Systemic Sclerosis Clinical and Biomarker Study

Key Inclusion Criteria:

Healthy volunteers

• Must be in good health as determined by the Investigator, based on medical history, physical examination, and vital signs.

Participants with diffuse cutaneous systemic sclerosis (dcSSc):

• Must fulfill the 2013 classification criteria for SSc of the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR).
• Absence of the anti-centromere autoantibody.

Participants with limited cutaneous systemic sclerosis (lcSSc):

• Must fulfill the 2013 classification criteria for SSc of the ACR and EULAR.
• Subjects with lcSSc must have disease duration of less than 5 years.

Key Exclusion Criteria:

• History of any clinically significant medical condition that can interfere with the conduct of the study, or that in the opinion of the Investigator, would compromise data interpretation.
• An active severe infection as determined by the Investigator.
• Female subjects who are pregnant or currently breastfeeding.
• A known history of malignancy.

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply