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Telephone-Based Re-education for Hp Eradication

2018年5月28日 更新者：He Shuixiang、First Affiliated Hospital Xi'an Jiaotong University

Telephone-Based Re-Education of Drug Administration for Helicobacter Pylori Eradication: a Multi-Center Randomized, Controlled Study

It was suggested that the patient compliance plans an important role in the Hp eradication. However, data on whether re-education could improve the eradication rate are lacking. We consider that re-education on patients by telephone during the process of drug administration could increase the eradication rate in Hp infected patients.

We hypothesized that telephone re-education during the whole process of drug administration would improve the compliance of patients and ultimately increase the Hp eradication rate.

研究概览

地位

完全的

条件

干预/治疗

研究类型

介入性

注册 (实际的)

162

阶段

  • 不适用

联系人和位置

本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。

学习地点

  • 中国
    • Shaanxi
      • Xi'an、Shaanxi、中国、710061
        • First Affiliated Hospital of Xi'an JiaoTong University

参与标准

研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。

资格标准

适合学习的年龄

18年 至 70年 (成人、年长者)

接受健康志愿者

不

有资格学习的性别

全部

描述

Inclusion Criteria:

  1. Prior informed consent
  2. 18-70 years of age
  3. Hp infected patients diagnosed by 13C urea breath test, including digestive ulcer, gastritis with dyspepsia symptoms, family history of gastric cancer, planning to use long-term non-steroidal anti-inflammatory drugs (NSAIDs), or personal request
  4. Ability to swallow oral medications
  5. No contraindication for the drugs used for Hp eradication
  6. Both men and women enrolled in this trial must use adequate barrier birth control during the course of the trial and 4 weeks after the completion of trial

Exclusion Criteria:

  1. Pregnant or breast-feeding subjects
  2. Previous failed treatment of Hp eradication
  3. Previous treatment with bismuth salts or antibiotics within 1 month before study enrollment, and treatment with proton pump inhibitor or H2 receptor antagonist within 2 weeks before study enrollment
  4. Any disease that could jeopardize the safety of subject and their compliance in the study (e.g. serious liver disease, heart disease, kidney disease, malignant tumor or alcoholism, etc.)
  5. Previous upper gastrointestinal surgery
  6. Inability to express complaint (e.g. mental disorder, psychoneurosis, unable to cooperation, etc.)
  7. Active clinically serious infections, except for Hepatitis B virus and hepatitis C virus infection
  8. Clinically significant gastrointestinal bleeding within 4 weeks prior to start of study drug

学习计划

本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。

研究是如何设计的？

设计细节

  • 主要用途：卫生服务研究
  • 分配：随机化
  • 介入模型：并行分配
  • 屏蔽：单身的

武器和干预

参与者组/臂
干预/治疗
实验性的：Re-education group
Patients in this arm will receive a repeated instruction by telephone in terms of both calling and message at the forth, seventh, tenth day after the start of treatment.
行为的：telephone-based re-education
Patients will receive a repeated instruction by telephone in terms of both calling and message at the forth, seventh, tenth day after the start of treatment.
行为的：First education at the clinic
Patients will receive an instruction card about the drug administration at the clinic by doctors.
有源比较器：Non re-education group
Patients in this arm only received an instruction card about the drug administration at the clinic by doctors but no re-education by telephone during treatment
行为的：First education at the clinic
Patients will receive an instruction card about the drug administration at the clinic by doctors.

研究衡量的是什么？

主要结果指标

结果测量
措施说明
大体时间
Hp eradication rate
大体时间：4-6 weeks after the end of drug administration
Eradication rate is the proportion of patients with eradicated-Hp. Hp infection was considered eradicated when negative results were obtained by 13carbon urea breath test at 4-6 weeks after the end of drug administration
4-6 weeks after the end of drug administration

次要结果测量

结果测量
措施说明
大体时间
Symptoms relief rate
大体时间：4-6 weeks after the end of drug administration
The symptoms were recorded according to Gastrointestinal Symptom Rating Scale.
4-6 weeks after the end of drug administration
Adverse events
大体时间：4-6 weeks after the end of drug administration
The terms and grade of adverse events will be presented according to the Common Terminology Criteria for Adverse Events (CTCAE: version 4.0)
4-6 weeks after the end of drug administration

合作者和调查者

在这里您可以找到参与这项研究的人员和组织。

赞助

First Affiliated Hospital Xi'an Jiaotong University

调查人员

  • 首席研究员：Shuixiang He, MD, PhD、First Affiliated Hospital Xi'an Jiaotong University

出版物和有用的链接

负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。

一般刊物

研究记录日期

这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。

研究主要日期

学习开始 (实际的)

2017年10月18日

初级完成 (实际的)

2018年3月30日

研究完成 (实际的)

2018年3月30日

研究注册日期

首次提交

2017年6月17日

首先提交符合 QC 标准的

2017年6月17日

首次发布 (实际的)

2017年6月20日

研究记录更新

最后更新发布 (实际的)

2018年5月30日

上次提交的符合 QC 标准的更新

2018年5月28日

最后验证

2018年5月1日

更多信息

与本研究相关的术语

关键字

其他研究编号

  • XAJTU-DG001

计划个人参与者数据 (IPD)

计划共享个人参与者数据 (IPD)？

不

药物和器械信息、研究文件

研究美国 FDA 监管的药品

不

研究美国 FDA 监管的设备产品

不

此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.

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