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Docetaxel, carboplatino, trastuzumab e pertuzumab con o senza privazione di estrogeni nel trattamento di pazienti con carcinoma mammario operabile o localmente avanzato con recettore ormonale positivo, HER2 positivo

15 settembre 2026 aggiornato da: National Cancer Institute (NCI)

Uno studio randomizzato di fase III che valuta i tassi di risposta patologica completa in pazienti con carcinoma mammario positivo al recettore ormonale, HER2 positivo, operabile di grandi dimensioni e localmente avanzato trattate con terapia neoadiuvante di docetaxel, carboplatino, trastuzumab e pertuzumab (TCHP) con o senza privazione di estrogeni

This randomized phase III trial studies docetaxel, carboplatin, trastuzumab, and pertuzumab with estrogen deprivation to see how they work compared to docetaxel, carboplatin, trastuzumab, and pertuzumab without estrogen deprivation in treating patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-positive breast cancer that is operable or has spread from where it started to nearby tissue or lymph nodes (locally advanced). Drugs used in chemotherapy, such as docetaxel, carboplatin, trastuzumab, and pertuzumab, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Estrogen can cause the growth of breast cancer cells. Hormone therapy using goserelin acetate and aromatase inhibition therapy may fight breast cancer by blocking the use of estrogen by the tumor cells. Radiation therapy uses high energy x rays to kill tumor cells. Giving combination chemotherapy and radiation therapy with or without hormone therapy may be an effective treatment for hormone receptor-positive, HER2-positive, operable or locally advanced breast cancer.

Panoramica dello studio

Stato

Stato

Indica lo stato di reclutamento attuale o lo stato di accesso ampliato.
Completato

Condizioni

Condizioni

La malattia, il disturbo, la sindrome, la malattia o la lesione oggetto di studio. Su ClinicalTrials.gov, le condizioni possono includere anche altri problemi relativi alla salute, come la durata della vita, la qualità della vita e i rischi per la salute.

Intervento / Trattamento

Intervento / Trattamento

Un processo o un'azione che è al centro di uno studio clinico. Gli interventi includono farmaci, dispositivi medici, procedure, vaccini e altri prodotti sperimentali o già disponibili. Gli interventi possono anche includere approcci non invasivi, come l'educazione o la modifica della dieta e dell'esercizio fisico.

Descrizione dettagliata

PRIMARY OBJECTIVES:

I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of therapy of docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) yields a greater rate of pathologic complete response (pCR) (breast and nodes) than TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.

SECONDARY OBJECTIVES:

I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP will increase the pCR rate in the breast compared to TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.

II. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves recurrence-free interval (RFI) in women with operable, hormone receptor-positive, HER2-positive breast cancer.

III. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves overall survival (OS) in women with operable, hormone receptor-positive, HER2-positive breast cancer.

IV. To compare the rates of second primary invasive cancer by treatment arm. V. Assessment of patterns of pCR, RFI, and OS by menopausal status. VI. To evaluate the cardiac toxicity associated with each of the regimens. VII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on endocrine-related symptoms in all patients by treatment arm.

VIII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on vasomotor symptoms, musculoskeletal, and vaginal complaints as well as quality of life.

IX. To determine a relationship between pCR and a potential mechanism of resistance/sensitivity in hormone receptor-positive, HER2-positive tumors.

X. To evaluate tumor infiltrating lymphocytes (TILs) and immune biomarkers as predictors of pCR.

XI. To study early changes in TILs and other immune biomarkers in response to TCHP.

OUTLINE: Patients are randomized to 1 of 2 treatments arms.

NEOADJUVANT:

ARM I: Patients receive docetaxel intravenously (IV) over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.

ARM II: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate subcutaneously (SC) every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.

SURGERY: Patients undergo lumpectomy or mastectomy.

RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery.

ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year.

After completion of study treatment, patients are followed up every 6, 9, 12, and 18 months for 5 years.

Tipo di studio

Tipo di studio

Descrive la natura di uno studio clinico. I tipi di studio includono studi interventistici (chiamati anche studi clinici), studi osservazionali (compresi i registri dei pazienti) e accesso allargato.
Interventistico

Iscrizione (Effettivo)

Iscrizione

Il numero di partecipanti a uno studio clinico. L'iscrizione "anticipata" è il numero target di partecipanti di cui i ricercatori hanno bisogno per lo studio.
315

Fase

Fase

La fase di una sperimentazione clinica che studia un farmaco o un prodotto biologico, sulla base delle definizioni sviluppate dalla Food and Drug Administration (FDA) statunitense. La fase si basa sull'obiettivo dello studio, sul numero di partecipanti e su altre caratteristiche. Ci sono cinque fasi: Early Phase 1 (precedentemente indicata come Fase 0), Phase 1, Phase 2, Phase 3 e Phase 4. Not Applicable è usato per descrivere sperimentazioni senza fasi definite dalla FDA, incluse sperimentazioni di dispositivi o interventi comportamentali.
  • Fase 3

