SMC Radiation Oncology Breast Cancer Cohort Study (RASCO)

August 6, 2026 updated by: Haeyoung Kim, Samsung Medical Center

Registry for Analysis of Impact of Radiation Dose to Skin on Cosmetic Outcome and Patient-reported Outcomes in Patients With Breast Cancer Treated With Radiation Therapy

The goal of this observational study is to learn about toxicities and cosmetic outcomes in breast cancer patients treated with hypofractionated radiotherapy.

The main question it aims to answer are:

  • Changes in breast skin
  • Factors related to breast skin changes
  • Patient-reported outcomes
  • Cosmetic outcomes

Participants will be assessed by multi-dimensional methods before and after radiotherapy:

  • Photographs
  • Fibrometer
  • Questionnaires (BREAST-Q)
  • CTCAE version 4.03 evaluated by treating physicians

Study Overview

Status

Status

Indicates the current recruitment status or the expanded access status.
Active, not recruiting

Conditions

Conditions

The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and health risks.

Intervention / Treatment

Intervention / Treatment

A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise.

Study Type

Study Type

Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.
Observational

Enrollment (Estimated)

Enrollment

The number of participants in a clinical study. The "anticipated" enrollment is the target number of participants that the researchers need for the study.
500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact

The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.

Study Contact Backup

Study Locations

  • South Korea
    • Seoul
      • Seoul, Seoul, South Korea, 06351
        • Samsung Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Eligibility Criteria

The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.

Ages Eligible for Study

18 years to 85 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Any breast cancer patients treated with curative surgery is eligible except for history of thoracic radiation therapy.

Description

Inclusion Criteria:

  • Breast cancer treated with curative surgery

Exclusion Criteria:

  • History of thoracic radiation therapy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Primary Outcome Measures

