Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight (ENLIGHTEN-4)
A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Osteoarthritis Knee Pain, and Obesity or Overweight (ENLIGHTEN-4)
Study Overview
Status
Status
Conditions
Conditions
Intervention / Treatment
Intervention / Treatment
Study Type
Study Type
Enrollment (Estimated)
Enrollment
Phase
Phase
- Phase 3
Contacts and Locations
Study Contact
Study Contact
- Name: Physicians interested in becoming principal investigators please contact
- Email: clinical_inquiry_hub@lilly.com
Study Contact Backup
- Name: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
- Phone Number: 317-615-4559
- Email: LillyTrials@Lilly.com
Study Locations
-
-
-
Buenos Aires, Argentina, C1427CCL
- Not yet recruiting
- Centro Medico Arsema
-
Contact:
- Phone Number: 1124691447
-
Principal Investigator:
- Federico Ariel
-
Buenos Aires, Argentina, C1023AAB
- Not yet recruiting
- STAT Research S.A.
-
Principal Investigator:
- ALEJANDRO ARROYO
-
Contact:
- Phone Number: 54 9 1167063598
-
Buenos Aires, Argentina, C1015ABO
- Not yet recruiting
- Organizacion Medica de Investigacion
-
Principal Investigator:
- Patricio Tate
-
Contact:
- Phone Number: 541143720308
-
Buenos Aires, Argentina, C1014ACP
- Not yet recruiting
- CARDIAMET Investigaciones Médicas
-
Principal Investigator:
- Virginia Durigan
-
Contact:
- Phone Number: 5491169139814
-
Buenos Aires, Argentina, 1417
- Not yet recruiting
- Centro Privado de Medicina Familiar / Mindout Research
-
Contact:
- Phone Number: 541145023759
-
Principal Investigator:
- Leonardo Naftal
-
Granadero Baigorria, Argentina, 2152
- Not yet recruiting
- Centro de Investigaciones Clinicas Baigorria
-
Contact:
- Phone Number: 543415593898
-
Principal Investigator:
- Juan Escalante
-
Rosario, Argentina, 2000
- Not yet recruiting
- INECO Neurociencias Oroño
-
Contact:
- Phone Number: 3415597777
-
Principal Investigator:
- Florencia Garavelli
-
Rosario, Argentina, 2000
- Not yet recruiting
- Instituto Especialidades de la Salud Rosario
-
Contact:
- Phone Number: 341- 6011549
-
Principal Investigator:
- Julieta Gentiletti
-
SAN M. de Tucuman, Argentina, T4000AXL
- Not yet recruiting
- Centro de Investigaciones Médicas Tucuman
-
Principal Investigator:
- Walter Spindler
-
Contact:
- Phone Number: 54-9-381-5537820
-
San Fernando, Argentina, 1646
- Not yet recruiting
- Medicina Reumatológica
-
Contact:
- Phone Number: 541169956547
-
Principal Investigator:
- Maria Cusa
-
San Isidro, Argentina, 1642
- Not yet recruiting
- Instituto de Alta Complejidad San Isidro
-
Contact:
- Phone Number: 54 9 1164620494
-
Principal Investigator:
- Maria Lazaro
-
San Juan, Argentina, 5400
- Not yet recruiting
- Centro Polivalente de Asistencia e Investigación Clínica - CER San Juan
-
Contact:
- Phone Number: 2644211086
-
Principal Investigator:
- Rodolfo Pardo Hidalgo
-
San Miguel de Tucumán, Argentina, 4000
- Not yet recruiting
- Centro de Investigaciones Reumatológicas
-
Contact:
- Phone Number: 543814301098
-
Principal Investigator:
- Luciana Gonzalez Lucero
-
San Nicolás, Argentina, 2900
- Not yet recruiting
- Go Centro Medico San Nicolas
-
Contact:
- Phone Number: 5493364571637
-
Principal Investigator:
- Paulina Lanchiotti
-
-
-
-
-
Edegem, Belgium, 2650
- Recruiting
- Antwerp University Hospital
-
Contact:
- Phone Number: 3238213478
-
Principal Investigator:
- eveline dirinck
-
Genk, Belgium, 3600
- Recruiting
- Reuma Clinic, Locatie Jaarbeurslaan
-
Principal Investigator:
- Johan Vanhoof
-
Contact:
- Phone Number: 089362977
-
Ghent, Belgium, 9000
- Recruiting
- UZ Gent
-
Contact:
- Phone Number: +3293320582
-
Principal Investigator:
- Ruth Wittoek
-
Kluisbergen, Belgium, 9690
- Recruiting
- KORMONT
-
Principal Investigator:
- Klaas Vercruysse
-
Contact:
- Phone Number: 32 496 376259
-
Leuven, Belgium, 3000
- Recruiting
- UZ Leuven
-
Contact:
- Phone Number: +3216342541
-
Principal Investigator:
- Kurt de Vlam
-
Mechelen, Belgium, 2800
- Recruiting
- Meclinas
-
Contact:
- Phone Number: 003215792797
-
Principal Investigator:
- Julie Casaer
-
Merksem, Belgium, 2170
- Not yet recruiting
- ZNA Jan Palfijn
-
Contact:
- Phone Number: +326402851
-
Principal Investigator:
- Alla Ishchenko
-
Sint-Martens-Latem, Belgium, 9830
- Not yet recruiting
- Medisch Centrum Latem (Hip Clinic) - Algemeen Ziekenhuis Maria Middelares Location
-
Principal Investigator:
- Pieter Vansintjan
-
Contact:
- Phone Number: 09 220 88 68
-
-
-
-
-
Campinas, Brazil, 13060-803
- Suspended
- Centro de Pesquisa São Lucas
-
Rio de Janeiro, Brazil, 20241-180
- Suspended
- IBPClin - Instituto Brasil de Pesquisa Clínica
-
São Paulo, Brazil, 01228-000
- Suspended
- CPHosp Medicina, Ensino e Pesquisa (CPQuali)
-
São Paulo, Brazil, 04266-010
- Suspended
- CEPIC - Centro Paulista de Investigação Clínica
-
São Paulo, Brazil, 04039-002
- Suspended
- INTEGRA - Pesquisa Clínica e Infusões
-
São Paulo, Brazil, 05403-000
- Suspended
- Hospital das Clinicas FMUSP
-
-
-
-
-
Guelph, Canada, N1G 0B4
- Recruiting
- Apex Trials
-
Contact:
- Phone Number: 519-341-3367
-
Principal Investigator:
- Ken Woo
-
Québec, Canada, G1V 4T3
- Recruiting
- Diex Recherche Inc. Division Quebec
-
Principal Investigator:
- Caroline Rheaume
-
Contact:
- Phone Number: 5144773439
-
Québec, Canada, G1V 4K5
- Not yet recruiting
- G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.
-
Principal Investigator:
- Louis Bessette
-
Contact:
- Phone Number: 418 650-2661
-
Stouffville, Canada, L4A 1H2
- Recruiting
- Stouffville Medical Research Institute Inc.
-
Principal Investigator:
- Nima Mirtorabi
-
Contact:
- Phone Number: (905) 640-3100
-
Toronto, Canada, M5G 1K2
- Recruiting
- Maple Leaf Research
-
Principal Investigator:
- Mona Loutfy
-
Toronto, Canada, M9V 4B4
- Recruiting
- Dr. Anil K. Gupta Medicine Professional Corporation
-
Contact:
- Phone Number: 6473442020
-
Principal Investigator:
- Anil Gupta
-
Victoriaville, Canada, G6P 3Z8
- Recruiting
- Diex Recherche Inc. Division Victoriaville
-
Contact:
- Phone Number: 819-260-1172
-
Principal Investigator:
- Eve Betit
-
-
-
-
-
Beijing, China, 100035
- Recruiting
- Beijing Ji Shui Tan Hospital
-
Principal Investigator:
- Xiaoli Deng
-
Bengbu, China, 233004
- Recruiting
- The First Afflilated Hospital of Bengbu Medical College
-
Principal Investigator:
- Xiaoyun Fan
-
Changchun, China, 130041
- Not yet recruiting
- The Second Hospital of Jilin University
-
Principal Investigator:
- Hanqing Cai
-
Changchun, China, 130021
- Recruiting
- Jilin Province People's Hospital
-
Principal Investigator:
- Guoping Jiang
-
Changsha, China, 410008
- Recruiting
- Xiangya Hospital Central South University
-
Principal Investigator:
- Wenfeng Xiao
-
Chongqing, China, 400000
- Recruiting
- 2nd Affiliated Hospital Chongqing Medical Universi
-
Principal Investigator:
- Mao Nie
-
Hangzhou, China, 310052
- Recruiting
- The Second Affiliated Hospital of Zhejiang University School of Medicine
-
Principal Investigator:
- Haobo Wu
-
Hefei, China, 230011
- Recruiting
- The Second People's Hospital of Hefei
-
Principal Investigator:
- Jun Ye
-
Contact:
- Phone Number: 86-13956099720
-
Jinan, China, 250013
- Recruiting
- Jinan Central Hospital
-
Principal Investigator:
- Nianrong Mi
-
Luoyang, China, 471003
- Recruiting
- The First Affiliated Hospital of Henan University of Science &Technology
-
Principal Investigator:
- Xiaofei Shi
-
Contact:
- Phone Number: 86 13663884080
-
Nanjing, China, 210029
- Recruiting
- Jiangsu Province Hospital
-
Principal Investigator:
- Hongwen Zhou
-
Nanjing, China, 210009
- Recruiting
