Investigating the Effect of 4-week Omega-3 Polyunsaturated Fatty Acid Supplementation on Inflammation (STC)

July 5, 2017 updated by: Bethan Hussey

Investigate the in vivo effects of n-3 PUFA supplementation on inflammation, gene expression and epigenetic signatures.

Ex vivo stimulation of peripheral blood mononuclear cells (PBMCs) collected pre and post n-3 supplementation and measurement of it's effect on inflammation, gene expression and epigenetic signatures.

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Unknown

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Interventional

Enrollment (Actual)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
17

Phase

Phase

The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioral interventions.
  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

18 years to 30 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Healthy males
  • Aged between 18 and 30 years

Exclusion Criteria:

  • Females (Due to differences in cell membrane incorporation of n-3 PUFAs between the sexes and the testing schedule being unable to fit in with menstrual cycle, therefore altering the blood markers that are being measured).
  • Aged below 18 or above 30.
  • Body mass index (BMI; in kg/ m2), below 18 or above 30.
  • Use of vitamin or fish oil supplements in the last 6 months.
  • High habitual oily fish consumption (<4 servings per month).
  • Smoking.
  • Changes in weight in the past 6 months (Dieting) or planning on changing dietary habits.
  • Habitual use of anti-inflammatory drugs.
  • Self-reported history of diabetes.
  • History of heart disease, coagulation/bleeding disorders, metabolic disease or Serious allergy.
  • Known to have blood-borne virus.
  • Receipt of inoculations within 2 months of starting the study or the intention to receive such during the study.
  • Donation of or intention to donate blood within 8 weeks of the first sample or at any point during the intervention.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm

Participant Group / Arm

A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.
Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.
Experimental: Supplementation
Omega-3 Polyunsaturated Fatty Acids
Dietary supplement: Omega-3 Polyunsaturated Fatty Acids Supplementation
28 days of a commercially available supplement. 4 capsules per day.
Other Names:
  • OmegaVia Pharmaceutical Grade Omega-3

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Epigenetic regulation of Cytokine Genes
Time Frame: Change from Baseline at 7, 14, 21 and 28 days
Blood Sample
Change from Baseline at 7, 14, 21 and 28 days

Secondary Outcome Measures

Secondary Outcome Measures

In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure.
Outcome Measure
Measure Description
Time Frame
Total Cholesterol
Time Frame: Baseline, 7, 14, 21 and 28 days
Biochemical variable
Baseline, 7, 14, 21 and 28 days
LDL (Low density lipoprotein)
Time Frame: Baseline, 7, 14, 21 and 28 days
Biochemical variable
Baseline, 7, 14, 21 and 28 days
HDL (High density lipoprotein)
Time Frame: Baseline, 7, 14, 21 and 28 days
Biochemical variable
Baseline, 7, 14, 21 and 28 days
Triglycerides
Time Frame: Baseline, 7, 14, 21 and 28 days
Biochemical variable
Baseline, 7, 14, 21 and 28 days
Fasting Glucose
Time Frame: Baseline, 7, 14, 21 and 28 days
Biochemical variable
Baseline, 7, 14, 21 and 28 days
Full Blood Count
Time Frame: Baseline, 7, 14, 21 and 28 days
Biochemical variable
Baseline, 7, 14, 21 and 28 days
Height
Time Frame: Baseline, 7, 14, 21 and 28 days
Standard Anthropometric Variables
Baseline, 7, 14, 21 and 28 days
Weight
Time Frame: Baseline, 7, 14, 21 and 28 days
Standard Anthropometric Variables
Baseline, 7, 14, 21 and 28 days
Hip Circumference
Time Frame: Baseline, 7, 14, 21 and 28 days
Standard Anthropometric Variables
Baseline, 7, 14, 21 and 28 days
Waist Circumference
Time Frame: Baseline, 7, 14, 21 and 28 days
Standard Anthropometric Variables
Baseline, 7, 14, 21 and 28 days
Systolic and Diastolic Blood Pressure
Time Frame: Baseline, 7, 14, 21 and 28 days
Standard Anthropometric Variables
Baseline, 7, 14, 21 and 28 days
Heart rate
Time Frame: Baseline, 7, 14, 21 and 28 days
Standard Anthropometric Variables
Baseline, 7, 14, 21 and 28 days
Food Diary
Time Frame: Baseline, 7, 14, 21 and 28 days
Self-reporting
Baseline, 7, 14, 21 and 28 days
Exercise Questionnaire
Time Frame: Baseline, 7, 14, 21 and 28 days
Questionnaire
Baseline, 7, 14, 21 and 28 days
Ethnic background
Time Frame: Baseline, 7, 14, 21 and 28 days
Questionnaire
Baseline, 7, 14, 21 and 28 days
Gene expression of Cytokine Genes
Time Frame: Baseline, 7, 14, 21 and 28 days
Extracted PBMCs
Baseline, 7, 14, 21 and 28 days
ex vivo stimulation of Human Derived Blood Cells
Time Frame: Baseline and 28 days
Extracted PBMCs
Baseline and 28 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Bethan Hussey

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
January 9, 2017

Primary Completion (Anticipated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
August 1, 2017

Study Completion (Anticipated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
January 1, 2018

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
July 4, 2017

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
July 5, 2017

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
July 7, 2017

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
July 7, 2017

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
July 5, 2017

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
July 1, 2017

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • R16-P138

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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