Docetaxel, Carboplatin, Trastuzumab og Pertuzumab med eller uten østrogenmangel ved behandling av pasienter med hormonreseptorpositiv, HER2-positiv operabel eller lokalt avansert brystkreft
15. september 2026 oppdatert av: National Cancer Institute (NCI)
En randomisert fase III-studie som evaluerer patologiske fullstendige responsrater hos pasienter med hormonreseptorpositive, HER2-positive, stor operable og lokalt avansert brystkreft behandlet med neoadjuvant terapi av docetaxel, karboplatin, trastuzumab og pertuzumab (TCHP) med deprivasjon (TCHP)
This randomized phase III trial studies docetaxel, carboplatin, trastuzumab, and pertuzumab with estrogen deprivation to see how they work compared to docetaxel, carboplatin, trastuzumab, and pertuzumab without estrogen deprivation in treating patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-positive breast cancer that is operable or has spread from where it started to nearby tissue or lymph nodes (locally advanced). Drugs used in chemotherapy, such as docetaxel, carboplatin, trastuzumab, and pertuzumab, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Estrogen can cause the growth of breast cancer cells. Hormone therapy using goserelin acetate and aromatase inhibition therapy may fight breast cancer by blocking the use of estrogen by the tumor cells. Radiation therapy uses high energy x rays to kill tumor cells. Giving combination chemotherapy and radiation therapy with or without hormone therapy may be an effective treatment for hormone receptor-positive, HER2-positive, operable or locally advanced breast cancer.
Studieoversikt
Status
Status
Fullført
Forhold
Forhold
Intervensjon / Behandling
Intervensjon / Behandling
- Legemiddel: Carboplatin
- Biologisk: Trastuzumab
- Annen: Laboratory Biomarker Analysis
- Annen: Quality-of-Life Assessment
- Legemiddel: Docetaxel
- Annen: Cytology Specimen Collection Procedure
- Biologisk: Pertuzumab
- Fremgangsmåte: Therapeutic Conventional Surgery
- Stråling: Whole Breast Irradiation
- Legemiddel: Aromatase Inhibition Therapy
- Legemiddel: Goserelin Acetate
Detaljert beskrivelse
PRIMARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of therapy of docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) yields a greater rate of pathologic complete response (pCR) (breast and nodes) than TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
SECONDARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP will increase the pCR rate in the breast compared to TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
II. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves recurrence-free interval (RFI) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
III. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves overall survival (OS) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
IV. To compare the rates of second primary invasive cancer by treatment arm. V. Assessment of patterns of pCR, RFI, and OS by menopausal status. VI. To evaluate the cardiac toxicity associated with each of the regimens. VII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on endocrine-related symptoms in all patients by treatment arm.
VIII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on vasomotor symptoms, musculoskeletal, and vaginal complaints as well as quality of life.
IX. To determine a relationship between pCR and a potential mechanism of resistance/sensitivity in hormone receptor-positive, HER2-positive tumors.
X. To evaluate tumor infiltrating lymphocytes (TILs) and immune biomarkers as predictors of pCR.
XI. To study early changes in TILs and other immune biomarkers in response to TCHP.
OUTLINE: Patients are randomized to 1 of 2 treatments arms.
NEOADJUVANT:
ARM I: Patients receive docetaxel intravenously (IV) over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
ARM II: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate subcutaneously (SC) every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
SURGERY: Patients undergo lumpectomy or mastectomy.
RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery.
ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year.
After completion of study treatment, patients are followed up every 6, 9, 12, and 18 months for 5 years.
Studietype
Studietype
Intervensjonell
Registrering (Faktiske)
Registrering
315
Fase
Fase
- Fase 3
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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Alaska
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Fairbanks, Alaska, Forente stater, 99701
- Fairbanks Memorial Hospital
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Arkansas
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Hot Springs, Arkansas, Forente stater, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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California
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Anaheim, California, Forente stater, 92806
- Kaiser Permanente-Anaheim
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Antioch, California, Forente stater, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Forente stater, 93420
- PCR Oncology
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Auburn, California, Forente stater, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Forente stater, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Baldwin Park, California, Forente stater, 91706
- Kaiser Permanente-Baldwin Park
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Bellflower, California, Forente stater, 90706
- Kaiser Permanente-Bellflower
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Berkeley, California, Forente stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, Forente stater, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, Forente stater, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Castro Valley, California, Forente stater, 94546
- Eden Hospital Medical Center
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Castro Valley, California, Forente stater, 94546
- East Bay Radiation Oncology Center
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Davis, California, Forente stater, 95616
- Sutter Davis Hospital
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Dublin, California, Forente stater, 94568
- Epic Care-Dublin
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Emeryville, California, Forente stater, 94608
- Bay Area Breast Surgeons Inc
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Emeryville, California, Forente stater, 94608
- Epic Care Partners in Cancer Care
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Fontana, California, Forente stater, 92335
- Kaiser Permanente-Fontana
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Fremont, California, Forente stater, 94538
- Kaiser Permanente-Fremont
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Fresno, California, Forente stater, 93720
- Kaiser Permanente-Fresno
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Harbor City, California, Forente stater, 90710
- Kaiser Permanente South Bay
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Irvine, California, Forente stater, 92618
- Kaiser Permanente-Irvine
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Loma Linda, California, Forente stater, 92354
- Loma Linda University Medical Center
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Los Angeles, California, Forente stater, 90027
- Kaiser Permanente Los Angeles Medical Center
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Los Angeles, California, Forente stater, 90048
- Cedars Sinai Medical Center
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Los Angeles, California, Forente stater, 90034
- Kaiser Permanente West Los Angeles
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Martinez, California, Forente stater, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, Forente stater, 95355
- Memorial Medical Center
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Modesto, California, Forente stater, 95356
- Kaiser Permanente-Modesto
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Mountain View, California, Forente stater, 94040
- El Camino Hospital
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Mountain View, California, Forente stater, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Forente stater, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Novato, California, Forente stater, 94945
- Sutter Cancer Research Consortium
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Oakland, California, Forente stater, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Forente stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Forente stater, 94609
- Hematology and Oncology Associates-Oakland
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Oakland, California, Forente stater, 94609
- Bay Area Tumor Institute
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Oakland, California, Forente stater, 94602
- Wilma Chan Highland Hospital
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Orange, California, Forente stater, 92868
- Saint Joseph Hospital - Orange
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Palo Alto, California, Forente stater, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Forente stater, 94301
- Palo Alto Medical Foundation Health Care
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Panorama City, California, Forente stater, 91402
- Kaiser Permanente - Panorama City
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Pleasanton, California, Forente stater, 94588
- Valley Medical Oncology Consultants
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Redwood City, California, Forente stater, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Forente stater, 94801
- Kaiser Permanente-Richmond
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Riverside, California, Forente stater, 92505
- Kaiser Permanente-Riverside
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Roseville, California, Forente stater, 95661
- Kaiser Permanente-Roseville
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Roseville, California, Forente stater, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Forente stater, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Forente stater, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Forente stater, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Forente stater, 95825
- Kaiser Permanente Sacramento Medical Center
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San Diego, California, Forente stater, 92120
- Kaiser Permanente-San Diego Zion
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San Diego, California, Forente stater, 92108
- Kaiser Permanente-San Diego Mission
