Pre-exposure Prophylaxis: A Miracle Drug or a Moral Hazard
研究概览
详细说明
研究类型
注册 (实际的)
联系人和位置
学习地点
-
-
-
Abu Dhabi、阿拉伯联合酋长国、00000
- New York University Abu Dhabi
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- 18 years or above
- living in the London, New York, Toronto or Sydney metro area
- self-reported sex at birth is male
- reported ever having sex with a male
Exclusion Criteria:
- not meeting the inclusion criteria
学习计划
研究是如何设计的？
设计细节
队列和干预
团体/队列 |
干预/治疗 |
|---|---|
|
Respondents on PrEP
On PrEP status will be operationalized in multiple ways, and sensitivity analyses will be conducted using multiple definitions as a result of the self-reported nature of the study.
A comparison group will be constructed by matching on a variety of characteristics, when this method is applied. Most importantly, age, and STD testing frequency among others, which influence the likelihood of being on PrEP and via that avenue sexual practices, as well as the likelihood of detecting STDs (i.e., ascertainment bias). In other models adjustments will be made for these factors. |
The investigators measure self-reported PrEP status as exposure, i.e., PrEP status is not confirmed via matched medical records or any other type of information directly collected form subjects.
|
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Syphilis diagnosis
大体时间：All diagnosis data is collected in a time-stamped fashion between January 2015 and December 2019; diagnosis is reported within the year, but not in a specific month/day
|
Self-reported diagnosis of syphilis
|
All diagnosis data is collected in a time-stamped fashion between January 2015 and December 2019; diagnosis is reported within the year, but not in a specific month/day
|
|
Chlamydia diagnosis
大体时间：All diagnosis data is collected in a time-stamped fashion between January 2015 and December 2019; diagnosis is reported within the year, but not in a specific month/day
|
Self-reported diagnosis of chlamydia
|
All diagnosis data is collected in a time-stamped fashion between January 2015 and December 2019; diagnosis is reported within the year, but not in a specific month/day
|
|
Gonorrhea diagnosis
大体时间：All diagnosis data is collected in a time-stamped fashion between January 2015 and December 2019; diagnosis is reported within the year, but not in a specific month/day
|
Self-reported diagnosis of gonorrhea
|
All diagnosis data is collected in a time-stamped fashion between January 2015 and December 2019; diagnosis is reported within the year, but not in a specific month/day
|
|
Sexually transmitted diseases
大体时间：All diagnosis data is collected in a time-stamped fashion between January 2015 and December 2019; diagnosis is reported within the year, but not in a specific month/day
|
Self-reported diagnosis of any STD
|
All diagnosis data is collected in a time-stamped fashion between January 2015 and December 2019; diagnosis is reported within the year, but not in a specific month/day
|
|
Percent of time that condoms were used in sexual intercourse
大体时间：12 months
|
Self-reported condom adherence
|
12 months
|
|
Number of ongoing sexual relationships
大体时间：Through study completion, approximately 2 months
|
Self-reported number of concurrent sexual partners
|
Through study completion, approximately 2 months
|
|
Number of sexual partners over the past 12 months
大体时间：12 months
|
Self-reported number of sexual partners over the past 12 months
|
12 months
|
|
Selecting a potential date with many recent partners
大体时间：Through study completion, approximately 2 months
|
The likelihood of selecting a potential date with 6 or more recent sexual partners in the conjoint experiment. Both AMCEs (average marginal component effects) and marginal means will be computed, see statistical analysis plan. As part of a conjoint experiment the investigators expose participants to a partner selection task. The attributes in the experiment and possible attribute values can be seen below: Race/ethnicity: White/Black/Asian Education: High school/Undergraduate degree/Graduate degree Number of sexual partners (past 3 months): 1/2-5 partners/6 or more Recreational drug use: Never/Sometimes/Often Seeking a...: Committed relationship/Casual relationship Use of condoms: Occasional/Frequent |
Through study completion, approximately 2 months
|
|
Selecting a potential date with frequent recreational drug use
大体时间：Through study completion, approximately 2 months
|
The likelihood of selecting a potential date with frequent recreational drug use in the conjoint experiment. Both AMCEs (average marginal component effects) and marginal means will be computed, see statistical analysis plan. As part of a conjoint experiment the investigators expose participants to a partner selection task. The attributes in the experiment and possible attribute values can be seen below: Race/ethnicity: White/Black/Asian Education: High school/Undergraduate degree/Graduate degree Number of sexual partners (past 3 months): 1/2-5 partners/6 or more Recreational drug use: Never/Sometimes/Often Seeking a...: Committed relationship/Casual relationship Use of condoms: Occasional/Frequent |
Through study completion, approximately 2 months
|
|
Selecting a potential date with occasional condom adherence
大体时间：Through study completion, approximately 2 months
|
The likelihood of selecting a potential date with occasional condom use in the conjoint experiment. Both AMCEs (average marginal component effects) and marginal means will be computed, see statistical analysis plan. As part of a conjoint experiment the investigators expose participants to a partner selection task. The attributes in the experiment and possible attribute values can be seen below: Race/ethnicity: White/Black/Asian Education: High school/Undergraduate degree/Graduate degree Number of sexual partners (past 3 months): 1/2-5 partners/6 or more Recreational drug use: Never/Sometimes/Often Seeking a...: Committed relationship/Casual relationship Use of condoms: Occasional/Frequent |
Through study completion, approximately 2 months
|
其他结果措施
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
The likelihood at which a respondent would engage a partner in casual sex with without using condoms
大体时间：Through study completion, approximately 2 months
|
This is collected as a follow-up question for each profile in the conjoint experiment as detailed above
|
Through study completion, approximately 2 months
|
合作者和调查者
调查人员
- 首席研究员：Kinga R Makovi, PhD、New York University Abu Dhabi
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.
PrEP的临床试验
-
Hilary L Surratt, PhDNational Institute on Drug Abuse (NIDA)完全的
-
Fred Hutchinson Cancer CenterKenya Medical Research Institute; Jhpiego招聘中
-
University of WashingtonKenyatta National Hospital; Fogarty International Center of the National Institute of Health主动，不招人
-
University of Illinois at ChicagoNational Institute of Nursing Research (NINR)招聘中
-
University of California, San FranciscoNational Institute of Nursing Research (NINR); San Francisco Department of Public Health完全的
-
University of WashingtonNational Institute of Allergy and Infectious Diseases (NIAID); Kenyatta National Hospital完全的
-
University of Massachusetts, WorcesterEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); Wayne... 和其他合作者招聘中