- Zhongda Hospital Southeast University
-
Principal Investigator:
- Jun Lu
-
Nanjing, China, 210011
- Recruiting
- The Second Affiliated Hospital of Nanjing Medical University
-
Principal Investigator:
- Yibing Lu
-
Contact:
- Phone Number: 18951762960
-
Nanjing, China, 210006
- Recruiting
- Nanjing First Hospital
-
Principal Investigator:
- Qian Li
-
Ningbo, China, 315010
- Recruiting
- The First Affiliated Hospital of Ningbo University
-
Principal Investigator:
- Xiudi Wu
-
Shanghai, China, 200040
- Recruiting
- Huashan Hospital, Fudan University
-
Principal Investigator:
- Yu Xue
-
Shanghai, China, 200032
- Recruiting
- Zhongshan Hospital,Fudan University
-
Principal Investigator:
- Yunchao Shao
-
Shanghai, China, 200023
- Recruiting
- Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
-
Principal Investigator:
- Jie Zhao
-
Suzhou, China, 215004
- Recruiting
- The Second Affiliated Hospital of Soochow University
-
Principal Investigator:
- Zhichun Liu
-
Tianjin, China, 300211
- Recruiting
- Tianjin Hospital
-
Principal Investigator:
- Jun Liu
-
Contact:
- Phone Number: 13389987163
-
Wenzhou, China, 315100
- Not yet recruiting
- The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
-
Contact:
- Phone Number: 13806542929
-
Principal Investigator:
- Chaoming Wu
-
Wuhan, China, 430030
- Recruiting
- Tongji Hospital Tongji Medical,Science & Technology
-
Contact:
- Phone Number: 18672912727
-
Principal Investigator:
- Lingli Dong
-
Xianyang, China, 712000
- Recruiting
- Xianyang Hospital of Yan'an University
-
Principal Investigator:
- Fang Wang
-
Contact:
- Phone Number: 18391081568
-
-
-
-
-
Brno, Czechia, 602 00
- Recruiting
- Pratia Brno
-
Contact:
- Phone Number: +420515550902
-
Principal Investigator:
- Simona Pappova
-
Brno, Czechia, 63800
- Recruiting
- Revmatologie.s.r.o.
-
Principal Investigator:
- Leona Prochazkova
-
Contact:
- Phone Number: +42545214556
-
Ostrava, Czechia, 70300
- Recruiting
- INREA s.r.o.
-
Contact:
- Phone Number: 420776153321
-
Principal Investigator:
- Martina Malcova
-
Pardubice, Czechia, 53002
- Recruiting
- Pratia Pardubice a.s.
-
Principal Investigator:
- Marcela Svobodova
-
Contact:
- Phone Number: 777691225
-
Uherské Hradiště, Czechia, 686 01
- Recruiting
- Medical Plus Research
-
Principal Investigator:
- Eva Dokoupilova
-
-
-
-
-
Gandrup, Denmark, 9362
- Recruiting
- Sanos Clinic - Nordjylland
-
Principal Investigator:
- Janani Umachanger
-
Herlev, Denmark, 2730
- Recruiting
- Sanos Clinic
-
Principal Investigator:
- Linda Bracher
-
Vejle, Denmark, 7100
- Recruiting
- Sanos Clinic - Syddanmark
-
Principal Investigator:
- SIDSEL BOLL
-
-
-
-
-
Bochum, Germany, 44787
- Recruiting
- Siteworks GmbH - Bochum
-
Contact:
- Phone Number: +49 234 60144350
-
Principal Investigator:
- Annemone Koechel
-
Bünde, Germany, 32257
- Recruiting
- Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann
-
Contact:
- Phone Number: 0049522314438
-
Principal Investigator:
- Kai Koenemann
-
Duisburg, Germany, 47269
- Recruiting
- StudyPoint Duisburg
-
Contact:
- Phone Number: +491725448897
-
Principal Investigator:
- Matthias Kuenster
-
Hamburg, Germany, 20095
- Recruiting
- HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T
-
Principal Investigator:
- Andrea Everding
-
Contact:
- Phone Number: 004940323103166
-
Karlsruhe, Germany, 76137
- Recruiting
- Siteworks GmbH - Zentrum für klinische Studien Karlsruhe
-
Contact:
- Phone Number: 004951151524740
-
Principal Investigator:
- Niels-Christian Hoellger
-
Leipzig, Germany, 04107
- Recruiting
- AmBeNet GmbH
-
Contact:
- Phone Number: 4934196276326
-
Principal Investigator:
- Hans-Detlev Stahl
-
München, Germany, 80809
- Recruiting
- CDG Studienambulanz Hartard
-
Principal Investigator:
- Manfred Hartard
-
Contact:
- Phone Number: 00498935819977
-