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

  • Porto Rico
      • San Juan, Porto Rico, 00936
        • San Juan City Hospital
  • Stati Uniti
    • Alaska
      • Fairbanks, Alaska, Stati Uniti, 99701
        • Fairbanks Memorial Hospital
    • Arkansas
      • Hot Springs, Arkansas, Stati Uniti, 71913
        • CHI Saint Vincent Cancer Center Hot Springs
    • California
      • Anaheim, California, Stati Uniti, 92806
        • Kaiser Permanente-Anaheim
      • Antioch, California, Stati Uniti, 94531
        • Kaiser Permanente-Deer Valley Medical Center
      • Arroyo Grande, California, Stati Uniti, 93420
        • PCR Oncology
      • Auburn, California, Stati Uniti, 95602
        • Sutter Auburn Faith Hospital
      • Auburn, California, Stati Uniti, 95603
        • Sutter Cancer Centers Radiation Oncology Services-Auburn
      • Baldwin Park, California, Stati Uniti, 91706
        • Kaiser Permanente-Baldwin Park
      • Bellflower, California, Stati Uniti, 90706
        • Kaiser Permanente-Bellflower
      • Berkeley, California, Stati Uniti, 94704
        • Alta Bates Summit Medical Center-Herrick Campus
      • Burlingame, California, Stati Uniti, 94010
        • Mills-Peninsula Medical Center
      • Cameron Park, California, Stati Uniti, 95682
        • Sutter Cancer Centers Radiation Oncology Services-Cameron Park
      • Castro Valley, California, Stati Uniti, 94546
        • Eden Hospital Medical Center
      • Castro Valley, California, Stati Uniti, 94546
        • East Bay Radiation Oncology Center
      • Davis, California, Stati Uniti, 95616
        • Sutter Davis Hospital
      • Dublin, California, Stati Uniti, 94568
        • Epic Care-Dublin
      • Emeryville, California, Stati Uniti, 94608
        • Bay Area Breast Surgeons Inc
      • Emeryville, California, Stati Uniti, 94608
        • Epic Care Partners in Cancer Care
      • Fontana, California, Stati Uniti, 92335
        • Kaiser Permanente-Fontana
      • Fremont, California, Stati Uniti, 94538
        • Kaiser Permanente-Fremont
      • Fresno, California, Stati Uniti, 93720
        • Kaiser Permanente-Fresno
      • Harbor City, California, Stati Uniti, 90710
        • Kaiser Permanente South Bay
      • Irvine, California, Stati Uniti, 92618
        • Kaiser Permanente-Irvine
      • Loma Linda, California, Stati Uniti, 92354
        • Loma Linda University Medical Center
      • Los Angeles, California, Stati Uniti, 90027
        • Kaiser Permanente Los Angeles Medical Center
      • Los Angeles, California, Stati Uniti, 90048
        • Cedars Sinai Medical Center
      • Los Angeles, California, Stati Uniti, 90034
        • Kaiser Permanente West Los Angeles
      • Martinez, California, Stati Uniti, 94553-3156
        • Contra Costa Regional Medical Center
      • Modesto, California, Stati Uniti, 95355
        • Memorial Medical Center
      • Modesto, California, Stati Uniti, 95356
        • Kaiser Permanente-Modesto
      • Mountain View, California, Stati Uniti, 94040
        • El Camino Hospital
      • Mountain View, California, Stati Uniti, 94040
        • Palo Alto Medical Foundation-Camino Division
      • Mountain View, California, Stati Uniti, 94040
        • Palo Alto Medical Foundation-Gynecologic Oncology
      • Novato, California, Stati Uniti, 94945
        • Sutter Cancer Research Consortium
      • Oakland, California, Stati Uniti, 94611
        • Kaiser Permanente-Oakland
      • Oakland, California, Stati Uniti, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, Stati Uniti, 94609
        • Hematology and Oncology Associates-Oakland
      • Oakland, California, Stati Uniti, 94609
        • Bay Area Tumor Institute
      • Oakland, California, Stati Uniti, 94602
        • Wilma Chan Highland Hospital
      • Orange, California, Stati Uniti, 92868
        • Saint Joseph Hospital - Orange
      • Palo Alto, California, Stati Uniti, 94304
        • Stanford Cancer Institute Palo Alto
      • Palo Alto, California, Stati Uniti, 94301
        • Palo Alto Medical Foundation Health Care
      • Panorama City, California, Stati Uniti, 91402
        • Kaiser Permanente - Panorama City
      • Pleasanton, California, Stati Uniti, 94588
        • Valley Medical Oncology Consultants
      • Redwood City, California, Stati Uniti, 94063
        • Kaiser Permanente-Redwood City
      • Richmond, California, Stati Uniti, 94801
        • Kaiser Permanente-Richmond
      • Riverside, California, Stati Uniti, 92505
        • Kaiser Permanente-Riverside
      • Roseville, California, Stati Uniti, 95661
        • Kaiser Permanente-Roseville
      • Roseville, California, Stati Uniti, 95661
        • Sutter Cancer Centers Radiation Oncology Services-Roseville
      • Roseville, California, Stati Uniti, 95661
        • Sutter Roseville Medical Center
      • Sacramento, California, Stati Uniti, 95816
        • Sutter Medical Center Sacramento
      • Sacramento, California, Stati Uniti, 95823
        • Kaiser Permanente-South Sacramento
      • Sacramento, California, Stati Uniti, 95825
        • Kaiser Permanente Sacramento Medical Center
      • San Diego, California, Stati Uniti, 92120
        • Kaiser Permanente-San Diego Zion
      • San Diego, California, Stati Uniti, 92108
        • Kaiser Permanente-San Diego Mission
      • San Francisco, California, Stati Uniti, 94115
        • Kaiser Permanente-San Francisco
      • San Francisco, California, Stati Uniti, 94115
        • California Pacific Medical Center-Pacific Campus
      • San Jose, California, Stati Uniti, 95119
        • Kaiser Permanente-Santa Teresa-San Jose
      • San Leandro, California, Stati Uniti, 94577
        • Kaiser Permanente San Leandro
      • San Marcos, California, Stati Uniti, 92078
        • Kaiser Permanente-San Marcos
      • San Pablo, California, Stati Uniti, 94806
        • Doctors Medical Center- JC Robinson Regional Cancer Center
      • San Rafael, California, Stati Uniti, 94903
        • Kaiser Permanente-San Rafael
      • Santa Clara, California, Stati Uniti, 95051
        • Kaiser Permanente Medical Center - Santa Clara
      • Santa Cruz, California, Stati Uniti, 95065
        • Palo Alto Medical Foundation-Santa Cruz
      • Santa Rosa, California, Stati Uniti, 95403
        • Kaiser Permanente-Santa Rosa
      • Santa Rosa, California, Stati Uniti, 95403
        • Sutter Pacific Medical Foundation
      • South San Francisco, California, Stati Uniti, 94080
        • Kaiser Permanente-South San Francisco
      • Stockton, California, Stati Uniti, 95210
        • Kaiser Permanente-Stockton
      • Sunnyvale, California, Stati Uniti, 94086
        • Palo Alto Medical Foundation-Sunnyvale
      • Vacaville, California, Stati Uniti, 95688
        • Kaiser Permanente Medical Center-Vacaville
      • Vallejo, California, Stati Uniti, 94589
        • Kaiser Permanente-Vallejo
      • Vallejo, California, Stati Uniti, 94589
        • Sutter Solano Medical Center/Cancer Center
      • Walnut Creek, California, Stati Uniti, 94596
        • Kaiser Permanente-Walnut Creek
      • Woodland Hills, California, Stati Uniti, 91367
        • Kaiser Permanente-Woodland Hills
    • Colorado
      • Aurora, Colorado, Stati Uniti, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Aurora, Colorado, Stati Uniti, 80012
        • The Medical Center of Aurora
      • Aurora, Colorado, Stati Uniti, 80045
        • UCHealth University of Colorado Hospital
      • Boulder, Colorado, Stati Uniti, 80303
        • Boulder Community Foothills Hospital
      • Boulder, Colorado, Stati Uniti, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Colorado Springs, Colorado, Stati Uniti, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Stati Uniti, 80909
        • UCHealth Memorial Hospital Central
      • Colorado Springs, Colorado, Stati Uniti, 80907
        • Rocky Mountain Cancer Centers-Penrose
      • Denver, Colorado, Stati Uniti, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Stati Uniti, 80220
        • Rose Medical Center
      • Denver, Colorado, Stati Uniti, 80218
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Stati Uniti, 80220
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Stati Uniti, 80218
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Stati Uniti, 80222
        • Western States Cancer Research NCORP
      • Denver, Colorado, Stati Uniti, 80218
        • Saint Joseph Hospital - Cancer Centers of Colorado
      • Denver, Colorado, Stati Uniti, 80210
        • AdventHealth Porter
      • Durango, Colorado, Stati Uniti, 81301
        • Mercy Medical Center
      • Durango, Colorado, Stati Uniti, 81301
        • Southwest Oncology PC
      • Englewood, Colorado, Stati Uniti, 80113
        • Mountain Blue Cancer Care Center - Swedish
      • Englewood, Colorado, Stati Uniti, 80113
        • Swedish Medical Center
      • Fort Collins, Colorado, Stati Uniti, 80524
        • Poudre Valley Hospital
      • Golden, Colorado, Stati Uniti, 80401
        • Mountain Blue Cancer Care Center
      • Greeley, Colorado, Stati Uniti, 80631
        • Banner North Colorado Medical Center
      • Greenwood Village, Colorado, Stati Uniti, 80111
        • Rocky Mountain Cancer Centers-Greenwood Village
      • Lakewood, Colorado, Stati Uniti, 80228
        • Saint Anthony Hospital
      • Lakewood, Colorado, Stati Uniti, 80228
        • Rocky Mountain Cancer Centers-Lakewood
      • Littleton, Colorado, Stati Uniti, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Littleton, Colorado, Stati Uniti, 80122
        • AdventHealth Littleton
      • Lone Tree, Colorado, Stati Uniti, 80124
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Stati Uniti, 80124
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Longmont, Colorado, Stati Uniti, 80501
        • Longmont United Hospital
      • Longmont, Colorado, Stati Uniti, 80501
        • Rocky Mountain Cancer Centers-Longmont
      • Loveland, Colorado, Stati Uniti, 80539
        • Banner McKee Medical Center
      • Parker, Colorado, Stati Uniti, 80138
        • Rocky Mountain Cancer Centers-Parker
      • Parker, Colorado, Stati Uniti, 80138
        • AdventHealth Parker
      • Pueblo, Colorado, Stati Uniti, 81004
        • Saint Mary Corwin Medical Center
      • Pueblo, Colorado, Stati Uniti, 81008
        • Rocky Mountain Cancer Centers - Pueblo
      • Thornton, Colorado, Stati Uniti, 80260
        • Rocky Mountain Cancer Centers-Thornton
      • Wheat Ridge, Colorado, Stati Uniti, 80401
        • Intermountain Health Lutheran Hospital
    • Connecticut
      • Hartford, Connecticut, Stati Uniti, 06105
        • Smilow Cancer Hospital Care Center at Saint Francis
      • Hartford, Connecticut, Stati Uniti, 06102
        • Hartford Hospital
    • Delaware
      • Lewes, Delaware, Stati Uniti, 19958
        • Beebe Medical Center
      • Newark, Delaware, Stati Uniti, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, Stati Uniti, 19713
        • Delaware Clinical and Laboratory Physicians PA
      • Newark, Delaware, Stati Uniti, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Stati Uniti, 19718
        • Christiana Care Health System-Christiana Hospital
      • Rehoboth Beach, Delaware, Stati Uniti, 19971
        • Beebe Health Campus
      • Seaford, Delaware, Stati Uniti, 19973
        • TidalHealth Nanticoke / Allen Cancer Center
      • Wilmington, Delaware, Stati Uniti, 19801
        • Christiana Care Health System-Wilmington Hospital
    • District of Columbia
      • Washington D.C., District of Columbia, Stati Uniti, 20010
        • MedStar Washington Hospital Center
      • Washington D.C., District of Columbia, Stati Uniti, 20007
        • MedStar Georgetown University Hospital
    • Florida
      • Deerfield Beach, Florida, Stati Uniti, 33442
        • UM Sylvester Comprehensive Cancer Center at Deerfield Beach
      • Gainesville, Florida, Stati Uniti, 32610
        • University of Florida Health Science Center - Gainesville
      • Miami, Florida, Stati Uniti, 33136
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
      • Orlando, Florida, Stati Uniti, 32806
        • Orlando Health Cancer Institute
      • Orlando, Florida, Stati Uniti, 32803
        • AdventHealth Orlando
    • Georgia
      • Athens, Georgia, Stati Uniti, 30607
        • University Cancer and Blood Center LLC
      • Atlanta, Georgia, Stati Uniti, 30342
        • Northside Hospital
      • Augusta, Georgia, Stati Uniti, 30912
        • Augusta University Medical Center
      • Cumming, Georgia, Stati Uniti, 30041
        • Northside Hospital-Forsyth
      • Decatur, Georgia, Stati Uniti, 30033
        • Emory Decatur Hospital
      • Gainesville, Georgia, Stati Uniti, 30501
        • Northeast Georgia Medical Center-Gainesville
      • Savannah, Georgia, Stati Uniti, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
      • Savannah, Georgia, Stati Uniti, 31404
        • Memorial Health University Medical Center
      • Savannah, Georgia, Stati Uniti, 31404
        • Summit Cancer Care-Memorial
      • Savannah, Georgia, Stati Uniti, 31404
        • Low Country Cancer Care
    • Hawaii
      • Honolulu, Hawaii, Stati Uniti, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Stati Uniti, 96817
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, Stati Uniti, 96813