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San Francisco, California, Forente stater, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Forente stater, 94115
- California Pacific Medical Center-Pacific Campus
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San Jose, California, Forente stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Forente stater, 94577
- Kaiser Permanente San Leandro
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San Marcos, California, Forente stater, 92078
- Kaiser Permanente-San Marcos
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San Pablo, California, Forente stater, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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San Rafael, California, Forente stater, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Forente stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Cruz, California, Forente stater, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Rosa, California, Forente stater, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Forente stater, 95403
- Sutter Pacific Medical Foundation
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South San Francisco, California, Forente stater, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Forente stater, 95210
- Kaiser Permanente-Stockton
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Sunnyvale, California, Forente stater, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Vacaville, California, Forente stater, 95688
- Kaiser Permanente Medical Center-Vacaville
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Vallejo, California, Forente stater, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, Forente stater, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Forente stater, 94596
- Kaiser Permanente-Walnut Creek
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Woodland Hills, California, Forente stater, 91367
- Kaiser Permanente-Woodland Hills
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Colorado
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Aurora, Colorado, Forente stater, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Forente stater, 80012
- The Medical Center of Aurora
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Aurora, Colorado, Forente stater, 80045
- UCHealth University of Colorado Hospital
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Boulder, Colorado, Forente stater, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Forente stater, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, Forente stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forente stater, 80909
- UCHealth Memorial Hospital Central
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Colorado Springs, Colorado, Forente stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Denver, Colorado, Forente stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forente stater, 80220
- Rose Medical Center
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Denver, Colorado, Forente stater, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Forente stater, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Forente stater, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Forente stater, 80222
- Western States Cancer Research NCORP
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Denver, Colorado, Forente stater, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
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Denver, Colorado, Forente stater, 80210
- AdventHealth Porter
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Durango, Colorado, Forente stater, 81301
- Mercy Medical Center
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Durango, Colorado, Forente stater, 81301
- Southwest Oncology PC
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Englewood, Colorado, Forente stater, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Forente stater, 80113
- Swedish Medical Center
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Fort Collins, Colorado, Forente stater, 80524
- Poudre Valley Hospital
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Golden, Colorado, Forente stater, 80401
- Mountain Blue Cancer Care Center
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Greeley, Colorado, Forente stater, 80631
- Banner North Colorado Medical Center
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Greenwood Village, Colorado, Forente stater, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
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Lakewood, Colorado, Forente stater, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, Forente stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, Forente stater, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Forente stater, 80122
- AdventHealth Littleton
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Lone Tree, Colorado, Forente stater, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Forente stater, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Forente stater, 80501
- Longmont United Hospital
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Longmont, Colorado, Forente stater, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Forente stater, 80539
- Banner McKee Medical Center
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Parker, Colorado, Forente stater, 80138
- Rocky Mountain Cancer Centers-Parker
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Parker, Colorado, Forente stater, 80138
- AdventHealth Parker
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Pueblo, Colorado, Forente stater, 81004
- Saint Mary Corwin Medical Center
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Pueblo, Colorado, Forente stater, 81008
- Rocky Mountain Cancer Centers - Pueblo
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Thornton, Colorado, Forente stater, 80260
- Rocky Mountain Cancer Centers-Thornton
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Wheat Ridge, Colorado, Forente stater, 80401
- Intermountain Health Lutheran Hospital
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Connecticut
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Hartford, Connecticut, Forente stater, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Hartford, Connecticut, Forente stater, 06102
- Hartford Hospital
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Delaware
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Lewes, Delaware, Forente stater, 19958
- Beebe Medical Center
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Newark, Delaware, Forente stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forente stater, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Forente stater, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Forente stater, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Forente stater, 19971
- Beebe Health Campus
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Seaford, Delaware, Forente stater, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Forente stater, 19801
- Christiana Care Health System-Wilmington Hospital
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District of Columbia
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Washington D.C., District of Columbia, Forente stater, 20010
- MedStar Washington Hospital Center
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Washington D.C., District of Columbia, Forente stater, 20007
- MedStar Georgetown University Hospital
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Florida
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Deerfield Beach, Florida, Forente stater, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
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Gainesville, Florida, Forente stater, 32610
- University of Florida Health Science Center - Gainesville
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Miami, Florida, Forente stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Orlando, Florida, Forente stater, 32806
- Orlando Health Cancer Institute
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Orlando, Florida, Forente stater, 32803
- AdventHealth Orlando
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Georgia
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Athens, Georgia, Forente stater, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Forente stater, 30342
- Northside Hospital
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Augusta, Georgia, Forente stater, 30912
- Augusta University Medical Center
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Cumming, Georgia, Forente stater, 30041
- Northside Hospital-Forsyth
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Decatur, Georgia, Forente stater, 30033
- Emory Decatur Hospital
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Gainesville, Georgia, Forente stater, 30501
- Northeast Georgia Medical Center-Gainesville
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Savannah, Georgia, Forente stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, Forente stater, 31404
- Memorial Health University Medical Center
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Savannah, Georgia, Forente stater, 31404
- Summit Cancer Care-Memorial
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Savannah, Georgia, Forente stater, 31404
- Low Country Cancer Care
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Hawaii
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Honolulu, Hawaii, Forente stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forente stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forente stater, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Forente stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forente stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forente stater, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Forente stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forente stater, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Forente stater, 96819
- Kaiser Permanente Moanalua Medical Center
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Kailua, Hawaii, Forente stater, 96734
- Castle Medical Center
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Lihue, Hawaii, Forente stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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‘Aiea, Hawaii, Forente stater, 96701
- Pali Momi Medical Center
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‘Aiea, Hawaii, Forente stater, 96701
- Queen's Cancer Center - Pearlridge
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‘Aiea, Hawaii, Forente stater, 96701
- The Cancer Center of Hawaii-Pali Momi
