糖尿病多神经病患者血管变化的低水平激光与经皮神经刺激

实验性的：低水平激光器

患者将接受低水平激光器，用两个波长可见的630 nm和接近红外810 nm接近每英尺的810 nm近810 nm，持续15分钟2个月

设备：低水平激光器

低水平激光组的患者将在脉冲模式下以35 Hz的频率，100 MW的峰值和5 mm的斑点直径为单位，并在脉冲模式下可见和接近红色的激光辐射。 15分钟的课程每周进行3次，共导两个月，每个激光的功率密度为0.35 mW/cm2，能量密度为32.08 j/cm2。

有源比较器：Transcutaneous auricular Vagus nerve stimulation

Patients will receive 30 minutes Transcutaneous auricular Vagus nerve stimulation 3 sessions per week for 2 months.

设备：经肌迷走神经刺激

患者将接受30分钟的经皮神经刺激2个月，每周进行5次疗程。 抗凝脂杆和Cymba Concha将用75％的酒精进行灭菌，并将附着电极。 设备参数包括0.2 ms±30％的波宽度，脉冲频率为20 Hz，逐渐增加强度为可耐受强度（4-6 mA），持续时间为30分钟。

assessment of change of vascular blood flow

The study uses Duplex Doppler ultrasound to assess vascular changes in the posterior tibial and anterior tibial, assessing anteroposterior diameter, Tunica intima thickness, and resistive index and peak systolic velocity using a variable frequency range.

评估神经性疼痛的变化

Douleur Neuropathique EN 4（DN4）是一份筛查问卷，包括面试问题和物理测试，以识别可能的神经性疼痛。 它具有高测试和评估者间的可靠性，ICC为0.8，Cohen的Kappa为0.8。 总分计算为10个项目的总和。 分数_ 4超出10，表明可能是神经性疼痛。

Assessment of change of Quality of life

The 12-Item Short Form Health Survey is a validated instrument used to assess health-related quality of life in clinical and research settings. It evaluates both physical and mental health through 12 questions derived from the short form-36 questionnaire, covering domains such as physical functioning, pain, general health, vitality, social functioning, and emotional well-being. The questionnaire generates two summary scores: the Physical Component Summary and the Mental Component Summary. Scoring is based on weighted responses to each item, with scores transformed to a standardized scale ranging from 0 to 100, where higher scores indicate better health status and quality of life. Due to its brevity, reliability, and ease of administration, the short form-12 is widely used for rapid assessment of overall patient health outcomes.