        • Hawaii Cancer Care Inc - Waterfront Plaza
      • Honolulu, Hawaii, Stati Uniti, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Stati Uniti, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Stati Uniti, 96817
        • Hawaii Cancer Care Inc-Liliha
      • Honolulu, Hawaii, Stati Uniti, 96817
        • Kuakini Medical Center
      • Honolulu, Hawaii, Stati Uniti, 96817
        • Queen's Cancer Center - Kuakini
      • Honolulu, Hawaii, Stati Uniti, 96819
        • Kaiser Permanente Moanalua Medical Center
      • Kailua, Hawaii, Stati Uniti, 96734
        • Castle Medical Center
      • Lihue, Hawaii, Stati Uniti, 96766
        • Wilcox Memorial Hospital and Kauai Medical Clinic
      • ‘Aiea, Hawaii, Stati Uniti, 96701
        • Pali Momi Medical Center
      • ‘Aiea, Hawaii, Stati Uniti, 96701
        • Queen's Cancer Center - Pearlridge
      • ‘Aiea, Hawaii, Stati Uniti, 96701
        • The Cancer Center of Hawaii-Pali Momi
    • Idaho
      • Boise, Idaho, Stati Uniti, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Coeur d'Alene, Idaho, Stati Uniti, 83814
        • Kootenai Health - Coeur d'Alene
      • Lewiston, Idaho, Stati Uniti, 83501
        • Saint Joseph Regional Medical Center
      • Post Falls, Idaho, Stati Uniti, 83854
        • Kootenai Clinic Cancer Services - Post Falls
      • Sandpoint, Idaho, Stati Uniti, 83864
        • Kootenai Clinic Cancer Services - Sandpoint
    • Illinois
      • Aurora, Illinois, Stati Uniti, 60504
        • Rush-Copley Medical Center
      • Bloomington, Illinois, Stati Uniti, 61704
        • Illinois CancerCare-Bloomington
      • Bloomington, Illinois, Stati Uniti, 61701
        • OSF Saint Joseph Medical Center
      • Canton, Illinois, Stati Uniti, 61520
        • Illinois CancerCare-Canton
      • Carbondale, Illinois, Stati Uniti, 62902
        • Memorial Hospital of Carbondale
      • Carthage, Illinois, Stati Uniti, 62321
        • Illinois CancerCare-Carthage
      • Centralia, Illinois, Stati Uniti, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Stati Uniti, 60612
        • University of Illinois
      • Chicago, Illinois, Stati Uniti, 60612
        • John H Stroger Jr Hospital of Cook County
      • Chicago, Illinois, Stati Uniti, 60608
        • Mount Sinai Hospital Medical Center
      • Chicago, Illinois, Stati Uniti, 60625
        • Swedish Covenant Hospital
      • Chicago, Illinois, Stati Uniti, 60631
        • Presence Resurrection Medical Center
      • Danville, Illinois, Stati Uniti, 61832
        • Carle at The Riverfront
      • Decatur, Illinois, Stati Uniti, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Stati Uniti, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Effingham, Illinois, Stati Uniti, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, Stati Uniti, 62401
        • Carle Physician Group-Effingham
      • Elk Grove Village, Illinois, Stati Uniti, 60007
        • Ascension Alexian Brothers - Elk Grove Village
      • Eureka, Illinois, Stati Uniti, 61530
        • Illinois CancerCare-Eureka
      • Evanston, Illinois, Stati Uniti, 60202
        • Saint Francis Hospital
      • Galesburg, Illinois, Stati Uniti, 61401
        • Western Illinois Cancer Treatment Center
      • Galesburg, Illinois, Stati Uniti, 61401
        • Illinois CancerCare-Galesburg
      • Geneva, Illinois, Stati Uniti, 60134
        • Northwestern Medicine Cancer Center Delnor
      • Harvey, Illinois, Stati Uniti, 60426
        • Ingalls Memorial Hospital
      • Kankakee, Illinois, Stati Uniti, 60901
        • Presence Saint Mary's Hospital
      • Kewanee, Illinois, Stati Uniti, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Macomb, Illinois, Stati Uniti, 61455
        • Illinois CancerCare-Macomb
      • Mattoon, Illinois, Stati Uniti, 61938
        • Carle Physician Group-Mattoon/Charleston
      • Mount Vernon, Illinois, Stati Uniti, 62864
        • SSM Health Good Samaritan
      • Naperville, Illinois, Stati Uniti, 60540
        • Edward Hospital/Cancer Center
      • O'Fallon, Illinois, Stati Uniti, 62269
        • Cancer Care Center of O'Fallon
      • Ottawa, Illinois, Stati Uniti, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Ottawa, Illinois, Stati Uniti, 61350
        • Radiation Oncology of Northern Illinois
      • Pekin, Illinois, Stati Uniti, 61554
        • Illinois CancerCare-Pekin
      • Pekin, Illinois, Stati Uniti, 61554
        • OSF Saint Francis Radiation Oncology at Pekin
      • Peoria, Illinois, Stati Uniti, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Stati Uniti, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, Stati Uniti, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, Stati Uniti, 61615
        • OSF Saint Francis Radiation Oncology at Peoria Cancer Center
      • Peru, Illinois, Stati Uniti, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, Stati Uniti, 61354
        • Valley Radiation Oncology
      • Plainfield, Illinois, Stati Uniti, 60585
        • Edward Hospital/Cancer Center?Plainfield
      • Princeton, Illinois, Stati Uniti, 61356
        • Illinois CancerCare-Princeton
      • Rockford, Illinois, Stati Uniti, 61108
        • OSF Saint Anthony Medical Center
      • Rockford, Illinois, Stati Uniti, 61114
        • UW Health Carbone Cancer Center Rockford
      • Springfield, Illinois, Stati Uniti, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Stati Uniti, 62702
        • Springfield Clinic
      • Springfield, Illinois, Stati Uniti, 62702
        • Central Illinois Hematology Oncology Center
      • Springfield, Illinois, Stati Uniti, 62781
        • Springfield Memorial Hospital
      • Urbana, Illinois, Stati Uniti, 61801
        • Carle Cancer Center
      • Urbana, Illinois, Stati Uniti, 61801
        • The Carle Foundation Hospital
      • Warrenville, Illinois, Stati Uniti, 60555
        • Northwestern Medicine Cancer Center Warrenville
      • Yorkville, Illinois, Stati Uniti, 60560
        • Rush-Copley Healthcare Center
    • Indiana
      • Crown Point, Indiana, Stati Uniti, 46307
        • Michiana Hematology Oncology PC-Crown Point
      • Elkhart, Indiana, Stati Uniti, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, Stati Uniti, 46514
        • Michiana Hematology Oncology PC-Elkhart
      • Elkhart, Indiana, Stati Uniti, 46514-2098
        • Elkhart Clinic
      • Indianapolis, Indiana, Stati Uniti, 46237
        • Franciscan Health Indianapolis
      • Kokomo, Indiana, Stati Uniti, 46904
        • Community Howard Regional Health
      • La Porte, Indiana, Stati Uniti, 46350
        • IU Health La Porte Hospital
      • Michigan City, Indiana, Stati Uniti, 46360
        • Franciscan Saint Anthony Health-Michigan City
      • Michigan City, Indiana, Stati Uniti, 46360
        • Woodland Cancer Care Center
      • Mishawaka, Indiana, Stati Uniti, 46545
        • Michiana Hematology Oncology PC-Mishawaka
      • Mishawaka, Indiana, Stati Uniti, 46545
        • Saint Joseph Regional Medical Center-Mishawaka
      • Munster, Indiana, Stati Uniti, 46321
        • The Community Hospital
      • Plymouth, Indiana, Stati Uniti, 46563
        • Michiana Hematology Oncology PC-Plymouth
      • Richmond, Indiana, Stati Uniti, 47374
        • Reid Health
      • South Bend, Indiana, Stati Uniti, 46628
        • Northern Indiana Cancer Research Consortium
      • Terre Haute, Indiana, Stati Uniti, 47804
        • Union Hospital
      • Westville, Indiana, Stati Uniti, 46391
        • Michiana Hematology Oncology PC-Westville
    • Iowa
      • Ames, Iowa, Stati Uniti, 50010
        • Mary Greeley Medical Center
      • Ames, Iowa, Stati Uniti, 50010
        • McFarland Clinic - Ames
      • Boone, Iowa, Stati Uniti, 50036
        • McFarland Clinic - Boone
      • Cedar Rapids, Iowa, Stati Uniti, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Stati Uniti, 52403
        • Oncology Associates at Mercy Medical Center
      • Clive, Iowa, Stati Uniti, 50325
        • Mercy Cancer Center-West Lakes
      • Clive, Iowa, Stati Uniti, 50325
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
      • Council Bluffs, Iowa, Stati Uniti, 51503
        • Alegent Health Mercy Hospital
      • Creston, Iowa, Stati Uniti, 50801
        • Greater Regional Medical Center
      • Des Moines, Iowa, Stati Uniti, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Stati Uniti, 50314
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
      • Fort Dodge, Iowa, Stati Uniti, 50501
        • McFarland Clinic - Trinity Cancer Center
      • Iowa City, Iowa, Stati Uniti, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • Jefferson, Iowa, Stati Uniti, 50129
        • McFarland Clinic - Jefferson
      • Marshalltown, Iowa, Stati Uniti, 50158
        • McFarland Clinic - Marshalltown
      • West Des Moines, Iowa, Stati Uniti, 50266
        • Mercy Medical Center-West Lakes
    • Kansas
      • Chanute, Kansas, Stati Uniti, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Stati Uniti, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, Stati Uniti, 67042
        • Cancer Center of Kansas - El Dorado
      • Fort Scott, Kansas, Stati Uniti, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, Stati Uniti, 67301
        • Cancer Center of Kansas-Independence
      • Kingman, Kansas, Stati Uniti, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, Stati Uniti, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, Stati Uniti, 67905
        • Cancer Center of Kansas-Liberal
      • Manhattan, Kansas, Stati Uniti, 66502
        • Cancer Center of Kansas-Manhattan
      • McPherson, Kansas, Stati Uniti, 67460
        • Cancer Center of Kansas - McPherson
      • Newton, Kansas, Stati Uniti, 67114
        • Cancer Center of Kansas - Newton
      • Parsons, Kansas, Stati Uniti, 67357
        • Cancer Center of Kansas - Parsons
      • Pratt, Kansas, Stati Uniti, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, Stati Uniti, 67401
        • Cancer Center of Kansas - Salina
      • Topeka, Kansas, Stati Uniti, 66606
        • Cotton O'Neil Cancer Center / Stormont Vail Health
      • Wellington, Kansas, Stati Uniti, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Stati Uniti, 67214
        • Ascension Via Christi Hospitals Wichita
      • Wichita, Kansas, Stati Uniti, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Stati Uniti, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, Stati Uniti, 67208
        • Associates In Womens Health
      • Wichita, Kansas, Stati Uniti, 67214
        • Wichita NCI Community Oncology Research Program
      • Winfield, Kansas, Stati Uniti, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Bardstown, Kentucky, Stati Uniti, 40004
        • Flaget Memorial Hospital
      • Corbin, Kentucky, Stati Uniti, 40701
        • Baptist Health Corbin
      • Corbin, Kentucky, Stati Uniti, 40701
        • Commonwealth Cancer Center-Corbin
      • Crestview Hills, Kentucky, Stati Uniti, 41017
        • Oncology Hematology Care Inc-Crestview
      • Elizabethtown, Kentucky, Stati Uniti, 42701
        • Baptist Health Hardin
      • Lexington, Kentucky, Stati Uniti, 40536
        • University of Kentucky/Markey Cancer Center
      • Lexington, Kentucky, Stati Uniti, 40504
        • Saint Joseph Radiation Oncology Resource Center
      • Lexington, Kentucky, Stati Uniti, 40509
        • Saint Joseph Hospital East
      • Lexington, Kentucky, Stati Uniti, 40503
        • Baptist Health Lexington
      • Louisville, Kentucky, Stati Uniti, 40202
        • The James Graham Brown Cancer Center at University of Louisville
      • Louisville, Kentucky, Stati Uniti, 40202
        • Jewish Hospital
      • Louisville, Kentucky, Stati Uniti, 40245
        • UofL Health Medical Center Northeast
      • Louisville, Kentucky, Stati Uniti, 40207
        • Baptist Health Louisville
      • Louisville, Kentucky, Stati Uniti, 40215
        • Saints Mary and Elizabeth Hospital
      • Madisonville, Kentucky, Stati Uniti, 42431
        • Baptist Health Madisonville/Merle Mahr Cancer Center
      • Paducah, Kentucky, Stati Uniti, 42003
        • Baptist Health Paducah
      • Shepherdsville, Kentucky, Stati Uniti, 40165
        • Jewish Hospital Medical Center South
    • Louisiana
      • Baton Rouge, Louisiana, Stati Uniti, 70809
        • Ochsner Health Center-Summa
      • Kenner, Louisiana, Stati Uniti, 70065
        • Ochsner Medical Center Kenner
      • New Orleans, Louisiana, Stati Uniti, 70121
        • Ochsner Medical Center Jefferson
    • Maine
      • Bangor, Maine, Stati Uniti, 04401
        • Eastern Maine Medical Center
      • Brewer, Maine, Stati Uniti, 04412
        • Lafayette Family Cancer Center-EMMC
    • Maryland
      • Baltimore, Maryland, Stati Uniti, 21237
        • MedStar Franklin Square Medical Center/Weinberg Cancer Institute
      • Baltimore, Maryland, Stati Uniti, 21204
        • Greater Baltimore Medical Center
      • Elkton, Maryland, Stati Uniti, 21921
        • Christiana Care - Union Hospital
      • Frederick, Maryland, Stati Uniti, 21701
        • Frederick Memorial Hospital
    • Massachusetts
      • Fall River, Massachusetts, Stati Uniti, 02721
        • Saint Anne's Hospital
      • Pittsfield, Massachusetts, Stati Uniti, 01201
        • Berkshire Medical Center - Cancer Center