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Idaho
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Boise, Idaho, Forente stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Coeur d'Alene, Idaho, Forente stater, 83814
- Kootenai Health - Coeur d'Alene
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Lewiston, Idaho, Forente stater, 83501
- Saint Joseph Regional Medical Center
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Post Falls, Idaho, Forente stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Forente stater, 83864
- Kootenai Clinic Cancer Services - Sandpoint
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Illinois
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Aurora, Illinois, Forente stater, 60504
- Rush-Copley Medical Center
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Bloomington, Illinois, Forente stater, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, Forente stater, 61701
- OSF Saint Joseph Medical Center
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Canton, Illinois, Forente stater, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Forente stater, 62902
- Memorial Hospital of Carbondale
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Carthage, Illinois, Forente stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forente stater, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, Forente stater, 60612
- University of Illinois
-
Chicago, Illinois, Forente stater, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Forente stater, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, Forente stater, 60625
- Swedish Covenant Hospital
-
Chicago, Illinois, Forente stater, 60631
- Presence Resurrection Medical Center
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Danville, Illinois, Forente stater, 61832
- Carle at The Riverfront
-
Decatur, Illinois, Forente stater, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Forente stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Effingham, Illinois, Forente stater, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Forente stater, 62401
- Carle Physician Group-Effingham
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Elk Grove Village, Illinois, Forente stater, 60007
- Ascension Alexian Brothers - Elk Grove Village
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Eureka, Illinois, Forente stater, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Forente stater, 60202
- Saint Francis Hospital
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Galesburg, Illinois, Forente stater, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Forente stater, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Forente stater, 60134
- Northwestern Medicine Cancer Center Delnor
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Harvey, Illinois, Forente stater, 60426
- Ingalls Memorial Hospital
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Kankakee, Illinois, Forente stater, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, Forente stater, 61443
- Illinois CancerCare-Kewanee Clinic
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Macomb, Illinois, Forente stater, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Forente stater, 61938
- Carle Physician Group-Mattoon/Charleston
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Mount Vernon, Illinois, Forente stater, 62864
- SSM Health Good Samaritan
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Naperville, Illinois, Forente stater, 60540
- Edward Hospital/Cancer Center
-
O'Fallon, Illinois, Forente stater, 62269
- Cancer Care Center of O'Fallon
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Ottawa, Illinois, Forente stater, 61350
- Illinois CancerCare-Ottawa Clinic
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Ottawa, Illinois, Forente stater, 61350
- Radiation Oncology of Northern Illinois
-
Pekin, Illinois, Forente stater, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Forente stater, 61554
- OSF Saint Francis Radiation Oncology at Pekin
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Peoria, Illinois, Forente stater, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Forente stater, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Forente stater, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Forente stater, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peru, Illinois, Forente stater, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Forente stater, 61354
- Valley Radiation Oncology
-
Plainfield, Illinois, Forente stater, 60585
- Edward Hospital/Cancer Center?Plainfield
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Princeton, Illinois, Forente stater, 61356
- Illinois CancerCare-Princeton
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Rockford, Illinois, Forente stater, 61108
- OSF Saint Anthony Medical Center
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Rockford, Illinois, Forente stater, 61114
- UW Health Carbone Cancer Center Rockford
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Springfield, Illinois, Forente stater, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Forente stater, 62702
- Springfield Clinic
-
Springfield, Illinois, Forente stater, 62702
- Central Illinois Hematology Oncology Center
-
Springfield, Illinois, Forente stater, 62781
- Springfield Memorial Hospital
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Urbana, Illinois, Forente stater, 61801
- Carle Cancer Center
-
Urbana, Illinois, Forente stater, 61801
- The Carle Foundation Hospital
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Warrenville, Illinois, Forente stater, 60555
- Northwestern Medicine Cancer Center Warrenville
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Yorkville, Illinois, Forente stater, 60560
- Rush-Copley Healthcare Center
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Indiana
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Crown Point, Indiana, Forente stater, 46307
- Michiana Hematology Oncology PC-Crown Point
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Elkhart, Indiana, Forente stater, 46515
- Elkhart General Hospital
-
Elkhart, Indiana, Forente stater, 46514
- Michiana Hematology Oncology PC-Elkhart
-
Elkhart, Indiana, Forente stater, 46514-2098
- Elkhart Clinic
-
Indianapolis, Indiana, Forente stater, 46237
- Franciscan Health Indianapolis
-
Kokomo, Indiana, Forente stater, 46904
- Community Howard Regional Health
-
La Porte, Indiana, Forente stater, 46350
- IU Health La Porte Hospital
-
Michigan City, Indiana, Forente stater, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, Forente stater, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, Forente stater, 46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka, Indiana, Forente stater, 46545
- Saint Joseph Regional Medical Center-Mishawaka
-
Munster, Indiana, Forente stater, 46321
- The Community Hospital
-
Plymouth, Indiana, Forente stater, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, Forente stater, 47374
- Reid Health
-
South Bend, Indiana, Forente stater, 46628
- Northern Indiana Cancer Research Consortium
-
Terre Haute, Indiana, Forente stater, 47804
- Union Hospital
-
Westville, Indiana, Forente stater, 46391
- Michiana Hematology Oncology PC-Westville
-
-
Iowa
-
Ames, Iowa, Forente stater, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Forente stater, 50010
- McFarland Clinic - Ames
-
Boone, Iowa, Forente stater, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, Forente stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forente stater, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, Forente stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forente stater, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Forente stater, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Forente stater, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Forente stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forente stater, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Forente stater, 50501
- McFarland Clinic - Trinity Cancer Center
-
Iowa City, Iowa, Forente stater, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Jefferson, Iowa, Forente stater, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Forente stater, 50158
- McFarland Clinic - Marshalltown
-
West Des Moines, Iowa, Forente stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Forente stater, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Forente stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forente stater, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Forente stater, 66701
- Cancer Center of Kansas - Fort Scott
-
Independence, Kansas, Forente stater, 67301
- Cancer Center of Kansas-Independence
-
Kingman, Kansas, Forente stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forente stater, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Forente stater, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Forente stater, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Forente stater, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Forente stater, 67114
- Cancer Center of Kansas - Newton
-
Parsons, Kansas, Forente stater, 67357
- Cancer Center of Kansas - Parsons
-
Pratt, Kansas, Forente stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forente stater, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Forente stater, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, Forente stater, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Forente stater, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Forente stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forente stater, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Forente stater, 67208
- Associates In Womens Health
-
Wichita, Kansas, Forente stater, 67214
- Wichita NCI Community Oncology Research Program
-
Winfield, Kansas, Forente stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, Forente stater, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Forente stater, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, Forente stater, 40701
- Commonwealth Cancer Center-Corbin
-
Crestview Hills, Kentucky, Forente stater, 41017
- Oncology Hematology Care Inc-Crestview
-
Elizabethtown, Kentucky, Forente stater, 42701
- Baptist Health Hardin
-
Lexington, Kentucky, Forente stater, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Forente stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forente stater, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, Forente stater, 40503
- Baptist Health Lexington
-
Louisville, Kentucky, Forente stater, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Forente stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forente stater, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Forente stater, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Forente stater, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, Forente stater, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Forente stater, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, Forente stater, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Forente stater, 70809
- Ochsner Health Center-Summa
-
Kenner, Louisiana, Forente stater, 70065
- Ochsner Medical Center Kenner
-
New Orleans, Louisiana, Forente stater, 70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Bangor, Maine, Forente stater, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, Forente stater, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore, Maryland, Forente stater, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Forente stater, 21204
- Greater Baltimore Medical Center
-
Elkton, Maryland, Forente stater, 21921
- Christiana Care - Union Hospital
-
Frederick, Maryland, Forente stater, 21701
- Frederick Memorial Hospital
-
-
Massachusetts
-
Fall River, Massachusetts, Forente stater, 02721
- Saint Anne's Hospital
-
Pittsfield, Massachusetts, Forente stater, 01201
- Berkshire Medical Center - Cancer Center
-
-
Michigan
-
Adrian, Michigan, Forente stater, 49221
- Bixby Medical Center
-
Adrian, Michigan, Forente stater, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Forente stater, 48106
- Michigan Cancer Research Consortium NCORP
-
Ann Arbor, Michigan, Forente stater, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Ann Arbor, Michigan, Forente stater, 48109
- University of Michigan Comprehensive Cancer Center
-
Dearborn, Michigan, Forente stater, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Forente stater, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Forente stater, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Forente stater, 48236
- Henry Ford Health Saint John Hospital
-
Farmington Hills, Michigan, Forente stater, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Forente stater, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Forente stater, 48503
- Hurley Medical Center
-
Flint, Michigan, Forente stater, 48503
- Genesys Hurley Cancer Institute
-
Grosse Pointe, Michigan, Forente stater, 48230
- William Beaumont Hospital-Grosse Pointe
-
Jackson, Michigan, Forente stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forente stater, 49007
- West Michigan Cancer Center
-
Lansing, Michigan, Forente stater, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Forente stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Midland, Michigan, Forente stater, 48670
- MyMichigan Medical Center Midland
-
Monroe, Michigan, Forente stater, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, Forente stater, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Pontiac, Michigan, Forente stater, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Port Huron, Michigan, Forente stater, 48060
- Lake Huron Medical Center
-
Roseville, Michigan, Forente stater, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, Forente stater, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, Forente stater, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Forente stater, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Forente stater, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Forente stater, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, Forente stater, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Forente stater, 48601
- MyMichigan Medical Center Saginaw
-
Sterling Heights, Michigan, Forente stater, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, Forente stater, 48314
- Mitchell Folbe MD PC
-
Troy, Michigan, Forente stater, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Forente stater, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, Forente stater, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Forente stater, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Forente stater, 48093
- Henry Ford Health Warren Hospital
-
-
Minnesota
-
Bemidji, Minnesota, Forente stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forente stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forente stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forente stater, 55433
- Mercy Hospital
-
Duluth, Minnesota, Forente stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forente stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forente stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forente stater, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Forente stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Forente stater, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Forente stater, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, Forente stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forente stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forente stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forente stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forente stater, 55454
- Health Partners Inc
-
New Ulm, Minnesota, Forente stater, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Forente stater, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Forente stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Forente stater, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, Forente stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forente stater, 55102
- United Hospital
-
Shakopee, Minnesota, Forente stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forente stater, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Forente stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forente stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forente stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Missouri
-
Ballwin, Missouri, Forente stater, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Forente stater, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Forente stater, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Forente stater, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Forente stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forente stater, 63703
- Mercy Cancer Center - Cape Girardeau
-
Columbia, Missouri, Forente stater, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Jefferson City, Missouri, Forente stater, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Forente stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forente stater, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, Forente stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Forente stater, 65401
- Phelps Health Delbert Day Cancer Institute
-
Sainte Genevieve, Missouri, Forente stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forente stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forente stater, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Forente stater, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Forente stater, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Forente stater, 63141
- Mercy Hospital Saint Louis
-
Sullivan, Missouri, Forente stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forente stater, 63127
- BJC Outpatient Center at Sunset Hills
-
-
Montana
-
Anaconda, Montana, Forente stater, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Forente stater, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Forente stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forente stater, 59102
- Montana Cancer Consortium NCORP
-
Bozeman, Montana, Forente stater, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Forente stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forente stater, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Forente stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forente stater, 59901
- Logan Health Medical Center
-
Missoula, Montana, Forente stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forente stater, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Forente stater, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Forente stater, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Forente stater, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, Forente stater, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Forente stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forente stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forente stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forente stater, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Forente stater, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Forente stater, 68046
- Midlands Community Hospital
-
-
Nevada
-
Henderson, Nevada, Forente stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forente stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forente stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forente stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forente stater, 89074
- GenesisCare USA - Henderson
-
Las Vegas, Nevada, Forente stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forente stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forente stater, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, Forente stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forente stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forente stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forente stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forente stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forente stater, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Forente stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forente stater, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Forente stater, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Forente stater, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Forente stater, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Forente stater, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Forente stater, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, Forente stater, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Forente stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forente stater, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, Forente stater, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Forente stater, 89120
- Nevada Cancer Research Foundation NCORP
-
Reno, Nevada, Forente stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forente stater, 89503
- Saint Mary's Regional Medical Center
-
-
New Hampshire
-
Lebanon, New Hampshire, Forente stater, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Elizabeth, New Jersey, Forente stater, 07207
- Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
-
Englewood, New Jersey, Forente stater, 07631
- Englewood Hospital and Medical Center
-
Flemington, New Jersey, Forente stater, 08822
- Hunterdon Medical Center
-
Mullica Hill, New Jersey, Forente stater, 08062
- Inspira Medical Center Mullica Hill
-
Newark, New Jersey, Forente stater, 07112
- Newark Beth Israel Medical Center
-
Newton, New Jersey, Forente stater, 07860
- Newton Medical Center
-
Pompton, New Jersey, Forente stater, 07444
- Chilton Medical Center
-
Summit, New Jersey, Forente stater, 07902
- Overlook Hospital
-
Vineland, New Jersey, Forente stater, 08360
- Inspira Medical Center Vineland
-
-
New Mexico
-
Albuquerque, New Mexico, Forente stater, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Forente stater, 87106
- Hematology Oncology Associates
-
Las Cruces, New Mexico, Forente stater, 88011
- Memorial Medical Center-Las Cruces
-
Santa Fe, New Mexico, Forente stater, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Buffalo, New York, Forente stater, 14263
- Roswell Park Cancer Institute
-
Glens Falls, New York, Forente stater, 12801
- Glens Falls Hospital
-
Middletown, New York, Forente stater, 10940
- Garnet Health Medical Center
-
New York, New York, Forente stater, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
-
North Carolina
-
Asheboro, North Carolina, Forente stater, 27203
- Randolph Hospital
-
Asheville, North Carolina, Forente stater, 28803
- AdventHealth Infusion Center Asheville
-
Burlington, North Carolina, Forente stater, 27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, Forente stater, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, Forente stater, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, Forente stater, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Forente stater, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Forente stater, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, Forente stater, 28792
- AdventHealth Hendersonville
-
Jacksonville, North Carolina, Forente stater, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kernersville, North Carolina, Forente stater, 27284
- Novant Health Cancer Institute - Kernersville
-
Kinston, North Carolina, Forente stater, 28501
- ECU Health Oncology Kinston
-
Mebane, North Carolina, Forente stater, 27302
- Cone Heath Cancer Center at Mebane
-
Mount Airy, North Carolina, Forente stater, 27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro, North Carolina, Forente stater, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Pinehurst, North Carolina, Forente stater, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Reidsville, North Carolina, Forente stater, 27320
- Annie Penn Memorial Hospital
-
Salisbury, North Carolina, Forente stater, 28144
- Novant Health Cancer Institute - Rowan
-
Statesville, North Carolina, Forente stater, 28677
- Iredell Memorial Hospital
-
Stateville, North Carolina, Forente stater, 28625
- Novant Health Cancer Institute - Statesville
-
Thomasville, North Carolina, Forente stater, 27360
- Novant Health Cancer Institute - Thomasville
-
Winston-Salem, North Carolina, Forente stater, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, Forente stater, 27103
- Novant Health Forsyth Medical Center
-
Winston-Salem, North Carolina, Forente stater, 27103
- Novant Health Oncology Specialists
-
Winston-Salem, North Carolina, Forente stater, 27103
- Winston-Salem Health Care
-
Winston-Salem, North Carolina, Forente stater, 27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Bismarck, North Dakota, Forente stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forente stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forente stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forente stater, 58122
- Sanford Broadway Medical Center
-
Grand Forks, North Dakota, Forente stater, 58201
- Altru Cancer Center
-
Minot, North Dakota, Forente stater, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron, Ohio, Forente stater, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, Forente stater, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, Forente stater, 44203
- Summa Health System - Barberton Campus
-
Belpre, Ohio, Forente stater, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, Forente stater, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, Forente stater, 44710
- Aultman Health Foundation
-
Centerville, Ohio, Forente stater, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Forente stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Forente stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forente stater, 45219
- The Christ Hospital
-
Cincinnati, Ohio, Forente stater, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Forente stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forente stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forente stater, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, Forente stater, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, Forente stater, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, Forente stater, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, Forente stater, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Forente stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forente stater, 45255
- TriHealth Cancer Institute-Anderson
-
Columbus, Ohio, Forente stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forente stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forente stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forente stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forente stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forente stater, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Forente stater, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, Forente stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forente stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forente stater, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Forente stater, 45459
- Dayton NCI Community Oncology Research Program
-
Dayton, Ohio, Forente stater, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, Forente stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forente stater, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, Forente stater, 43015
- Grady Memorial Hospital
-
Fairfield, Ohio, Forente stater, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, Forente stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forente stater, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Forente stater, 45840
- Orion Cancer Care
-
Franklin, Ohio, Forente stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Forente stater, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, Forente stater, 45331
- Wayne Hospital
-
Greenville, Ohio, Forente stater, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, Forente stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forente stater, 45409
- Greater Dayton Cancer Center
-
Lancaster, Ohio, Forente stater, 43130
- Fairfield Medical Center
-
Lancaster, Ohio, Forente stater, 43130
- Lancaster Radiation Oncology
-
Lima, Ohio, Forente stater, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, Forente stater, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Forente stater, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Forente stater, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Medina, Ohio, Forente stater, 44256
- Summa Health Medina Medical Center
-
Middletown, Ohio, Forente stater, 45042
- Dayton Physicians LLC-Signal Point
-
Mount Vernon, Ohio, Forente stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forente stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forente stater, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, Forente stater, 43616
- Saint Charles Hospital
-
Oregon, Ohio, Forente stater, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Portsmouth, Ohio, Forente stater, 45662
- Southern Ohio Medical Center
-
Sidney, Ohio, Forente stater, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, Forente stater, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Forente stater, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, Forente stater, 43560
- ProMedica Flower Hospital
-
Tiffin, Ohio, Forente stater, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, Forente stater, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, Forente stater, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Forente stater, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Forente stater, 43614
- University of Toledo
-
Toledo, Ohio, Forente stater, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo, Ohio, Forente stater, 43608
- Mercy Health - Saint Vincent Hospital
-
Troy, Ohio, Forente stater, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Forente stater, 45373
- Dayton Physicians LLC - Troy
-
Wauseon, Ohio, Forente stater, 43567
- Fulton County Health Center
-
West Chester, Ohio, Forente stater, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Forente stater, 43081
- Saint Ann's Hospital
-
Wpafb, Ohio, Forente stater, 45433
- Wright-Patterson Medical Center
-
Zanesville, Ohio, Forente stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forente stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forente stater, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, Forente stater, 74136
- Natalie Warren Bryant Cancer Center at Saint Francis
-
Tulsa, Oklahoma, Forente stater, 74136
- Surgical Associates Inc
-
Tulsa, Oklahoma, Forente stater, 74146
- Warren Clinic Oncology-Tulsa
-
-
Oregon
-
Portland, Oregon, Forente stater, 97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Beaver, Pennsylvania, Forente stater, 15009
- UPMC-Heritage Valley Health System Beaver
-
Chadds Ford, Pennsylvania, Forente stater, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, Forente stater, 17822
- Geisinger Medical Center
-
Easton, Pennsylvania, Forente stater, 18042
- Easton Hospital
-
Greensburg, Pennsylvania, Forente stater, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Harrisburg, Pennsylvania, Forente stater, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton, Pennsylvania, Forente stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Forente stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Jefferson Hills, Pennsylvania, Forente stater, 15025
- Jefferson Hospital
-
Johnstown, Pennsylvania, Forente stater, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, Forente stater, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Forente stater, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, Forente stater, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Monroeville, Pennsylvania, Forente stater, 15146
