The Link Between Mental Imagery and the Reduction of Fear in Imaginal Extinction
2019年10月31日 更新者：Uppsala University
Imaginal exposure is a widely used psychological treatment technique.
Imaginal extinction is an experimental analogue of imaginal exposure, that allows the study of this treatment technique under controlled circumstances (Agren, Björkstrand, & Fredrikson, 2017).
During imaginal extinction, experimentally induced fear is diminished through repeated exposure to mental imagery of the feared (conditioned) stimulus.
However, it is not known to what extent fear reduction depends on the mental imagery produced during this procedure.
A better understanding of the mechanisms driving the effects of imaginal exposure and the factors moderating fear reduction could have significant clinical utility, by suggesting mechanistically informed ways to improve this treatment.
研究概览
详细说明
The study takes part over three consecutive days, with fear conditioning to visual stimuli on day 1, imaginal extinction on day 2, and a fear reinstatement procedure, again to visual stimuli, on day 3. Skin conductance is used to measure fear responses.
Participants' are randomized to receive conditioning, extinction and reinstatement with either complex or simple stimuli. During imaginal extinction, imagery of each experimental stimulus is prompted through different verbal instructions.
研究类型
介入性
注册 (实际的)
60
阶段
- 不适用
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习地点
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Uppsala、瑞典
- Uppsala University, Departement of Psychology
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参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 及以上 (成人、年长者)
接受健康志愿者
是的
有资格学习的性别
全部
描述
Inclusion Criteria:
Age 18 or over
Fluent in Swedish
Willing and able to provide informed consent and complete study procedures
Exclusion Criteria:
Current psychiatric disorder
Use of psychotropic medication within 6 months prior to study start
Receiving psychological treatment within 6 months prior to study start
Current neurological condition
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：基础科学
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的：Simple stimuli
Two perceptually simple stimuli are used during all experimental phases (geometrical figures).
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Day 1. Participants are exposed to two different visual stimuli.
One of these stimuli is paired with a mild electric shock (i.e.
conditioned stimuli).
Day 2 (24 hours after Day 1).
Participants are exposed to mental imagery of the stimuli used during fear conditioning.
Imagery is prompted through different verbal instructions presented in a pseudo-randomized order.
No shocks are delivered.
Prior to imaginal extinction, participants receive task specific training.
Day 3 (48 h after day1).
Participants are exposed to the same stimuli used during fear conditioning (day 1) and imaginal extinction (day 2).
Two unsignaled shocks are delivered at the beginning of the experiment, prior to the presentation of the first visual stimulus.
No further shocks are delivered.
This procedure allows the study of long term effects of imaginal extinction.
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实验性的：Complex stimuli
Two complex stimuli are used in all experimental phases.
Stimuli consist of photographs of real objects of the same size and shape as the simple stimuli, but include perceptually more complex patterns, details and colors.
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Day 1. Participants are exposed to two different visual stimuli.
One of these stimuli is paired with a mild electric shock (i.e.
conditioned stimuli).
Day 2 (24 hours after Day 1).
Participants are exposed to mental imagery of the stimuli used during fear conditioning.
Imagery is prompted through different verbal instructions presented in a pseudo-randomized order.
No shocks are delivered.
Prior to imaginal extinction, participants receive task specific training.
Day 3 (48 h after day1).
Participants are exposed to the same stimuli used during fear conditioning (day 1) and imaginal extinction (day 2).
Two unsignaled shocks are delivered at the beginning of the experiment, prior to the presentation of the first visual stimulus.
No further shocks are delivered.
This procedure allows the study of long term effects of imaginal extinction.
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研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Skin conductance response (SCR)
大体时间：Day 1
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SCR is used as a measure of physiological fear responses.
Differences in fear responses are used to assess fear learning during fear acquisition and to explore main effects and interactions between fear learning, stimulus complexity and capacity for mental imagery.
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Day 1
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Skin conductance response (SCR)
大体时间：Day 2 (24 h after day1)
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SCR is used as a measure of physiological fear responses.Differences in fear responses are used to assess fear reduction during imaginal extinction, and to explore main effects and interactions between fear reduction, stimulus complexity and capacity for mental imagery.
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Day 2 (24 h after day1)
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Skin conductance response (SCR)
大体时间：Day 3 (48 h after day 1)
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SCR is used as a measure of physiological fear responses.Differences in fear response are used to assess return of fear during reinstatement, and to explore main effects and interactions between return of fear, stimulus complexity and capacity for mental imagery.