    • Michigan
      • Adrian, Michigan, Stati Uniti, 49221
        • Bixby Medical Center
      • Adrian, Michigan, Stati Uniti, 49221
        • Hickman Cancer Center
      • Ann Arbor, Michigan, Stati Uniti, 48106
        • Michigan Cancer Research Consortium NCORP
      • Ann Arbor, Michigan, Stati Uniti, 48106
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
      • Ann Arbor, Michigan, Stati Uniti, 48109
        • University of Michigan Comprehensive Cancer Center
      • Dearborn, Michigan, Stati Uniti, 48124
        • Corewell Health Dearborn Hospital
      • Detroit, Michigan, Stati Uniti, 48202
        • Henry Ford Hospital
      • Detroit, Michigan, Stati Uniti, 48201
        • Wayne State University/Karmanos Cancer Institute
      • Detroit, Michigan, Stati Uniti, 48236
        • Henry Ford Health Saint John Hospital
      • Farmington Hills, Michigan, Stati Uniti, 48334
        • Weisberg Cancer Treatment Center
      • Farmington Hills, Michigan, Stati Uniti, 48336
        • Corewell Health Farmington Hills Hospital
      • Flint, Michigan, Stati Uniti, 48503
        • Hurley Medical Center
      • Flint, Michigan, Stati Uniti, 48503
        • Genesys Hurley Cancer Institute
      • Grosse Pointe, Michigan, Stati Uniti, 48230
        • William Beaumont Hospital-Grosse Pointe
      • Jackson, Michigan, Stati Uniti, 49201
        • Allegiance Health
      • Kalamazoo, Michigan, Stati Uniti, 49007
        • West Michigan Cancer Center
      • Lansing, Michigan, Stati Uniti, 48912
        • University of Michigan Health - Sparrow Lansing
      • Livonia, Michigan, Stati Uniti, 48154
        • Trinity Health Saint Mary Mercy Livonia Hospital
      • Midland, Michigan, Stati Uniti, 48670
        • MyMichigan Medical Center Midland
      • Monroe, Michigan, Stati Uniti, 48162
        • Mercy Memorial Hospital
      • Monroe, Michigan, Stati Uniti, 48162
        • Toledo Clinic Cancer Centers-Monroe
      • Pontiac, Michigan, Stati Uniti, 48341
        • Trinity Health Saint Joseph Mercy Oakland Hospital
      • Port Huron, Michigan, Stati Uniti, 48060
        • Lake Huron Medical Center
      • Roseville, Michigan, Stati Uniti, 48066
        • Michigan Cancer Specialists
      • Royal Oak, Michigan, Stati Uniti, 48073
        • Cancer Care Associates PC
      • Royal Oak, Michigan, Stati Uniti, 48073
        • Comprehensive Medical Center PLLC
      • Royal Oak, Michigan, Stati Uniti, 48073
        • Oakland Medical Group
      • Royal Oak, Michigan, Stati Uniti, 48067
        • Oakland Colon Rectal Associates
      • Royal Oak, Michigan, Stati Uniti, 48073
        • Hematology Oncology Consultants PC-Royal Oak
      • Royal Oak, Michigan, Stati Uniti, 48073
        • Corewell Health William Beaumont University Hospital
      • Saginaw, Michigan, Stati Uniti, 48601
        • MyMichigan Medical Center Saginaw
      • Sterling Heights, Michigan, Stati Uniti, 48312
        • Premier Hematology Oncology Care
      • Sterling Heights, Michigan, Stati Uniti, 48314
        • Mitchell Folbe MD PC
      • Troy, Michigan, Stati Uniti, 48084
        • Michigan Institute of Urology-Town Center
      • Troy, Michigan, Stati Uniti, 48085
        • Claudia BR Herke MD PC
      • Troy, Michigan, Stati Uniti, 48098
        • Hematology Oncology Consultants PC-Troy
      • Troy, Michigan, Stati Uniti, 48085
        • Corewell Health Beaumont Troy Hospital
      • Warren, Michigan, Stati Uniti, 48093
        • Henry Ford Health Warren Hospital
    • Minnesota
      • Bemidji, Minnesota, Stati Uniti, 56601
        • Sanford Joe Lueken Cancer Center
      • Brainerd, Minnesota, Stati Uniti, 56401
        • Essentia Health Saint Joseph's Medical Center
      • Burnsville, Minnesota, Stati Uniti, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Stati Uniti, 55433
        • Mercy Hospital
      • Duluth, Minnesota, Stati Uniti, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, Stati Uniti, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Stati Uniti, 55805
        • Miller-Dwan Hospital
      • Edina, Minnesota, Stati Uniti, 55435
        • Fairview Southdale Hospital
      • Fergus Falls, Minnesota, Stati Uniti, 56537
        • Lake Region Healthcare Corporation-Cancer Care
      • Fridley, Minnesota, Stati Uniti, 55432
        • Unity Hospital
      • Hutchinson, Minnesota, Stati Uniti, 55350
        • Hutchinson Area Health Care
      • Maplewood, Minnesota, Stati Uniti, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Stati Uniti, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Stati Uniti, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Stati Uniti, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Stati Uniti, 55454
        • Health Partners Inc
      • New Ulm, Minnesota, Stati Uniti, 56073
        • New Ulm Medical Center
      • Robbinsdale, Minnesota, Stati Uniti, 55422
        • North Memorial Medical Health Center
      • Saint Louis Park, Minnesota, Stati Uniti, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Louis Park, Minnesota, Stati Uniti, 55416
        • Metro Minnesota Community Oncology Research Consortium
      • Saint Paul, Minnesota, Stati Uniti, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Stati Uniti, 55102
        • United Hospital
      • Shakopee, Minnesota, Stati Uniti, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Stati Uniti, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, Stati Uniti, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Stati Uniti, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Stati Uniti, 55125
        • Minnesota Oncology Hematology PA-Woodbury
    • Missouri
      • Ballwin, Missouri, Stati Uniti, 63011
        • Mercy Oncology and Hematology - Clayton-Clarkson
      • Bolivar, Missouri, Stati Uniti, 65613
        • Central Care Cancer Center - Bolivar
      • Bonne Terre, Missouri, Stati Uniti, 63628
        • Parkland Health Center-Bonne Terre
      • Branson, Missouri, Stati Uniti, 65616
        • Cox Cancer Center Branson
      • Cape Girardeau, Missouri, Stati Uniti, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Stati Uniti, 63703
        • Mercy Cancer Center - Cape Girardeau
      • Columbia, Missouri, Stati Uniti, 65212
        • MU Health - University Hospital/Ellis Fischel Cancer Center
      • Jefferson City, Missouri, Stati Uniti, 65109
        • MU Health Care Goldschmidt Cancer Center
      • Joplin, Missouri, Stati Uniti, 64804
        • Freeman Health System
      • Joplin, Missouri, Stati Uniti, 64804
        • Mercy Hospital Joplin
      • Rolla, Missouri, Stati Uniti, 65401
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Rolla, Missouri, Stati Uniti, 65401
        • Phelps Health Delbert Day Cancer Institute
      • Sainte Genevieve, Missouri, Stati Uniti, 63670
        • Sainte Genevieve County Memorial Hospital
      • Springfield, Missouri, Stati Uniti, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Stati Uniti, 65804
        • Mercy Hospital Springfield
      • St Louis, Missouri, Stati Uniti, 63131
        • Missouri Baptist Medical Center
      • St Louis, Missouri, Stati Uniti, 63109
        • Mercy Infusion Center - Chippewa
      • St Louis, Missouri, Stati Uniti, 63141
        • Mercy Hospital Saint Louis
      • Sullivan, Missouri, Stati Uniti, 63080
        • Missouri Baptist Sullivan Hospital
      • Sunset Hills, Missouri, Stati Uniti, 63127
        • BJC Outpatient Center at Sunset Hills
    • Montana
      • Anaconda, Montana, Stati Uniti, 59711
        • Community Hospital of Anaconda
      • Billings, Montana, Stati Uniti, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, Stati Uniti, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, Stati Uniti, 59102
        • Montana Cancer Consortium NCORP
      • Bozeman, Montana, Stati Uniti, 59715
        • Bozeman Health Deaconess Hospital
      • Butte, Montana, Stati Uniti, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Stati Uniti, 59405
        • Benefis Sletten Cancer Institute
      • Helena, Montana, Stati Uniti, 59601
        • Saint Peter's Community Hospital
      • Kalispell, Montana, Stati Uniti, 59901
        • Logan Health Medical Center
      • Missoula, Montana, Stati Uniti, 59802
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Stati Uniti, 59804
        • Community Medical Center
    • Nebraska
      • Grand Island, Nebraska, Stati Uniti, 68803
        • Nebraska Cancer Specialists/Oncology Hematology West PC
      • Kearney, Nebraska, Stati Uniti, 68847
        • CHI Health Good Samaritan
      • Kearney, Nebraska, Stati Uniti, 68845
        • Fred and Pamela Buffett Cancer Center - Kearney
      • Lincoln, Nebraska, Stati Uniti, 68510
        • Saint Elizabeth Regional Medical Center
      • Omaha, Nebraska, Stati Uniti, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Stati Uniti, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Stati Uniti, 68130
        • Alegent Health Lakeside Hospital
      • Omaha, Nebraska, Stati Uniti, 68131
        • Creighton University Medical Center
      • Omaha, Nebraska, Stati Uniti, 68122
        • Hematology and Oncology Consultants PC
      • Papillion, Nebraska, Stati Uniti, 68046
        • Midlands Community Hospital
    • Nevada
      • Henderson, Nevada, Stati Uniti, 89052
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, Stati Uniti, 89052
        • Cancer and Blood Specialists-Henderson
      • Henderson, Nevada, Stati Uniti, 89052
        • Las Vegas Cancer Center-Henderson
      • Henderson, Nevada, Stati Uniti, 89074
        • Comprehensive Cancer Centers of Nevada-Southeast Henderson
      • Henderson, Nevada, Stati Uniti, 89074
        • GenesisCare USA - Henderson
      • Las Vegas, Nevada, Stati Uniti, 89144
        • Summerlin Hospital Medical Center
      • Las Vegas, Nevada, Stati Uniti, 89106
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, Stati Uniti, 89109
        • GenesisCare USA - Las Vegas
      • Las Vegas, Nevada, Stati Uniti, 89119
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, Stati Uniti, 89128
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, Stati Uniti, 89135
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
      • Las Vegas, Nevada, Stati Uniti, 89144
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, Stati Uniti, 89148
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Stati Uniti, 89148
        • OptumCare Cancer Care at Fort Apache
      • Las Vegas, Nevada, Stati Uniti, 89169
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Stati Uniti, 89106
        • Cancer and Blood Specialists-Shadow
      • Las Vegas, Nevada, Stati Uniti, 89109
        • HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
      • Las Vegas, Nevada, Stati Uniti, 89113
        • HealthCare Partners Medical Group Oncology/Hematology-San Martin
      • Las Vegas, Nevada, Stati Uniti, 89121
        • Cancer Therapy and Integrative Medicine
      • Las Vegas, Nevada, Stati Uniti, 89128
        • Cancer and Blood Specialists-Tenaya
      • Las Vegas, Nevada, Stati Uniti, 89128
        • GenesisCare USA - Vegas Tenaya
      • Las Vegas, Nevada, Stati Uniti, 89128
        • HealthCare Partners Medical Group Oncology/Hematology-Tenaya
      • Las Vegas, Nevada, Stati Uniti, 89148-2405
        • Las Vegas Cancer Center-Medical Center
      • Las Vegas, Nevada, Stati Uniti, 89148
        • GenesisCare USA - Fort Apache
      • Las Vegas, Nevada, Stati Uniti, 89149
        • HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
      • Las Vegas, Nevada, Stati Uniti, 89120
        • Nevada Cancer Research Foundation NCORP
      • Reno, Nevada, Stati Uniti, 89502
        • Renown Regional Medical Center
      • Reno, Nevada, Stati Uniti, 89503
        • Saint Mary's Regional Medical Center
    • New Hampshire
      • Lebanon, New Hampshire, Stati Uniti, 03756
        • Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
    • New Jersey
      • Elizabeth, New Jersey, Stati Uniti, 07207
        • Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
      • Englewood, New Jersey, Stati Uniti, 07631
        • Englewood Hospital and Medical Center
      • Flemington, New Jersey, Stati Uniti, 08822
        • Hunterdon Medical Center
      • Mullica Hill, New Jersey, Stati Uniti, 08062
        • Inspira Medical Center Mullica Hill
      • Newark, New Jersey, Stati Uniti, 07112
        • Newark Beth Israel Medical Center
      • Newton, New Jersey, Stati Uniti, 07860
        • Newton Medical Center
      • Pompton, New Jersey, Stati Uniti, 07444
        • Chilton Medical Center
      • Summit, New Jersey, Stati Uniti, 07902
        • Overlook Hospital
      • Vineland, New Jersey, Stati Uniti, 08360
        • Inspira Medical Center Vineland
    • New Mexico
      • Albuquerque, New Mexico, Stati Uniti, 87106
        • University of New Mexico Cancer Center
      • Albuquerque, New Mexico, Stati Uniti, 87106
        • Hematology Oncology Associates
      • Las Cruces, New Mexico, Stati Uniti, 88011
        • Memorial Medical Center-Las Cruces
      • Santa Fe, New Mexico, Stati Uniti, 87505
        • Christus Saint Vincent Regional Cancer Center
    • New York
      • Buffalo, New York, Stati Uniti, 14263
        • Roswell Park Cancer Institute
      • Glens Falls, New York, Stati Uniti, 12801