- Forbes Hospital
-
Moon Township, Pennsylvania, Forente stater, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Philadelphia, Pennsylvania, Forente stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forente stater, 19114
- Jefferson Torresdale Hospital
-
Phoenixville, Pennsylvania, Forente stater, 19460
- Reading Hospital McGlinn Cancer Institute at Phoenixville
-
Pittsburgh, Pennsylvania, Forente stater, 15212
- Allegheny General Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15224
- West Penn Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, Forente stater, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Forente stater, 15236
- UPMC Jefferson Regional Radiation Oncology
-
Pittsburgh, Pennsylvania, Forente stater, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Forente stater, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, Forente stater, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Forente stater, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Seneca, Pennsylvania, Forente stater, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, Forente stater, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, Forente stater, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, Forente stater, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Chester, Pennsylvania, Forente stater, 19380
- Chester County Hospital
-
West Grove, Pennsylvania, Forente stater, 19390
- Jennersville Regional Hospital
-
West Reading, Pennsylvania, Forente stater, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Forente stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Forente stater, 17701
- UPMC Susquehanna
-
-
Rhode Island
-
Providence, Rhode Island, Forente stater, 02905
- Women and Infants Hospital
-
Warwick, Rhode Island, Forente stater, 02886
- Kent Hospital
-
-
South Carolina
-
Anderson, South Carolina, Forente stater, 29621
- AnMed Health Cancer Center
-
Boiling Springs, South Carolina, Forente stater, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, Forente stater, 29640
- Prisma Health Cancer Institute - Easley
-
Georgetown, South Carolina, Forente stater, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Forente stater, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Forente stater, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Forente stater, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Forente stater, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, Forente stater, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greer, South Carolina, Forente stater, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Forente stater, 29651
- Gibbs Cancer Center-Pelham
-
Lancaster, South Carolina, Forente stater, 29720
- Carolina Blood and Cancer Care Associates PA-Lancaster
-
Rock Hill, South Carolina, Forente stater, 29732
- Carolina Blood and Cancer Care Associates PA
-
Seneca, South Carolina, Forente stater, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Forente stater, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Forente stater, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Sioux Falls, South Dakota, Forente stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forente stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forente stater, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, Forente stater, 37404
- Memorial Hospital
-
Hixson, Tennessee, Forente stater, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Jackson, Tennessee, Forente stater, 38301
- Jackson-Madison County General Hospital
-
Nashville, Tennessee, Forente stater, 37208
- Meharry Medical College
-
Ooltewah, Tennessee, Forente stater, 37363
- Memorial GYN Plus
-
-
Texas
-
Abilene, Texas, Forente stater, 79601
- Hendrick Medical Center
-
Houston, Texas, Forente stater, 77026-1967
- Lyndon Baines Johnson General Hospital
-
Houston, Texas, Forente stater, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, Forente stater, 77030
- Ben Taub General Hospital
-
Laredo, Texas, Forente stater, 78041
- Doctor's Hospital of Laredo
-
San Antonio, Texas, Forente stater, 78229
- University Hospital
-
San Antonio, Texas, Forente stater, 78229
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Forente stater, 78229
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
-
-
Utah
-
Salt Lake City, Utah, Forente stater, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Vermont
-
Berlin Corners, Vermont, Forente stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forente stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forente stater, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Fredericksburg, Virginia, Forente stater, 22401
- Fredericksburg Oncology Inc
-
Fredericksburg, Virginia, Forente stater, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Mechanicsville, Virginia, Forente stater, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Forente stater, 23114
- Bon Secours Saint Francis Medical Center
-
Richmond, Virginia, Forente stater, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Forente stater, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Forente stater, 23970
- VCU Community Memorial Health Center
-
Winchester, Virginia, Forente stater, 22601
- Shenandoah Oncology PC
-
-
Washington
-
Auburn, Washington, Forente stater, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, Forente stater, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, Forente stater, 98004
- Overlake Medical Center
-
Burien, Washington, Forente stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forente stater, 98531
- Providence Regional Cancer System-Centralia
-
Enumclaw, Washington, Forente stater, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Forente stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forente stater, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, Forente stater, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Forente stater, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, Forente stater, 98335
- MultiCare Gig Harbor Medical Park
-
Kennewick, Washington, Forente stater, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, Forente stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forente stater, 98499
- Saint Clare Hospital
-
Lynnwood, Washington, Forente stater, 98036
- Virginia Mason Lynnwood Medical Center
-
Olympia, Washington, Forente stater, 98506-5166
- Providence - Saint Peter Hospital
-
Olympia, Washington, Forente stater, 98507
- Capital Medical Center
-
Port Townsend, Washington, Forente stater, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Forente stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Poulsbo, Washington, Forente stater, 98370
- Peninsula Cancer Center
-
Puyallup, Washington, Forente stater, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, Forente stater, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Seattle, Washington, Forente stater, 98101
- Virginia Mason Medical Center
-
Silverdale, Washington, Forente stater, 98383
- Saint Michael Cancer Center
-
Tacoma, Washington, Forente stater, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Forente stater, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Forente stater, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, Forente stater, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, Forente stater, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Tacoma, Washington, Forente stater, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, Forente stater, 98405
- Northwest NCI Community Oncology Research Program
-
Tacoma, Washington, Forente stater, 98405
- Saint Joseph Medical Center
-
-
West Virginia
-
Bridgeport, West Virginia, Forente stater, 26330
- United Hospital Center
-
Charleston, West Virginia, Forente stater, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, Forente stater, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, Forente stater, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, Forente stater, 26506
- West Virginia University Healthcare
-
Morgantown, West Virginia, Forente stater, 26505
- Monongalia Hospital
-
Parkersburg, West Virginia, Forente stater, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Burlington, Wisconsin, Forente stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Forente stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forente stater, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Forente stater, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac, Wisconsin, Forente stater, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Forente stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forente stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forente stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forente stater, 54301
- Bellin Memorial Hospital
-
Janesville, Wisconsin, Forente stater, 53548
- Mercyhealth Hospital and Cancer Center - Janesville
-
Kenosha, Wisconsin, Forente stater, 53142
- Aurora Cancer Care-Kenosha South
-
Ladysmith, Wisconsin, Forente stater, 54848
- Marshfield Medical Center - Ladysmith
-
Marinette, Wisconsin, Forente stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Forente stater, 54449
- Marshfield Medical Center-Marshfield
-
Marshfield, Wisconsin, Forente stater, 54449
- Marshfield Medical Center
-
Milwaukee, Wisconsin, Forente stater, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Forente stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forente stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forente stater, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Forente stater, 54548
- Marshfield Medical Center - Minocqua
-
New Richmond, Wisconsin, Forente stater, 54017
- Cancer Center of Western Wisconsin
-
Oshkosh, Wisconsin, Forente stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forente stater, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, Forente stater, 54501
- Saint Mary's Hospital
-
Rhinelander, Wisconsin, Forente stater, 54501
- Aspirus Cancer Care - James Beck Cancer Center
-
Rice Lake, Wisconsin, Forente stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forente stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Forente stater, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, Forente stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forente stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Forente stater, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, Forente stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forente stater, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Forente stater, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Forente stater, 54476