Offenbach, Germany, 63065
- Recruiting
- Dedicated Research Site FutureMeds
-
Principal Investigator:
- Christel Contzen
-
Contact:
- Phone Number: 0049 69 247433849
-
-
-
-
-
Chiba, Japan, 260-8606
- Recruiting
- National Hospital Organization Chiba Medical Center
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Akihiko Okawa
-
Chūōku, Japan, 103-0027
- Recruiting
- Tokyo-Eki Center-building Clinic
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Arihiro Kiyosue
-
Chūōku, Japan, 104-0031
- Recruiting
- Tokyo Asbo Clinic
-
Principal Investigator:
- Akiyoshi Uchiyama
-
Contact:
- Phone Number: 81120023812
-
Kitakyushu-Shi, Japan, 800-0057
- Recruiting
- Shin Komonji Hospital
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Motonori Sato
-
Miyazaki, Japan, 880-0835
- Recruiting
- Goto Orthopedic Surgery Clinic
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Keisuke Goto
-
Nagareyama, Japan, 270-0113
- Recruiting
- Komagidai Clinic
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Hideki Iizuka
-
Saitama, Japan, 336-8522
- Recruiting
- Saitama City Hospital
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Kentaro Takeda
-
Sashima, Japan, 306-0433
- Recruiting
- Ibaraki Seinan Medical Center Hospital
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Masafumi Uesugi
-
Sendai, Japan, 980-0011
- Recruiting
- Ogura Orthopedics Surgery
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Ken Ogura
-
Sendai, Japan, 981-3134
- Recruiting
- Katsura Garden Orthopedics
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Masakazu Kogawa
-
Shinagawa-ku Tokyo, Japan, 140-0014
- Recruiting
- Ooimachi Orthopedic Surgery and surgery Clinic
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Omata Masanari
-
Suginami City, Japan, 167-0051
- Recruiting
- Masumoto Orthopedics Clinic
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Kou Masumoto
-
Toyohashi, Japan, 440-8510
- Recruiting
- National Hospital Organization Toyohashi Medical Center
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Yasuhiro Shibata
-
Yamagata, Japan, 990-0834
- Recruiting
- Yamagata Tokushukai Hospital
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Eita Togashi
-
Ōita, Japan, 870-0942
- Recruiting
- Fujigaki Clinic
-
Contact:
- Phone Number: 81120023812
-
Principal Investigator:
- Toru Fujigaki
-
-
-
-
-
Dorado, Puerto Rico, 00646
- Recruiting
- Dorado Medical Complex
-
Principal Investigator:
- Luis Pagan-Cardona
-
Contact:
- Phone Number: 787-278-1576
-
San Juan, Puerto Rico, 00917
- Recruiting
- GCM Medical Group, PSC - Hato Rey Site
-
Principal Investigator:
- Karina Vila-Rivera
-
Contact:
- Phone Number: 17877268396
-
-
-
-
-
Daegu, South Korea, 42601
- Recruiting
- Keimyung University Dongsan Hospital
-
Principal Investigator:
- Ki Cheor Bae
-
Dongjak-gu, South Korea, 07061
- Recruiting
- Boramae Medical Center
-
Principal Investigator:
- Moonjong Chang
-
Seoul, South Korea, 05505
- Recruiting
- Asan Medical Center
-
Principal Investigator:
- JONG-MIN KIM
-
Contact:
- Phone Number: +82-2-3010-3897
-
Seoul, South Korea, 03080
- Recruiting
- Seoul National University Hospital
-
Principal Investigator:
- Hyuk-Soo Han
-
Seoul, South Korea, 03722
- Recruiting
- Severance Hospital, Yonsei University Health System
-
Contact:
- Phone Number: +821047054262
-
Principal Investigator:
- Sunghwan Kim
-
Seoul, South Korea, 06591
- Recruiting
- The Catholic Univ. of Korea Seoul St. Mary's Hospital
-
Contact:
- Phone Number: 010-9044-5228
-
Principal Investigator:
- yong in
-
Seoul, South Korea, 07441
- Recruiting
- Hallym University Kangnam Sacred Heart Hospital
-
Contact:
- Phone Number: 82-10-8762-7089
-
Principal Investigator:
- Joongil Kim
-
Uijeongbu-si, South Korea, 11765
- Recruiting
- The Catholic University of Korea, Uijeongbu ST. Mary's Hospital