        • Glens Falls Hospital
      • Middletown, New York, Stati Uniti, 10940
        • Garnet Health Medical Center
      • New York, New York, Stati Uniti, 10032
        • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
    • North Carolina
      • Asheboro, North Carolina, Stati Uniti, 27203
        • Randolph Hospital
      • Asheville, North Carolina, Stati Uniti, 28803
        • AdventHealth Infusion Center Asheville
      • Burlington, North Carolina, Stati Uniti, 27215
        • Cone Health Cancer Center at Alamance Regional
      • Chapel Hill, North Carolina, Stati Uniti, 27599
        • UNC Lineberger Comprehensive Cancer Center
      • Clinton, North Carolina, Stati Uniti, 28328
        • Southeastern Medical Oncology Center-Clinton
      • Goldsboro, North Carolina, Stati Uniti, 27534
        • Southeastern Medical Oncology Center-Goldsboro
      • Goldsboro, North Carolina, Stati Uniti, 27534
        • Wayne Memorial Hospital
      • Greensboro, North Carolina, Stati Uniti, 27403
        • Cone Health Cancer Center
      • Hendersonville, North Carolina, Stati Uniti, 28792
        • AdventHealth Hendersonville
      • Jacksonville, North Carolina, Stati Uniti, 28546
        • Southeastern Medical Oncology Center-Jacksonville
      • Kernersville, North Carolina, Stati Uniti, 27284
        • Novant Health Cancer Institute - Kernersville
      • Kinston, North Carolina, Stati Uniti, 28501
        • ECU Health Oncology Kinston
      • Mebane, North Carolina, Stati Uniti, 27302
        • Cone Heath Cancer Center at Mebane
      • Mount Airy, North Carolina, Stati Uniti, 27030
        • Novant Health Cancer Institute - Mount Airy
      • North Wilkesboro, North Carolina, Stati Uniti, 28659
        • Novant Health Cancer Institute - Wilkesboro
      • Pinehurst, North Carolina, Stati Uniti, 28374
        • FirstHealth of the Carolinas-Moore Regional Hospital
      • Reidsville, North Carolina, Stati Uniti, 27320
        • Annie Penn Memorial Hospital
      • Salisbury, North Carolina, Stati Uniti, 28144
        • Novant Health Cancer Institute - Rowan
      • Statesville, North Carolina, Stati Uniti, 28677
        • Iredell Memorial Hospital
      • Stateville, North Carolina, Stati Uniti, 28625
        • Novant Health Cancer Institute - Statesville
      • Thomasville, North Carolina, Stati Uniti, 27360
        • Novant Health Cancer Institute - Thomasville
      • Winston-Salem, North Carolina, Stati Uniti, 27157
        • Wake Forest University Health Sciences
      • Winston-Salem, North Carolina, Stati Uniti, 27103
        • Novant Health Forsyth Medical Center
      • Winston-Salem, North Carolina, Stati Uniti, 27103
        • Novant Health Oncology Specialists
      • Winston-Salem, North Carolina, Stati Uniti, 27103
        • Winston-Salem Health Care
      • Winston-Salem, North Carolina, Stati Uniti, 27104
        • Southeast Clinical Oncology Research Consortium NCORP
    • North Dakota
      • Bismarck, North Dakota, Stati Uniti, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Stati Uniti, 58122
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Stati Uniti, 58103
        • Essentia Health Cancer Center-South University Clinic
      • Fargo, North Dakota, Stati Uniti, 58122
        • Sanford Broadway Medical Center
      • Grand Forks, North Dakota, Stati Uniti, 58201
        • Altru Cancer Center
      • Minot, North Dakota, Stati Uniti, 58701
        • Trinity Cancer Care Center
    • Ohio
      • Akron, Ohio, Stati Uniti, 44307
        • Cleveland Clinic Akron General
      • Akron, Ohio, Stati Uniti, 44304
        • Summa Health System - Akron Campus
      • Barberton, Ohio, Stati Uniti, 44203
        • Summa Health System - Barberton Campus
      • Belpre, Ohio, Stati Uniti, 45714
        • Strecker Cancer Center-Belpre
      • Bowling Green, Ohio, Stati Uniti, 43402
        • Toledo Clinic Cancer Centers-Bowling Green
      • Canton, Ohio, Stati Uniti, 44710
        • Aultman Health Foundation
      • Centerville, Ohio, Stati Uniti, 45459
        • Miami Valley Hospital South
      • Centerville, Ohio, Stati Uniti, 45459
        • Dayton Physicians LLC-Miami Valley South
      • Chillicothe, Ohio, Stati Uniti, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, Stati Uniti, 45219
        • The Christ Hospital
      • Cincinnati, Ohio, Stati Uniti, 45219
        • University of Cincinnati Cancer Center-UC Medical Center
      • Cincinnati, Ohio, Stati Uniti, 45220
        • Good Samaritan Hospital - Cincinnati
      • Cincinnati, Ohio, Stati Uniti, 45242
        • Bethesda North Hospital
      • Cincinnati, Ohio, Stati Uniti, 45242
        • Oncology Hematology Care Inc-Blue Ash
      • Cincinnati, Ohio, Stati Uniti, 45202
        • Oncology Hematology Care Inc-Eden Park
      • Cincinnati, Ohio, Stati Uniti, 45211
        • Oncology Hematology Care Inc-Mercy West
      • Cincinnati, Ohio, Stati Uniti, 45230
        • Oncology Hematology Care Inc-Anderson
      • Cincinnati, Ohio, Stati Uniti, 45236
        • Oncology Hematology Care Inc-Kenwood
      • Cincinnati, Ohio, Stati Uniti, 45247
        • TriHealth Cancer Institute-Westside
      • Cincinnati, Ohio, Stati Uniti, 45255
        • TriHealth Cancer Institute-Anderson
      • Columbus, Ohio, Stati Uniti, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Stati Uniti, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Stati Uniti, 43214
        • Columbus Oncology and Hematology Associates Inc
      • Columbus, Ohio, Stati Uniti, 43228
        • Doctors Hospital
      • Columbus, Ohio, Stati Uniti, 43215
        • Grant Medical Center
      • Columbus, Ohio, Stati Uniti, 43222
        • Mount Carmel Health Center West
      • Columbus, Ohio, Stati Uniti, 43215
        • Columbus NCI Community Oncology Research Program
      • Dayton, Ohio, Stati Uniti, 45406
        • Good Samaritan Hospital - Dayton
      • Dayton, Ohio, Stati Uniti, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, Stati Uniti, 45415
        • Miami Valley Hospital North
      • Dayton, Ohio, Stati Uniti, 45459
        • Dayton NCI Community Oncology Research Program
      • Dayton, Ohio, Stati Uniti, 45415
        • Dayton Physician LLC - Englewood
      • Delaware, Ohio, Stati Uniti, 43015
        • Delaware Health Center-Grady Cancer Center
      • Delaware, Ohio, Stati Uniti, 43015
        • Delaware Radiation Oncology
      • Delaware, Ohio, Stati Uniti, 43015
        • Grady Memorial Hospital
      • Fairfield, Ohio, Stati Uniti, 45014
        • Oncology Hematology Care Inc-Healthplex
      • Findlay, Ohio, Stati Uniti, 45840
        • Blanchard Valley Hospital
      • Findlay, Ohio, Stati Uniti, 45840
        • Armes Family Cancer Center
      • Findlay, Ohio, Stati Uniti, 45840
        • Orion Cancer Care
      • Franklin, Ohio, Stati Uniti, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Franklin, Ohio, Stati Uniti, 45005
        • Dayton Physicians LLC-Atrium
      • Greenville, Ohio, Stati Uniti, 45331
        • Wayne Hospital
      • Greenville, Ohio, Stati Uniti, 45331
        • Dayton Physicians LLC-Wayne
      • Kettering, Ohio, Stati Uniti, 45429
        • Kettering Medical Center
      • Kettering, Ohio, Stati Uniti, 45409
        • Greater Dayton Cancer Center
      • Lancaster, Ohio, Stati Uniti, 43130
        • Fairfield Medical Center
      • Lancaster, Ohio, Stati Uniti, 43130
        • Lancaster Radiation Oncology
      • Lima, Ohio, Stati Uniti, 45804
        • Lima Memorial Hospital
      • Marietta, Ohio, Stati Uniti, 45750
        • Marietta Memorial Hospital
      • Maumee, Ohio, Stati Uniti, 43537
        • Toledo Clinic Cancer Centers-Maumee
      • Maumee, Ohio, Stati Uniti, 43537
        • Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
      • Medina, Ohio, Stati Uniti, 44256
        • Summa Health Medina Medical Center
      • Middletown, Ohio, Stati Uniti, 45042
        • Dayton Physicians LLC-Signal Point
      • Mount Vernon, Ohio, Stati Uniti, 43050
        • Knox Community Hospital
      • Newark, Ohio, Stati Uniti, 43055
        • Licking Memorial Hospital
      • Newark, Ohio, Stati Uniti, 43055
        • Newark Radiation Oncology
      • Oregon, Ohio, Stati Uniti, 43616
        • Saint Charles Hospital
      • Oregon, Ohio, Stati Uniti, 43616
        • Toledo Clinic Cancer Centers-Oregon
      • Portsmouth, Ohio, Stati Uniti, 45662
        • Southern Ohio Medical Center
      • Sidney, Ohio, Stati Uniti, 45365
        • Dayton Physicians LLC-Wilson
      • Springfield, Ohio, Stati Uniti, 45504
        • Springfield Regional Cancer Center
      • Springfield, Ohio, Stati Uniti, 45504
        • Springfield Regional Medical Center
      • Sylvania, Ohio, Stati Uniti, 43560
        • ProMedica Flower Hospital
      • Tiffin, Ohio, Stati Uniti, 44883
        • Mercy Hospital of Tiffin
      • Toledo, Ohio, Stati Uniti, 43606
        • ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
      • Toledo, Ohio, Stati Uniti, 43623
        • Mercy Health - Saint Anne Hospital
      • Toledo, Ohio, Stati Uniti, 43623
        • Toledo Clinic Cancer Centers-Toledo
      • Toledo, Ohio, Stati Uniti, 43614
        • University of Toledo
      • Toledo, Ohio, Stati Uniti, 43617
        • Toledo Community Hospital Oncology Program CCOP
      • Toledo, Ohio, Stati Uniti, 43608
        • Mercy Health - Saint Vincent Hospital
      • Troy, Ohio, Stati Uniti, 45373
        • Upper Valley Medical Center
      • Troy, Ohio, Stati Uniti, 45373
        • Dayton Physicians LLC - Troy
      • Wauseon, Ohio, Stati Uniti, 43567
        • Fulton County Health Center
      • West Chester, Ohio, Stati Uniti, 45069
        • University of Cincinnati Cancer Center-West Chester
      • Westerville, Ohio, Stati Uniti, 43081
        • Saint Ann's Hospital
      • Wpafb, Ohio, Stati Uniti, 45433
        • Wright-Patterson Medical Center
      • Zanesville, Ohio, Stati Uniti, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Lawton, Oklahoma, Stati Uniti, 73505
        • Cancer Centers of Southwest Oklahoma Research
      • Oklahoma City, Oklahoma, Stati Uniti, 73104
        • University of Oklahoma Health Sciences Center
      • Tulsa, Oklahoma, Stati Uniti, 74136
        • Natalie Warren Bryant Cancer Center at Saint Francis
      • Tulsa, Oklahoma, Stati Uniti, 74136
        • Surgical Associates Inc
      • Tulsa, Oklahoma, Stati Uniti, 74146
        • Warren Clinic Oncology-Tulsa
    • Oregon
      • Portland, Oregon, Stati Uniti, 97227
        • Kaiser Permanente Northwest
    • Pennsylvania
      • Beaver, Pennsylvania, Stati Uniti, 15009
        • UPMC-Heritage Valley Health System Beaver
      • Chadds Ford, Pennsylvania, Stati Uniti, 19317
        • Christiana Care Health System-Concord Health Center
      • Danville, Pennsylvania, Stati Uniti, 17822
        • Geisinger Medical Center
      • Easton, Pennsylvania, Stati Uniti, 18042
        • Easton Hospital
      • Greensburg, Pennsylvania, Stati Uniti, 15601
        • UPMC Cancer Centers - Arnold Palmer Pavilion
      • Harrisburg, Pennsylvania, Stati Uniti, 17109
        • UPMC Pinnacle Cancer Center/Community Osteopathic Campus
      • Hazleton, Pennsylvania, Stati Uniti, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Hershey, Pennsylvania, Stati Uniti, 17033-0850
        • Penn State Milton S Hershey Medical Center
      • Jefferson Hills, Pennsylvania, Stati Uniti, 15025
        • Jefferson Hospital
      • Johnstown, Pennsylvania, Stati Uniti, 15901
        • UPMC-Johnstown/John P. Murtha Regional Cancer Center
      • Lewisburg, Pennsylvania, Stati Uniti, 17837
        • Geisinger Medical Oncology-Lewisburg
      • Lewistown, Pennsylvania, Stati Uniti, 17044
        • Lewistown Hospital
      • McKeesport, Pennsylvania, Stati Uniti, 15132
        • UPMC Cancer Center at UPMC McKeesport
      • Monroeville, Pennsylvania, Stati Uniti, 15146
        • Forbes Hospital
      • Moon Township, Pennsylvania, Stati Uniti, 15108
        • UPMC Hillman Cancer Center in Coraopolis
      • Philadelphia, Pennsylvania, Stati Uniti, 19107
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, Stati Uniti, 19114
        • Jefferson Torresdale Hospital
      • Phoenixville, Pennsylvania, Stati Uniti, 19460
        • Reading Hospital McGlinn Cancer Institute at Phoenixville
      • Pittsburgh, Pennsylvania, Stati Uniti, 15212
        • Allegheny General Hospital
      • Pittsburgh, Pennsylvania, Stati Uniti, 15224
        • West Penn Hospital
      • Pittsburgh, Pennsylvania, Stati Uniti, 15213
        • UPMC-Magee Womens Hospital
      • Pittsburgh, Pennsylvania, Stati Uniti, 15232
        • University of Pittsburgh Cancer Institute (UPCI)
      • Pittsburgh, Pennsylvania, Stati Uniti, 15232
        • UPMC-Shadyside Hospital
      • Pittsburgh, Pennsylvania, Stati Uniti, 15213
        • UPMC-Presbyterian Hospital
      • Pittsburgh, Pennsylvania, Stati Uniti, 15215
        • UPMC-Saint Margaret
      • Pittsburgh, Pennsylvania, Stati Uniti, 15236
        • UPMC Jefferson Regional Radiation Oncology
      • Pittsburgh, Pennsylvania, Stati Uniti, 15237
        • UPMC-Passavant Hospital
      • Pittsburgh, Pennsylvania, Stati Uniti, 15243
        • UPMC-Saint Clair Hospital Cancer Center
      • Pottsville, Pennsylvania, Stati Uniti, 17901
        • Geisinger Cancer Services-Pottsville