In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.
Outcome Measure
Measure Description
Time Frame
Change of cosmesis from baseline
Time Frame: After 2-3 weeks after the start of radiation therapy (During radiation therapy)
Evaluated by two blinded independent physicians based on photographs
After 2-3 weeks after the start of radiation therapy (During radiation therapy)
Change of cosmesis from baseline
Time Frame: 2-3 weeks after the completion of radiation therapy
Evaluated by two blinded independent physicians based on photographs
2-3 weeks after the completion of radiation therapy
Change of cosmesis from baseline
Time Frame: 6 months after radiation therapy
Evaluated by two blinded independent physicians based on photographs
6 months after radiation therapy
Change of cosmesis from baseline
Time Frame: 1 year after radiation therapy
Evaluated by two blinded independent physicians based on photographs
1 year after radiation therapy
Change of cosmesis from baseline
Time Frame: 2 year after radiation therapy
Evaluated by two blinded independent physicians based on photographs
2 year after radiation therapy
Change of cosmesis from baseline
Time Frame: 5 year after radiation therapy
Evaluated by two blinded independent physicians based on photographs
5 year after radiation therapy
Change of fibrosis from baseline
Time Frame: After 2-3 weeks after the start of radiation therapy (During radiation therapy)
Evaluated using fibrometer measuring both breast
After 2-3 weeks after the start of radiation therapy (During radiation therapy)
Change of fibrosis from baseline
Time Frame: 2-3 weeks after the completion of radiation therapy
Evaluated using fibrometer measuring both breast
2-3 weeks after the completion of radiation therapy
Change of fibrosis from baseline
Time Frame: 6 months after radiation therapy
Evaluated using fibrometer measuring both breast
6 months after radiation therapy
Change of fibrosis from baseline
Time Frame: 1 year after radiation therapy
Evaluated using fibrometer measuring both breast
1 year after radiation therapy
Change of fibrosis from baseline
Time Frame: 2 year after radiation therapy
Evaluated using fibrometer measuring both breast
2 year after radiation therapy
Change of fibrosis from baseline
Time Frame: 5 year after radiation therapy
Evaluated using fibrometer measuring both breast
5 year after radiation therapy
Change of patient-reported outcome from baseline
Time Frame: After 2-3 weeks after the start of radiation therapy (During radiation therapy)
BREAST-Q questionnaire is used to evaluate patient-reported outcome.
After 2-3 weeks after the start of radiation therapy (During radiation therapy)
Change of patient-reported outcome from baseline
Time Frame: 2-3 weeks after the completion of radiation therapy
BREAST-Q questionnaire is used to evaluate patient-reported outcome.
2-3 weeks after the completion of radiation therapy
Change of patient-reported outcome from baseline
Time Frame: 6 months after radiation therapy
BREAST-Q questionnaire is used to evaluate patient-reported outcome.
6 months after radiation therapy
Change of patient-reported outcome from baseline
Time Frame: 1 year after radiation therapy
BREAST-Q questionnaire is used to evaluate patient-reported outcome.
1 year after radiation therapy
Change of patient-reported outcome from baseline
Time Frame: 2 year after radiation therapy
BREAST-Q questionnaire is used to evaluate patient-reported outcome.
2 year after radiation therapy
Change of patient-reported outcome from baseline
Time Frame: 5 year after radiation therapy
BREAST-Q questionnaire is used to evaluate patient-reported outcome.
5 year after radiation therapy
Physician assessed toxicity
Time Frame: After 2-3 weeks after the start of radiation therapy
CTCAE version 4.03 is used to evaluate physician-assessed toxicities.
After 2-3 weeks after the start of radiation therapy
Physician assessed toxicity
Time Frame: 2-3 weeks after the completion of radiation therapy
CTCAE version 4.03 is used to evaluate physician-assessed toxicities.
2-3 weeks after the completion of radiation therapy
Physician assessed toxicity
Time Frame: 6 months after radiation therapy
CTCAE version 4.03 is used to evaluate physician-assessed toxicities.
6 months after radiation therapy
Physician assessed toxicity
Time Frame: 1 year after radiation therapy
CTCAE version 4.03 is used to evaluate physician-assessed toxicities.
1 year after radiation therapy
Physician assessed toxicity
Time Frame: 2 year after radiation therapy
CTCAE version 4.03 is used to evaluate physician-assessed toxicities.
2 year after radiation therapy
Physician assessed toxicity
Time Frame: 5 year after radiation therapy
CTCAE version 4.03 is used to evaluate physician-assessed toxicities.
5 year after radiation therapy

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sponsor

The organization or person who initiates the study and who has authority and control over the study.
Samsung Medical Center

Investigators

Investigators

A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator.
  • Principal Investigator: Haeyoung Kim, MD, PhD, Samsung Medical Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

Study Start

The actual date on which the first participant was enrolled in a clinical study. The "anticipated" study start date is the date that the researchers think will be the study start date.
January 1, 2021

Primary Completion (Estimated)

Primary Completion

The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "anticipated" primary completion date is the date that the researchers think will be the primary completion date for the study.
December 31, 2030

Study Completion (Estimated)

Study Completion

The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "anticipated" study completion date is the date that the researchers think will be the study completion date.
December 31, 2030

Study Registration Dates

First Submitted

First Submitted

The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date).
February 15, 2023

First Submitted That Met QC Criteria

First Submitted That Met QC Criteria

The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
March 7, 2023

First Posted (Actual)

First Posted

The date on which the study record was first available on ClinicalTrials.gov after National Library of Medicine (NLM) quality control (QC) review has concluded. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.
March 20, 2023

Study Record Updates

Last Update Posted (Actual)

Last Update Posted

The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last update posted date.
August 10, 2026

Last Update Submitted That Met QC Criteria

Last Update Submitted That Met QC Criteria

The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.
August 6, 2026

Last Verified

Last Verified

The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status is shown as unknown.
August 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Other Study ID Numbers

Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.
  • SMC 2021-05-045

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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