Studying Common Genetic Mutations Related to Mucositis in Patients With Multiple Myeloma Receiving High-Dose Melphalan
Genetic Analysis of Toxicity Associated With High-Dose Melphalan
RATIONALE: Studying blood or mouthwash samples in the laboratory from patients receiving melphalan for cancer may help doctors learn more about changes that occur in DNA, identify biomarkers related to cancer, and help predict how patients will respond to treatment.
PURPOSE: This clinical trial is studying common genetic mutations related to mucositis in patients with multiple myeloma receiving high-dose melphalan.
研究概览
详细说明
OBJECTIVES:
- To determine whether single nucleotide polymorphisms (SNPs) in genes that encode the melphalan transporters are associated with the development and/or severity of mucositis in patients with multiple myeloma receiving high-dose melphalan.
- To determine whether SNPs in genes that influence melphalan metabolism are associated with the development and/or severity of mucositis in these patients.
OUTLINE: This is a multicenter study.
Blood or mouthwash samples are collected and DNA isolated from these specimens is analyzed for single nucleotide polymorphisms (SNPs) in LAT1 or other candidate genes. Public databases (i.e., dbSNP and HapMap) are reviewed to select representative SNPs for genotype analysis.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Tennessee
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Nashville、Tennessee、美国、37232-6838
- Vanderbilt-Ingram Cancer Center
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Nashville、Tennessee、美国、37212
- Veterans Affairs Medical Center - Nashville
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Nashville、Tennessee、美国、37064
- Vanderbilt-Ingram Cancer Center at Franklin
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
DISEASE CHARACTERISTICS:
- Diagnosis of multiple myeloma
Receiving treatment with high-dose melphalan for an autologous stem cell transplantation at any of these facilities:
- Vanderbilt University Medical Center
- Nashville Veteran's Administration Medical Center (VAMC)
- Seattle VAMC
- San Antonio VAMC
PATIENT CHARACTERISTICS:
- Not pregnant
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
- No palifermin
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
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Retrospective sample
People who have been diagnosed with multiple myeloma and have received high-dose melphalan.
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Blood or cheek cells wil be collected.
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Prospective sample
People who have been diagnosed with multiple myeloma and will be receiving high-dose melphalan.
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Blood or cheek cells wil be collected.
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研究衡量的是什么？
主要结果指标
结果测量 |
大体时间 |
|---|---|
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Association between single nucleotide polymorphisms (SNPs) in genes that encode the melphalan transporters and development and/or severity of mucositis
大体时间：4 weeks
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4 weeks
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Association between SNPs in genes that influence melphalan metabolism and development and/or severity of mucositis
大体时间：4 weeks
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4 weeks
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合作者和调查者
调查人员
- 首席研究员：Stephen Brandt, MD、Vanderbilt-Ingram Cancer Center
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
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