      • Scranton, Pennsylvania, Stati Uniti, 18508
        • Hematology and Oncology Associates of North East Pennsylvania
      • Seneca, Pennsylvania, Stati Uniti, 16346
        • UPMC Cancer Center at UPMC Northwest
      • State College, Pennsylvania, Stati Uniti, 16801
        • Geisinger Medical Group
      • Uniontown, Pennsylvania, Stati Uniti, 15401
        • UPMC Uniontown Hospital Radiation Oncology
      • Washington, Pennsylvania, Stati Uniti, 15301
        • UPMC Washington Hospital Radiation Oncology
      • West Chester, Pennsylvania, Stati Uniti, 19380
        • Chester County Hospital
      • West Grove, Pennsylvania, Stati Uniti, 19390
        • Jennersville Regional Hospital
      • West Reading, Pennsylvania, Stati Uniti, 19611
        • Reading Hospital
      • Wilkes-Barre, Pennsylvania, Stati Uniti, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
      • Williamsport, Pennsylvania, Stati Uniti, 17701
        • UPMC Susquehanna
    • Rhode Island
      • Providence, Rhode Island, Stati Uniti, 02905
        • Women and Infants Hospital
      • Warwick, Rhode Island, Stati Uniti, 02886
        • Kent Hospital
    • South Carolina
      • Anderson, South Carolina, Stati Uniti, 29621
        • AnMed Health Cancer Center
      • Boiling Springs, South Carolina, Stati Uniti, 29316
        • Prisma Health Cancer Institute - Spartanburg
      • Easley, South Carolina, Stati Uniti, 29640
        • Prisma Health Cancer Institute - Easley
      • Georgetown, South Carolina, Stati Uniti, 29440
        • Tidelands Georgetown Memorial Hospital
      • Greenville, South Carolina, Stati Uniti, 29605
        • Prisma Health Cancer Institute - Faris
      • Greenville, South Carolina, Stati Uniti, 29607
        • Saint Francis Cancer Center
      • Greenville, South Carolina, Stati Uniti, 29615
        • Prisma Health Cancer Institute - Eastside
      • Greenville, South Carolina, Stati Uniti, 29605
        • Prisma Health Cancer Institute - Butternut
      • Greenville, South Carolina, Stati Uniti, 29601
        • Saint Francis Hospital
      • Greenville, South Carolina, Stati Uniti, 29605
        • Prisma Health Greenville Memorial Hospital
      • Greenville, South Carolina, Stati Uniti, 29601
        • Greenville Health System Cancer Institute-Andrews
      • Greer, South Carolina, Stati Uniti, 29650
        • Prisma Health Cancer Institute - Greer
      • Greer, South Carolina, Stati Uniti, 29651
        • Gibbs Cancer Center-Pelham
      • Lancaster, South Carolina, Stati Uniti, 29720
        • Carolina Blood and Cancer Care Associates PA-Lancaster
      • Rock Hill, South Carolina, Stati Uniti, 29732
        • Carolina Blood and Cancer Care Associates PA
      • Seneca, South Carolina, Stati Uniti, 29672
        • Prisma Health Cancer Institute - Seneca
      • Spartanburg, South Carolina, Stati Uniti, 29303
        • Spartanburg Medical Center
      • Union, South Carolina, Stati Uniti, 29379
        • SMC Center for Hematology Oncology Union
    • South Dakota
      • Sioux Falls, South Dakota, Stati Uniti, 57105
        • Avera Cancer Institute
      • Sioux Falls, South Dakota, Stati Uniti, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Stati Uniti, 57104
        • Sanford Cancer Center Oncology Clinic
    • Tennessee
      • Chattanooga, Tennessee, Stati Uniti, 37404
        • Memorial Hospital
      • Hixson, Tennessee, Stati Uniti, 37343
        • Pulmonary Medicine Center of Chattanooga-Hixson
      • Jackson, Tennessee, Stati Uniti, 38301
        • Jackson-Madison County General Hospital
      • Nashville, Tennessee, Stati Uniti, 37208
        • Meharry Medical College
      • Ooltewah, Tennessee, Stati Uniti, 37363
        • Memorial GYN Plus
    • Texas
      • Abilene, Texas, Stati Uniti, 79601
        • Hendrick Medical Center
      • Houston, Texas, Stati Uniti, 77026-1967
        • Lyndon Baines Johnson General Hospital
      • Houston, Texas, Stati Uniti, 77030
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
      • Houston, Texas, Stati Uniti, 77030
        • Ben Taub General Hospital
      • Laredo, Texas, Stati Uniti, 78041
        • Doctor's Hospital of Laredo
      • San Antonio, Texas, Stati Uniti, 78229
        • University Hospital
      • San Antonio, Texas, Stati Uniti, 78229
        • University of Texas Health Science Center at San Antonio
      • San Antonio, Texas, Stati Uniti, 78229
        • Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
    • Utah
      • Salt Lake City, Utah, Stati Uniti, 84112
        • Huntsman Cancer Institute/University of Utah
    • Vermont
      • Berlin Corners, Vermont, Stati Uniti, 05602
        • Central Vermont Medical Center/National Life Cancer Treatment
      • Burlington, Vermont, Stati Uniti, 05401
        • University of Vermont Medical Center
      • Burlington, Vermont, Stati Uniti, 05405
        • University of Vermont and State Agricultural College
    • Virginia
      • Fredericksburg, Virginia, Stati Uniti, 22401
        • Fredericksburg Oncology Inc
      • Fredericksburg, Virginia, Stati Uniti, 22408
        • Hematology Oncology Associates of Fredericksburg Inc
      • Mechanicsville, Virginia, Stati Uniti, 23116
        • Bon Secours Memorial Regional Medical Center
      • Midlothian, Virginia, Stati Uniti, 23114
        • Bon Secours Saint Francis Medical Center
      • Richmond, Virginia, Stati Uniti, 23226
        • Bon Secours Saint Mary's Hospital
      • Richmond, Virginia, Stati Uniti, 23298
        • VCU Massey Comprehensive Cancer Center
      • South Hill, Virginia, Stati Uniti, 23970
        • VCU Community Memorial Health Center
      • Winchester, Virginia, Stati Uniti, 22601
        • Shenandoah Oncology PC
    • Washington
      • Auburn, Washington, Stati Uniti, 98001
        • MultiCare Auburn Medical Center
      • Bainbridge Island, Washington, Stati Uniti, 98110
        • Virginia Mason Bainbridge Island Medical Center
      • Bellevue, Washington, Stati Uniti, 98004
        • Overlake Medical Center
      • Burien, Washington, Stati Uniti, 98166
        • Highline Medical Center-Main Campus
      • Centralia, Washington, Stati Uniti, 98531
        • Providence Regional Cancer System-Centralia
      • Enumclaw, Washington, Stati Uniti, 98022
        • Saint Elizabeth Hospital
      • Everett, Washington, Stati Uniti, 98201
        • Providence Regional Cancer Partnership
      • Federal Way, Washington, Stati Uniti, 98002
        • Virginia Mason Federal Way Medical Center
      • Federal Way, Washington, Stati Uniti, 98003
        • Saint Francis Hospital
      • Gig Harbor, Washington, Stati Uniti, 98332
        • Tacoma/Valley Radiation Oncology Centers-Gig Harbor
      • Gig Harbor, Washington, Stati Uniti, 98335
        • MultiCare Gig Harbor Medical Park
      • Kennewick, Washington, Stati Uniti, 99336
        • Northwest Cancer Clinic
      • Lacey, Washington, Stati Uniti, 98503
        • Providence Regional Cancer System-Lacey
      • Lakewood, Washington, Stati Uniti, 98499
        • Saint Clare Hospital
      • Lynnwood, Washington, Stati Uniti, 98036
        • Virginia Mason Lynnwood Medical Center
      • Olympia, Washington, Stati Uniti, 98506-5166
        • Providence - Saint Peter Hospital
      • Olympia, Washington, Stati Uniti, 98507
        • Capital Medical Center
      • Port Townsend, Washington, Stati Uniti, 98368
        • Jefferson Healthcare
      • Poulsbo, Washington, Stati Uniti, 98370
        • Harrison HealthPartners Hematology and Oncology-Poulsbo
      • Poulsbo, Washington, Stati Uniti, 98370
        • Peninsula Cancer Center
      • Puyallup, Washington, Stati Uniti, 98372
        • MultiCare Good Samaritan Hospital
      • Puyallup, Washington, Stati Uniti, 98372
        • Tacoma/Valley Radiation Oncology Centers-Puyallup
      • Seattle, Washington, Stati Uniti, 98101
        • Virginia Mason Medical Center
      • Silverdale, Washington, Stati Uniti, 98383
        • Saint Michael Cancer Center
      • Tacoma, Washington, Stati Uniti, 98405
        • Northwest Medical Specialties PLLC
      • Tacoma, Washington, Stati Uniti, 98405
        • MultiCare Tacoma General Hospital
      • Tacoma, Washington, Stati Uniti, 98405
        • Tacoma/Valley Radiation Oncology Centers-Saint Joe's
      • Tacoma, Washington, Stati Uniti, 97405
        • Tacoma/Valley Radiation Oncology Centers-Jackson Hall
      • Tacoma, Washington, Stati Uniti, 98405
        • Franciscan Research Center-Northwest Medical Plaza
      • Tacoma, Washington, Stati Uniti, 98405
        • MultiCare Allenmore Hospital
      • Tacoma, Washington, Stati Uniti, 98405
        • Northwest NCI Community Oncology Research Program
      • Tacoma, Washington, Stati Uniti, 98405
        • Saint Joseph Medical Center
    • West Virginia
      • Bridgeport, West Virginia, Stati Uniti, 26330
        • United Hospital Center
      • Charleston, West Virginia, Stati Uniti, 25304
        • West Virginia University Charleston Division
      • Huntington, West Virginia, Stati Uniti, 25701
        • Edwards Comprehensive Cancer Center
      • Martinsburg, West Virginia, Stati Uniti, 25401
        • WVUH-Berkely Medical Center
      • Morgantown, West Virginia, Stati Uniti, 26506
        • West Virginia University Healthcare
      • Morgantown, West Virginia, Stati Uniti, 26505
        • Monongalia Hospital
      • Parkersburg, West Virginia, Stati Uniti, 26101
        • Camden Clark Medical Center
    • Wisconsin
      • Burlington, Wisconsin, Stati Uniti, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Chippewa Falls, Wisconsin, Stati Uniti, 54729
        • Marshfield Clinic-Chippewa Center
      • Eau Claire, Wisconsin, Stati Uniti, 54701
        • HSHS Sacred Heart Hospital
      • Eau Claire, Wisconsin, Stati Uniti, 54701
        • Marshfield Clinic Cancer Center at Sacred Heart
      • Fond du Lac, Wisconsin, Stati Uniti, 54937
        • Aurora Health Center-Fond du Lac
      • Germantown, Wisconsin, Stati Uniti, 53022
        • Aurora Health Care Germantown Health Center
      • Grafton, Wisconsin, Stati Uniti, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Stati Uniti, 54311
        • Aurora BayCare Medical Center
      • Green Bay, Wisconsin, Stati Uniti, 54301
        • Bellin Memorial Hospital
      • Janesville, Wisconsin, Stati Uniti, 53548
        • Mercyhealth Hospital and Cancer Center - Janesville
      • Kenosha, Wisconsin, Stati Uniti, 53142
        • Aurora Cancer Care-Kenosha South
      • Ladysmith, Wisconsin, Stati Uniti, 54848
        • Marshfield Medical Center - Ladysmith
      • Marinette, Wisconsin, Stati Uniti, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marshfield, Wisconsin, Stati Uniti, 54449
        • Marshfield Medical Center-Marshfield
      • Marshfield, Wisconsin, Stati Uniti, 54449
        • Marshfield Medical Center
      • Milwaukee, Wisconsin, Stati Uniti, 53226
        • Medical College of Wisconsin
      • Milwaukee, Wisconsin, Stati Uniti, 53209
        • Aurora Cancer Care-Milwaukee
      • Milwaukee, Wisconsin, Stati Uniti, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Stati Uniti, 53233
        • Aurora Sinai Medical Center
      • Minocqua, Wisconsin, Stati Uniti, 54548
        • Marshfield Medical Center - Minocqua
      • New Richmond, Wisconsin, Stati Uniti, 54017
        • Cancer Center of Western Wisconsin
      • Oshkosh, Wisconsin, Stati Uniti, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, Stati Uniti, 53406
        • Aurora Cancer Care-Racine
      • Rhinelander, Wisconsin, Stati Uniti, 54501
        • Saint Mary's Hospital
      • Rhinelander, Wisconsin, Stati Uniti, 54501
        • Aspirus Cancer Care - James Beck Cancer Center
      • Rice Lake, Wisconsin, Stati Uniti, 54868
        • Marshfield Medical Center-Rice Lake
      • Sheboygan, Wisconsin, Stati Uniti, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Stevens Point, Wisconsin, Stati Uniti, 54481
        • Aspirus Cancer Care - Stevens Point
      • Summit, Wisconsin, Stati Uniti, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Stati Uniti, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Waukesha, Wisconsin, Stati Uniti, 53188
        • Aurora Cancer Care-Waukesha
      • Wausau, Wisconsin, Stati Uniti, 54401
        • Marshfield Clinic-Wausau Center
      • Wauwatosa, Wisconsin, Stati Uniti, 53226
        • Aurora Cancer Care-Milwaukee West
      • West Allis, Wisconsin, Stati Uniti, 53227
        • Aurora West Allis Medical Center
      • Weston, Wisconsin, Stati Uniti, 54476
        • Marshfield Medical Center - Weston
      • Weston, Wisconsin, Stati Uniti, 54476
        • Diagnostic and Treatment Center
      • Weston, Wisconsin, Stati Uniti, 54476
        • Ascension Saint Clare's Hospital
      • Wisconsin Rapids, Wisconsin, Stati Uniti, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
    • Wyoming
      • Casper, Wyoming, Stati Uniti, 82609
        • Rocky Mountain Oncology
      • Cheyenne, Wyoming, Stati Uniti, 82001
        • Cheyenne Regional Medical Center-West
      • Cody, Wyoming, Stati Uniti, 82414
        • Big Horn Basin Cancer Center
      • Cody, Wyoming, Stati Uniti, 82414
        • Billings Clinic-Cody
      • Sheridan, Wyoming, Stati Uniti, 82801
        • Welch Cancer Center

