Docetaksel, karboplatyna, trastuzumab i pertuzumab z deprywacją estrogenową lub bez niej w leczeniu pacjentów z rakiem piersi z dodatnim receptorem hormonalnym, HER2-dodatnim operacyjnym lub miejscowo zaawansowanym rakiem piersi
15 września 2026 zaktualizowane przez: National Cancer Institute (NCI)
Randomizowane badanie fazy III oceniające odsetek całkowitych odpowiedzi patologicznych u pacjentek z rakiem piersi z dodatnim receptorem hormonalnym, HER2-dodatnim, dużym operacyjnym i miejscowo zaawansowanym rakiem piersi leczonych terapią neoadiuwantową docetakselem, karboplatyną, trastuzumabem i pertuzumabem (TCHP) z deprywacją estrogenową lub bez niej
This randomized phase III trial studies docetaxel, carboplatin, trastuzumab, and pertuzumab with estrogen deprivation to see how they work compared to docetaxel, carboplatin, trastuzumab, and pertuzumab without estrogen deprivation in treating patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-positive breast cancer that is operable or has spread from where it started to nearby tissue or lymph nodes (locally advanced). Drugs used in chemotherapy, such as docetaxel, carboplatin, trastuzumab, and pertuzumab, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Estrogen can cause the growth of breast cancer cells. Hormone therapy using goserelin acetate and aromatase inhibition therapy may fight breast cancer by blocking the use of estrogen by the tumor cells. Radiation therapy uses high energy x rays to kill tumor cells. Giving combination chemotherapy and radiation therapy with or without hormone therapy may be an effective treatment for hormone receptor-positive, HER2-positive, operable or locally advanced breast cancer.
Przegląd badań
Status
Status
Zakończony
Warunki
Warunki
Interwencja / Leczenie
Interwencja / Leczenie
- Lek: Carboplatin
- Biologiczny: Trastuzumab
- Inny: Laboratory Biomarker Analysis
- Inny: Quality-of-Life Assessment
- Lek: Docetaxel
- Inny: Cytology Specimen Collection Procedure
- Biologiczny: Pertuzumab
- Procedura: Therapeutic Conventional Surgery
- Promieniowanie: Whole Breast Irradiation
- Lek: Aromatase Inhibition Therapy
- Lek: Goserelin Acetate
Szczegółowy opis
PRIMARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of therapy of docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) yields a greater rate of pathologic complete response (pCR) (breast and nodes) than TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
SECONDARY OBJECTIVES:
I. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP will increase the pCR rate in the breast compared to TCHP alone when administered to women with operable, hormone receptor-positive, HER2-positive breast cancer.
II. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves recurrence-free interval (RFI) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
III. To determine whether the addition of estrogen deprivation to neoadjuvant therapy consisting of TCHP improves overall survival (OS) in women with operable, hormone receptor-positive, HER2-positive breast cancer.
IV. To compare the rates of second primary invasive cancer by treatment arm. V. Assessment of patterns of pCR, RFI, and OS by menopausal status. VI. To evaluate the cardiac toxicity associated with each of the regimens. VII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on endocrine-related symptoms in all patients by treatment arm.
VIII. To compare the effect of adding estrogen deprivation to neoadjuvant therapy on vasomotor symptoms, musculoskeletal, and vaginal complaints as well as quality of life.
IX. To determine a relationship between pCR and a potential mechanism of resistance/sensitivity in hormone receptor-positive, HER2-positive tumors.
X. To evaluate tumor infiltrating lymphocytes (TILs) and immune biomarkers as predictors of pCR.
XI. To study early changes in TILs and other immune biomarkers in response to TCHP.
OUTLINE: Patients are randomized to 1 of 2 treatments arms.
NEOADJUVANT:
ARM I: Patients receive docetaxel intravenously (IV) over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
ARM II: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate subcutaneously (SC) every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment.
SURGERY: Patients undergo lumpectomy or mastectomy.
RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery.
ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year.
After completion of study treatment, patients are followed up every 6, 9, 12, and 18 months for 5 years.
Typ studiów
Typ studiów
Interwencyjne
Zapisy (Rzeczywisty)
Zapisy
315
Faza
Faza
- Faza 3
Kontakty i lokalizacje
Ta sekcja zawiera dane kontaktowe osób prowadzących badanie oraz informacje o tym, gdzie badanie jest przeprowadzane.
Lokalizacje studiów
-
-
-
San Juan, Portoryko, 00936
- San Juan City Hospital
-
-
-
-
Alaska
-
Fairbanks, Alaska, Stany Zjednoczone, 99701
- Fairbanks Memorial Hospital
-
-
Arkansas
-
Hot Springs, Arkansas, Stany Zjednoczone, 71913
- CHI Saint Vincent Cancer Center Hot Springs
-
-
California
-
Anaheim, California, Stany Zjednoczone, 92806
- Kaiser Permanente-Anaheim
-
Antioch, California, Stany Zjednoczone, 94531
- Kaiser Permanente-Deer Valley Medical Center
-
Arroyo Grande, California, Stany Zjednoczone, 93420
- PCR Oncology
-
Auburn, California, Stany Zjednoczone, 95602
- Sutter Auburn Faith Hospital
-
Auburn, California, Stany Zjednoczone, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
-
Baldwin Park, California, Stany Zjednoczone, 91706
- Kaiser Permanente-Baldwin Park
-
Bellflower, California, Stany Zjednoczone, 90706
- Kaiser Permanente-Bellflower
-
Berkeley, California, Stany Zjednoczone, 94704
- Alta Bates Summit Medical Center-Herrick Campus
-
Burlingame, California, Stany Zjednoczone, 94010
- Mills-Peninsula Medical Center
-
Cameron Park, California, Stany Zjednoczone, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
-
Castro Valley, California, Stany Zjednoczone, 94546
- Eden Hospital Medical Center
-
Castro Valley, California, Stany Zjednoczone, 94546
- East Bay Radiation Oncology Center
-
Davis, California, Stany Zjednoczone, 95616
- Sutter Davis Hospital
-
Dublin, California, Stany Zjednoczone, 94568
- Epic Care-Dublin
-
Emeryville, California, Stany Zjednoczone, 94608
- Bay Area Breast Surgeons Inc
-
Emeryville, California, Stany Zjednoczone, 94608
- Epic Care Partners in Cancer Care
-
Fontana, California, Stany Zjednoczone, 92335
- Kaiser Permanente-Fontana
-
Fremont, California, Stany Zjednoczone, 94538
- Kaiser Permanente-Fremont
-
Fresno, California, Stany Zjednoczone, 93720
- Kaiser Permanente-Fresno
-
Harbor City, California, Stany Zjednoczone, 90710
- Kaiser Permanente South Bay
-
Irvine, California, Stany Zjednoczone, 92618
- Kaiser Permanente-Irvine
-
Loma Linda, California, Stany Zjednoczone, 92354
- Loma Linda University Medical Center
-
Los Angeles, California, Stany Zjednoczone, 90027
- Kaiser Permanente Los Angeles Medical Center
-
Los Angeles, California, Stany Zjednoczone, 90048
- Cedars Sinai Medical Center
-
Los Angeles, California, Stany Zjednoczone, 90034
- Kaiser Permanente West Los Angeles
-
Martinez, California, Stany Zjednoczone, 94553-3156
- Contra Costa Regional Medical Center
-
Modesto, California, Stany Zjednoczone, 95355
- Memorial Medical Center
-
Modesto, California, Stany Zjednoczone, 95356
- Kaiser Permanente-Modesto
-
Mountain View, California, Stany Zjednoczone, 94040
- El Camino Hospital
-
Mountain View, California, Stany Zjednoczone, 94040
- Palo Alto Medical Foundation-Camino Division
-
Mountain View, California, Stany Zjednoczone, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
-
Novato, California, Stany Zjednoczone, 94945
- Sutter Cancer Research Consortium
-
Oakland, California, Stany Zjednoczone, 94611
- Kaiser Permanente-Oakland
-
Oakland, California, Stany Zjednoczone, 94609
- Alta Bates Summit Medical Center - Summit Campus
-
Oakland, California, Stany Zjednoczone, 94609
- Hematology and Oncology Associates-Oakland
-
Oakland, California, Stany Zjednoczone, 94609
- Bay Area Tumor Institute
-
Oakland, California, Stany Zjednoczone, 94602
- Wilma Chan Highland Hospital
-
Orange, California, Stany Zjednoczone, 92868
- Saint Joseph Hospital - Orange
-
Palo Alto, California, Stany Zjednoczone, 94304
- Stanford Cancer Institute Palo Alto
-
Palo Alto, California, Stany Zjednoczone, 94301
- Palo Alto Medical Foundation Health Care
-
Panorama City, California, Stany Zjednoczone, 91402
- Kaiser Permanente - Panorama City
-
Pleasanton, California, Stany Zjednoczone, 94588
- Valley Medical Oncology Consultants
-
Redwood City, California, Stany Zjednoczone, 94063
- Kaiser Permanente-Redwood City
-
Richmond, California, Stany Zjednoczone, 94801
- Kaiser Permanente-Richmond
-
Riverside, California, Stany Zjednoczone, 92505
- Kaiser Permanente-Riverside
-
Roseville, California, Stany Zjednoczone, 95661
- Kaiser Permanente-Roseville
-
Roseville, California, Stany Zjednoczone, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
-
Roseville, California, Stany Zjednoczone, 95661
- Sutter Roseville Medical Center
-
Sacramento, California, Stany Zjednoczone, 95816
- Sutter Medical Center Sacramento
-
Sacramento, California, Stany Zjednoczone, 95823
- Kaiser Permanente-South Sacramento
-
Sacramento, California, Stany Zjednoczone, 95825
- Kaiser Permanente Sacramento Medical Center
-
San Diego, California, Stany Zjednoczone, 92120
- Kaiser Permanente-San Diego Zion
-
San Diego, California, Stany Zjednoczone, 92108
- Kaiser Permanente-San Diego Mission
-
San Francisco, California, Stany Zjednoczone, 94115
- Kaiser Permanente-San Francisco
-
San Francisco, California, Stany Zjednoczone, 94115
- California Pacific Medical Center-Pacific Campus
-
San Jose, California, Stany Zjednoczone, 95119
- Kaiser Permanente-Santa Teresa-San Jose
-
San Leandro, California, Stany Zjednoczone, 94577
- Kaiser Permanente San Leandro
-
San Marcos, California, Stany Zjednoczone, 92078
- Kaiser Permanente-San Marcos
-
San Pablo, California, Stany Zjednoczone, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
-
San Rafael, California, Stany Zjednoczone, 94903
- Kaiser Permanente-San Rafael
-
Santa Clara, California, Stany Zjednoczone, 95051
- Kaiser Permanente Medical Center - Santa Clara
-
Santa Cruz, California, Stany Zjednoczone, 95065
- Palo Alto Medical Foundation-Santa Cruz
-
Santa Rosa, California, Stany Zjednoczone, 95403
- Kaiser Permanente-Santa Rosa
-
Santa Rosa, California, Stany Zjednoczone, 95403
- Sutter Pacific Medical Foundation
-
South San Francisco, California, Stany Zjednoczone, 94080
- Kaiser Permanente-South San Francisco
-
Stockton, California, Stany Zjednoczone, 95210
- Kaiser Permanente-Stockton
-
Sunnyvale, California, Stany Zjednoczone, 94086
- Palo Alto Medical Foundation-Sunnyvale
-
Vacaville, California, Stany Zjednoczone, 95688
- Kaiser Permanente Medical Center-Vacaville
-
Vallejo, California, Stany Zjednoczone, 94589
- Kaiser Permanente-Vallejo
-
Vallejo, California, Stany Zjednoczone, 94589
- Sutter Solano Medical Center/Cancer Center
-
Walnut Creek, California, Stany Zjednoczone, 94596
- Kaiser Permanente-Walnut Creek
-
Woodland Hills, California, Stany Zjednoczone, 91367
- Kaiser Permanente-Woodland Hills
-
-
Colorado
-
Aurora, Colorado, Stany Zjednoczone, 80012
- Rocky Mountain Cancer Centers-Aurora
-
Aurora, Colorado, Stany Zjednoczone, 80012
- The Medical Center of Aurora
-
Aurora, Colorado, Stany Zjednoczone, 80045
- UCHealth University of Colorado Hospital
-
Boulder, Colorado, Stany Zjednoczone, 80303
- Boulder Community Foothills Hospital
-
Boulder, Colorado, Stany Zjednoczone, 80304
- Rocky Mountain Cancer Centers-Boulder
-
Colorado Springs, Colorado, Stany Zjednoczone, 80907
- Penrose-Saint Francis Healthcare
-
Colorado Springs, Colorado, Stany Zjednoczone, 80909
- UCHealth Memorial Hospital Central
-
Colorado Springs, Colorado, Stany Zjednoczone, 80907
- Rocky Mountain Cancer Centers-Penrose
-
Denver, Colorado, Stany Zjednoczone, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
-
Denver, Colorado, Stany Zjednoczone, 80220
- Rose Medical Center
-
Denver, Colorado, Stany Zjednoczone, 80218
- Rocky Mountain Cancer Centers-Midtown
-
Denver, Colorado, Stany Zjednoczone, 80220
- Rocky Mountain Cancer Centers-Rose
-
Denver, Colorado, Stany Zjednoczone, 80218
- Colorado Blood Cancer Institute
-
Denver, Colorado, Stany Zjednoczone, 80222
- Western States Cancer Research NCORP
-
Denver, Colorado, Stany Zjednoczone, 80218
- Saint Joseph Hospital - Cancer Centers of Colorado
-
Denver, Colorado, Stany Zjednoczone, 80210
- AdventHealth Porter
-
Durango, Colorado, Stany Zjednoczone, 81301
- Mercy Medical Center
-
Durango, Colorado, Stany Zjednoczone, 81301
- Southwest Oncology PC
-
Englewood, Colorado, Stany Zjednoczone, 80113
- Mountain Blue Cancer Care Center - Swedish
-
Englewood, Colorado, Stany Zjednoczone, 80113
- Swedish Medical Center
-
Fort Collins, Colorado, Stany Zjednoczone, 80524
- Poudre Valley Hospital
-
Golden, Colorado, Stany Zjednoczone, 80401
- Mountain Blue Cancer Care Center
-
Greeley, Colorado, Stany Zjednoczone, 80631
- Banner North Colorado Medical Center
-
Greenwood Village, Colorado, Stany Zjednoczone, 80111
- Rocky Mountain Cancer Centers-Greenwood Village
-
Lakewood, Colorado, Stany Zjednoczone, 80228
- Saint Anthony Hospital
-
Lakewood, Colorado, Stany Zjednoczone, 80228
- Rocky Mountain Cancer Centers-Lakewood
-
Littleton, Colorado, Stany Zjednoczone, 80120
- Rocky Mountain Cancer Centers-Littleton
-
Littleton, Colorado, Stany Zjednoczone, 80122
- AdventHealth Littleton
-
Lone Tree, Colorado, Stany Zjednoczone, 80124
- Sky Ridge Medical Center
-
Lone Tree, Colorado, Stany Zjednoczone, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
-
Longmont, Colorado, Stany Zjednoczone, 80501
- Longmont United Hospital
-
Longmont, Colorado, Stany Zjednoczone, 80501
- Rocky Mountain Cancer Centers-Longmont
-
Loveland, Colorado, Stany Zjednoczone, 80539
- Banner McKee Medical Center
-
Parker, Colorado, Stany Zjednoczone, 80138
- Rocky Mountain Cancer Centers-Parker
-
Parker, Colorado, Stany Zjednoczone, 80138
- AdventHealth Parker
-
Pueblo, Colorado, Stany Zjednoczone, 81004
- Saint Mary Corwin Medical Center
-
Pueblo, Colorado, Stany Zjednoczone, 81008
- Rocky Mountain Cancer Centers - Pueblo
-
Thornton, Colorado, Stany Zjednoczone, 80260
- Rocky Mountain Cancer Centers-Thornton
-
Wheat Ridge, Colorado, Stany Zjednoczone, 80401
- Intermountain Health Lutheran Hospital
-
-
Connecticut
-
Hartford, Connecticut, Stany Zjednoczone, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
-
Hartford, Connecticut, Stany Zjednoczone, 06102
- Hartford Hospital
-
-
Delaware
-
Lewes, Delaware, Stany Zjednoczone, 19958
- Beebe Medical Center
-
Newark, Delaware, Stany Zjednoczone, 19713
- Helen F Graham Cancer Center
-
Newark, Delaware, Stany Zjednoczone, 19713
- Delaware Clinical and Laboratory Physicians PA
-
Newark, Delaware, Stany Zjednoczone, 19713
- Medical Oncology Hematology Consultants PA
-
Newark, Delaware, Stany Zjednoczone, 19718
- Christiana Care Health System-Christiana Hospital
-
Rehoboth Beach, Delaware, Stany Zjednoczone, 19971
- Beebe Health Campus
-
Seaford, Delaware, Stany Zjednoczone, 19973
- TidalHealth Nanticoke / Allen Cancer Center
-
Wilmington, Delaware, Stany Zjednoczone, 19801
- Christiana Care Health System-Wilmington Hospital
-
-
District of Columbia
-
Washington D.C., District of Columbia, Stany Zjednoczone, 20010
- MedStar Washington Hospital Center
-
Washington D.C., District of Columbia, Stany Zjednoczone, 20007
- MedStar Georgetown University Hospital
-
-
Florida
-
Deerfield Beach, Florida, Stany Zjednoczone, 33442
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
-
Gainesville, Florida, Stany Zjednoczone, 32610
- University of Florida Health Science Center - Gainesville
-
Miami, Florida, Stany Zjednoczone, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
-
Orlando, Florida, Stany Zjednoczone, 32806
- Orlando Health Cancer Institute
-
Orlando, Florida, Stany Zjednoczone, 32803
- AdventHealth Orlando
-
-
Georgia
-
Athens, Georgia, Stany Zjednoczone, 30607
- University Cancer and Blood Center LLC
-
Atlanta, Georgia, Stany Zjednoczone, 30342
- Northside Hospital
-
Augusta, Georgia, Stany Zjednoczone, 30912
- Augusta University Medical Center
-
Cumming, Georgia, Stany Zjednoczone, 30041
- Northside Hospital-Forsyth
-
Decatur, Georgia, Stany Zjednoczone, 30033
- Emory Decatur Hospital
-
Gainesville, Georgia, Stany Zjednoczone, 30501
- Northeast Georgia Medical Center-Gainesville
-
Savannah, Georgia, Stany Zjednoczone, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
-
Savannah, Georgia, Stany Zjednoczone, 31404
- Memorial Health University Medical Center
-
Savannah, Georgia, Stany Zjednoczone, 31404
- Summit Cancer Care-Memorial
-
Savannah, Georgia, Stany Zjednoczone, 31404
- Low Country Cancer Care
-
-
Hawaii
-
Honolulu, Hawaii, Stany Zjednoczone, 96813
- Queen's Medical Center
-
Honolulu, Hawaii, Stany Zjednoczone, 96817
- The Cancer Center of Hawaii-Liliha
-
Honolulu, Hawaii, Stany Zjednoczone, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Honolulu, Hawaii, Stany Zjednoczone, 96813
- Straub Clinic and Hospital
-
Honolulu, Hawaii, Stany Zjednoczone, 96813
- University of Hawaii Cancer Center
-
Honolulu, Hawaii, Stany Zjednoczone, 96817
- Hawaii Cancer Care Inc-Liliha
-
Honolulu, Hawaii, Stany Zjednoczone, 96817
- Kuakini Medical Center
-
Honolulu, Hawaii, Stany Zjednoczone, 96817
- Queen's Cancer Center - Kuakini
-
Honolulu, Hawaii, Stany Zjednoczone, 96819
- Kaiser Permanente Moanalua Medical Center
-
Kailua, Hawaii, Stany Zjednoczone, 96734
- Castle Medical Center
-
Lihue, Hawaii, Stany Zjednoczone, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
-
‘Aiea, Hawaii, Stany Zjednoczone, 96701
- Pali Momi Medical Center
-
‘Aiea, Hawaii, Stany Zjednoczone, 96701
- Queen's Cancer Center - Pearlridge
-
‘Aiea, Hawaii, Stany Zjednoczone, 96701
- The Cancer Center of Hawaii-Pali Momi
-
-
Idaho
-
Boise, Idaho, Stany Zjednoczone, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Coeur d'Alene, Idaho, Stany Zjednoczone, 83814
- Kootenai Health - Coeur d'Alene
-
Lewiston, Idaho, Stany Zjednoczone, 83501
- Saint Joseph Regional Medical Center
-
Post Falls, Idaho, Stany Zjednoczone, 83854
- Kootenai Clinic Cancer Services - Post Falls
-
Sandpoint, Idaho, Stany Zjednoczone, 83864
- Kootenai Clinic Cancer Services - Sandpoint
-
-
Illinois
-
Aurora, Illinois, Stany Zjednoczone, 60504
- Rush-Copley Medical Center
-
Bloomington, Illinois, Stany Zjednoczone, 61704
- Illinois CancerCare-Bloomington
-
Bloomington, Illinois, Stany Zjednoczone, 61701
- OSF Saint Joseph Medical Center
-
Canton, Illinois, Stany Zjednoczone, 61520
- Illinois CancerCare-Canton
-
Carbondale, Illinois, Stany Zjednoczone, 62902
- Memorial Hospital of Carbondale
-
Carthage, Illinois, Stany Zjednoczone, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, Stany Zjednoczone, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, Stany Zjednoczone, 60612
- University of Illinois
-
Chicago, Illinois, Stany Zjednoczone, 60612
- John H Stroger Jr Hospital of Cook County
-
Chicago, Illinois, Stany Zjednoczone, 60608
- Mount Sinai Hospital Medical Center
-
Chicago, Illinois, Stany Zjednoczone, 60625
- Swedish Covenant Hospital
-
Chicago, Illinois, Stany Zjednoczone, 60631
- Presence Resurrection Medical Center
-
Danville, Illinois, Stany Zjednoczone, 61832
- Carle at The Riverfront
-
Decatur, Illinois, Stany Zjednoczone, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, Stany Zjednoczone, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Effingham, Illinois, Stany Zjednoczone, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, Stany Zjednoczone, 62401
- Carle Physician Group-Effingham
-
Elk Grove Village, Illinois, Stany Zjednoczone, 60007
- Ascension Alexian Brothers - Elk Grove Village
-
Eureka, Illinois, Stany Zjednoczone, 61530
- Illinois CancerCare-Eureka
-
Evanston, Illinois, Stany Zjednoczone, 60202
- Saint Francis Hospital
-
Galesburg, Illinois, Stany Zjednoczone, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, Stany Zjednoczone, 61401
- Illinois CancerCare-Galesburg
-
Geneva, Illinois, Stany Zjednoczone, 60134
- Northwestern Medicine Cancer Center Delnor
-
Harvey, Illinois, Stany Zjednoczone, 60426
- Ingalls Memorial Hospital
-
Kankakee, Illinois, Stany Zjednoczone, 60901
- Presence Saint Mary's Hospital
-
Kewanee, Illinois, Stany Zjednoczone, 61443
- Illinois CancerCare-Kewanee Clinic
-
Macomb, Illinois, Stany Zjednoczone, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, Stany Zjednoczone, 61938
- Carle Physician Group-Mattoon/Charleston
-
Mount Vernon, Illinois, Stany Zjednoczone, 62864
- SSM Health Good Samaritan
-
Naperville, Illinois, Stany Zjednoczone, 60540
- Edward Hospital/Cancer Center
-
O'Fallon, Illinois, Stany Zjednoczone, 62269
- Cancer Care Center of O'Fallon
-
Ottawa, Illinois, Stany Zjednoczone, 61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa, Illinois, Stany Zjednoczone, 61350
- Radiation Oncology of Northern Illinois
-
Pekin, Illinois, Stany Zjednoczone, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Stany Zjednoczone, 61554
- OSF Saint Francis Radiation Oncology at Pekin
-
Peoria, Illinois, Stany Zjednoczone, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Stany Zjednoczone, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Stany Zjednoczone, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Stany Zjednoczone, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, Stany Zjednoczone, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Stany Zjednoczone, 61354
- Valley Radiation Oncology
-
Plainfield, Illinois, Stany Zjednoczone, 60585
- Edward Hospital/Cancer Center?Plainfield
-
Princeton, Illinois, Stany Zjednoczone, 61356
- Illinois CancerCare-Princeton
-
Rockford, Illinois, Stany Zjednoczone, 61108
- OSF Saint Anthony Medical Center
-
Rockford, Illinois, Stany Zjednoczone, 61114
- UW Health Carbone Cancer Center Rockford
-
Springfield, Illinois, Stany Zjednoczone, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Stany Zjednoczone, 62702
- Springfield Clinic
-
Springfield, Illinois, Stany Zjednoczone, 62702
- Central Illinois Hematology Oncology Center
-
Springfield, Illinois, Stany Zjednoczone, 62781
- Springfield Memorial Hospital
-
Urbana, Illinois, Stany Zjednoczone, 61801
- Carle Cancer Center
-
Urbana, Illinois, Stany Zjednoczone, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Stany Zjednoczone, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Yorkville, Illinois, Stany Zjednoczone, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Crown Point, Indiana, Stany Zjednoczone, 46307
- Michiana Hematology Oncology PC-Crown Point
-
Elkhart, Indiana, Stany Zjednoczone, 46515
- Elkhart General Hospital
-
Elkhart, Indiana, Stany Zjednoczone, 46514
- Michiana Hematology Oncology PC-Elkhart
-
Elkhart, Indiana, Stany Zjednoczone, 46514-2098
- Elkhart Clinic
-
Indianapolis, Indiana, Stany Zjednoczone, 46237
- Franciscan Health Indianapolis
-
Kokomo, Indiana, Stany Zjednoczone, 46904
- Community Howard Regional Health
-
La Porte, Indiana, Stany Zjednoczone, 46350
- IU Health La Porte Hospital
-
Michigan City, Indiana, Stany Zjednoczone, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Michigan City, Indiana, Stany Zjednoczone, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, Stany Zjednoczone, 46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka, Indiana, Stany Zjednoczone, 46545
- Saint Joseph Regional Medical Center-Mishawaka
-
Munster, Indiana, Stany Zjednoczone, 46321
- The Community Hospital
-
Plymouth, Indiana, Stany Zjednoczone, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, Stany Zjednoczone, 47374
- Reid Health
-
South Bend, Indiana, Stany Zjednoczone, 46628
- Northern Indiana Cancer Research Consortium
-
Terre Haute, Indiana, Stany Zjednoczone, 47804
- Union Hospital
-
Westville, Indiana, Stany Zjednoczone, 46391
- Michiana Hematology Oncology PC-Westville
-
-
Iowa
-
Ames, Iowa, Stany Zjednoczone, 50010
- Mary Greeley Medical Center
-
Ames, Iowa, Stany Zjednoczone, 50010
- McFarland Clinic - Ames
-
Boone, Iowa, Stany Zjednoczone, 50036
- McFarland Clinic - Boone
-
Cedar Rapids, Iowa, Stany Zjednoczone, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Stany Zjednoczone, 52403
- Oncology Associates at Mercy Medical Center
-
Clive, Iowa, Stany Zjednoczone, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Stany Zjednoczone, 50325
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic
-
Council Bluffs, Iowa, Stany Zjednoczone, 51503
- Alegent Health Mercy Hospital
-
Creston, Iowa, Stany Zjednoczone, 50801
- Greater Regional Medical Center
-
Des Moines, Iowa, Stany Zjednoczone, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Stany Zjednoczone, 50314
- UI Health Care Mission Cancer and Blood - Laurel Clinic
-
Fort Dodge, Iowa, Stany Zjednoczone, 50501
- McFarland Clinic - Trinity Cancer Center
-
Iowa City, Iowa, Stany Zjednoczone, 52242
- University of Iowa/Holden Comprehensive Cancer Center
-
Jefferson, Iowa, Stany Zjednoczone, 50129
- McFarland Clinic - Jefferson
-
Marshalltown, Iowa, Stany Zjednoczone, 50158
- McFarland Clinic - Marshalltown
-
West Des Moines, Iowa, Stany Zjednoczone, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Chanute, Kansas, Stany Zjednoczone, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Stany Zjednoczone, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Stany Zjednoczone, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Stany Zjednoczone, 66701
- Cancer Center of Kansas - Fort Scott
-
Independence, Kansas, Stany Zjednoczone, 67301
- Cancer Center of Kansas-Independence
-
Kingman, Kansas, Stany Zjednoczone, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Stany Zjednoczone, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Stany Zjednoczone, 67905
- Cancer Center of Kansas-Liberal
-
Manhattan, Kansas, Stany Zjednoczone, 66502
- Cancer Center of Kansas-Manhattan
-
McPherson, Kansas, Stany Zjednoczone, 67460
- Cancer Center of Kansas - McPherson
-
Newton, Kansas, Stany Zjednoczone, 67114
- Cancer Center of Kansas - Newton
-
Parsons, Kansas, Stany Zjednoczone, 67357
- Cancer Center of Kansas - Parsons
-
Pratt, Kansas, Stany Zjednoczone, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Stany Zjednoczone, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Stany Zjednoczone, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, Stany Zjednoczone, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Stany Zjednoczone, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Stany Zjednoczone, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Stany Zjednoczone, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Stany Zjednoczone, 67208
- Associates In Womens Health
-
Wichita, Kansas, Stany Zjednoczone, 67214
- Wichita NCI Community Oncology Research Program
-
Winfield, Kansas, Stany Zjednoczone, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Bardstown, Kentucky, Stany Zjednoczone, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Stany Zjednoczone, 40701
- Baptist Health Corbin
-
Corbin, Kentucky, Stany Zjednoczone, 40701
- Commonwealth Cancer Center-Corbin
-
Crestview Hills, Kentucky, Stany Zjednoczone, 41017
- Oncology Hematology Care Inc-Crestview
-
Elizabethtown, Kentucky, Stany Zjednoczone, 42701
- Baptist Health Hardin
-
Lexington, Kentucky, Stany Zjednoczone, 40536
- University of Kentucky/Markey Cancer Center
-
Lexington, Kentucky, Stany Zjednoczone, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Stany Zjednoczone, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, Stany Zjednoczone, 40503
- Baptist Health Lexington
-
Louisville, Kentucky, Stany Zjednoczone, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Stany Zjednoczone, 40202
- Jewish Hospital
-
Louisville, Kentucky, Stany Zjednoczone, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Stany Zjednoczone, 40207
- Baptist Health Louisville
-
Louisville, Kentucky, Stany Zjednoczone, 40215
- Saints Mary and Elizabeth Hospital
-
Madisonville, Kentucky, Stany Zjednoczone, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, Stany Zjednoczone, 42003
- Baptist Health Paducah
-
Shepherdsville, Kentucky, Stany Zjednoczone, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Stany Zjednoczone, 70809
- Ochsner Health Center-Summa
-
Kenner, Louisiana, Stany Zjednoczone, 70065
- Ochsner Medical Center Kenner
-
New Orleans, Louisiana, Stany Zjednoczone, 70121
- Ochsner Medical Center Jefferson
-
-
Maine
-
Bangor, Maine, Stany Zjednoczone, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, Stany Zjednoczone, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Baltimore, Maryland, Stany Zjednoczone, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Stany Zjednoczone, 21204
- Greater Baltimore Medical Center
-
Elkton, Maryland, Stany Zjednoczone, 21921
- Christiana Care - Union Hospital
-
Frederick, Maryland, Stany Zjednoczone, 21701
- Frederick Memorial Hospital
-
-
Massachusetts
-
Fall River, Massachusetts, Stany Zjednoczone, 02721
- Saint Anne's Hospital
-
Pittsfield, Massachusetts, Stany Zjednoczone, 01201
- Berkshire Medical Center - Cancer Center
-
-
Michigan
-
Adrian, Michigan, Stany Zjednoczone, 49221
- Bixby Medical Center
-
Adrian, Michigan, Stany Zjednoczone, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Stany Zjednoczone, 48106
- Michigan Cancer Research Consortium NCORP
-
Ann Arbor, Michigan, Stany Zjednoczone, 48106
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor
-
Ann Arbor, Michigan, Stany Zjednoczone, 48109
- University of Michigan Comprehensive Cancer Center
-
Dearborn, Michigan, Stany Zjednoczone, 48124
- Corewell Health Dearborn Hospital
-
Detroit, Michigan, Stany Zjednoczone, 48202
- Henry Ford Hospital
-
Detroit, Michigan, Stany Zjednoczone, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Stany Zjednoczone, 48236
- Henry Ford Health Saint John Hospital
-
Farmington Hills, Michigan, Stany Zjednoczone, 48334
- Weisberg Cancer Treatment Center
-
Farmington Hills, Michigan, Stany Zjednoczone, 48336
- Corewell Health Farmington Hills Hospital
-
Flint, Michigan, Stany Zjednoczone, 48503
- Hurley Medical Center
-
Flint, Michigan, Stany Zjednoczone, 48503
- Genesys Hurley Cancer Institute
-
Grosse Pointe, Michigan, Stany Zjednoczone, 48230
- William Beaumont Hospital-Grosse Pointe
-
Jackson, Michigan, Stany Zjednoczone, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Stany Zjednoczone, 49007
- West Michigan Cancer Center
-
Lansing, Michigan, Stany Zjednoczone, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Stany Zjednoczone, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Midland, Michigan, Stany Zjednoczone, 48670
- MyMichigan Medical Center Midland
-
Monroe, Michigan, Stany Zjednoczone, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, Stany Zjednoczone, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Pontiac, Michigan, Stany Zjednoczone, 48341
- Trinity Health Saint Joseph Mercy Oakland Hospital
-
Port Huron, Michigan, Stany Zjednoczone, 48060
- Lake Huron Medical Center
-
Roseville, Michigan, Stany Zjednoczone, 48066
- Michigan Cancer Specialists
-
Royal Oak, Michigan, Stany Zjednoczone, 48073
- Cancer Care Associates PC
-
Royal Oak, Michigan, Stany Zjednoczone, 48073
- Comprehensive Medical Center PLLC
-
Royal Oak, Michigan, Stany Zjednoczone, 48073
- Oakland Medical Group
-
Royal Oak, Michigan, Stany Zjednoczone, 48067
- Oakland Colon Rectal Associates
-
Royal Oak, Michigan, Stany Zjednoczone, 48073
- Hematology Oncology Consultants PC-Royal Oak
-
Royal Oak, Michigan, Stany Zjednoczone, 48073
- Corewell Health William Beaumont University Hospital
-
Saginaw, Michigan, Stany Zjednoczone, 48601
- MyMichigan Medical Center Saginaw
-
Sterling Heights, Michigan, Stany Zjednoczone, 48312
- Premier Hematology Oncology Care
-
Sterling Heights, Michigan, Stany Zjednoczone, 48314
- Mitchell Folbe MD PC
-
Troy, Michigan, Stany Zjednoczone, 48084
- Michigan Institute of Urology-Town Center
-
Troy, Michigan, Stany Zjednoczone, 48085
- Claudia BR Herke MD PC
-
Troy, Michigan, Stany Zjednoczone, 48098
- Hematology Oncology Consultants PC-Troy
-
Troy, Michigan, Stany Zjednoczone, 48085
- Corewell Health Beaumont Troy Hospital
-
Warren, Michigan, Stany Zjednoczone, 48093
- Henry Ford Health Warren Hospital
-
-
Minnesota
-
Bemidji, Minnesota, Stany Zjednoczone, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Stany Zjednoczone, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Stany Zjednoczone, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Stany Zjednoczone, 55433
- Mercy Hospital
-
Duluth, Minnesota, Stany Zjednoczone, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Stany Zjednoczone, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Stany Zjednoczone, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Stany Zjednoczone, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Stany Zjednoczone, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fridley, Minnesota, Stany Zjednoczone, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Stany Zjednoczone, 55350
- Hutchinson Area Health Care
-
Maplewood, Minnesota, Stany Zjednoczone, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Stany Zjednoczone, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Stany Zjednoczone, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Stany Zjednoczone, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Stany Zjednoczone, 55454
- Health Partners Inc
-
New Ulm, Minnesota, Stany Zjednoczone, 56073
- New Ulm Medical Center
-
Robbinsdale, Minnesota, Stany Zjednoczone, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Stany Zjednoczone, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Stany Zjednoczone, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, Stany Zjednoczone, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Stany Zjednoczone, 55102
- United Hospital
-
Shakopee, Minnesota, Stany Zjednoczone, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Stany Zjednoczone, 55082
- Lakeview Hospital
-
Waconia, Minnesota, Stany Zjednoczone, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Stany Zjednoczone, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Stany Zjednoczone, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
-
Missouri
-
Ballwin, Missouri, Stany Zjednoczone, 63011
- Mercy Oncology and Hematology - Clayton-Clarkson
-
Bolivar, Missouri, Stany Zjednoczone, 65613
- Central Care Cancer Center - Bolivar
-
Bonne Terre, Missouri, Stany Zjednoczone, 63628
- Parkland Health Center-Bonne Terre
-
Branson, Missouri, Stany Zjednoczone, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Stany Zjednoczone, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Stany Zjednoczone, 63703
- Mercy Cancer Center - Cape Girardeau
-
Columbia, Missouri, Stany Zjednoczone, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Jefferson City, Missouri, Stany Zjednoczone, 65109
- MU Health Care Goldschmidt Cancer Center
-
Joplin, Missouri, Stany Zjednoczone, 64804
- Freeman Health System
-
Joplin, Missouri, Stany Zjednoczone, 64804
- Mercy Hospital Joplin
-
Rolla, Missouri, Stany Zjednoczone, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Rolla, Missouri, Stany Zjednoczone, 65401
- Phelps Health Delbert Day Cancer Institute
-
Sainte Genevieve, Missouri, Stany Zjednoczone, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Stany Zjednoczone, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Stany Zjednoczone, 65804
- Mercy Hospital Springfield
-
St Louis, Missouri, Stany Zjednoczone, 63131
- Missouri Baptist Medical Center
-
St Louis, Missouri, Stany Zjednoczone, 63109
- Mercy Infusion Center - Chippewa
-
St Louis, Missouri, Stany Zjednoczone, 63141
- Mercy Hospital Saint Louis
-
Sullivan, Missouri, Stany Zjednoczone, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Stany Zjednoczone, 63127
- BJC Outpatient Center at Sunset Hills
-
-
Montana
-
Anaconda, Montana, Stany Zjednoczone, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Stany Zjednoczone, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Stany Zjednoczone, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Stany Zjednoczone, 59102
- Montana Cancer Consortium NCORP
-
Bozeman, Montana, Stany Zjednoczone, 59715
- Bozeman Health Deaconess Hospital
-
Butte, Montana, Stany Zjednoczone, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Stany Zjednoczone, 59405
- Benefis Sletten Cancer Institute
-
Helena, Montana, Stany Zjednoczone, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Stany Zjednoczone, 59901
- Logan Health Medical Center
-
Missoula, Montana, Stany Zjednoczone, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Stany Zjednoczone, 59804
- Community Medical Center
-
-
Nebraska
-
Grand Island, Nebraska, Stany Zjednoczone, 68803
- Nebraska Cancer Specialists/Oncology Hematology West PC
-
Kearney, Nebraska, Stany Zjednoczone, 68847
- CHI Health Good Samaritan
-
Kearney, Nebraska, Stany Zjednoczone, 68845
- Fred and Pamela Buffett Cancer Center - Kearney
-
Lincoln, Nebraska, Stany Zjednoczone, 68510
- Saint Elizabeth Regional Medical Center
-
Omaha, Nebraska, Stany Zjednoczone, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Stany Zjednoczone, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Stany Zjednoczone, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Stany Zjednoczone, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Stany Zjednoczone, 68122
- Hematology and Oncology Consultants PC
-
Papillion, Nebraska, Stany Zjednoczone, 68046
- Midlands Community Hospital
-
-
Nevada
-
Henderson, Nevada, Stany Zjednoczone, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Stany Zjednoczone, 89074
- GenesisCare USA - Henderson
-
Las Vegas, Nevada, Stany Zjednoczone, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Stany Zjednoczone, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Stany Zjednoczone, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, Stany Zjednoczone, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Stany Zjednoczone, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Stany Zjednoczone, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Stany Zjednoczone, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Stany Zjednoczone, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Stany Zjednoczone, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Stany Zjednoczone, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, Stany Zjednoczone, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Stany Zjednoczone, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Stany Zjednoczone, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, Stany Zjednoczone, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Stany Zjednoczone, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Stany Zjednoczone, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, Stany Zjednoczone, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Stany Zjednoczone, 89120
- Nevada Cancer Research Foundation NCORP
-
Reno, Nevada, Stany Zjednoczone, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Stany Zjednoczone, 89503
- Saint Mary's Regional Medical Center
-
-
New Hampshire
-
Lebanon, New Hampshire, Stany Zjednoczone, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
-
New Jersey
-
Elizabeth, New Jersey, Stany Zjednoczone, 07207
- Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
-
Englewood, New Jersey, Stany Zjednoczone, 07631
- Englewood Hospital and Medical Center
-
Flemington, New Jersey, Stany Zjednoczone, 08822
- Hunterdon Medical Center
-
Mullica Hill, New Jersey, Stany Zjednoczone, 08062
- Inspira Medical Center Mullica Hill
-
Newark, New Jersey, Stany Zjednoczone, 07112
- Newark Beth Israel Medical Center
-
Newton, New Jersey, Stany Zjednoczone, 07860
- Newton Medical Center
-
Pompton, New Jersey, Stany Zjednoczone, 07444
- Chilton Medical Center
-
Summit, New Jersey, Stany Zjednoczone, 07902
- Overlook Hospital
-
Vineland, New Jersey, Stany Zjednoczone, 08360
- Inspira Medical Center Vineland
-
-
New Mexico
-
Albuquerque, New Mexico, Stany Zjednoczone, 87106
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Stany Zjednoczone, 87106
- Hematology Oncology Associates
-
Las Cruces, New Mexico, Stany Zjednoczone, 88011
- Memorial Medical Center-Las Cruces
-
Santa Fe, New Mexico, Stany Zjednoczone, 87505
- Christus Saint Vincent Regional Cancer Center
-
-
New York
-
Buffalo, New York, Stany Zjednoczone, 14263
- Roswell Park Cancer Institute
-
Glens Falls, New York, Stany Zjednoczone, 12801
- Glens Falls Hospital
-
Middletown, New York, Stany Zjednoczone, 10940
- Garnet Health Medical Center
-
New York, New York, Stany Zjednoczone, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
-
North Carolina
-
Asheboro, North Carolina, Stany Zjednoczone, 27203
- Randolph Hospital
-
Asheville, North Carolina, Stany Zjednoczone, 28803
- AdventHealth Infusion Center Asheville
-
Burlington, North Carolina, Stany Zjednoczone, 27215
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, Stany Zjednoczone, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Clinton, North Carolina, Stany Zjednoczone, 28328
- Southeastern Medical Oncology Center-Clinton
-
Goldsboro, North Carolina, Stany Zjednoczone, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Stany Zjednoczone, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Stany Zjednoczone, 27403
- Cone Health Cancer Center
-
Hendersonville, North Carolina, Stany Zjednoczone, 28792
- AdventHealth Hendersonville
-
Jacksonville, North Carolina, Stany Zjednoczone, 28546
- Southeastern Medical Oncology Center-Jacksonville
-
Kernersville, North Carolina, Stany Zjednoczone, 27284
- Novant Health Cancer Institute - Kernersville
-
Kinston, North Carolina, Stany Zjednoczone, 28501
- ECU Health Oncology Kinston
-
Mebane, North Carolina, Stany Zjednoczone, 27302
- Cone Heath Cancer Center at Mebane
-
Mount Airy, North Carolina, Stany Zjednoczone, 27030
- Novant Health Cancer Institute - Mount Airy
-
North Wilkesboro, North Carolina, Stany Zjednoczone, 28659
- Novant Health Cancer Institute - Wilkesboro
-
Pinehurst, North Carolina, Stany Zjednoczone, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Reidsville, North Carolina, Stany Zjednoczone, 27320
- Annie Penn Memorial Hospital
-
Salisbury, North Carolina, Stany Zjednoczone, 28144
- Novant Health Cancer Institute - Rowan
-
Statesville, North Carolina, Stany Zjednoczone, 28677
- Iredell Memorial Hospital
-
Stateville, North Carolina, Stany Zjednoczone, 28625
- Novant Health Cancer Institute - Statesville
-
Thomasville, North Carolina, Stany Zjednoczone, 27360
- Novant Health Cancer Institute - Thomasville
-
Winston-Salem, North Carolina, Stany Zjednoczone, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, Stany Zjednoczone, 27103
- Novant Health Forsyth Medical Center
-
Winston-Salem, North Carolina, Stany Zjednoczone, 27103
- Novant Health Oncology Specialists
-
Winston-Salem, North Carolina, Stany Zjednoczone, 27103
- Winston-Salem Health Care
-
Winston-Salem, North Carolina, Stany Zjednoczone, 27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Bismarck, North Dakota, Stany Zjednoczone, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Stany Zjednoczone, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Stany Zjednoczone, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Stany Zjednoczone, 58122
- Sanford Broadway Medical Center
-
Grand Forks, North Dakota, Stany Zjednoczone, 58201
- Altru Cancer Center
-
Minot, North Dakota, Stany Zjednoczone, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron, Ohio, Stany Zjednoczone, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, Stany Zjednoczone, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, Stany Zjednoczone, 44203
- Summa Health System - Barberton Campus
-
Belpre, Ohio, Stany Zjednoczone, 45714
- Strecker Cancer Center-Belpre
-
Bowling Green, Ohio, Stany Zjednoczone, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, Stany Zjednoczone, 44710
- Aultman Health Foundation
-
Centerville, Ohio, Stany Zjednoczone, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Stany Zjednoczone, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Stany Zjednoczone, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Stany Zjednoczone, 45219
- The Christ Hospital
-
Cincinnati, Ohio, Stany Zjednoczone, 45219
- University of Cincinnati Cancer Center-UC Medical Center
-
Cincinnati, Ohio, Stany Zjednoczone, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Stany Zjednoczone, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Stany Zjednoczone, 45242
- Oncology Hematology Care Inc-Blue Ash
-
Cincinnati, Ohio, Stany Zjednoczone, 45202
- Oncology Hematology Care Inc-Eden Park
-
Cincinnati, Ohio, Stany Zjednoczone, 45211
- Oncology Hematology Care Inc-Mercy West
-
Cincinnati, Ohio, Stany Zjednoczone, 45230
- Oncology Hematology Care Inc-Anderson
-
Cincinnati, Ohio, Stany Zjednoczone, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Stany Zjednoczone, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Stany Zjednoczone, 45255
- TriHealth Cancer Institute-Anderson
-
Columbus, Ohio, Stany Zjednoczone, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Stany Zjednoczone, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Stany Zjednoczone, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Stany Zjednoczone, 43228
- Doctors Hospital
-
Columbus, Ohio, Stany Zjednoczone, 43215
- Grant Medical Center
-
Columbus, Ohio, Stany Zjednoczone, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Stany Zjednoczone, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, Stany Zjednoczone, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Stany Zjednoczone, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Stany Zjednoczone, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Stany Zjednoczone, 45459
- Dayton NCI Community Oncology Research Program
-
Dayton, Ohio, Stany Zjednoczone, 45415
- Dayton Physician LLC - Englewood
-
Delaware, Ohio, Stany Zjednoczone, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Stany Zjednoczone, 43015
- Delaware Radiation Oncology
-
Delaware, Ohio, Stany Zjednoczone, 43015
- Grady Memorial Hospital
-
Fairfield, Ohio, Stany Zjednoczone, 45014
- Oncology Hematology Care Inc-Healthplex
-
Findlay, Ohio, Stany Zjednoczone, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Stany Zjednoczone, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Stany Zjednoczone, 45840
- Orion Cancer Care
-
Franklin, Ohio, Stany Zjednoczone, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Stany Zjednoczone, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, Stany Zjednoczone, 45331
- Wayne Hospital
-
Greenville, Ohio, Stany Zjednoczone, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, Stany Zjednoczone, 45429
- Kettering Medical Center
-
Kettering, Ohio, Stany Zjednoczone, 45409
- Greater Dayton Cancer Center
-
Lancaster, Ohio, Stany Zjednoczone, 43130
- Fairfield Medical Center
-
Lancaster, Ohio, Stany Zjednoczone, 43130
- Lancaster Radiation Oncology
-
Lima, Ohio, Stany Zjednoczone, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, Stany Zjednoczone, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Stany Zjednoczone, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Stany Zjednoczone, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Medina, Ohio, Stany Zjednoczone, 44256
- Summa Health Medina Medical Center
-
Middletown, Ohio, Stany Zjednoczone, 45042
- Dayton Physicians LLC-Signal Point
-
Mount Vernon, Ohio, Stany Zjednoczone, 43050
- Knox Community Hospital
-
Newark, Ohio, Stany Zjednoczone, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Stany Zjednoczone, 43055
- Newark Radiation Oncology
-
Oregon, Ohio, Stany Zjednoczone, 43616
- Saint Charles Hospital
-
Oregon, Ohio, Stany Zjednoczone, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Portsmouth, Ohio, Stany Zjednoczone, 45662
- Southern Ohio Medical Center
-
Sidney, Ohio, Stany Zjednoczone, 45365
- Dayton Physicians LLC-Wilson
-
Springfield, Ohio, Stany Zjednoczone, 45504
- Springfield Regional Cancer Center
-
Springfield, Ohio, Stany Zjednoczone, 45504
- Springfield Regional Medical Center
-
Sylvania, Ohio, Stany Zjednoczone, 43560
- ProMedica Flower Hospital
-
Tiffin, Ohio, Stany Zjednoczone, 44883
- Mercy Hospital of Tiffin
-
Toledo, Ohio, Stany Zjednoczone, 43606
- ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
-
Toledo, Ohio, Stany Zjednoczone, 43623
- Mercy Health - Saint Anne Hospital
-
Toledo, Ohio, Stany Zjednoczone, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Stany Zjednoczone, 43614
- University of Toledo
-
Toledo, Ohio, Stany Zjednoczone, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo, Ohio, Stany Zjednoczone, 43608
- Mercy Health - Saint Vincent Hospital
-
Troy, Ohio, Stany Zjednoczone, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Stany Zjednoczone, 45373
- Dayton Physicians LLC - Troy
-
Wauseon, Ohio, Stany Zjednoczone, 43567
- Fulton County Health Center
-
West Chester, Ohio, Stany Zjednoczone, 45069
- University of Cincinnati Cancer Center-West Chester
-
Westerville, Ohio, Stany Zjednoczone, 43081
- Saint Ann's Hospital
-
Wpafb, Ohio, Stany Zjednoczone, 45433
- Wright-Patterson Medical Center
-
Zanesville, Ohio, Stany Zjednoczone, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Stany Zjednoczone, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Stany Zjednoczone, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, Stany Zjednoczone, 74136
- Natalie Warren Bryant Cancer Center at Saint Francis
-
Tulsa, Oklahoma, Stany Zjednoczone, 74136
- Surgical Associates Inc
-
Tulsa, Oklahoma, Stany Zjednoczone, 74146
- Warren Clinic Oncology-Tulsa
-
-
Oregon
-
Portland, Oregon, Stany Zjednoczone, 97227
- Kaiser Permanente Northwest
-
-
Pennsylvania
-
Beaver, Pennsylvania, Stany Zjednoczone, 15009
- UPMC-Heritage Valley Health System Beaver
-
Chadds Ford, Pennsylvania, Stany Zjednoczone, 19317
- Christiana Care Health System-Concord Health Center
-
Danville, Pennsylvania, Stany Zjednoczone, 17822
- Geisinger Medical Center
-
Easton, Pennsylvania, Stany Zjednoczone, 18042
- Easton Hospital
-
Greensburg, Pennsylvania, Stany Zjednoczone, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Harrisburg, Pennsylvania, Stany Zjednoczone, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton, Pennsylvania, Stany Zjednoczone, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Stany Zjednoczone, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Jefferson Hills, Pennsylvania, Stany Zjednoczone, 15025
- Jefferson Hospital
-
Johnstown, Pennsylvania, Stany Zjednoczone, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, Stany Zjednoczone, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, Stany Zjednoczone, 17044
- Lewistown Hospital
-
McKeesport, Pennsylvania, Stany Zjednoczone, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Monroeville, Pennsylvania, Stany Zjednoczone, 15146
- Forbes Hospital
-
Moon Township, Pennsylvania, Stany Zjednoczone, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
Philadelphia, Pennsylvania, Stany Zjednoczone, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Stany Zjednoczone, 19114
- Jefferson Torresdale Hospital
-
Phoenixville, Pennsylvania, Stany Zjednoczone, 19460
- Reading Hospital McGlinn Cancer Institute at Phoenixville
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15212
- Allegheny General Hospital
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15224
- West Penn Hospital
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15213
- UPMC-Presbyterian Hospital
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15236
- UPMC Jefferson Regional Radiation Oncology
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Stany Zjednoczone, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottsville, Pennsylvania, Stany Zjednoczone, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, Stany Zjednoczone, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Seneca, Pennsylvania, Stany Zjednoczone, 16346
- UPMC Cancer Center at UPMC Northwest
-
State College, Pennsylvania, Stany Zjednoczone, 16801
- Geisinger Medical Group
-
Uniontown, Pennsylvania, Stany Zjednoczone, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, Stany Zjednoczone, 15301
- UPMC Washington Hospital Radiation Oncology
-
West Chester, Pennsylvania, Stany Zjednoczone, 19380
- Chester County Hospital
-
West Grove, Pennsylvania, Stany Zjednoczone, 19390
- Jennersville Regional Hospital
-
West Reading, Pennsylvania, Stany Zjednoczone, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Stany Zjednoczone, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Williamsport, Pennsylvania, Stany Zjednoczone, 17701
- UPMC Susquehanna
-
-
Rhode Island
-
Providence, Rhode Island, Stany Zjednoczone, 02905
- Women and Infants Hospital
-
Warwick, Rhode Island, Stany Zjednoczone, 02886
- Kent Hospital
-
-
South Carolina
-
Anderson, South Carolina, Stany Zjednoczone, 29621
- AnMed Health Cancer Center
-
Boiling Springs, South Carolina, Stany Zjednoczone, 29316
- Prisma Health Cancer Institute - Spartanburg
-
Easley, South Carolina, Stany Zjednoczone, 29640
- Prisma Health Cancer Institute - Easley
-
Georgetown, South Carolina, Stany Zjednoczone, 29440
- Tidelands Georgetown Memorial Hospital
-
Greenville, South Carolina, Stany Zjednoczone, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, Stany Zjednoczone, 29607
- Saint Francis Cancer Center
-
Greenville, South Carolina, Stany Zjednoczone, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, Stany Zjednoczone, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, Stany Zjednoczone, 29601
- Saint Francis Hospital
-
Greenville, South Carolina, Stany Zjednoczone, 29605
- Prisma Health Greenville Memorial Hospital
-
Greenville, South Carolina, Stany Zjednoczone, 29601
- Greenville Health System Cancer Institute-Andrews
-
Greer, South Carolina, Stany Zjednoczone, 29650
- Prisma Health Cancer Institute - Greer
-
Greer, South Carolina, Stany Zjednoczone, 29651
- Gibbs Cancer Center-Pelham
-
Lancaster, South Carolina, Stany Zjednoczone, 29720
- Carolina Blood and Cancer Care Associates PA-Lancaster
-
Rock Hill, South Carolina, Stany Zjednoczone, 29732
- Carolina Blood and Cancer Care Associates PA
-
Seneca, South Carolina, Stany Zjednoczone, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, Stany Zjednoczone, 29303
- Spartanburg Medical Center
-
Union, South Carolina, Stany Zjednoczone, 29379
- SMC Center for Hematology Oncology Union
-
-
South Dakota
-
Sioux Falls, South Dakota, Stany Zjednoczone, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Stany Zjednoczone, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Stany Zjednoczone, 57104
- Sanford Cancer Center Oncology Clinic
-
-
Tennessee
-
Chattanooga, Tennessee, Stany Zjednoczone, 37404
- Memorial Hospital
-
Hixson, Tennessee, Stany Zjednoczone, 37343
- Pulmonary Medicine Center of Chattanooga-Hixson
-
Jackson, Tennessee, Stany Zjednoczone, 38301
- Jackson-Madison County General Hospital
-
Nashville, Tennessee, Stany Zjednoczone, 37208
- Meharry Medical College
-
Ooltewah, Tennessee, Stany Zjednoczone, 37363
- Memorial GYN Plus
-
-
Texas
-
Abilene, Texas, Stany Zjednoczone, 79601
- Hendrick Medical Center
-
Houston, Texas, Stany Zjednoczone, 77026-1967
- Lyndon Baines Johnson General Hospital
-
Houston, Texas, Stany Zjednoczone, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Houston, Texas, Stany Zjednoczone, 77030
- Ben Taub General Hospital
-
Laredo, Texas, Stany Zjednoczone, 78041
- Doctor's Hospital of Laredo
-
San Antonio, Texas, Stany Zjednoczone, 78229
- University Hospital
-
San Antonio, Texas, Stany Zjednoczone, 78229
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Stany Zjednoczone, 78229
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
-
-
Utah
-
Salt Lake City, Utah, Stany Zjednoczone, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Vermont
-
Berlin Corners, Vermont, Stany Zjednoczone, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Stany Zjednoczone, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Stany Zjednoczone, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Fredericksburg, Virginia, Stany Zjednoczone, 22401
- Fredericksburg Oncology Inc
-
Fredericksburg, Virginia, Stany Zjednoczone, 22408
- Hematology Oncology Associates of Fredericksburg Inc
-
Mechanicsville, Virginia, Stany Zjednoczone, 23116
- Bon Secours Memorial Regional Medical Center
-
Midlothian, Virginia, Stany Zjednoczone, 23114
- Bon Secours Saint Francis Medical Center
-
Richmond, Virginia, Stany Zjednoczone, 23226
- Bon Secours Saint Mary's Hospital
-
Richmond, Virginia, Stany Zjednoczone, 23298
- VCU Massey Comprehensive Cancer Center
-
South Hill, Virginia, Stany Zjednoczone, 23970
- VCU Community Memorial Health Center
-
Winchester, Virginia, Stany Zjednoczone, 22601
- Shenandoah Oncology PC
-
-
Washington
-
Auburn, Washington, Stany Zjednoczone, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, Stany Zjednoczone, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, Stany Zjednoczone, 98004
- Overlake Medical Center
-
Burien, Washington, Stany Zjednoczone, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Stany Zjednoczone, 98531
- Providence Regional Cancer System-Centralia
-
Enumclaw, Washington, Stany Zjednoczone, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Stany Zjednoczone, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Stany Zjednoczone, 98002
- Virginia Mason Federal Way Medical Center
-
Federal Way, Washington, Stany Zjednoczone, 98003
- Saint Francis Hospital
-
Gig Harbor, Washington, Stany Zjednoczone, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, Stany Zjednoczone, 98335
- MultiCare Gig Harbor Medical Park
-
Kennewick, Washington, Stany Zjednoczone, 99336
- Northwest Cancer Clinic
-
Lacey, Washington, Stany Zjednoczone, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Stany Zjednoczone, 98499
- Saint Clare Hospital
-
Lynnwood, Washington, Stany Zjednoczone, 98036
- Virginia Mason Lynnwood Medical Center
-
Olympia, Washington, Stany Zjednoczone, 98506-5166
- Providence - Saint Peter Hospital
-
Olympia, Washington, Stany Zjednoczone, 98507
- Capital Medical Center
-
Port Townsend, Washington, Stany Zjednoczone, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Stany Zjednoczone, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Poulsbo, Washington, Stany Zjednoczone, 98370
- Peninsula Cancer Center
-
Puyallup, Washington, Stany Zjednoczone, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, Stany Zjednoczone, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Seattle, Washington, Stany Zjednoczone, 98101
- Virginia Mason Medical Center
-
Silverdale, Washington, Stany Zjednoczone, 98383
- Saint Michael Cancer Center
-
Tacoma, Washington, Stany Zjednoczone, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Stany Zjednoczone, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Stany Zjednoczone, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, Stany Zjednoczone, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Tacoma, Washington, Stany Zjednoczone, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Tacoma, Washington, Stany Zjednoczone, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, Stany Zjednoczone, 98405
- Northwest NCI Community Oncology Research Program
-
Tacoma, Washington, Stany Zjednoczone, 98405
- Saint Joseph Medical Center
-
-
West Virginia
-
Bridgeport, West Virginia, Stany Zjednoczone, 26330
- United Hospital Center
-
Charleston, West Virginia, Stany Zjednoczone, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, Stany Zjednoczone, 25701
- Edwards Comprehensive Cancer Center
-
Martinsburg, West Virginia, Stany Zjednoczone, 25401
- WVUH-Berkely Medical Center
-
Morgantown, West Virginia, Stany Zjednoczone, 26506
- West Virginia University Healthcare
-
Morgantown, West Virginia, Stany Zjednoczone, 26505
- Monongalia Hospital
-
Parkersburg, West Virginia, Stany Zjednoczone, 26101
- Camden Clark Medical Center
-
-
Wisconsin
-
Burlington, Wisconsin, Stany Zjednoczone, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Stany Zjednoczone, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Stany Zjednoczone, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Stany Zjednoczone, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond du Lac, Wisconsin, Stany Zjednoczone, 54937
- Aurora Health Center-Fond du Lac
-
Germantown, Wisconsin, Stany Zjednoczone, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Stany Zjednoczone, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Stany Zjednoczone, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Stany Zjednoczone, 54301
- Bellin Memorial Hospital
-
Janesville, Wisconsin, Stany Zjednoczone, 53548
- Mercyhealth Hospital and Cancer Center - Janesville
-
Kenosha, Wisconsin, Stany Zjednoczone, 53142
- Aurora Cancer Care-Kenosha South
-
Ladysmith, Wisconsin, Stany Zjednoczone, 54848
- Marshfield Medical Center - Ladysmith
-
Marinette, Wisconsin, Stany Zjednoczone, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Stany Zjednoczone, 54449
- Marshfield Medical Center-Marshfield
-
Marshfield, Wisconsin, Stany Zjednoczone, 54449
- Marshfield Medical Center
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Stany Zjednoczone, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Stany Zjednoczone, 54548
- Marshfield Medical Center - Minocqua
-
New Richmond, Wisconsin, Stany Zjednoczone, 54017
- Cancer Center of Western Wisconsin
-
Oshkosh, Wisconsin, Stany Zjednoczone, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Stany Zjednoczone, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, Stany Zjednoczone, 54501
- Saint Mary's Hospital
-
Rhinelander, Wisconsin, Stany Zjednoczone, 54501
- Aspirus Cancer Care - James Beck Cancer Center
-
Rice Lake, Wisconsin, Stany Zjednoczone, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Stany Zjednoczone, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Stany Zjednoczone, 54481
- Aspirus Cancer Care - Stevens Point
-
Summit, Wisconsin, Stany Zjednoczone, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Stany Zjednoczone, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Stany Zjednoczone, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, Stany Zjednoczone, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Stany Zjednoczone, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Stany Zjednoczone, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Stany Zjednoczone, 54476
- Marshfield Medical Center - Weston
-
Weston, Wisconsin, Stany Zjednoczone, 54476
- Diagnostic and Treatment Center
-
Weston, Wisconsin, Stany Zjednoczone, 54476
- Ascension Saint Clare's Hospital
-
Wisconsin Rapids, Wisconsin, Stany Zjednoczone, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Casper, Wyoming, Stany Zjednoczone, 82609
- Rocky Mountain Oncology
-
Cheyenne, Wyoming, Stany Zjednoczone, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Stany Zjednoczone, 82414
- Big Horn Basin Cancer Center
-
Cody, Wyoming, Stany Zjednoczone, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Stany Zjednoczone, 82801
- Welch Cancer Center
-
-
Kryteria uczestnictwa
Badacze szukają osób, które pasują do określonego opisu, zwanego kryteriami kwalifikacyjnymi. Niektóre przykłady tych kryteriów to ogólny stan zdrowia danej osoby lub wcześniejsze leczenie.
Kryteria kwalifikacji
Kryteria kwalifikacji
Wiek uprawniający do nauki
18 lat i starsze (Dorosły, Starszy dorosły)
Akceptuje zdrowych ochotników
Nie
Płeć kwalifikująca się do nauki
Kobieta
Opis
Inclusion Criteria:
-
Patients should have a life expectancy of at least 10 years, excluding their diagnosis of breast cancer; (comorbid conditions should be taken into consideration, but not the diagnosis of breast cancer)
-
Women of reproductive potential must agree to use an effective non-hormonal method of contraception during study therapy (chemotherapy, trastuzumab, pertuzumab, and estrogen deprivation therapy) and for at least 7 months after the last dose of study therapy
-
Submission of tumor samples is required for all patients; the local pathology department policy regarding release of tumor samples must be considered in the screening process; patients whose tumor samples are located in a pathology department that by policy will not submit any samples for research purposes should not be approached for participation in the B-52 trial
-
The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
-
The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
-
Clinical staging for the primary tumor can be cT1c (must be 2.0 cm) or T2-T4 if clinically node negative; if the regional lymph nodes are cN1 and cytologically or histologically positive or if cN2-N3 with or without a biopsy, the primary breast tumor can be cT0-T4
-
The diagnosis of invasive adenocarcinoma of the breast must have been made by core needle biopsy
-
Ipsilateral axillary lymph nodes must be evaluated by imaging (mammogram, ultrasound, and/or magnetic resonance imaging [MRI]) within 6 weeks prior to randomization; if suspicious or abnormal, fine needle aspirate (FNA) or core biopsy is recommended, also within 6 weeks prior to randomization; findings of these evaluations will be used to determine the nodal status prior to randomization:
-
Nodal status - negative
- Imaging of the axilla is negative
- Imaging is suspicious or abnormal but the FNA or core biopsy of the questionable node(s) on imaging is negative
-
Nodal status - positive
- FNA or core biopsy of the node(s) is cytologically or histologically suspicious or positive
- Imaging is suspicious or abnormal but FNA or core biopsy was not performed
-
-
Patients may be premenopausal or postmenopausal at the time of randomization; for study purposes, postmenopausal is defined as:
- Age 56 or older with no spontaneous menses for at least 12 months prior to study entry; or
- Age 55 or younger with no spontaneous menses for at least 12 months prior to study entry (e.g., spontaneous or secondary to hysterectomy) and with a documented estradiol level in the postmenopausal range according to local institutional/laboratory standard; or
- Documented bilateral oophorectomy
-
The tumor must have been determined to be HER2-postive as follows:
- Immunohistochemistry (IHC) 3+ or
- In situ hybridization (ISH)-positive (defined by ratio of HER2 to circulating endothelial progenitors [CEP]17 >= 2.0 or HER2 gene copy number >= 6 per nucleus)
-
The tumor must have been determined to be estrogen receptor (ER) and/or progesterone (PgR) positive assessed by current American Society of Clinical Oncology (ASCO)/College of American Pathologist (CAP) guideline recommendations for hormone receptor testing; patients with >= 1% ER or PgR staining by IHC are considered positive
-
Absolute neutrophil count (ANC) must be >= 1200/mm^3
-
Platelet count must be >= 100,000/mm^3
-
Hemoglobin must be >= 10 g/dL
-
Total bilirubin must be =< upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation > ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin
-
Alkaline phosphatase must be =< 2.5 x ULN for the lab
-
Aspartate aminotransferase (AST) must be =< 1.5 x ULN for the lab
-
Alkaline phosphatase and AST may not both be > the ULN; for example, if the alkaline phosphatase is > the ULN but =< 2.5 x ULN, the AST must be =< the ULN; if the AST is > the ULN but =< 1.5 x ULN, the alkaline phosphatase must be =< ULN; Note: If alanine aminotransferase (ALT) is performed instead of AST (per institution's standard practice), the ALT value must be =< 1.5 x ULN; if both were performed, the AST must be =< 1.5 x ULN
-
Patients with AST or alkaline phosphatase > ULN are eligible for inclusion in the study if liver imaging (computed tomography [CT], MRI, positron emission tomography [PET]-CT, or PET scan) performed within 6 weeks prior to randomization does not demonstrate metastatic disease and the requirements are met
-
Patients with alkaline phosphatase that is > ULN but =< 2.5 x ULN or unexplained bone pain are eligible for inclusion in the study if a bone scan, PET-CT scan, or PET scan performed within 6 weeks prior to randomization does not demonstrate metastatic disease
-
Within 6 weeks prior to randomization, the most recent serum creatinine must be =< ULN or measured or calculated creatinine clearance must be > 60 mL/min
-
Left ventricular ejection fraction (LVEF) assessment must be performed within 90 days prior to randomization; (LVEF assessment performed by 2-dimensional [2-D] echocardiogram is preferred; however, multi gated acquisition scan [MUGA] scan may be substituted based on institutional preferences); the LVEF must be >= 50% regardless of the cardiac imaging facility's lower limit of normal; note: since the pre-entry LVEF serves as the baseline for comparing subsequent LVEF assessments, it is critical that this baseline study be an accurate assessment; if the baseline LVEF is > 65%, the investigator is encouraged to have the accuracy of the initial LVEF result confirmed and repeat the test if the accuracy is uncertain
Exclusion Criteria:
-
FNA alone to diagnose the breast cancer
-
Excisional biopsy or lumpectomy performed prior to randomization
-
Surgical axillary staging procedure prior to randomization; pre-neoadjuvant therapy sentinel node biopsy is not permitted
-
Definitive clinical or radiologic evidence of metastatic disease; (chest imaging [mandatory for all patients] and other imaging [if required] must have been performed within 90 days prior to randomization)
-
Synchronous bilateral invasive breast cancer
-
Synchronous or previous contralateral invasive breast cancer; (patients with synchronous and/or previous contralateral ductal carcinoma in situ [DCIS] or lobular carcinoma in situ [LCIS] are eligible)
-
Any previous history of ipsilateral invasive breast cancer or ipsilateral DCIS; (patients with synchronous or previous ipsilateral LCIS are eligible)
-
Treatment including radiation therapy (RT), chemotherapy, targeted therapy, or endocrine therapy for the currently diagnosed breast cancer prior to randomization
-
Previous endocrine therapy such as raloxifene or tamoxifen (or other selective estrogen receptor modulator [SERM]) or an aromatase inhibitor for any malignancy
-
Previous therapy with anthracycline, taxanes, carboplatin, trastuzumab, or other HER2 targeted therapies for any malignancy
-
Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. (these patients are eligible if this therapy is discontinued prior to randomization)
-
History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
-
Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens; this includes but is not confined to:
-
Active cardiac disease:
- Angina pectoris that requires the use of anti-anginal medication;
- Ventricular arrhythmias except for benign premature ventricular contractions;
- Supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication;
- Conduction abnormality requiring a pacemaker;
- Valvular disease with documented compromise in cardiac function; and
- Symptomatic pericarditis
-
History of cardiac disease:
- Myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of left ventricular (LV) function;
- History of documented congestive heart failure (CHF); and
- Documented cardiomyopathy
-
-
Uncontrolled hypertension defined as sustained systolic blood pressure (BP) > 150 mmHg or diastolic BP > 90 mmHg; (patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria)
-
Active hepatitis B or hepatitis C with abnormal liver function tests
-
Intrinsic lung disease resulting in dyspnea
-
Poorly controlled diabetes mellitus
-
Active infection or chronic infection requiring chronic suppressive antibiotics
-
Patients known to be human immunodeficiency virus (HIV) positive with a baseline cluster of differentiation (CD)4 count of < 250 cells/mm^3 or have a history of acquired immune deficiency syndrome (AIDS) indicator conditions; patients taking anti-retroviral therapy that may have a potential overlapping toxicity with the study therapy are not eligible
-
Nervous system disorder (paresthesia, peripheral motor neuropathy, or peripheral sensory neuropathy) >= grade 2, per the Common Terminology Criteria for Adverse Events version 4.0 (CTCAE v4.0)
-
Malabsorption syndrome, ulcerative colitis, resection of the stomach or small bowel, or other disease significantly affecting gastrointestinal function
-
Other non-malignant systemic disease that would preclude treatment with any of the treatment regimens or would prevent required follow-up
-
Conditions that would prohibit administration of corticosteroids
-
Chronic daily treatment with corticosteroids with a dose of >= 10 mg/day methylprednisolone equivalent (excluding inhaled steroids)
-
Known hypersensitivity to any of the study drugs or any of the ingredients or excipients of these drugs (e.g., polysorbate 80), including sensitivity to benzyl alcohol
-
Pregnancy or lactation at the time of study entry; (note: pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
-
Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements
-
Use of any investigational product within 30 days prior to randomization
Plan studiów
Ta sekcja zawiera szczegółowe informacje na temat planu badania, w tym sposób zaprojektowania badania i jego pomiary.
Jak projektuje się badanie?
Szczegóły projektu
- Główny cel: Leczenie
- Przydział: Randomizowane
- Model interwencyjny: Przydział równoległy
- Maskowanie: Brak (otwarta etykieta)
Liczba ramion
2
Broń i interwencje
Grupa uczestników / ArmGrupa uczestników / Arm |
Interwencja / LeczenieInterwencja / Leczenie |
|---|---|
|
Aktywny komparator: Arm I (combination chemotherapy, surgery, radiation)
NEOADJUVANT: Patients receive docetaxel IV over 60 minutes, carboplatin IV over 30-60 minutes, trastuzumab IV over 30-90 minutes, and pertuzumab IV over 30-60 on day 1. Treatment repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
Inne nazwy:
Given IV
Inne nazwy:
Correlative studies Ancillary studies
Inne nazwy:
Given IV
Inne nazwy:
Undergo 2 core biopsies
Inne nazwy:
Given IV
Inne nazwy:
Undergo lumpectomy or mastectomy Undergo whole breast irradiation |
|
Eksperymentalny: Arm II (chemo, estrogen deprivation, surgery, radiation)
NEOADJUVANT: All patients receive docetaxel, carboplatin, trastuzumab, and pertuzumab as in arm I. Premenopausal patients also receive goserelin acetate SC every 28 days until surgery and aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Postmenopausal patients receive aromatase inhibition therapy at the investigator's discretion daily until 1 day before surgery. Patients enrolled after Amendment #4 undergo 2 core biopsies prior to course 3 of treatment. SURGERY: Patients undergo lumpectomy or mastectomy. RADIATION: Patients undergo whole breast irradiation within 8 weeks following surgery. ADJUVANT: Patients receive trastuzumab IV over 30-60 minutes every 21 days for up to 1 year. |
Given IV
Inne nazwy:
Given IV
Inne nazwy:
Correlative studies Ancillary studies
Inne nazwy:
Given IV
Inne nazwy:
Undergo 2 core biopsies
Inne nazwy:
Given IV
Inne nazwy:
Undergo lumpectomy or mastectomy Undergo whole breast irradiation Given at the investigator's discretion
Inne nazwy:
Given SC
Inne nazwy:
|
Co mierzy badanie?
Podstawowe miary wyniku
Podstawowe miary wyniku
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes
Ramy czasowe: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
Miary wyników drugorzędnych
Miary wyników drugorzędnych
Miara wyniku |
Opis środka |
Ramy czasowe |
|---|---|---|
|
Percent of Patients With Pathologic Complete Response (pCR) in the Breast
Ramy czasowe: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR in the breast, defined as the absence of any invasive component in the resected breast specimen. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Recurrence Free Interval (RFI)
Ramy czasowe: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 8.4 years
|
|
Overall Survival (OS)
Ramy czasowe: Time from randomization until death from any cause, assessed up to 8.4 years
|
Kaplan-Meier estimates of the percentages of patients surviving. |
Time from randomization until death from any cause, assessed up to 8.4 years
|
|
Second Primary Cancer of Any Type
Ramy czasowe: Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
Number of second primary cancers for the two treatment groups |
Time from randomization to the development of a second primary invasive cancer of any site excluding squamous and basal cell carcinoma of the skin, assessed up to 8.4 years
|
|
Percent of Patients With Pathological Complete Response (pCR) in the Breast and Post Therapy Lymph Nodes by Menopausal Status
Ramy czasowe: Up to 2.8 years (when all patients completed primary breast surgery)
|
Proportion of patients with pCR evaluated histologically, and defined as the absence of any invasive component in the resected breast specimen and all resected lymph nodes following completion of neoadjuvant therapy calculated separately for premenopausal and postmenopausal women. |
Up to 2.8 years (when all patients completed primary breast surgery)
|
|
Patterns of Recurrence Free Interval (RFI) by Menopausal Status
Ramy czasowe: Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients free from recurrence by menopausal status. |
Time from surgery to invasive local, regional or distant recurrence, or death from breast cancer for patients with operable disease and for patients with inoperable progressive disease, assessed up to 5 years
|
|
Patterns of Overall Survival (OS) by Menopausal Status
Ramy czasowe: Time from randomization until death from any cause, assessed up to 5 years
|
Kaplan-Meier estimates of the percentages of patients surviving by menopausal status. |
Time from randomization until death from any cause, assessed up to 5 years
|
|
Percentage of Participants With Cardiac Toxicity Categorized According to National Cancer Institute CTCAE Version 4.0
Ramy czasowe: Up to 6 weeks post surgery
|
Percentage of patients with grade 1 or higher toxicity from the Cardiac Disorders System Organ Class. |
Up to 6 weeks post surgery
|
|
Median Percentage of Tumor-infiltrating Lymphocytes (sTILS)
Ramy czasowe: 2.8 years
|
Percentage of Tumor-infiltrating lymphocytes present in the stroma in tissue specimen. |
2.8 years
|
|
Change in Endocrine-related Symptoms Using Breast Cancer Prevention Trial (BCPT) Symptom Checklist
Ramy czasowe: The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
The Breast Cancer Prevention Trial (BCPT) symptom checklist contains 17 endocrine-related symptoms and problems. For each item, the patient was asked how bothersome the problem or symptom was during the past four weeks. Possible answers ranged from not at all (1) to extremely (5). The summary score was calculated for each participant as the average severity of all 17 items. The total mean summary score was calculated as the average summary score by treatment group. The range is 1-5 with higher scores indicating worse outcome. |
The outcome measure was assessed and is presented at three time points included baseline, Prior to cycle 4 (approximately 77 days), and 2-4 weeks after the last dose of chemotherapy prior to surgery (approximately 133-147 days)
|
Współpracownicy i badacze
Tutaj znajdziesz osoby i organizacje zaangażowane w to badanie.
Sponsor
Sponsor
Współpracownicy
Współpracownicy
Śledczy
Śledczy
- Główny śledczy: Mothaffar F Rimawi, NRG Oncology
Daty zapisu na studia
Daty te śledzą postęp w przesyłaniu rekordów badań i podsumowań wyników do ClinicalTrials.gov. Zapisy badań i zgłoszone wyniki są przeglądane przez National Library of Medicine (NLM), aby upewnić się, że spełniają określone standardy kontroli jakości, zanim zostaną opublikowane na publicznej stronie internetowej.
Główne daty studiów
Rozpoczęcie studiów (Rzeczywisty)
Rozpoczęcie studiów
18 lutego 2014
Zakończenie podstawowe (Rzeczywisty)
Zakończenie podstawowe
31 października 2016
Ukończenie studiów (Rzeczywisty)
Ukończenie studiów
30 czerwca 2025
Daty rejestracji na studia
Pierwszy przesłany
Pierwszy przesłany
2 grudnia 2013
Pierwszy przesłany, który spełnia kryteria kontroli jakości
Pierwszy przesłany, który spełnia kryteria kontroli jakości
2 grudnia 2013
Pierwszy wysłany (Szacowany)
Pierwszy wysłany
6 grudnia 2013
Aktualizacje rekordów badań
Ostatnia wysłana aktualizacja (Rzeczywisty)
Ostatnia wysłana aktualizacja
6 października 2026
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
Ostatnia przesłana aktualizacja, która spełniała kryteria kontroli jakości
15 września 2026
Ostatnia weryfikacja
Ostatnia weryfikacja
1 września 2026
Więcej informacji
Terminy związane z tym badaniem
Dodatkowe istotne warunki MeSH
- Nowotwory według lokalizacji
- Nowotwory
- Choroby skórne
- Choroby piersi
- Choroby skóry i tkanki łącznej
- Nowotwory piersi
- Fizjologiczne skutki narkotyków
- Molekularne mechanizmy działania farmakologicznego
- Hormony
- Hormony, substytuty hormonów i antagoniści hormonów
- Inhibitory enzymów
- Inhibitory syntezy steroidów
- Antagoniści hormonów
- Antagoniści estrogenów
- Hormony uwalniające hormony przysadki
- Hormony podwzgórza
- Hormony peptydowe
- Neuropeptydy
- Peptydy
- Aminokwasy, peptydy i białka
- Oligopeptydy
- Białka tkanek nerwowych
- Białka
- Organiczne chemikalia
- Działania farmakologiczne
- Działania i zastosowania chemiczne
- Węglowodory
- Cykloparafiny
- Węglowodory, Alicyklic
- Węglowodory, cykliczne
- Terpeny
- Przeciwciała, monoklonalne, humanizowane
- Przeciwciała, monoklonalne
- Przeciwciała
- Immunoglobuliny
- Immunoproteiny
- Białka krwi
- Globuliny w surowicy
- Globuliny
- Kompleksy koordynacyjne
- Taksoidy
- Cyklodekan
- Diterpenes
- Hormon uwalniający gonadotropinę
- Docetaksel
- Trastuzumab
- Karboplatyna
- Goserelina
- Inhibitory aromatazy
- pertuzumab
- Przeciwciało 2C4
- CT-p6
- PF-05280014
- Trastuzumab Biozimilar HLX02
- Ogivri
- Ontruzant
Inne numery identyfikacyjne badania
Inne numery identyfikacyjne badania
- NCI-2013-02228
- U10CA180868 (Grant/umowa NIH USA)
- U10CA012027 (Grant/umowa NIH USA)
- NCI-2013-02228 (Identyfikator rejestru: CTRP (Clinical Trial Reporting Program))
- NSABP-B-52 (Inny identyfikator: CTEP)
- NSABP-B-52 (Inny identyfikator: NRG Oncology)
Te informacje zostały pobrane bezpośrednio ze strony internetowej clinicaltrials.gov bez żadnych zmian. Jeśli chcesz zmienić, usunąć lub zaktualizować dane swojego badania, skontaktuj się z register@clinicaltrials.gov. Gdy tylko zmiana zostanie wprowadzona na stronie clinicaltrials.gov, zostanie ona automatycznie zaktualizowana również na naszej stronie internetowej .