Multi-organ Imaging of Microvascular and Metabolic Function

Inclusion Criteria:

• Adults aged 18 years and older
• For patients with cardiovascular disease: Documented diagnosis of ischemic heart disease based on standard clinical, radiologic, and/or histopathologic criteria, as documented in the medical record; or a clinical nuclear cardiac stress PET test within 1 year.
• For healthy subjects: No diagnosis of cardiometabolic disease, cancer, or other major disease within the past 5 years

Exclusion Criteria:

• Contraindications to PET due to:

  1. Research-related radiation exposure exceeding current MGB Radiology Department guidelines (i.e., 50 mSv in the prior 12 months);
  2. Inability to lie comfortably on the bed inside the scanner;
  3. Body weight > 300 lbs (weight limit of the scanner table);
  4. Pregnancy or breastfeeding;
• Individuals with fasting plasma glucose level of >200 mg/dL;
• Claustrophobia
• Employed under the direct supervision of the PI conducting the research.