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Criteri di ammissibilità

I requisiti chiave che devono soddisfare le persone che vogliono partecipare a uno studio clinico o le caratteristiche che devono avere. I criteri di ammissibilità sono costituiti sia da criteri di inclusione (necessari a una persona per partecipare allo studio) sia da criteri di esclusione (che impediscono a una persona di partecipare). I tipi di criteri di ammissibilità includono se uno studio accetta volontari sani, ha requisiti di età o gruppo di età o è limitato dal sesso.

Età idonea allo studio

18 anni e precedenti (Adulto, Adulto più anziano)

Accetta volontari sani

No

Sessi ammissibili allo studio

Femmina

Descrizione

Inclusion Criteria:

  • Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer; (comorbid conditions should be taken into consideration, but not the diagnosis of breast cancer)

  • Women of reproductive potential must agree to use an effective non-hormonal method of contraception during study therapy (chemotherapy, trastuzumab, pertuzumab, and estrogen deprivation therapy) and for at least 7 months after the last dose of study therapy

  • Submission of tumor samples is required for all patients; the local pathology department policy regarding release of tumor samples must be considered in the screening process; patients whose tumor samples are located in a pathology department that by policy will not submit any samples for research purposes should not be approached for participation in the B-52 trial

  • The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines

  • The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

  • Clinical staging for the primary tumor can be cT1c (must be 2.0 cm) or T2-T4 if clinically node negative; if the regional lymph nodes are cN1 and cytologically or histologically positive or if cN2-N3 with or without a biopsy, the primary breast tumor can be cT0-T4

  • The diagnosis of invasive adenocarcinoma of the breast must have been made by core needle biopsy

  • Ipsilateral axillary lymph nodes must be evaluated by imaging (mammogram, ultrasound, and/or magnetic resonance imaging [MRI]) within 6 weeks prior to randomization; if suspicious or abnormal, fine needle aspirate (FNA) or core biopsy is recommended, also within 6 weeks prior to randomization; findings of these evaluations will be used to determine the nodal status prior to randomization:

    • Nodal status - negative

      • Imaging of the axilla is negative
      • Imaging is suspicious or abnormal but the FNA or core biopsy of the questionable node(s) on imaging is negative

    • Nodal status - positive

      • FNA or core biopsy of the node(s) is cytologically or histologically suspicious or positive
      • Imaging is suspicious or abnormal but FNA or core biopsy was not performed

  • Patients may be premenopausal or postmenopausal at the time of randomization; for study purposes, postmenopausal is defined as:

    • Age 56 or older with no spontaneous menses for at least 12 months prior to study entry; or
    • Age 55 or younger with no spontaneous menses for at least 12 months prior to study entry (e.g., spontaneous or secondary to hysterectomy) and with a documented estradiol level in the postmenopausal range according to local institutional/laboratory standard; or
    • Documented bilateral oophorectomy

  • The tumor must have been determined to be HER2-postive as follows:

    • Immunohistochemistry (IHC) 3+ or
    • In situ hybridization (ISH)-positive (defined by ratio of HER2 to circulating endothelial progenitors [CEP]17 >= 2.0 or HER2 gene copy number >= 6 per nucleus)

  • The tumor must have been determined to be estrogen receptor (ER) and/or progesterone (PgR) positive assessed by current American Society of Clinical Oncology (ASCO)/College of American Pathologist (CAP) guideline recommendations for hormone receptor testing; patients with >= 1% ER or PgR staining by IHC are considered positive

  • Absolute neutrophil count (ANC) must be >= 1200/mm^3

  • Platelet count must be >= 100,000/mm^3

  • Hemoglobin must be >= 10 g/dL

  • Total bilirubin must be =< upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin

  • Alkaline phosphatase must be =< 2.5 x ULN for the lab

  • Aspartate aminotransferase (AST) must be =< 1.5 x ULN for the lab

  • Alkaline phosphatase and AST may not both be > the ULN; for example, if the alkaline phosphatase is > the ULN but =< 2.5 x ULN, the AST must be =< the ULN; if the AST is > the ULN but =< 1.5 x ULN, the alkaline phosphatase must be =< ULN; Note: If alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< 1.5 x ULN; if both were performed, the AST must be =< 1.5 x ULN

  • Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (computed tomography [CT], MRI, positron emission tomography [PET]-CT, or PET scan) performed within 6 weeks prior to randomization does not demonstrate metastatic disease and the requirements are met

  • Patients with alkaline phosphatase that is > ULN but =< 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 6 weeks prior to randomization does not demonstrate metastatic disease

  • Within 6 weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > 60 mL/min

  • Left ventricular ejection fraction (LVEF) assessment must be performed within 90 days prior to randomization; (LVEF assessment performed by 2-dimensional [2-D] echocardiogram is preferred; however, multi gated acquisition scan [MUGA] scan may be substituted based on institutional preferences); the LVEF must be >= 50% regardless of the cardiac imaging facility's lower limit of normal; note: since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment; if the baseline LVEF is > 65%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain

Exclusion Criteria:

  • FNA alone to diagnose the breast cancer

  • Excisional biopsy or lumpectomy performed prior to randomization

  • Surgical axillary staging procedure prior to randomization; pre-neoadjuvant therapy sentinel node biopsy is not permitted

  • Definitive clinical or radiologic evidence of metastatic disease; (chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 90 days prior to randomization)

  • Synchronous bilateral invasive breast cancer

  • Synchronous or previous contralateral invasive breast cancer; (patients with synchronous and/or previous contralateral ductal carcinoma in situ [DCIS] or lobular carcinoma in situ [LCIS] are eligible)

  • Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible)

  • Treatment including radiation therapy (RT), chemotherapy, targeted therapy, or endocrine therapy for the currently diagnosed breast cancer prior to randomization

  • Previous endocrine therapy such as raloxifene or tamoxifen (or other selective estrogen receptor modulator [SERM]) or an aromatase inhibitor for any malignancy

  • Previous therapy with anthracycline, taxanes, carboplatin, trastuzumab, or other HER2 targeted therapies for any malignancy

  • Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. (these patients are eligible if this therapy is discontinued prior to randomization)

  • History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization

  • Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens; this includes but is not confined to:

    • Active cardiac disease:

      • Angina pectoris that requires the use of anti-anginal medication;
      • Ventricular arrhythmias except for benign premature ventricular contractions;
      • Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication;
      • Conduction abnormality requiring a pacemaker;
      • Valvular disease with documented compromise in cardiac function; and
      • Symptomatic pericarditis

    • History of cardiac disease:

      • Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function;
      • History of documented congestive heart failure (CHF); and
      • Documented cardiomyopathy

  • Uncontrolled hypertension defined as sustained systolic blood pressure (BP) > 150 mmHg or diastolic BP > 90 mmHg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)

  • Active hepatitis B or hepatitis C with abnormal liver function tests

  • Intrinsic lung disease resulting in dyspnea

  • Poorly controlled diabetes mellitus

  • Active infection or chronic infection requiring chronic suppressive antibiotics

  • Patients known to be human immunodeficiency virus (HIV) positive with a baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 or have a history of acquired immune deficiency syndrome (AIDS) indicator conditions; patients taking anti-retroviral therapy that may have a potential overlapping toxicity with the study therapy are not eligible

  • Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) >= grade 2, per the Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v4.0)

  • Malabsorption syndrome, ulcerative colitis, resection of the stomach or small bowel, or other disease significantly affecting gastrointestinal function

  • Other non-malignant systemic disease that would preclude treatment with any of the treatment regimens or would prevent required follow-up

  • Conditions that would prohibit administration of corticosteroids

  • Chronic daily treatment with corticosteroids with a dose of >= 10 mg/day methylprednisolone equivalent (excluding inhaled steroids)

  • Known hypersensitivity to any of the study drugs or any of the ingredients or excipients of these drugs (e.g., polysorbate 80), including sensitivity to benzyl alcohol

  • Pregnancy or lactation at the time of study entry; (note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)

  • Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements

  • Use of any investigational product within 30 days prior to randomization

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Trattamento
  • Assegnazione: Randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Nessuno (etichetta aperta)

Armi e interventi

Gruppo di partecipanti / Arm

Gruppo di partecipanti / Arm

Un gruppo o sottogruppo di partecipanti a uno studio clinico che riceve un intervento/trattamento specifico o nessun intervento, secondo il protocollo dello studio.
Intervento / Trattamento

Intervento / Trattamento

Un processo o un'azione che è al centro di uno studio clinico. Gli interventi includono farmaci, dispositivi medici, procedure, vaccini e altri prodotti sperimentali o già disponibili. Gli interventi possono anche includere approcci non invasivi, come l'educazione o la modifica della dieta e dell'esercizio fisico.
Comparatore attivo: Arm I (combination chemotherapy, surgery, radiation)

NEOADJUVANT: Patients receive docetaxel IV over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.

SURGERY: Patients undergo lumpectomy or mastectomy.

RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery.

ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year.
Droga: Carboplatin

Given IV

Altri nomi:
  • Blastocarb
  • Carboplat
  • Carboplatino Hexal
  • Carboplatino
  • Carbosina
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatino
  • Paraplatino
  • Paraplatino AQ
  • Platino
  • Ribocarbonio
  • JM8
Biologico: Trastuzumab

Given IV

Altri nomi:
  • Herceptin
  • ABP 980
  • ALT02
  • Herceptin biosimilare PF-05280014
  • Herceptin Trastuzumab Biosimilare PF-05280014
  • Erzuma
  • Ogivri
  • Ontruzzante
  • PF-05280014
  • rhuMAb HER2
  • RO0452317
  • SB3
  • Trastuzumab biosimilare ABP 980
  • Trastuzumab biosimilare ALT02
  • trastuzumab biosimilare EG12014
  • Trastuzumab biosimilare HLX02
  • Trastuzumab biosimilare PF-05280014
  • Trastuzumab biosimilare SB3
  • Trastuzumab-dkst
  • Trastuzumab-dttb
  • Trastuzumab-pkrb
  • Trazimera
  • Kanjinti
  • Trastuzumab biosimilare SIBP-01
  • Trastuzumab-anns
  • Trastuzumab-qyyp
  • Herclon
  • Zercepac
  • QL 1701
  • QL-1701
  • QL1701
  • Trastuzumab biosimilare QL1701
  • CT-P06
  • CT-P6
  • Trastuzumab biosimilare CT-P6
  • Bicelti
  • CANMab
  • Hertraz
  • Hercessi
  • Trastuzumab-strf
  • Herwenda
  • Trastuzumab-herw
  • Trastuzumab-zerc
  • HLX02
  • HLX-02
  • PF05280014
Altro: Laboratory Biomarker Analysis

Correlative studies

Altro: Quality-of-Life Assessment

Ancillary studies

Altri nomi:
  • Valutazione della qualità della vita
Droga: Docetaxel

Given IV

Altri nomi:
  • Taxotere
  • Doccad
  • RP56976
  • Taxotere concentrato per iniezione
  • RP 56976
  • RP-56976
Altro: Cytology Specimen Collection Procedure

Undergo 2 core biopsies

Altri nomi:
  • Campionamento citologico
Biologico: Pertuzumab

Given IV

Altri nomi:
  • Perjeta
  • 2C4
  • Anticorpo 2C4
  • EG1206A
  • HLX11
  • HS627
  • MoAb 2C4
  • Anticorpo monoclonale 2C4
  • Omnitarg
  • Pertuzumab biosimilare EG1206A
  • Pertuzumab biosimilare HLX11
  • Pertuzumab biosimilare HS627
  • rhuMAb2C4
  • RO4368451
  • BCD-178
  • Pertuzumab biosimilare BCD-178
  • Rhumab 2C4
  • Pertuzumab biosimilare TQB2440
  • TQB2440
  • TQB-2440
Procedura: Therapeutic Conventional Surgery

Undergo lumpectomy or mastectomy

Radiazione: Whole Breast Irradiation

Undergo whole breast irradiation
Sperimentale: Arm II (chemo, estrogen deprivation, surgery, radiation)

NEOADJUVANT: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate SC every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.

