Dietary Arachidonic Acid, Obesity and Atopic Respiratory Disease
13 августа 2015 г. обновлено: Anthony R. Tagliaferro, University of New Hampshire
Obesity and Atopic-related Respiratory Disease: Possible Role of Dietary Omega 6 and 3 Fatty Acids
Epidemiological studies have shown obesity to be a risk factor of asthma.
Research evidence of obesity and atopic(ie.
allergic)-related respiratory diseases, has been less clear.
The purpose of the present study was to test the hypothesis that the relationship between obesity and atopic-related respiratory disease in premenopausal women is mediated by a dietary imbalance of omega 6 and 3 polyunsaturated fatty acids.
Обзор исследования
Подробное описание
Sixty young adult obese and non obese women, with, and without asthma, were studied using a cross-sectional design.
Body composition was measured by plethysmography.
A fasted blood sample was taken to measure: specific and total immunoglobulin (IgE) antibodies,biochemical markers of atopy; glucose and insulin to measure insulin sensitivity; estrogen(17β-estradiol) and sex hormone-binding globulin to measure estrogen status of the women; hormone-products of fat tissue ( leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFα), interleukins (IL-6,IL-18), that have been associated with both obesity and immune processes involved in asthma and allergy.
Dietary intake of omega 6: linoleic acid (LA), arachidonic acid(AA); and omega 3 fatty acids: α linolenic (ALA), eicosapentanoic (EPA) and docosahexanoic (DHA) and other nutrients were assessed by food frequency questionnaire.
Тип исследования
Наблюдательный
Регистрация (Действительный)
60
Критерии участия
Исследователи ищут людей, которые соответствуют определенному описанию, называемому критериям приемлемости. Некоторыми примерами этих критериев являются общее состояние здоровья человека или предшествующее лечение.
Критерии приемлемости
Возраст, подходящий для обучения
От 18 лет до 40 лет (Взрослый)
Принимает здоровых добровольцев
Да
Полы, имеющие право на обучение
Женский
Метод выборки
Невероятностная выборка
Исследуемая популяция
Female subjects were recruited from the University and surrounding local communities, using posted flyers, website announcements, personal announcements in classes, referrals from local physicians, and word of mouth.
Prospective subjects were interviewed initially by telephone.
Описание
Inclusion Criteria:
- For asthmatics, only individuals that were willing and capable of not using asthma medications for two days prior to laboratory testing.
Exclusion Criteria:
- An individual was excluded from the study if she had a history of high blood pressure, diabetes, heart disease, cigarette smoking, or eating disorders.
- Women that were pregnant or lactating.
Учебный план
В этом разделе представлена подробная информация о плане исследования, в том числе о том, как планируется исследование и что оно измеряет.
Как устроено исследование?
Детали дизайна
Что измеряет исследование?
Первичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
|---|---|---|
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Predictors of serum concentration of specific and total IgE antibodies in obesity
Временное ограничение: one day
|
Measures of insulin sensitivity, plasma concentrations of leptin, adiponectin, , estrogen, IL-18,and dietary arachidonic, eicosapentanoic, docosahexanoic fatty acids were entered as independent variables; and serum concentration of specific and total IgE antibodies as dependent variable, in a forward stepwise multivariate linear regression analysis to identify which factor(s) had the greatest influence on serum concentrations of IgE antibodies in obesity.
|
one day
|
Вторичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
|---|---|---|
|
Relationship between dietary levels of arachidonic, eicosapentanoic, docosahexanoic fatty acids and plasma concentration of leptin in obesity
Временное ограничение: one day
|
Dietary intake of the omega 6 and 3 fatty acids of were analyzed in relation to plasma concentration of leptin in obese and non obese women.
|
one day
|
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Correlation between dietary arachidonic, eicosapentanoic,and docoshexanoic fatty acids and plasma concentration of adiponectin in obesity
Временное ограничение: one day
|
Dietary intake of the omega 6 and 3 fatty acids of were analyzed in relation to plasma concentration of adiponectin in obese and non obese women.
|
one day
|
Соавторы и исследователи
Здесь вы найдете людей и организации, участвующие в этом исследовании.
Спонсор
Публикации и полезные ссылки
Лицо, ответственное за внесение сведений об исследовании, добровольно предоставляет эти публикации. Это может быть что угодно, связанное с исследованием.
Общие публикации
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Даты записи исследования
Эти даты отслеживают ход отправки отчетов об исследованиях и сводных результатов на сайт ClinicalTrials.gov. Записи исследований и сообщаемые результаты проверяются Национальной медицинской библиотекой (NLM), чтобы убедиться, что они соответствуют определенным стандартам контроля качества, прежде чем публиковать их на общедоступном веб-сайте.
Изучение основных дат
Начало исследования
1 октября 2001 г.
Первичное завершение (Действительный)
1 мая 2003 г.
Завершение исследования (Действительный)
1 мая 2003 г.
Даты регистрации исследования
Первый отправленный
15 июня 2015 г.
Впервые представлено, что соответствует критериям контроля качества
13 августа 2015 г.
Первый опубликованный (Оценивать)
17 августа 2015 г.
Обновления учебных записей
Последнее опубликованное обновление (Оценивать)
17 августа 2015 г.
Последнее отправленное обновление, отвечающее критериям контроля качества
13 августа 2015 г.
Последняя проверка
1 июля 2015 г.
Дополнительная информация
Термины, связанные с этим исследованием
Ключевые слова
Дополнительные соответствующие термины MeSH
Другие идентификационные номера исследования
- UNH-01-2536-01
Эта информация была получена непосредственно с веб-сайта clinicaltrials.gov без каких-либо изменений. Если у вас есть запросы на изменение, удаление или обновление сведений об исследовании, обращайтесь по адресу register@clinicaltrials.gov. Как только изменение будет реализовано на clinicaltrials.gov, оно будет автоматически обновлено и на нашем веб-сайте. .