-
Principal Investigator:
- SEOK JUNG KIM
-
-
-
-
-
Changhua County, Taiwan, 50006
- Recruiting
- Changhua Christian Hospital
-
Principal Investigator:
- Ing-Lin Chang
-
Kaohsiung Niao Sung Dist, Taiwan, 83301
- Not yet recruiting
- Chang Gung Memorial Hospital at Kaohsiung
-
Contact:
- Phone Number: 8860975056125
-
Principal Investigator:
- Ying-Chou Chen
-
Taichung, Taiwan, 404332
- Recruiting
- China Medical University Hospital
-
Contact:
- Phone Number: 886923832500
-
Principal Investigator:
- Wen-Yuan Lin
-
Tainan, Taiwan, 704
- Recruiting
- National Cheng Kung University Hospital
-
Contact:
- Phone Number: 06-2353535
-
Principal Investigator:
- Po-Ting Wu
-
Taipei, Taiwan, 10002
- Recruiting
- National Taiwan University Hospital
-
Principal Investigator:
- Chia-Wen Lu
-
Taipei, Taiwan, 114
- Recruiting
- Tri-Service General Hospital
-
Contact:
- Phone Number: 88687927135
-
Principal Investigator:
- Yu-Hsiu Chen
-
Taipei, Taiwan, 110
- Recruiting
- Taipei Medical University Hospital
-
Principal Investigator:
- Chi-Ching Chang
-
-
-
-
-
Bristol, United Kingdom, BS8 2RA
- Recruiting
- Velocity Clinical Research, Bristol
-
Principal Investigator:
- Kirsten Peacey
-
Contact:
- Phone Number: +44 1174 611208
-
Glasgow, United Kingdom, G20 7BE
- Recruiting
- FutureMeds Glasgow - CPS Research
-
Contact:
- Phone Number: 0141 9467888
-
Principal Investigator:
- Kristen Laing
-
London, United Kingdom, NW10 2PB
- Recruiting
- FutureMeds - London
-
Principal Investigator:
- Pembe Ozunlu
-
Contact:
- Phone Number: 07858413118
-
Newcastle, United Kingdom, NE6 1SG
- Recruiting
- Futuremeds-Newcastle
-
Principal Investigator:
- William Aspinall
-
Penzance, United Kingdom, TR18 3DX
- Recruiting
- Atlantic Medical
-
Principal Investigator:
- Alex Dewdney
-
Rotherham, United Kingdom, S61 1AH
- Recruiting
- Woodstock Bower Surgery
-
Contact:
- Phone Number: 07551985998
-
Principal Investigator:
- Shahbaz Ali
-
Sheffield, United Kingdom, S2 5FX
- Recruiting
- Panthera Biopartners - Sheffield
-
Contact:
- Phone Number: 01143503730
-
Principal Investigator:
- Hannah Collins
-
York, United Kingdom, YO24 4LJ
- Recruiting
- Panthera Clinic - York
-
Contact:
- Phone Number: 01772 237822
-
Principal Investigator:
- Mahadev Ramjee
-
-
-
-
Alabama
-
Mobile, Alabama, United States, 36608
- Recruiting
- AMR Clinical
-
Contact:
- Phone Number: 251-414-1984
-
Principal Investigator:
- Harry Studdard
-
-
Arizona
-
Mesa, Arizona, United States, 85206
- Recruiting
- Care Access - 801 South Power Road, Mesa
-
Principal Investigator:
- Michael Waters
-
Contact:
- Phone Number: 877-791-0656
-
Mesa, Arizona, United States, 85209
- Recruiting
- Elite Pain and Spine Institute - South Crimson Road
-
Principal Investigator:
- Zeeshan Malik
-
Phoenix, Arizona, United States, 85018
- Recruiting
- Elite Clinical Studies, LLC
-
Principal Investigator:
- Joseph Lillo, DO
-
Contact:
- Phone Number: 602-788-3437
-
Tucson, Arizona, United States, 85712
- Recruiting
- Tucson Orthopaedic Institute - North Wyatt Drive
-
Principal Investigator:
- Nebojsa Skrepnik
-
Contact:
- Phone Number: 520-404-0276
-
-
California
-
Fountain Valley, California, United States, 92708
- Recruiting
- ARK Clinical Research - Fountain Valley
-
Principal Investigator:
- Mark Leibowitz
-
Contact:
- Phone Number: 714-988-2021
-
Santa Ana, California, United States, 92706
- Recruiting
- Wolverine Clinical Trials
-
Contact:
- Phone Number: 714-617-2426
-
Principal Investigator:
- Behnam Khaleghi
-
Spring Valley, California, United States, 91978
- Recruiting
- Encompass Clinical Research
-
Contact:
- Phone Number: 619-660-9068
-
Principal Investigator:
- Hanid Audish
-
Walnut Creek, California, United States, 94598
- Recruiting
- Diablo Clinical Research, Inc.
