outcome.

Change in S-FMDRS at 2 and 6 Months After Real iTBS vs Sham iTBS

The Simplified Functional Movement Disorders Rating Scale (S-FMDRS) measures abnormal movements in 7 body regions as well as gait and speech. Symptom severity in each body region is rated from 0 to 3 (0=none, 1=mild, 2=moderate, 3=severe) and duration from 0 to 3 (0=none; 1=occasionally, 2=frequent, 3= constant). All severity and duration scores are added to yield a total score. The total score ranges from minimum 0 to maximum 68, high score representing worse outcome.

Change in Hospital Anxiety and Depression Scale (HADS) at 1, 2 and 6 Months After Real iTBS vs Sham iTBS

Hospital Anxiety and Depression Scale (HADS) is a continuous numeric scale in depression and anxiety (depression 0-21 and anxiety 0-21, higher score representing worse outcome) and the questions ask about the feeling in the past week. This was repeatedly measured at baseline, then at 1 month, 2 months and 6 months after iTBS vs sham and was compared between iTBS vs sham group.

CGI at 1, 2, and 6 Months After Real iTBS vs Sham iTBS

The Clinical Global Impression (CGI) can assess patient's view of the patient's global functioning prior to and after initiating a study medication. The CGI scale of 1-7 is a measure of clinical improvement from the intervention, higher score presenting worse outcome. (1 = Very much improved, 2 = Much improved, 3 = Minimally improved, 4 = No change, 5 = Minimally worse, 6 = Much worse, 7 = Very much worse)

Change in SF-36 at 1, 2, and 6 Months After Real iTBS vs Sham iTBS

The short form (36) health survey is an indicator of health-related quality of life using 36 questions. It has eight domains; the scores are weighted sums of the questions in each domain. Scores range from 0 - 100 in each domain (lower scores = more disability, higher scores = less disability).

1. Physical Functioning (PF) - ability to perform physical activities (e.g., walking, climbing stairs)
2. Role Physical (RP) - limitations in work or daily activities due to physical health
3. Bodily Pain (BP) - intensity of pain and its impact on normal work
4. General Health (GH) - overall perception of personal health
5. Vitality (VT) - energy level and fatigue
6. Social Functioning (SF) - impact of physical or emotional health on social activities
7. Role Emotional (RE) - limitations in work or daily activities due to emotional problems
8. Mental Health (MH) - psychological distress and well-being (e.g., anxiety, depression)