- Marshfield Medical Center - Weston
-
Weston, Wisconsin, Forente stater, 54476
- Diagnostic and Treatment Center
-
Weston, Wisconsin, Forente stater, 54476
- Ascension Saint Clare's Hospital
-
Wisconsin Rapids, Wisconsin, Forente stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Casper, Wyoming, Forente stater, 82609
- Rocky Mountain Oncology
-
Cheyenne, Wyoming, Forente stater, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Forente stater, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, Forente stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forente stater, 82801
- Welch Cancer Center
-
-
-
-
-
San Juan, Puerto Rico, 00936
- San Juan City Hospital
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år og eldre (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Hunn
Beskrivelse
Inclusion Criteria:
-
Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer; (comorbid conditions should be taken into consideration, but not the diagnosis of breast cancer)
-
Women of reproductive potential must agree to use an effective non-hormonal method of contraception during study therapy (chemotherapy, trastuzumab, pertuzumab, and estrogen deprivation therapy) and for at least 7 months after the last dose of study therapy
-
Submission of tumor samples is required for all patients; the local pathology department policy regarding release of tumor samples must be considered in the screening process; patients whose tumor samples are located in a pathology department that by policy will not submit any samples for research purposes should not be approached for participation in the B-52 trial
-
The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
-
The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
-
Clinical staging for the primary tumor can be cT1c (must be 2.0 cm) or T2-T4 if clinically node negative; if the regional lymph nodes are cN1 and cytologically or histologically positive or if cN2-N3 with or without a biopsy, the primary breast tumor can be cT0-T4
-
The diagnosis of invasive adenocarcinoma of the breast must have been made by core needle biopsy
-
Ipsilateral axillary lymph nodes must be evaluated by imaging (mammogram, ultrasound, and/or magnetic resonance imaging [MRI]) within 6 weeks prior to randomization; if suspicious or abnormal, fine needle aspirate (FNA) or core biopsy is recommended, also within 6 weeks prior to randomization; findings of these evaluations will be used to determine the nodal status prior to randomization:
-
Nodal status - negative
- Imaging of the axilla is negative
- Imaging is suspicious or abnormal but the FNA or core biopsy of the questionable node(s) on imaging is negative
-
Nodal status - positive
- FNA or core biopsy of the node(s) is cytologically or histologically suspicious or positive
- Imaging is suspicious or abnormal but FNA or core biopsy was not performed
-
-
Patients may be premenopausal or postmenopausal at the time of randomization; for study purposes, postmenopausal is defined as:
- Age 56 or older with no spontaneous menses for at least 12 months prior to study entry; or
- Age 55 or younger with no spontaneous menses for at least 12 months prior to study entry (e.g., spontaneous or secondary to hysterectomy) and with a documented estradiol level in the postmenopausal range according to local institutional/laboratory standard; or
- Documented bilateral oophorectomy
-
The tumor must have been determined to be HER2-postive as follows:
- Immunohistochemistry (IHC) 3+ or
- In situ hybridization (ISH)-positive (defined by ratio of HER2 to circulating endothelial progenitors [CEP]17 >= 2.0 or HER2 gene copy number >= 6 per nucleus)
-
The tumor must have been determined to be estrogen receptor (ER) and/or progesterone (PgR) positive assessed by current American Society of Clinical Oncology (ASCO)/College of American Pathologist (CAP) guideline recommendations for hormone receptor testing; patients with >= 1% ER or PgR staining by IHC are considered positive
-
Absolute neutrophil count (ANC) must be >= 1200/mm^3
-
Platelet count must be >= 100,000/mm^3
-
Hemoglobin must be >= 10 g/dL
-
Total bilirubin must be =< upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin
-
Alkaline phosphatase must be =< 2.5 x ULN for the lab
-
Aspartate aminotransferase (AST) must be =< 1.5 x ULN for the lab
-
Alkaline phosphatase and AST may not both be > the ULN; for example, if the alkaline phosphatase is > the ULN but =< 2.5 x ULN, the AST must be =< the ULN; if the AST is > the ULN but =< 1.5 x ULN, the alkaline phosphatase must be =< ULN; Note: If alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< 1.5 x ULN; if both were performed, the AST must be =< 1.5 x ULN
-
Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (computed tomography [CT], MRI, positron emission tomography [PET]-CT, or PET scan) performed within 6 weeks prior to randomization does not demonstrate metastatic disease and the requirements are met
-
Patients with alkaline phosphatase that is > ULN but =< 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 6 weeks prior to randomization does not demonstrate metastatic disease
-
Within 6 weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > 60 mL/min
-
Left ventricular ejection fraction (LVEF) assessment must be performed within 90 days prior to randomization; (LVEF assessment performed by 2-dimensional [2-D] echocardiogram is preferred; however, multi gated acquisition scan [MUGA] scan may be substituted based on institutional preferences); the LVEF must be >= 50% regardless of the cardiac imaging facility's lower limit of normal; note: since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment; if the baseline LVEF is > 65%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain
Exclusion Criteria:
-
FNA alone to diagnose the breast cancer
-
Excisional biopsy or lumpectomy performed prior to randomization
-
Surgical axillary staging procedure prior to randomization; pre-neoadjuvant therapy sentinel node biopsy is not permitted
-
Definitive clinical or radiologic evidence of metastatic disease; (chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 90 days prior to randomization)
-
Synchronous bilateral invasive breast cancer
-
Synchronous or previous contralateral invasive breast cancer; (patients with synchronous and/or previous contralateral ductal carcinoma in situ [DCIS] or lobular carcinoma in situ [LCIS] are eligible)
-
Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible)
-
Treatment including radiation therapy (RT), chemotherapy, targeted therapy, or endocrine therapy for the currently diagnosed breast cancer prior to randomization
-
Previous endocrine therapy such as raloxifene or tamoxifen (or other selective estrogen receptor modulator [SERM]) or an aromatase inhibitor for any malignancy
-
Previous therapy with anthracycline, taxanes, carboplatin, trastuzumab, or other HER2 targeted therapies for any malignancy
-
Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. (these patients are eligible if this therapy is discontinued prior to randomization)
-
History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
-
Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens; this includes but is not confined to:
-
Active cardiac disease:
- Angina pectoris that requires the use of anti-anginal medication;
- Ventricular arrhythmias except for benign premature ventricular contractions;
- Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication;
- Conduction abnormality requiring a pacemaker;
- Valvular disease with documented compromise in cardiac function; and
- Symptomatic pericarditis
-
History of cardiac disease:
- Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function;
- History of documented congestive heart failure (CHF); and
- Documented cardiomyopathy
-
-
Uncontrolled hypertension defined as sustained systolic blood pressure (BP) > 150 mmHg or diastolic BP > 90 mmHg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)
-
Active hepatitis B or hepatitis C with abnormal liver function tests
-
Intrinsic lung disease resulting in dyspnea
-
Poorly controlled diabetes mellitus
-
Active infection or chronic infection requiring chronic suppressive antibiotics
-
Patients known to be human immunodeficiency virus (HIV) positive with a baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 or have a history of acquired immune deficiency syndrome (AIDS) indicator conditions; patients taking anti-retroviral therapy that may have a potential overlapping toxicity with the study therapy are not eligible
-
Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) >= grade 2, per the Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v4.0)
-
Malabsorption syndrome, ulcerative colitis, resection of the stomach or small bowel, or other disease significantly affecting gastrointestinal function
-
Other non-malignant systemic disease that would preclude treatment with any of the treatment regimens or would prevent required follow-up
-
Conditions that would prohibit administration of corticosteroids
-
Chronic daily treatment with corticosteroids with a dose of >= 10 mg/day methylprednisolone equivalent (excluding inhaled steroids)
-
Known hypersensitivity to any of the study drugs or any of the ingredients or excipients of these drugs (e.g., polysorbate 80), including sensitivity to benzyl alcohol
-
Pregnancy or lactation at the time of study entry; (note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
-
Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements
-
Use of any investigational product within 30 days prior to randomization
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Ingen (Open Label)
Antall våpen
2
Våpen og intervensjoner
Deltakergruppe / ArmDeltakergruppe / Arm |
Intervensjon / BehandlingIntervensjon / Behandling |
|---|---|
|
Aktiv komparator: Arm I (combination chemotherapy, surgery, radiation)
NEOADJUVANT: Patients receive docetaxel IV over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
Andre navn:
Given IV
Andre navn:
Correlative studies Ancillary studies
Andre navn:
Given IV
Andre navn:
Undergo 2 core biopsies
Andre navn:
Given IV
Andre navn:
Undergo lumpectomy or mastectomy Undergo whole breast irradiation |
|
Eksperimentell: Arm II (chemo, estrogen deprivation, surgery, radiation)
NEOADJUVANT: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate SC every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
Andre navn:
Given IV
Andre navn:
Correlative studies Ancillary studies
Andre navn:
Given IV
Andre navn:
Undergo 2 core biopsies
Andre navn:
Given IV
Andre navn:
Undergo lumpectomy or mastectomy Undergo whole breast irradiation Given at the investigator's discretion
Andre navn:
Given SC
Andre navn:
|
Hva måler studien?
