Paricalcitol in Treating Patients With Myelodysplastic Syndrome
A Phase II Trial Of Paricalcitol In Myelodysplastic Syndromes
RATIONALE: Paricalcitol is a form of vitamin D that may help myelodysplastic cells develop into normal bone marrow cells.
PURPOSE: Phase II trial to study the effectiveness of paricalcitol in treating patients who have myelodysplastic syndrome.
研究概览
详细说明
OBJECTIVES:
- Determine the clinical effects of paricalcitol in patients with myelodysplastic syndromes.
- Determine whether this drug can improve RBC, WBC, or platelet counts in these patients.
- Determine whether this drug can decrease the risk of development of leukemia without causing undue toxicity in these patients.
OUTLINE: Patients receive oral paricalcitol daily for 4 months in the absence of disease progression or unacceptable toxicity.
Patients are followed at 1 month.
PROJECTED ACCRUAL: A total of 20 patients will be accrued for this study within 8 months.
研究类型
阶段
- 阶段2
联系人和位置
学习地点
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-
California
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Los Angeles、California、美国、90048
- Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center
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-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
DISEASE CHARACTERISTICS:
Clinical diagnosis of myelodysplastic syndromes according to the modified FAB classification
- Confirmed by bone marrow aspiration showing blast and promyelocyte count no greater than 30% of the bone marrow differential
- Patients with refractory anemia with ringed sideroblasts are eligible provided there was no response to a 3-week course of prior high-dose pyridoxine
PATIENT CHARACTERISTICS:
Age
- 25 to 100
Performance status
- Karnofsky 60-100%
Life expectancy
- At least 12 weeks
Hematopoietic
- See Disease Characteristics
Hepatic
- Bilirubin less than 2.0 mg/dL
Renal
- Creatinine less than 2.5 mg/dL
- Calcium normal
Other
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- No prior sensitivity to paricalcitol or any component of its formulation
- No prior cholecalciferol toxicity
- No other concurrent acute illness
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- More than 5 weeks since prior chemotherapy
Endocrine therapy
- Not specified
Radiotherapy
- More than 5 weeks since prior radiotherapy
Surgery
- Prior recent surgery allowed, if fully recovered
Other
- More than 5 weeks since prior megadose vitamins
- No concurrent cholecalciferol, phosphate, calcium, or cholestyramine
- No concurrent digoxin
学习计划
研究是如何设计的?
设计细节
- 主要用途:治疗
- 屏蔽:无(打开标签)
合作者和调查者
合作者
调查人员
- 学习椅:H. Phillip Koeffler, MD、Cedars-Sinai Medical Center
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
与本研究相关的术语
关键字
其他研究编号
- CDR0000315451
- CSMC-IRB-4107-01
药物和器械信息、研究文件
研究美国 FDA 监管的药品
研究美国 FDA 监管的设备产品
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