Iressa Versus Docetaxel (Taxotere)

May 12, 2011 updated by: AstraZeneca

A Randomized, Open-Label, Parallel Group, International, Multicenter, Phase III Study of Oral ZD1839 (IRESSA®) Versus Intravenous Docetaxel (TAXOTERE®) in Patients With Locally Advanced or Metastatic Recurrent Non-Small Cell Lung Cancer Who Have Previously Received Platinum-Based Chemotherapy

The purpose of this study is to compare the effects of ZD1839 or docetaxel in patients with advanced non-small cell lung cancer (NSCLC) that has recurred or progressed after receiving prior treatment with platinum-based chemotherapy.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Completed

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
1440

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Argentina
      • Buenos Aires, Argentina
        • Research Site
      • Cordoba, Argentina
        • Research Site
      • El Palomar, Argentina
        • Research Site
      • Mar del Plata, Argentina
        • Research Site
      • Quilmes, Argentina
        • Research Site
      • Rosario, Argentina
        • Research Site
      • San Miguel de Tucuman, Argentina
        • Research Site
      • Santa Fe, Argentina
        • Research Site
  • Belgium
      • Charleroi, Belgium
        • Research Site
      • Edegem, Belgium
        • Research Site
      • Genk, Belgium
        • Research Site
      • Godinne, Belgium
        • Research Site
      • Kortrijk, Belgium
        • Research Site
      • Leuven, Belgium
        • Research Site
      • Liège, Belgium
        • Research Site
      • Yvoir, Belgium
        • Research Site
  • Brazil
    • RJ
      • Rio de Janeiro, RJ, Brazil
        • Research Site
    • RS
      • Porto Alegre, RS, Brazil
        • Research Site
    • SP
      • Sao Paulo, SP, Brazil
        • Research Site
  • Canada
    • Alberta
      • Edmonton, Alberta, Canada
        • Research Site
    • British Columbia
      • Surrey, British Columbia, Canada
        • Research Site
    • New Brunswick
      • Moncton, New Brunswick, Canada
        • Research Site
    • Nova Scotia
      • Halifax, Nova Scotia, Canada
        • Research Site
    • Ontario
      • Hamilton, Ontario, Canada
        • Research Site
      • London, Ontario, Canada
        • Research Site
      • Newmarket, Ontario, Canada
        • Research Site
      • St. Catherines, Ontario, Canada
        • Research Site
      • Sudbury, Ontario, Canada
        • Research Site
      • Toronto, Ontario, Canada
        • Research Site
      • York, Ontario, Canada
        • Research Site
    • Quebec
      • Laval, Quebec, Canada
        • Research Site
      • Montreal, Quebec, Canada
        • Research Site
      • Ste-Foy, Quebec, Canada
        • Research Site
  • China
      • Beijing, China
        • Research Site
      • Guangzhou, China
        • Research Site
      • Shanghai, China
        • Research Site
  • Croatia
      • Split, Croatia
        • Research Site
      • Zagreb, Croatia
        • Research Site
  • Denmark
      • Aalborg, Denmark
        • Research Site
      • Arhus C, Denmark
        • Research Site
      • Glostrup, Denmark
        • Research Site
      • Herlev, Denmark
        • Research Site
      • København Ø, Denmark
        • Research Site
      • Vejle, Denmark
        • Research Site
  • Estonia
      • Tallinn, Estonia
        • Research Site
      • Tartu, Estonia
        • Research Site
  • France
      • Blois, France
        • Research Site
      • Boulogne Billancourt, France
        • Research Site
      • Caen Cedex, France
        • Research Site
      • Grenoble Cedex 09, France
        • Research Site
      • Le Mans, France
        • Research Site
      • Lille Cedex, France
        • Research Site
      • Nantes, France
        • Research Site
      • Niort, France
        • Research Site
      • Saint Herblain, France
        • Research Site
      • Vandoeuvre Les Nancy, France
        • Research Site
      • Vesoul Cedex, France
        • Research Site
  • Germany
      • Berlin, Germany
        • Research Site
      • Bonn, Germany
        • Research Site
      • Großhansdorf, Germany
        • Research Site
      • Köln, Germany
        • Research Site
      • Leverkusen, Germany
        • Research Site
      • Löwenstein, Germany
        • Research Site
      • Mannheim, Germany
        • Research Site
      • München, Germany
        • Research Site
      • Stuttgart, Germany
        • Research Site
      • Wiesbaden, Germany
        • Research Site
    • Baden-Württemberg
      • Heidelberg, Baden-Württemberg, Germany
        • Research Site
      • Ulm, Baden-Württemberg, Germany
        • Research Site
    • Brandenburg
      • Cottbus, Brandenburg, Germany
        • Research Site
    • Hessen
      • Frankfurt, Hessen, Germany
        • Research Site
    • Nordrhein-Westfalen
      • Düsseldorf, Nordrhein-Westfalen, Germany
        • Research Site
    • Rheinland-Pfalz
      • Mainz, Rheinland-Pfalz, Germany
        • Research Site
    • Schleswig-Holstein
      • Bad Segeberg, Schleswig-Holstein, Germany
        • Research Site
  • Hong Kong
      • Hong Kong, Hong Kong
        • Research Site
  • Indonesia
      • Jakarta, Indonesia
        • Research Site
      • Yogyakarta, Indonesia
        • Research Site
  • Italy
      • Napoli, Italy
        • Research Site
      • Roma, Italy
        • Research Site
    • Ancona
      • La Torretta, Ancona, Italy
        • Research Site
    • BA
      • Bari, BA, Italy
        • Research Site
    • BG
      • Bergamo, BG, Italy
        • Research Site
    • BO
      • Bologna, BO, Italy
        • Research Site
    • CN
      • Cuneo, CN, Italy
        • Research Site
    • CT
      • Catania, CT, Italy
        • Research Site
    • FO
      • Forli', FO, Italy
        • Research Site
    • MI
      • Melegnano, MI, Italy
        • Research Site
      • Rozzano, MI, Italy
        • Research Site
    • MO
      • Modena, MO, Italy
        • Research Site
    • PR
      • Parma, PR, Italy
        • Research Site
    • TO
      • Torino, TO, Italy
        • Research Site
  • Latvia
      • Riga, Latvia
        • Research Site
  • Malaysia
      • Kuala Lumpur, Malaysia
        • Research Site
      • Nilai, Malaysia
        • Research Site
  • Mexico
      • Guadalajara, Mexico
        • Research Site
      • Monterrey, Mexico
        • Research Site
      • Morelia, Mexico
        • Research Site
      • Torreon, Mexico
        • Research Site
  • Philippines
      • Manila, Philippines
        • Research Site
      • Quezon City, Philippines
        • Research Site
  • Singapore
      • Singapore, Singapore
        • Research Site
  • Slovenia
      • Ljubliana, Slovenia
        • Research Site
  • Spain
      • Barcelona, Spain
        • Research Site
      • Gerona, Spain
        • Research Site
      • Madrid, Spain
        • Research Site
      • Málaga, Spain
        • Research Site
      • Sevilla, Spain
        • Research Site
      • Valencia, Spain
        • Research Site
      • Vitoria, Spain
        • Research Site
      • Zaragoza, Spain
        • Research Site
    • Alicante
      • Elche, Alicante, Spain
        • Research Site
  • Sweden
      • Goteborg, Sweden
        • Research Site
      • Luleå, Sweden
        • Research Site
      • Skövde, Sweden
        • Research Site
      • Stockholm, Sweden
        • Research Site
      • Sundsvall, Sweden
        • Research Site
      • Umeå, Sweden
        • Research Site
      • Vasteras, Sweden
        • Research Site
      • Örebro, Sweden
        • Research Site
      • Östersund, Sweden
        • Research Site
  • Switzerland
      • Bellinzona, Switzerland
        • Research Site
      • St. Gallen, Switzerland
        • Research Site
      • Zürich, Switzerland
        • Research Site
  • Thailand
      • Chiang Mai, Thailand
        • Research Site
  • Turkey
      • Ankara, Turkey
        • Research Site
      • Istanbul, Turkey
        • Research Site
      • Izmir, Turkey
        • Research Site
  • United States
    • Alabama
      • Birmingham, Alabama, United States
        • Research Site
    • California
      • Fountain Valley, California, United States
        • Research Site
      • Los Angeles, California, United States, 90048
        • Research Site
      • Santa Rosa, California, United States
        • Research Site
      • Stockton, California, United States, 95204
        • Research Site
    • Colorado
      • Colorado Springs, Colorado, United States
        • Research Site
    • Connecticut
      • Norwich, Connecticut, United States
        • Research Site
    • Delaware
      • Newark, Delaware, United States
        • Research Site
    • Florida
      • Boca Raton, Florida, United States
        • Research Site
      • Orlando, Florida, United States, 32806
        • Research Site
    • Georgia
      • Macon, Georgia, United States
        • Research Site
      • Tucker, Georgia, United States
        • Research Site
    • Illinois
      • Skokie, Illinois, United States, 60077
        • Research Site
    • Kentucky
      • Knoxville, Kentucky, United States
        • Research Site
    • Minnesota
      • St. Louis Park, Minnesota, United States
        • Research Site
    • New York
      • Great Neck, New York, United States, 11021
        • Research Site
      • Rochester, New York, United States, 14621
        • Research Site
      • Syracuse, New York, United States, 13210
        • Research Site
    • North Carolina
      • Chapel Hill, North Carolina, United States, 27599
        • Research Site
      • Charlotte, North Carolina, United States
        • Research Site
      • Durham, North Carolina, United States, 27710
        • Research Site
    • Ohio
      • Cleveland, Ohio, United States, 44195
        • Research Site
    • Oregon
      • Portland, Oregon, United States
        • Research Site
    • Pennsylvania
      • Philadelphia, Pennsylvania, United States
        • Research Site
      • Pittsburgh, Pennsylvania, United States
        • Research Site
    • South Carolina
      • Columbia, South Carolina, United States
        • Research Site
    • Tennessee
      • Nashville, Tennessee, United States
        • Research Site
    • Texas
      • Austin, Texas, United States
        • Research Site
      • Dallas, Texas, United States
        • Research Site
      • Houston, Texas, United States, 77030-4009
        • Research Site
      • Tyler, Texas, United States
        • Research Site
    • Utah
      • Salt Lake City, Utah, United States
        • Research Site
    • Virginia
      • Fairfax, Virginia, United States
        • Research Site
    • Washington
      • Seattle, Washington, United States
        • Research Site
    • Wisconsin
      • Racine, Wisconsin, United States
        • Research Site