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Day 3 (48 h after day 1)
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
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Fear ratings
大体时间：Day 1
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Ratings of subjective fear during the experimental procedure.
Scale: 0 -100 (no fear at all - extreme fear)
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Day 1
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State-Trait Anxiety Inventory
大体时间：Day 1
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This is a self-rated questionnaire measuring trait anxiety.
Higher scores indicate higher level of trait-anxiety (range 20-80)
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Day 1
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Difficulties in emotion regulation scale
大体时间：Day 1
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This is a self-rated questionnaire measuring difficulties in emotion regulation.
Higher scores indicate higher level of difficulties in emotion regulation (range 36-180)
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Day 1
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Fear ratings
大体时间：Day 2 (24 h after day 1)
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Ratings of subjective fear during the experimental procedure.
Scale: 0 -100 (no fear at all - extreme fear)
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Day 2 (24 h after day 1)
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Vividness of mental imagery during imaginal extinction
大体时间：Day 2 (24 h after day 1)
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Scale: 1-5; no image at all - image as clear and vivid as real life
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Day 2 (24 h after day 1)
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The Plymouth Sensory Imagery Questionnaire
大体时间：Day 2 (24 h after day 1)
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This is a self-rated questionnaire measuring vividness of mental imagery across different sensory modalities.
Higher scores indicate higher level of vividness.
(range 0-70)
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Day 2 (24 h after day 1)
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The Vividness of Visual Imagery Questionnaire
大体时间：Day 2 (24 h after day 1)
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This is a self-rated questionnaire measuring vividness of visual mental imagery.
Only eyes open section is administered.
Higher scores indicate higher level of vividness (range 0-80)
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Day 2 (24 h after day 1)
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Spontaneous use of imagery scale
大体时间：Day 2 (24 h after day 1)
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This is a self-rated questionnaire measuring spontaneous use of imagery.
Higher scores higher levels use of spontaneous use of imagery (range 12- 60)
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Day 2 (24 h after day 1)
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Expectancy ratings
大体时间：Day 2 (24 h after day 1)
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After the imaginal extinction procedure, participants are asked to rate to what extent they believed that electric shocks would be delivered during the procedure on a scale ranging from 0 - 100 %
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Day 2 (24 h after day 1)
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Fear ratings
大体时间：Day 3 (48 h after day 1)
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Ratings of subjective fear during the experimental procedure.
Scale: 0 -100 (no fear at all - extreme fear)
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Day 3 (48 h after day 1)
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Expectancy ratings
大体时间：Day 3 (48 h after day 1)
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After the reinstatement procedure, participants are asked to rate to what extent they believed that electric shocks would be delivered during the procedure on a scale ranging from 0 - 100 %
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Day 3 (48 h after day 1)
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其他结果措施
结果测量 |
措施说明 |
大体时间 |
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Task compliance
大体时间：Day 1
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Questions asking participants to rate to what extent they followed the instructions during the experimental procedure on a scale ranging from 0 - 100 %.
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Day 1
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Task compliance
大体时间：Day 2 (24 h after day 1)
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Questions asking participants to rate to what extent they followed the instructions during the experimental procedure on a scale ranging from 0 - 100 %.
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Day 2 (24 h after day 1)
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Task compliance
大体时间：Day 3 (48 h after day 1)
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Questions asking participants to rate to what extent they followed the instructions during the experimental procedure on a scale ranging from 0 - 100 %.
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Day 3 (48 h after day 1)
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合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2019年2月25日
初级完成 (实际的)
2019年10月30日
研究完成 (实际的)
2019年10月30日
研究注册日期
首次提交
2019年6月13日
首先提交符合 QC 标准的
2019年6月13日
首次发布 (实际的)
2019年6月18日
研究记录更新
最后更新发布 (实际的)
2019年11月4日
上次提交的符合 QC 标准的更新
2019年10月31日
最后验证
2019年10月1日
更多信息
与本研究相关的术语
其他研究编号
- 2019-00524
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
是的
IPD 共享时间框架
Data will be available upon publication.
IPD 共享支持信息类型
- 研究方案
- 国际碳纤维联合会
药物和器械信息、研究文件
研究美国 FDA 监管的药品
不
研究美国 FDA 监管的设备产品
不
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.