A Phase I Study of Bendamustine Hydrochloride in Patients With Indolent B-cell Non-Hodgkin's Lymphoma

Inclusion Criteria:

Indolent B cell Non-Hodgkin's lymphoma patients with prior therapy who satisfy the conditions listed below. No restrictions regarding gender.

• Patients with histologically or cytologically confirmed indolent B cell Non-Hodgkin's lymphoma.
• Patients who had not received treatment (chemotherapy, antibody therapy and radiation/ radiotherapy) for more than 4 weeks following prior therapy and who are judged to carry no effect from the prior therapy.
• Patients aged from 20 to less than 75 years.
• Patients who had agreed in-patient during first course therapy.
• Patients from whom written consent to participate in this study has been obtained.

Exclusion Criteria:Patients who meet any of the following criteria will be excluded.

• Patients with apparent infections.
• Patients with serious complications (hepatic failure or renal failure).
• Patients with complication or history of serious heart failure (e.g. cardiac infarction, ischemic heart disease).
• Patients with serious digestive symptoms (nausea/ vomiting/ diarrhea).
• Patients who are known to be positive for HBV, HCV or HIC.
• Patients receiving other investigational drugs within 3 months before registration in the study.
• Patients with allogenic transplant.
• Women who are pregnant, of childbearing potential, or lactating.
• Patients who do not agree to contraception.
• Otherwise, patients who are judged by the investigator as being unsuitable for inclusion in the study.