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Measurable (uni dimensional) disease by RECIST criteria in a lesion not previously irradiated or non measurable disease
  • Locally advanced or metastatic NSCLC, not amenable to curative surgery or radiotherapy
  • Advanced non-small cell lung cancer (NSCLC) that has recurred or progressed after receiving prior treatment with platinum-based chemotherapy
  • WHO performance status (PS) 0-2
  • Absolute Neutrophil Count (ANC) >1.5 x 109/liter (L) and platelets >100 x 109/L
  • Life expectancy of at least 8 weeks

Exclusion Criteria:

  • Prior ZD1839 therapy
  • Prior docetaxel treatment for NSCLC
  • Less than 14 days since completion of prior radiotherapy
  • Less than 21 days since prior chemotherapy, immunotherapy or biological systemic anticancer therapy
  • Evidence of clinically active Interstitial Lung Disease
  • Other co-existing malignancies or malignancies diagnosed within the last 5 years with the exception of basal cell carcinoma or cervical cancer in situ
  • Newly diagnosed CNS metastases that have not yet been treated with surgery and/or radiation. Patients with previously diagnosed and treated CNS metastases or spinal cord compression may be considered if they have evidence of clinically SD (no steroid therapy or steroid dose being tapered) for at least 28 days
  • Patients with pre existing peripheral neuropathy >= grade 2 (NCI CTC criteria)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
To compare overall survival between ZD1839 and docetaxel

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
To compare time to progression (TTP) between ZD1839 and docetaxel
To compare progression-free rates at 4 months and 6 months between ZD1839 and docetaxel
To compare the overall objective tumor response rate between ZD1839 and docetaxel
To compare patient-reported functionality (PRF) and quality of life (QoL) between ZD1839 and docetaxel
To compare safety and tolerability of ZD1839 and docetaxel

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
AstraZeneca

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Study Director: AstraZeneca Iressa Medical Science Director, MD, AstraZeneca

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
February 1, 2004

Primary Completion (Actual)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
March 1, 2007

Study Completion (Actual)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
October 1, 2007

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
January 21, 2004

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
January 22, 2004

First Posted (Estimate)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
January 23, 2004

Study Record Updates

Last Update Posted (Estimate)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
May 13, 2011

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
May 12, 2011

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
May 1, 2011

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • D791GC00001
  • EudraCT No: 2004-002943-28
  • 1839IL/0721

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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