-
Contact:
- Phone Number: 925-930-7267
-
Principal Investigator:
- Helen Stacey
-
-
Colorado
-
Colorado Springs, Colorado, United States, 80917
- Recruiting
- Skylight Health Research - Colorado Springs
-
Principal Investigator:
- Renee Flick
-
-
Florida
-
Jacksonville, Florida, United States, 32205
- Recruiting
- Westside Center for Clinical Research
-
Principal Investigator:
- Matthew Braddock
-
Contact:
- Phone Number: 904-693-1490
-
St. Petersburg, Florida, United States, 33710
- Recruiting
- Care Access - St. Petersburg
-
Principal Investigator:
- Gigi Lefebvre
-
Contact:
- Phone Number: 877-791-0656
-
Winter Park, Florida, United States, 32789
- Recruiting
- Conquest Research
-
Principal Investigator:
- Anand Patel
-
Contact:
- Phone Number: 407-916-0060
-
-
Georgia
-
Decatur, Georgia, United States, 30034
- Recruiting
- Orita Clinical Research
-
Principal Investigator:
- Ahmad Jingo
-
-
Idaho
-
Ammon, Idaho, United States, 83406
- Recruiting
- Medical Research Partners
-
Principal Investigator:
- Joseph Moore
-
Contact:
- Phone Number: 208-681-9070
-
-
Illinois
-
Chicago, Illinois, United States, 60640
- Recruiting
- Great Lakes Clinical Trials - Ravenswood
-
Contact:
- Phone Number: 773-275-3500
-
Principal Investigator:
- Manish Jain
-
-
Indiana
-
Evansville, Indiana, United States, 47715
- Recruiting
- Qualmedica Research, LLC
-
Contact:
- Phone Number: 812-205-2475
-
Principal Investigator:
- Moges Sisay
-
-
Kansas
-
Newton, Kansas, United States, 67114
- Recruiting
- AMR Clinical
-
Contact:
- Phone Number: 316-804-7304
-
Principal Investigator:
- Troy Holdeman
-
-
Kentucky
-
Louisville, Kentucky, United States, 40213
- Recruiting
- Monroe Biomedical Research - Louisville
-
Contact:
- Phone Number: 502-515-5672
-
Principal Investigator:
- Harold Bays
-
-
Massachusetts
-
Burlington, Massachusetts, United States, 01803
- Recruiting
- Skylight Health Research - Burlington
-
Principal Investigator:
- Timothy McAlindon
-
Contact:
- Phone Number: 781-653-4281
-
Quincy, Massachusetts, United States, 02169
- Recruiting
- Care Access - Quincy
-
Contact:
- Phone Number: 877-791-0656
-
Principal Investigator:
- Chih Chao Yang
-
-
New York
-
Brooklyn, New York, United States, 11215
- Recruiting
- Ellipsis Research Group - Brooklyn - 7th Street
-
Principal Investigator:
- Jorge Serje
-
Contact:
- Phone Number: 347-422-0317
-
Buffalo, New York, United States, 14127
- Recruiting
- Rochester Clinical Research - Buffalo
-
Principal Investigator:
- Rajiv Jain
-
Long Island City, New York, United States, 11106
- Recruiting
- NYC Research INC
-
Principal Investigator:
- Anastasios Manessis
-
Contact:
- Phone Number: 516-574-9232
-
Rochester, New York, United States, 14609
- Recruiting
- Rochester Clinical Research, LLC
-
Contact:
- Phone Number: 585-288-0890
-
Principal Investigator:
- Patrick Connors
-
-
Oklahoma
-
Tulsa, Oklahoma, United States, 74136
- Recruiting
- Central States Research
-
Contact:
- Phone Number: 918-645-5400
-
Principal Investigator:
- Sarah Land
-
-
Pennsylvania
-
Plymouth Meeting, Pennsylvania, United States, 19462
- Recruiting
- Keystone Clinical Studies
-
Principal Investigator:
- Cameron Olezene
-
-
Texas
-
Bellaire, Texas, United States, 77401
- Recruiting
- JCCT - Juno Bellaire Site
-
Contact:
- Phone Number: 713-779-5494
-
Principal Investigator:
- Rocio Harbison
-
DeSoto, Texas, United States, 75115
- Recruiting
- Epic Medical Research - DeSoto
-
Principal Investigator:
- Haresh Boghara
-
Contact:
- Phone Number: 197-277-7695
-
Fort Worth, Texas, United States, 76164
- Recruiting
- Valley Institute of Research - Fort Worth
-
Contact:
- Phone Number: 817-625-7733
-
Principal Investigator:
- Alex Guevara
-
Houston, Texas, United States, 77054
- Recruiting
- Care Access - Houston
-
Principal Investigator:
- Ali Bajwa
-
Contact:
- Phone Number: 877-791-0656
-
San Antonio, Texas, United States, 78240
- Recruiting
- Endeavor Clinical Trials
-
Principal Investigator:
- Nitendra Agarwal
-
Contact:
- Phone Number: 518-428-6859
-
San Antonio, Texas, United States, 78230
- Recruiting
- VIP Trials
-
Contact:
- Phone Number: 210-569-2672
-
Principal Investigator:
- Juan Garza
-
Shavano Park, Texas, United States, 78231
- Recruiting
- Consano Clinical Research, LLC
-
Contact:
- Phone Number: 210-545-4900
-
Principal Investigator:
- Michelle Welch
-
Weslaco, Texas, United States, 78596
- Recruiting
- Texas Valley Clinical Research
-
Principal Investigator:
- Eduardo Luna
-
Contact:
- Phone Number: 956-431-8090
-
-
Utah
-
South Jordan, Utah, United States, 84095
- Recruiting
- AMR Clinical
-
Principal Investigator:
- Curtis Andrews
-
-
Virginia
-
Charlottesville, Virginia, United States, 22911
- Recruiting
- Charlottesville Medical Research
-
Contact:
- Phone Number: 434-817-2442
-
Principal Investigator:
- James Clark
-
-
Washington
-
Kirkland, Washington, United States, 98034
- Recruiting
- Paramount Clinical Research - Data Point Clinical Research
-
Principal Investigator:
- Javier Nazar
-
Contact:
- Phone Number: 425-577-1107
-
-
Participation Criteria
Eligibility Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
- Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
- Have tried at least once to lose weight through diet but were unsuccessful
Have osteoarthritis of the knee and at least one of the following conditions:
- Be over 50 years old
- Have morning knee stiffness that lasts about 30 minutes
- Have a crackling or grinding sound or feeling in the knee
Exclusion Criteria:
- Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening)
- Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
- Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
- Have an active knee infection
Have had within 90 days prior to screening:
- heart attack
- stroke
- coronary artery revascularization
- unstable angina, or
- hospitalization due to congestive heart failure
- Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
- Have taken medications or alternative remedies intended for weight loss within 90 days of screening
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Number of Arms
Arms and Interventions
Participant Group / ArmParticipant Group / Arm |
Intervention / TreatmentIntervention / Treatment |
|---|---|
|
Experimental: Eloralintide (YOA1)
Participants will receive eloralintide subcutaneously (SC)
|
Administered SC
Other Names:
|
|
Placebo Comparator: Placebo (YOA1)
Participants will receive placebo SC
|
Placebo administered SC
|
|
Experimental: Eloralintide (YOA2)
Participants will receive eloralintide SC
|
Administered SC
Other Names:
|
|
Placebo Comparator: Placebo (YOA2)
Participants will receive placebo SC
|
Placebo administered SC
|
What is the study measuring?
Primary Outcome Measures
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Percent Change from Baseline in Body Weight
Time Frame: Baseline, Week 64
|
Percent Change from Baseline in Body Weight
|
Baseline, Week 64
|
|
Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score
Time Frame: Baseline, Week 64
|
Change from Baseline in the WOMAC Pain Subscale Score
|
Baseline, Week 64
|
Secondary Outcome Measures
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Change from Baseline in Systolic Blood Pressure (SBP)
Time Frame: Baseline, Week 64
|
Change from Baseline in SBP
|
Baseline, Week 64
|
|
Percent Change from Baseline in Triglycerides
Time Frame: Baseline, Week 64
|
Percent Change in Baseline in Triglycerides
|
Baseline, Week 64
|
|
Change from Baseline in Short Form-36 (SF-36 v2) Acute Form Physical Functioning Domain Score
Time Frame: Baseline, Week 64
|
Change from Baseline in SF-36 v2 Score
|
Baseline, Week 64
|
|
Percent Change from Baseline in High Sensitivity, C-reactive Protein (hsCRP)
Time Frame: Baseline, Week 64
|
Percent Change from Baseline in hsCRP
|
Baseline, Week 64
|
|
Change from Baseline in the WOMAC Physical Function Subscale Score
Time Frame: Baseline, Week 40, Week 64
|
Change from Baseline in the WOMAC Physical Function Subscale Score
|
Baseline, Week 40, Week 64
|
|
Change from Baseline WOMAC Pain Subscale Score
Time Frame: Baseline, Week 40
|
Change from Baseline WOMAC Pain Subscale Score
|
Baseline, Week 40
|
|
Change from Baseline in Distance Walked During the 6-Minute Walk Test
Time Frame: Baseline, Week 64
|