Primære resultatmål
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes
Tidsramme: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
Sekundære resultatmål
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Percent of Patients With Pathologic Complete Response (pCR) in the Breast
Tidsramme: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR in the breast, defined as the absence of any invasive component in the resected breast specimen. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Recurrence Free Interval (RFI)
Tidsramme: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
|
Overall Survival (OS)
Tidsramme: Time from randomization until death from any cause, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients surviving. |
Time from randomization until death from any cause, assessed up to 8.4 years
|
|
Second Primary Cancer of Any Type
Tidsramme: Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
Number of second primary cancers for the two treatment groups |
Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes by Menopausal Status
Tidsramme: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy calculated separately for premenopausal and postmenopausal women. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Patterns of Recurrence Free Interval (RFI) by Menopausal Status
Tidsramme: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence by menopausal status. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
|
Patterns of Overall Survival (OS) by Menopausal Status
Tidsramme: Time from randomization until death from any cause, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients surviving by menopausal status. |
Time from randomization until death from any cause, assessed up to 5 years
|
|
Percentage of Participants With Cardiac Toxicity Categorized According to National Cancer Institute CTCAE Version 4.0
Tidsramme: Up to 6 weeks post surgery
|
Percentage of patients with grade 1 or higher toxicity from the Cardiac Disorders System Organ Class. |
Up to 6 weeks post surgery
|
|
Median Percentage of Tumor-infiltrating Lymphocytes (sTILS)
Tidsramme: 2.8 years
|
Percentage of Tumor-infiltrating lymphocytes present in the stroma in tissue specimen. |
2.8 years
|
|
Change in Endocrine-related Symptoms Using Breast Cancer Prevention Trial (BCPT) Symptom Checklist
Tidsramme: The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
The Breast Cancer Prevention Trial (BCPT) symptom checklist contains 17 endocrine-related symptoms and problems. For each item, the patient was asked how bothersome the problem or symptom was during the past four weeks. Possible answers ranged from not at all (1) to extremely (5). The summary score was calculated for each participant as the average severity of all 17 items. The total mean summary score was calculated as the average summary score by treatment group. The range is 1-5 with higher scores indicating worse outcome. |
The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Sponsor
Samarbeidspartnere
Samarbeidspartnere
Etterforskere
Etterforskere
- Hovedetterforsker: Mothaffar F Rimawi, NRG Oncology
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
Studiestart
18. februar 2014
Primær fullføring (Faktiske)
Primær fullføring
31. oktober 2016
Studiet fullført (Faktiske)
Studiet fullført
30. juni 2025
Datoer for studieregistrering
Først innsendt
Først innsendt
2. desember 2013
Først innsendt som oppfylte QC-kriteriene
Først innsendt som oppfylte QC-kriteriene
2. desember 2013
Først lagt ut (Antatt)
Først lagt ut
6. desember 2013
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Sist oppdatering lagt ut
6. oktober 2026
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Siste oppdatering sendt inn som oppfylte QC-kriteriene
15. september 2026
Sist bekreftet
Sist bekreftet
1. september 2026
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
- Neoplasmer etter nettsted
- Neoplasmer
- Hudsykdommer
- Bryst sykdommer
- Hud- og bindevevssykdommer
- Brystneoplasmer
- Fysiologiske effekter av legemidler
- Molekylære mekanismer for farmakologisk virkning
- Hormoner
- Hormoner, hormonsubstitutter og hormonantagonister
- Enzymhemmere
- Steroidesyntesehemmere
- Hormonantagonister
- Østrogenantagonister
- Humofyshormonfrigjørende hormoner
- Hypotalamiske hormoner
- Peptidhormoner
- Nevropeptider
- Peptider
- Aminosyrer, peptider og proteiner
- Oligopeptider
- Nervevevsproteiner
- Proteiner
- Organiske kjemikalier
- Farmakologiske handlinger
- Kjemiske handlinger og bruk
- Hydrokarboner
- Cycloparaffins
- Hydrokarboner, alicyklisk
- Hydrokarboner, syklisk
- Terpener
- Antistoffer, monoklonalt, humanisert
- Antistoffer, monoklonalt
- Antistoffer
- Immunoglobuliner
- Immunoproteiner
- Blodproteiner
- Serumglobuliner
- Globuliner
- Koordinasjonskomplekser
- Taxoider
- Cyclodecanes
- Diterpenes
- Gonadotropinfrigjørende hormon
- Docetaxel
- Trastuzumab
- Karboplatin
- Goserelin
- Aromatasehemmere
- Pertuzumab
- 2C4 antistoff
- CT-P6
- PF-05280014
- trastuzumab biosimilar hlx02
- Ogivri
- Ontruzant
Andre studie-ID-numre
Andre studie-ID-numre
- NCI-2013-02228
- U10CA180868 (U.S. NIH-stipend/kontrakt)
- U10CA012027 (U.S. NIH-stipend/kontrakt)
- NCI-2013-02228 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
- NSABP-B-52 (Annen identifikator: CTEP)
- NSABP-B-52 (Annen identifikator: NRG Oncology)
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .