- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT00005184
Immunogenetic Factors of Coronary Heart Disease
Studieoversikt
Status
Detaljert beskrivelse
BACKGROUND:
Although the familial clustering of coronary heart disease has been well documented, it is unclear as to whether the familial clustering can be explained by shared environmental factors by members of a family or by clustering of risk factors having a genetic component such as blood pressure, familial hyperlipidemia and/or diabetes. Studies indicate that a family history of coronary disease may be an independent risk factor. Major histocompatibility complex genetic markers to identify individuals at risk within a family may be useful. In 1985 when the study began, there was a paucity of data dealing with the interrelationship of family history, genetic markers, immunological markers, and traditional risk factors.
DESIGN NARRATIVE:
In this case-control study, the study population consisted of incident cases who presented to the Georgia Heart Clinic in La Grange, Georgia with coronary heart disease. The majority of the subjects were from three counties in mideastern Alabama and from counties in midwestern Georgia. All subjects had undergone diagnostic coronary angiography. A determination was made in patients and controls of the association of major histocompatibility complex genetic markers HLA-A, -B, -C, -DR, C4 and BF, C3, the restriction fragment length polymorphisms (RFLP's) flanking the apolipoprotein AI and insulin genes, presence of autoantibodies, and family history of coronary disease, diabetes, or hypothyroidism. The frequency of these variables was compared with the standard coronary risk factors of family history, hypertension, lipid abnormalities, lifestyle, Type A behavior, obesity and with diseases such as diabetes and hypothyroidism. An analysis was made of the strength of these variables for predicting those individuals at risk and whether there were variables which predict severity of disease based on 1, 2, or 3 vessel involvement.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Studietype
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Studieplan
Hvordan er studiet utformet?
Samarbeidspartnere og etterforskere
Publikasjoner og nyttige lenker
Generelle publikasjoner
- Go R, Acton R, Roseman J, Barger B, Perkins L, Vanichanan T, Moore P, Brand J, Gore T, Brennan J, Cousins L, Copeland R: Immunogenetic Risk Factors for Premature Coronary Artery Disease in Southeastern USA Population. Genome, 30:34, 1988
- Acton R, Bamberg R, Go R, Roseman J: Utilization of Genetic and Other Laboratory Test Results to Predict and Reduce the Risk of Disease. In: Proceedings of the Society of Prospective Medicine, 1988. 1988.
- Bamberg R, Copeland R, Barger B, Roseman J, Go R, Vanichanan C, Brand J, Moore P, Acton R: Genetic Risk Information as an Impetus to Health Related Behavioral Change. In: Proceedings of the Society of Prospective Medicine, 1988. 1988.
- Pancharuniti N, Lewis CA, Sauberlich HE, Perkins LL, Go RC, Alvarez JO, Macaluso M, Acton RT, Copeland RB, Cousins AL, et al. Plasma homocyst(e)ine, folate, and vitamin B-12 concentrations and risk for early-onset coronary artery disease. Am J Clin Nutr. 1994 Apr;59(4):940-8. doi: 10.1093/ajcn/59.4.940. Erratum In: Am J Clin Nutr 1996 Apr;63(4):609.
Studierekorddatoer
Studer hoveddatoer
Studiestart
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Anslag)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Anslag)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- 1062
- R01HL033959 (U.S. NIH-stipend/kontrakt)
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