Computed Tomography Dose Reduction Using Sequential or Fast Pitch Sprial Technique (CTDOSE)
Computed Tomography Dose Reduction Using Sequential or Fast Pitch Sprial Technique Employed in Cardiothoracic Imaging
研究概览
详细说明
The development of a novel CT scanner capable of sequential or fast-pitch spiral techniques in most patients (Siemens Definition Flash) represents a potentially crucial technical innovation at a particularly critical juncture. National healthcare systems are under pressure to deliver accurate and cost-effective diagnosis of an increasing number of patients and CT angiography in various settings is a proven, highly accurate technique that has been shown to improve diagnostic efficiency and reduce the cost of care.
However, there has been increasing concern about the lifetime attributable risk of cancer from radiation related to diagnostic procedures. Such concern extends to other radiation-based procedures that contribute to the cumulative lifetime radiation exposure of patients. The Flash scanner holds the promise of substantially reducing exposure resulting from a variety of examinations.
The CT DOSE multicenter trial is therefore designed to validate the extent of dose reduction attendant to the use of the Flash scanner in cardiothoracic scanning, and to determine whether image quality is preserved in spite of significant dose reduction.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Kingdom of Saudi Arabia
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Riyadh、Kingdom of Saudi Arabia、沙特阿拉伯、11426
- King Abdul-Aziz Cardiac Center, national Guard Health Affairs
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California
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San Diego、California、美国、92134
- Naval Medical Center
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Massachusetts
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Boston、Massachusetts、美国、02114
- Massachusetts General Hospital
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Michigan
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Royal Oak、Michigan、美国、48073
- William Beaumont Hospital-Royal Oak
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Troy、Michigan、美国、48085
- William Beaumont Hospital-Troy
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Minnesota
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Minneapolis、Minnesota、美国、55407
- Minneapolis Heart Institute/ Abbott Northwestern
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New York
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New York、New York、美国、10006
- NYU Langone Medical Center
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Ohio
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Cleveland、Ohio、美国、44195
- Cleveland Clinic Foundation
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South Carolina
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Charleston、South Carolina、美国、29425
- Medical University of South Carolina
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Scans from patients undergoing clinically indicated pulmonary angiography, aortography and/or CCTA.
- Age greater than or equal to 18 years.
Exclusion Criteria:
- No exclusions
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
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Control Group
Data from patients in the control group will be obtained retrospectively from patient medical records and stored image data
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Prospective Patient Group
Data from patients in the Flash group will be obtained prospectively from scanner consoles and medical records.
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Radiation dose
大体时间:Time of CT scan
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The primary endpoint is radiation dose, measured as dose-length-product (DLP, in mGy∙cm) and effective radiation dose, calculated as DLP x 0.014 (in mSv).
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Time of CT scan
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
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Assessment of Image Quality
大体时间:Time of CT Scan
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Signal noise (standard deviation of attenuation in Hounsfield units) will be determined in regions of interest in: A) air anterior to the chest wall, B) mid-LV septum and C) mid thoracic aorta or main PA.
This will be done in a sequential sample of every 5th case (approximately 600 cases total).
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Time of CT Scan
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合作者和调查者
调查人员
- 首席研究员:Gilbert Raff, MD、William Beaumont Hospitals
研究记录日期
研究主要日期
学习开始
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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