SURGERY: Patients undergo lumpectomy or mastectomy.

RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery.

ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year.
Droga: Carboplatin

Given IV

Altri nomi:
  • Blastocarb
  • Carboplat
  • Carboplatino Hexal
  • Carboplatino
  • Carbosina
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatino
  • Paraplatino
  • Paraplatino AQ
  • Platino
  • Ribocarbonio
  • JM8
Biologico: Trastuzumab

Given IV

Altri nomi:
  • Herceptin
  • ABP 980
  • ALT02
  • Herceptin biosimilare PF-05280014
  • Herceptin Trastuzumab Biosimilare PF-05280014
  • Erzuma
  • Ogivri
  • Ontruzzante
  • PF-05280014
  • rhuMAb HER2
  • RO0452317
  • SB3
  • Trastuzumab biosimilare ABP 980
  • Trastuzumab biosimilare ALT02
  • trastuzumab biosimilare EG12014
  • Trastuzumab biosimilare HLX02
  • Trastuzumab biosimilare PF-05280014
  • Trastuzumab biosimilare SB3
  • Trastuzumab-dkst
  • Trastuzumab-dttb
  • Trastuzumab-pkrb
  • Trazimera
  • Kanjinti
  • Trastuzumab biosimilare SIBP-01
  • Trastuzumab-anns
  • Trastuzumab-qyyp
  • Herclon
  • Zercepac
  • QL 1701
  • QL-1701
  • QL1701
  • Trastuzumab biosimilare QL1701
  • CT-P06
  • CT-P6
  • Trastuzumab biosimilare CT-P6
  • Bicelti
  • CANMab
  • Hertraz
  • Hercessi
  • Trastuzumab-strf
  • Herwenda
  • Trastuzumab-herw
  • Trastuzumab-zerc
  • HLX02
  • HLX-02
  • PF05280014
Altro: Laboratory Biomarker Analysis

Correlative studies

Altro: Quality-of-Life Assessment

Ancillary studies

Altri nomi:
  • Valutazione della qualità della vita
Droga: Docetaxel

Given IV

Altri nomi:
  • Taxotere
  • Doccad
  • RP56976
  • Taxotere concentrato per iniezione
  • RP 56976
  • RP-56976
Altro: Cytology Specimen Collection Procedure

Undergo 2 core biopsies

Altri nomi:
  • Campionamento citologico
Biologico: Pertuzumab

Given IV

Altri nomi:
  • Perjeta
  • 2C4
  • Anticorpo 2C4
  • EG1206A
  • HLX11
  • HS627
  • MoAb 2C4
  • Anticorpo monoclonale 2C4
  • Omnitarg
  • Pertuzumab biosimilare EG1206A
  • Pertuzumab biosimilare HLX11
  • Pertuzumab biosimilare HS627
  • rhuMAb2C4
  • RO4368451
  • BCD-178
  • Pertuzumab biosimilare BCD-178
  • Rhumab 2C4
  • Pertuzumab biosimilare TQB2440
  • TQB2440
  • TQB-2440
Procedura: Therapeutic Conventional Surgery

Undergo lumpectomy or mastectomy

Radiazione: Whole Breast Irradiation

Undergo whole breast irradiation

Droga: Aromatase Inhibition Therapy

Given at the investigator's discretion

Altri nomi:
  • Inibizione dell'aromatasi
Droga: Goserelin Acetate

Given SC

Altri nomi:
  • ZDX
  • Zoladex

Cosa sta misurando lo studio?

Misure di risultato primarie

Misure di risultato primarie

Nel protocollo di uno studio clinico, la misura dell'esito pianificato più importante per valutare l'effetto di un intervento/trattamento. La maggior parte degli studi clinici ha una misura di esito primaria, ma alcuni ne hanno più di una.
Misura del risultato
Misura Descrizione
Lasso di tempo
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes
Lasso di tempo: Up to 2.8 years (when all patients completed primary breast surgery)

Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy.
Up to 2.8 years (when all patients completed primary breast surgery)

Misure di risultato secondarie

Misure di risultato secondarie

Nel protocollo di uno studio clinico, una misura dell'esito pianificato che non è importante quanto la misura dell'esito primario per valutare l'effetto di un intervento ma è comunque di interesse. La maggior parte degli studi clinici ha più di una misura di esito secondaria.
Misura del risultato
Misura Descrizione
Lasso di tempo
Percent of Patients With Pathologic Complete Response (pCR) in the Breast
Lasso di tempo: Up to 2.8 years (when all patients completed primary breast surgery)

Proportion of patients with pCR in the breast, defined as the absence of any invasive component in the resected breast specimen.
Up to 2.8 years (when all patients completed primary breast surgery)
Recurrence Free Interval (RFI)
Lasso di tempo: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years

Kaplan-Meier estimates of the percentages of patients free from recurrence.
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
Overall Survival (OS)
Lasso di tempo: Time from randomization until death from any cause, assessed up to 8.4 years

Kaplan-Meier estimates of the percentages of patients surviving.
Time from randomization until death from any cause, assessed up to 8.4 years
Second Primary Cancer of Any Type
Lasso di tempo: Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years

Number of second primary cancers for the two treatment groups
Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes by Menopausal Status
Lasso di tempo: Up to 2.8 years (when all patients completed primary breast surgery)

Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy calculated separately for premenopausal and postmenopausal women.
Up to 2.8 years (when all patients completed primary breast surgery)
Patterns of Recurrence Free Interval (RFI) by Menopausal Status
Lasso di tempo: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years

Kaplan-Meier estimates of the percentages of patients free from recurrence by menopausal status.
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
Patterns of Overall Survival (OS) by Menopausal Status
Lasso di tempo: Time from randomization until death from any cause, assessed up to 5 years

Kaplan-Meier estimates of the percentages of patients surviving by menopausal status.
Time from randomization until death from any cause, assessed up to 5 years
Percentage of Participants With Cardiac Toxicity Categorized According to National Cancer Institute CTCAE Version 4.0
Lasso di tempo: Up to 6 weeks post surgery

Percentage of patients with grade 1 or higher toxicity from the Cardiac Disorders System Organ Class.
Up to 6 weeks post surgery
Median Percentage of Tumor-infiltrating Lymphocytes (sTILS)
Lasso di tempo: 2.8 years

Percentage of Tumor-infiltrating lymphocytes present in the stroma in tissue specimen.
2.8 years
Change in Endocrine-related Symptoms Using Breast Cancer Prevention Trial (BCPT) Symptom Checklist
Lasso di tempo: The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)

The Breast Cancer Prevention Trial (BCPT) symptom checklist contains 17 endocrine-related symptoms and problems. For each item, the patient was asked how bothersome the problem or symptom was during the past four weeks. Possible answers ranged from not at all (1) to extremely (5). The summary score was calculated for each participant as the average severity of all 17 items. The total mean summary score was calculated as the average summary score by treatment group. The range is 1-5 with higher scores indicating worse outcome.
The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

Sponsor

L'organizzazione o la persona che avvia lo studio e che ha autorità e controllo sullo studio.
National Cancer Institute (NCI)

Collaboratori

Collaboratori

Un'organizzazione diversa dallo sponsor che fornisce supporto per uno studio clinico. Questo supporto può includere attività relative al finanziamento, alla progettazione, all'implementazione, all'analisi dei dati o al reporting.
NRG Oncology

Investigatori

Investigatori

Un ricercatore coinvolto in uno studio clinico. I termini correlati includono il ricercatore principale del sito, il ricercatore secondario del sito, il presidente dello studio, il direttore dello studio e il ricercatore principale dello studio.
  • Investigatore principale: Mothaffar F Rimawi, NRG Oncology

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

Inizio studio

La data effettiva in cui il primo partecipante è stato arruolato in uno studio clinico. La data di inizio dello studio "prevista" è la data che i ricercatori pensano sarà la data di inizio dello studio.
18 febbraio 2014

Completamento primario (Effettivo)

Completamento primario

La data in cui l'ultimo partecipante a uno studio clinico è stato esaminato o ha ricevuto un intervento per raccogliere i dati finali per la misura dell'esito primario. Il fatto che lo studio clinico sia terminato secondo il protocollo o sia stato interrotto non influisce su questa data. Per gli studi clinici con più di una misura di esito primario con diverse date di completamento, questo termine si riferisce alla data in cui la raccolta dei dati è completata per tutte le misure di esito primario. La data di completamento principale "prevista" è la data che i ricercatori ritengono sarà la data di completamento principale per lo studio.
31 ottobre 2016

Completamento dello studio (Effettivo)

Completamento dello studio

La data in cui l'ultimo partecipante a uno studio clinico è stato esaminato o ha ricevuto un intervento/trattamento per raccogliere i dati finali per le misure di esito primarie, le misure di esito secondarie e gli eventi avversi (ovvero l'ultima visita dell'ultimo partecipante). La data di completamento dello studio "prevista" è la data che i ricercatori ritengono sarà la data di completamento dello studio.
30 giugno 2025

Date di iscrizione allo studio

Primo inviato

Primo inviato

La data in cui lo sponsor o il ricercatore dello studio ha inviato per la prima volta un record di studio a ClinicalTrials.gov. In genere c'è un ritardo di alcuni giorni tra la prima data di invio e la disponibilità del record su ClinicalTrials.gov (la prima data di invio).
2 dicembre 2013

Primo inviato che soddisfa i criteri di controllo qualità

Primo inviato che soddisfa i criteri di controllo qualità

La data in cui lo sponsor dello studio o il ricercatore invia per la prima volta un record di studio che è coerente con i criteri di revisione del controllo di qualità (QC) della National Library of Medicine (NLM). Lo sponsor o lo sperimentatore potrebbe dover rivedere e inviare un record di studio una o più volte prima che i criteri di revisione QC di NLM siano soddisfatti. È responsabilità dello sponsor o dello sperimentatore garantire che il record dello studio sia coerente con i criteri di revisione QC NLM.
2 dicembre 2013

Primo Inserito (Stimato)

Primo Inserito

La data in cui il record dello studio è stato disponibile per la prima volta su ClinicalTrials.gov dopo la conclusione della revisione del controllo di qualità (QC) della National Library of Medicine (NLM). In genere c'è un ritardo di alcuni giorni tra la data in cui lo sponsor dello studio o lo sperimentatore ha presentato il record dello studio e la prima data pubblicata.
6 dicembre 2013

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

Ultimo aggiornamento pubblicato

La data più recente in cui le modifiche al record di uno studio sono state rese disponibili su ClinicalTrials.gov. Potrebbe esserci un ritardo tra il momento in cui le modifiche sono state inviate a ClinicalTrials.gov dallo sponsor o dallo sperimentatore dello studio (data di invio dell'ultimo aggiornamento) e la data di pubblicazione dell'ultimo aggiornamento.
6 ottobre 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

Ultimo aggiornamento inviato che soddisfa i criteri QC

La data più recente in cui lo sponsor dello studio o il ricercatore ha presentato modifiche a un record di studio che sono coerenti con i criteri di revisione del controllo di qualità (QC) della National Library of Medicine (NLM). È responsabilità dello sponsor o dello sperimentatore garantire che il record dello studio sia coerente con i criteri di revisione QC NLM.
15 settembre 2026

Ultimo verificato

Ultimo verificato

La data più recente in cui lo sponsor dello studio o il ricercatore ha confermato che le informazioni su uno studio clinico su ClinicalTrials.gov sono accurate e aggiornate. Se uno studio con stato di reclutamento di reclutamento; non ancora reclutamento; o attivo, non reclutamento non è stato confermato negli ultimi 2 anni, lo stato di reclutamento dello studio viene mostrato come sconosciuto.
1 settembre 2026

Maggiori informazioni

Termini relativi a questo studio

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

Altri numeri di identificazione dello studio

Identificatori o numeri ID diversi dal numero NCT assegnati a uno studio clinico dallo sponsor, dai finanziatori o da altri dello studio. Questi numeri possono includere identificatori univoci di altri registri di sperimentazione e numeri di sovvenzioni del National Institutes of Health.
  • NCI-2013-02228
  • U10CA180868 (Sovvenzione/contratto NIH degli Stati Uniti)
  • U10CA012027 (Sovvenzione/contratto NIH degli Stati Uniti)
  • NCI-2013-02228 (Identificatore di registro: CTRP (Clinical Trial Reporting Program))
  • NSABP-B-52 (Altro identificatore: CTEP)
  • NSABP-B-52 (Altro identificatore: NRG Oncology)

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

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