Dietary Arachidonic Acid, Obesity and Atopic Respiratory Disease
13 augusti 2015 uppdaterad av: Anthony R. Tagliaferro, University of New Hampshire
Obesity and Atopic-related Respiratory Disease: Possible Role of Dietary Omega 6 and 3 Fatty Acids
Epidemiological studies have shown obesity to be a risk factor of asthma.
Research evidence of obesity and atopic(ie.
allergic)-related respiratory diseases, has been less clear.
The purpose of the present study was to test the hypothesis that the relationship between obesity and atopic-related respiratory disease in premenopausal women is mediated by a dietary imbalance of omega 6 and 3 polyunsaturated fatty acids.
Studieöversikt
Detaljerad beskrivning
Sixty young adult obese and non obese women, with, and without asthma, were studied using a cross-sectional design.
Body composition was measured by plethysmography.
A fasted blood sample was taken to measure: specific and total immunoglobulin (IgE) antibodies,biochemical markers of atopy; glucose and insulin to measure insulin sensitivity; estrogen(17β-estradiol) and sex hormone-binding globulin to measure estrogen status of the women; hormone-products of fat tissue ( leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFα), interleukins (IL-6,IL-18), that have been associated with both obesity and immune processes involved in asthma and allergy.
Dietary intake of omega 6: linoleic acid (LA), arachidonic acid(AA); and omega 3 fatty acids: α linolenic (ALA), eicosapentanoic (EPA) and docosahexanoic (DHA) and other nutrients were assessed by food frequency questionnaire.
Studietyp
Observationell
Inskrivning (Faktisk)
60
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
18 år till 40 år (Vuxen)
Tar emot friska volontärer
Ja
Kön som är behöriga för studier
Kvinna
Testmetod
Icke-sannolikhetsprov
Studera befolkning
Female subjects were recruited from the University and surrounding local communities, using posted flyers, website announcements, personal announcements in classes, referrals from local physicians, and word of mouth.
Prospective subjects were interviewed initially by telephone.
Beskrivning
Inclusion Criteria:
- For asthmatics, only individuals that were willing and capable of not using asthma medications for two days prior to laboratory testing.
Exclusion Criteria:
- An individual was excluded from the study if she had a history of high blood pressure, diabetes, heart disease, cigarette smoking, or eating disorders.
- Women that were pregnant or lactating.
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
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Predictors of serum concentration of specific and total IgE antibodies in obesity
Tidsram: one day
|
Measures of insulin sensitivity, plasma concentrations of leptin, adiponectin, , estrogen, IL-18,and dietary arachidonic, eicosapentanoic, docosahexanoic fatty acids were entered as independent variables; and serum concentration of specific and total IgE antibodies as dependent variable, in a forward stepwise multivariate linear regression analysis to identify which factor(s) had the greatest influence on serum concentrations of IgE antibodies in obesity.
|
one day
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Relationship between dietary levels of arachidonic, eicosapentanoic, docosahexanoic fatty acids and plasma concentration of leptin in obesity
Tidsram: one day
|
Dietary intake of the omega 6 and 3 fatty acids of were analyzed in relation to plasma concentration of leptin in obese and non obese women.
|
one day
|
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Correlation between dietary arachidonic, eicosapentanoic,and docoshexanoic fatty acids and plasma concentration of adiponectin in obesity
Tidsram: one day
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Dietary intake of the omega 6 and 3 fatty acids of were analyzed in relation to plasma concentration of adiponectin in obese and non obese women.
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one day
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Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
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Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart
1 oktober 2001
Primärt slutförande (Faktisk)
1 maj 2003
Avslutad studie (Faktisk)
1 maj 2003
Studieregistreringsdatum
Först inskickad
15 juni 2015
Först inskickad som uppfyllde QC-kriterierna
13 augusti 2015
Första postat (Uppskatta)
17 augusti 2015
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
17 augusti 2015
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
13 augusti 2015
Senast verifierad
1 juli 2015
Mer information
Termer relaterade till denna studie
Nyckelord
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- UNH-01-2536-01
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