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Anatomiske og funksjonelle spådommer om blindsyn hos pasienter med homonym lateral hemianopsi (PRE-SIGHT)

30. september 2026 oppdatert av: Fondation Ophtalmologique Adolphe de Rothschild

Homonymous lateral hemianopia (HLH) is characterized by loss of vision in half the visual field, and is the most common neurovisual disorder following stroke.

Numerous behavioral and neuroanatomical studies have focused on the phenomenon of blindsight, corresponding to patients' unconscious residual visual capacities in the blind hemifield. Cohort studies of patients have highlighted different types of blindsight, and a low occurrence of the phenomenon initially described: (1) type 1 blindsight (≈12%), unconscious visual abilities; (2) type 2 blindsight, visual abilities associated with sensations in the blind field (≈18%); (3) blindsense, sensations in the blind field without visual abilities (≈30%); and (4) no blindsight (≈40%). The heterogeneity of these blindsight abilities in the HLH population is closely related to patients' neuroanatomical and functional profiles.

In particular, resting-state functional imaging (r-fMRI) and default mode network analysis have highlighted a significant correlation between the degree of inter-hemispheric connection (between the healthy and injured hemispheres) and the rate of spontaneous visual field recovery. To our knowledge, this degree of functional connectivity has not yet been studied in relation to blindsight abilities. However, this functional MRI measurement tool represents a potential predictive factor for patients' residual performance in their blindsight field, in order to assess the level of visuo-cognitive impairment and, ultimately, to adapt care.

Studieoversikt

Status

Har ikke rekruttert ennå

Forhold

Studietype

Observasjonsmessig

Registrering (Antatt)

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiekontakt

Navn: Amelie Yavchitz, Dr
Telefonnummer: 0148036454
E-post: ayavchitz@for.paris

Studer Kontakt Backup

Navn: Sadia MEDAOURI
Telefonnummer: 0148036277
E-post: smedaouri@for.paris

Studiesteder

Frankrike
- - Paris, Frankrike, 75019
    - Hopital Fondation Adolphe de Rothschild
    - Ta kontakt med:
      
      clementine GARRIC
      
      E-post: clgarric@for.paris

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Prøvetakingsmetode

Ikke-sannsynlighetsprøve

Studiepopulasjon

Patients over 18 years of age with homonymous lateral hemianopia undergoing cerebral MRI for follow-up and rehabilitation following stroke

Beskrivelse

Inclusion Criteria:

Subjects aged 18 and over
with homonymous visual field amputation sequelae of a retrochiasmatic lesion of vascular origin (stroke), including the occipital region (primary visual cortex, optic radiations, associated occipital areas)
Requires follow-up brain MRI as part of treatment
Able to perform experimental tasks on computer
Express consent to participate in the study
Member or beneficiary of a social security scheme

Exclusion Criteria:

Severe neuropsychological disorders (language, memory, attention, vigilance, reasoning)
Severe ophthalmological disorders or visual acuity below 3/10 prior to stroke
Progressive ophthalmological disorders (cataract or glaucoma) likely to bias measurements
Major psychiatric or behavioral disorders making care impossible
Patient benefiting from a legal protection measure
Pregnant or breast-feeding women (declarative information)

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Observasjonsmodeller: CASE_ONLY
Tidsperspektiver: CROSS_SECTIONAL

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Description of resting-state functional MRI measurement of the degree of Resting State Functional Connectivity (RSFC) between left and right hemisphere regions. Tidsramme: DAY 0	Comparison of the degree of inter-hemispheric Resting State Functional Connectivity between the four patient groups: absence of blindsight, type I blindsight, type II blindsight and blindsense.	DAY 0

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Correlation between inter-hemispheric functional connectivity and blindsight performance Tidsramme: DAY 0	Resting-state functional MRI measurement of the degree of RSFC between left and right hemisphere regions of interest. Blindsight performance assessed by measuring the sensitivity of discrimination of spatial orientation (horizontal/vertical) of lines presented in the patient's blind field (blindsight).	DAY 0
Density and intensity of visual and attentional default networks in each type of blindsight Tidsramme: DAY 0	Calculation (Graph Theory) of neural network matrices, weighted and created on the basis of correlations of activations in different brain regions during resting-state functional MRI measurement .	DAY 0
Blindsight performance according to the laterality of the lesion (left or right hemisphere) Tidsramme: DAY 0	Blindsight performance assessed by measuring the sensitivity of discrimination of spatial orientation (horizontal/vertical) of lines presented in the patient's blind field (blindsight)	DAY 0
Correlation between the level of inter-hemispheric functional connectivity and blindsight performance Tidsramme: DAY 0	Resting-state functional MRI measurement of the degree of Resting State Functional Connectivity (RSFC) between left and right hemisphere regions of interest, blindsight performance assessed by measuring the sensitivity of spatial orientation discrimination (horizontal/vertical) of lines presented in the blindsight field.	DAY 0
Correlation between visual default network density and intensity and blindsight performance Tidsramme: DAY 0	Computation (Graph Theory) of neural network matrices, weighted and created on the basis of correlations of activations of different brain regions during Resting-state functional MRI measurement. Blindsight performance assessed by measuring the sensitivity of discrimination of spatial orientation (horizontal/vertical) of lines presented in the patient's blind field (blindsight).	DAY 0
Correlation between lesion volume and blindsight performance Tidsramme: DAY 0	Blindsight performance assessed by measuring the sensitivity of spatial orientation discrimination (horizontal/vertical) of lines presented in the patient's blind field (blindsight).	DAY 0

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Etterforskere

Hovedetterforsker: Clémentine GARRIC, Integrative Neuroscience and Cognition Center

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Antatt)

1. oktober 2026

Primær fullføring (Antatt)

1. oktober 2029

Studiet fullført (Antatt)

1. oktober 2029

Datoer for studieregistrering

Først innsendt

9. august 2024

Først innsendt som oppfylte QC-kriteriene

10. oktober 2024

Først lagt ut (Faktiske)

15. oktober 2024

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)