Oculocardiac Reflex Brain Wave Monitor (OCRBIS)
The Oculocardiac Reflex Influenced at Different Levels of Brain Wave Monitoring
Oculocardiac reflex during routine strabismus surgery was prospectively observed in association with routine brain wave monitoring.
Providence Hospital institutional review board (IRB) approved this observational study without need for consent.
研究概览
详细说明
Introduction: The oculocardiac reflex (OCR), bradycardia that occurs during strabismus surgery, is blocked by anticholinergics and enhanced by opioids and dexmedetomidine. Two recent studies suggest that deeper inhalational anesthesia monitored by bispectral index (BIS) protects against OCR; the investigators wondered if our data correlated similarly.
Methods: In an ongoing, prospective study of OCR elicited by 10-second, 200 gram square-wave traction on extraocular muscles (EOM) from 2009 to 2013, anesthetic depth was estimated in cohorts using either BIS or Narcotrend monitors. The depth of anesthesia was deliberately varied between first and second EOM tested.
研究类型
注册 (实际的)
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- all
Exclusion Criteria:
- those receiving anticholinergic medications
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
BIS
Monitored with BIS (bispectral index) monitor in addition to other conventional monitors of blood pressure, ECG, oxygen saturation and anesthetic agent concentration.
|
cutaneous EEG monitor
其他名称：
|
|
Narcotrend
Monitored with Narcotrend monitor in addition to other conventional monitors of blood pressure, ECG, oxygen saturation and anesthetic agent concentration.
|
cutaneous EEG monitor
其他名称：
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
heart rate change
大体时间：intraoperative 10 seconds
|
bradycardia with extra ocular muscle tension
|
intraoperative 10 seconds
|
合作者和调查者
调查人员
- 首席研究员：Robert W Arnold, MD、Alaska Childrens EYE & Strabismus
出版物和有用的链接
一般刊物
- Arnold RW, Bond AN, McCall M, Lunoe L. The oculocardiac reflex and depth of anesthesia measured by brain wave. BMC Anesthesiol. 2019 Mar 14;19(1):36. doi: 10.1186/s12871-019-0712-z.
- Arnold RW, Biggs RE, Beerle BJ. Intravenous dexmedetomidine augments the oculocardiac reflex. J AAPOS. 2018 Jun;22(3):211-213.e1. doi: 10.1016/j.jaapos.2018.01.016. Epub 2018 May 5.
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
non-invasive monitor的临床试验
-
Centre Hospitalier Universitaire de Nice撤销
-
Medtronic Cardiac Rhythm and Heart Failure完全的
-
Children's Mercy Hospital Kansas CityGabi SmartCare完全的