- ICH GCP
- Amerikanska kliniska prövningsregistret
- Klinisk prövning NCT01423461
Personalized Asthma Care Team (PACT)
Individualized Health Care for Children With Common Chronic Diseases
"Individualized health care" refers to the development of strategies for disease management and health promotion that are informed by specific data on genetics and physiological processes that uniquely determine each person's health profile and potential responsiveness to interventions or susceptibility to environmental exposures.
Asthma, an inflammatory disorder of the airway, appears to be determined by multiple interacting genetic and environmental factors. Such risk factors include allergic responses, small airways, excess body weight, specific properties of airway smooth muscle, airway and generalized metabolic and inflammatory homeostasis, and exposures to environmental irritants, allergens, and psychosocial stressors. To date, asthma treatment strategies have been guided by "severity" guidelines rather than by characteristics of the child's specific phenotype (a child's underlying allergic tendency, extent of airway inflammation and airway smooth muscle dysfunction, or underlying obesity and metabolic perturbations). The growing availability of new classes of asthma medications that more directly target specific pathophysiological derangements will require accessing data on each child's asthma risk profiles to optimize selection of medications and other interventions that most specifically address the underlying pathophysiology while minimizing adverse treatment side effects.
The investigators propose to develop a model program for collecting relevant clinical information and genetic data on a high risk group of asthmatic children, including data on common co-morbidities, specifically obesity and sleep disorders; use this information to develop a comprehensive model database for characterizing children according to their health profiles; and use this characterization to initiate targeted interventions, while continuing long term follow up of these children to determine differential responsiveness to medications.
Studieöversikt
Status
Betingelser
Studietyp
Inskrivning (Faktisk)
Deltagandekriterier
Urvalskriterier
Åldrar som är berättigade till studier
Tar emot friska volontärer
Kön som är behöriga för studier
Testmetod
Studera befolkning
Beskrivning
Inclusion Criteria:
- ages 4 to 18 years
- diagnosis of asthma or symptoms of persistent wheeze, unexplained by an etiology other than asthma
Exclusion Criteria:
- other severe co-morbidity (cystic fibrosis, sickle cell disease, chronic lung disease of prematurity, interstitial lung disease, cerebral palsy)
- inability of family to provide informed consent
- plans of the family to move out of the greater Cleveland area in the subsequent 24 months
- or inability to participate in regular follow up visits
Studieplan
Hur är studien utformad?
Designdetaljer
Samarbetspartners och utredare
Sponsor
Samarbetspartners
Utredare
- Studierektor: Susan Redline, M.D., M.P.H., Brigham and Women's Hospital
- Huvudutredare: Kristie Ross, M.D., University Hospitals Cleveland Medical Center
- Huvudutredare: Meeghan Hart, M.D., University Hospitals Cleveland Medical Center
- Huvudutredare: Carol Rosen, M.D., University Hospitals Cleveland Medical Center
Studieavstämningsdatum
Studera stora datum
Studiestart
Primärt slutförande (Faktisk)
Avslutad studie (Faktisk)
Studieregistreringsdatum
Först inskickad
Först inskickad som uppfyllde QC-kriterierna
Första postat (Uppskatta)
Uppdateringar av studier
Senaste uppdatering publicerad (Uppskatta)
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
Senast verifierad
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- L2005-0254
- M01RR000080 (U.S.S. NIH-anslag/kontrakt)
- KL2RR024990 (U.S.S. NIH-anslag/kontrakt)
- UL1RR024989 (U.S.S. NIH-anslag/kontrakt)
- 1U54CA116867 (U.S.S. NIH-anslag/kontrakt)
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Kliniska prövningar på Fetma
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SanionaAvslutadHypothalamic Injury-induced Obesity (HIO)Danmark