Tissue Perfusion Indices as Predictor of Outcome in Poly Trauma Patients
Central Venous-arterial Carbon Dioxide Pressure Difference in Correlation to Dynamic Changes of Serum Lactate as an Indicator of Tissue Perfusion in Polytruama Patients
研究概览
详细说明
Poly trauma patients have high incidence of mortality and morbidity in spite of improvements and advances in facilities. However, no doubt that early resuscitation and interventions make a big difference upon the overall outcome.
A lot of methods, indices, laboratory and biomarkers have been utilized to evaluate the progress and quality of resuscitation and the early hospital interventions in such group of critically ill patients including central venous pressures, urine output, mixed venous oxygen saturation, and gastric tonometry. Most of recent means focus upon the regional tissue perfusion rather than global, however some researches have tried the difference between arterial and venous CO2,oxygen tension or content ( Pv -a co2& Pa -v O2 ) in addition to dynamic changes in lactate(3) as predictors for tissue perfusion in sepsis patients after establishment of sepsis campaign (bundle).
研究类型
注册 (预期的)
阶段
- 不适用
联系人和位置
学习联系方式
- 姓名：Emad Zarief Kamel Said, MD
- 电话号码：00201007046058
- 邮箱：emadzarief@yahoo.com
学习地点
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Assiut、埃及、71111
- 招聘中
- Emad Zarief Kamel Said
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- multiple trauma patients Adult patients
Exclusion Criteria:
- cardiac renal chronic chest disease diabetic more than 3 years
学习计划
研究是如何设计的？
设计细节
- 主要用途：支持治疗
- 分配：不适用
- 介入模型：单组作业
- 屏蔽：无（打开标签）
武器和干预
参与者组/臂 |
干预/治疗 |
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其他：optimal resuscitation
This group of multiple trauma patients will be resuscitated with crystalloids, analgesics, blood products as needed.
Then follow up of the difference between arterial and venous CO2 to difference between arterial and venous oxygen tension, serum lactate, renal function, other organ affection along over the short hospital stay period
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optimal resuscitation to achieve mean arterial blood pressure above 65 mmHG , Central venous pressure more than 8 mmHg , urine out put more than 0.5 ml /Kg/hour
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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the difference between partial pressure of oxygen in arterial and venous blood
大体时间：6 hours
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6 hours
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the difference between partial pressure of carbon dioxide in arterial and venous blood
大体时间：6 hours
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6 hours
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serum level of lactate and its changes
大体时间：6 hours
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as an index for tissue oxygenation
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6 hours
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
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Kidney function
大体时间：72 hours
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serum creatinine in mg/ dl and urine output/ hour
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72 hours
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hemodynamic stability including pulse rate and mean arterial blood pressure
大体时间：72 hours
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72 hours
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duration of stay in the critical care unit
大体时间：72 hours
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72 hours
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合作者和调查者
调查人员
- 研究主任：Emad Zarief Kamel Said, MD、Assiut University
研究记录日期
研究主要日期
学习开始
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (估计)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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