Change from Baseline in Distance Walked During the 6-Minute Walk Test
|
Baseline, Week 64
|
|
Change from Baseline in Body Mass Index (BMI)
Time Frame: Baseline, Week 64
|
Change from Baseline in BMI
|
Baseline, Week 64
|
|
Change in Medication Use
Time Frame: Baseline, Week 64
|
Change in Medication Use
|
Baseline, Week 64
|
|
Change from Baseline in SF-36v2 Acute Form Domain Scores With Exception of the Physical Functioning Domain Score
Time Frame: Baseline, Week 64
|
Change from Baseline in SF-36v2 Acute Form Domain Scores With Exception of the Physical Functioning Domain Score
|
Baseline, Week 64
|
|
Change from Baseline in Health Status EQ-5D-5L Health State Utility
Time Frame: Baseline, Week 64
|
Change from Baseline in Health Status EQ-5D-5L Health State Utility
|
Baseline, Week 64
|
|
Percent Change from Baseline in Fasting Insulin
Time Frame: Baseline, Week 64
|
Percent Change from Baseline in Fasting Insulin
|
Baseline, Week 64
|
|
Percent Change from Baseline in Total Cholesterol
Time Frame: Baseline, Week 64
|
Percent Change from Baseline in Total Cholesterol
|
Baseline, Week 64
|
|
Change from Baseline in Waist Circumference
Time Frame: Baseline, Week 64
|
Change from Baseline in Waist Circumference
|
Baseline, Week 64
|
|
Percent Change from Baseline in Hemoglobin A1c (HbA1c)
Time Frame: Baseline, Week 64
|
Percent Change from Baseline in HbA1c
|
Baseline, Week 64
|
|
Change from Baseline in WOMAC Stiffness Subscale Score
Time Frame: Baseline, Week 64
|
Change from Baseline in WOMAC Stiffness Subscale Score
|
Baseline, Week 64
|
|
Change from Baseline in WOMAC Total Score
Time Frame: Baseline, Week 64
|
Change from Baseline in WOMAC Total Score
|
Baseline, Week 64
|
|
Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) - Target Knee Pain
Time Frame: Baseline, Week 64
|
Achievement of Improved Categorical Shift in PGIS - Target Knee Pain
|
Baseline, Week 64
|
|
Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) - Target Knee Function
Time Frame: Baseline, Week 64
|
Achievement of Improved Categorical Shift in PGIS - Target Knee Function
|
Baseline, Week 64
|
|
Change from Baseline in Average Pain Intensity Numeric Rating Scale (API-NRS) Score
Time Frame: Baseline, Week 64
|
Change from Baseline in API-NRS Score
|
Baseline, Week 64
|
|
Change from Baseline in Worst Pain Intensity Numeric Rating Scale (WPI-NRS) Score
Time Frame: Baseline, Week 64
|
Change from Baseline in WPI-NRS Score
|
Baseline, Week 64
|
|
Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax, ss)
Time Frame: Baseline through Week 64
|
PK: Cmax, ss
|
Baseline through Week 64
|
|
PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-T)ss)
Time Frame: Baseline through Week 64
|
PK: AUC(0-T)ss
|
Baseline through Week 64
|
|
Number of Participants with Allowed Concomitant Pain Medication
Time Frame: Baseline, Week 64
|
Number of Participants with Allowed Concomitant Pain Medication
|
Baseline, Week 64
|
Collaborators and Investigators
Sponsor
Sponsor
Investigators
Investigators
- Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company
Publications and helpful links
Helpful Links
Study record dates
Study Major Dates
Study Start (Actual)
Study Start
Primary Completion (Estimated)
Primary Completion
Study Completion (Estimated)
Study Completion
Study Registration Dates
First Submitted
First Submitted
First Submitted That Met QC Criteria
First Submitted That Met QC Criteria
First Posted (Actual)
First Posted
Study Record Updates
Last Update Posted (Actual)
Last Update Posted
Last Update Submitted That Met QC Criteria
Last Update Submitted That Met QC Criteria
Last Verified
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
Other Study ID Numbers
- 27761
- 2025 (U.S. NIH Grant/Contract: Faculty of Social Sciences Scientific Grant at the University of Gdańsk)
- 2025-523768-19-00 (Ctis)
- J3R-MC-YDAN (Other Identifier: Eli Lilly and Company)
- J3R-MC-YOA1 (Other Identifier: Eli Lilly and Company)
- J3R-MC-YOA2 (Other Identifier: Eli Lilly and Company)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- CSR
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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