17-AAG and Irinotecan in Treating Patients With Locally Advanced or Metastatic Solid Tumors

An Open-Labeled Non-Randomized Phase I Study of 17-N-allylamino-17-demethoxy Geldanamycin (17AAG) Administered With Irinotecan (CPT-11) in Patients With Advanced Solid Tumors

This phase I trial is studying the side effects and best dose of 17-AAG and irinotecan in treating patients with locally advanced or metastatic solid tumors. Drugs used in chemotherapy, such as 17-AAG and irinotecan, work in different ways to stop the growth of tumor cells either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.

Study Overview

• Status: Completed
• Conditions: Unspecified Adult Solid Tumor, Protocol Specific
• Intervention / Treatment: Drug: irinotecan hydrochloride; Drug: tanespimycin

Detailed Description

PRIMARY OBJECTIVES:

I. To determine the maximum tolerated dose (MTD) of combined 17AAG and irinotecan given weekly for two weeks in a 21-day cycle that can be used for future phase II studies.

SECONDARY OBJECTIVES:

I. To explore the effects of the combination on the expression of Hsp90 client proteins in peripheral mononuclear cells and tumor tissues. Tumor biopsies will be performed before and after 17AAG treatment in 12 patients at the MTD ("Expanded Cohort") only.

II. To investigate the clinical pharmacokinetics of intravenous 17AAG, irinotecan, and their metabolites, in this combination.

III. To obtain preliminary data on the therapeutic activity of 17AAG in combination with irinotecan in patients with advanced solid tumors.

IV. To obtain preliminary result in the relationship between tumor response and p53-status.

OUTLINE: This is an open-label, non-randomized, dose-escalation study.

Patients receive irinotecan IV over 30 minutes followed by 17-N-allylamino-17-demethoxygeldanamycin (17-AAG)* IV over 2 hours on days 1 and 8. Treatment repeats every 21 days for at least 2 courses in the absence of disease progression or unacceptable toxicity. Patients achieving stable or improved disease after course 2 may receive additional courses of treatment.

NOTE: *17-AAG is administered on days 2 and 8 during course 2 for patients treated at non-maximum tolerated doses (MTD) (dose-escalation portion) and on day 8 only during course 1 for patients treated at the MTD (expanded cohort).Cohorts of 3-6 patients receive escalating doses of 17-AAG and irinotecan until the MTD is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. An additional 12 patients are treated at the MTD.

• Study Type: Interventional
• Enrollment (Actual): 48
• Phase: Phase 1

Contacts and Locations

Study Locations

• United States
  • New York
    • New York, New York, United States, 10065
      • Memorial Sloan Kettering Cancer Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Histologically confirmed solid tumor, excluding primary CNS tumors

  • Locally advanced or metastatic disease that is refractory to standard therapy OR for which no standard therapy exists

• Tumor assessible for biopsy by Tru-cut^®, CT guidance, or endoscopy (for patients treated at the maximum tolerated dose [expanded cohort only])

  • Pleural effusions or abdominal ascites are not considered biopsy-accessible tissue
• No known new CNS metastases that have not been previously treated
• Performance status - Karnofsky 60-100%
• WBC ≥ 3,000/mm^3
• Absolute neutrophil count ≥ 1,500/mm^3
• Platelet count ≥ 100,000/mm^3
• Bilirubin ≤ 1.5 mg/dL
• AST and ALT ≤ 3 times upper limit of normal (ULN) (5 times ULN if liver metastases are present)
• Creatinine ≤ 1.5 mg/dL
• No history of cardiac arrhythmias
• No myocardial infarction within the past 12 months
• No active ischemic heart disease within the past 12 months
• No New York Heart Association class III-IV congestive heart failure or LVEF < 40% by MUGA
• No history of uncontrolled cardiac dysrhythmia or dysrhthmias requiring medication
• No history of serious ventricular arrhythmia (i.e., ventricular tachycardia or ventricular fibrillation ≥ 3 beats in a row)
• No congenital long QT syndrome
• No left bundle branch block
• QTc < 450 msec (for male patients)
• QTc < 470 msec (for female patients)
• Not pregnant
• No nursing during and for 2 months after study participation
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 2 months after study participation
• No serious or uncontrolled infection
• No history of serious allergic reaction to eggs or egg products
• No other medical condition that would preclude study participation
• At least 3 weeks since prior immunotherapy
• No concurrent prophylactic filgrastim (G-CSF) or sargramostim (GM-CSF)
• At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)
• Prior irinotecan allowed
• No prior 17-N-allylamino-17-demethoxygeldanamycin (17-AAG)
• At least 2 weeks since prior non-myelosuppressive chemotherapy (at the discretion of the principal investigator)
• At least 3 weeks since prior radiotherapy
• No prior radiotherapy field that included the heart (e.g., mantle)
• Recovered from all prior therapy
• At least 3 weeks since prior anticancer investigational therapeutic drugs

• More than 7 days since prior and no concurrent inducers, inhibitors, or modifiers of CYP3A4, including any of the following:

  • Fluconazole
  • Itraconazole
  • Ketoconazole
  • Azithromycin
  • Clarithromycin
  • Erythromycin
  • Troleandomycin
  • Nifedipine
  • Verapamil
  • Diltiazem
  • Nefazodone
  • Cyclosporine
  • Grapefruit juice (> 1 quart/day)
  • Indinavir
  • Nelfinavir
  • Ritonavir
  • Saquinavir
  • Carbamazepine
  • Phenobarbital
  • Phenytoin
  • Rifampin
  • Hydrastis canadensis (goldenseal)
  • Hypericum perforatum (St. John's wort)
  • Uncaria tomentosa (cat's claw)
  • Echinacea angustifolia root
  • Trifolium pratense (wild cherry)
  • Matricaria chamomila (chamomile)
  • Glycyrrhiza glabra (licorice)
  • Dillapiol
  • Hypericin
  • Naringenin
• No concurrent medications that would prolong QTc

• No concurrent vitamins, antioxidants, herbal preparations, or supplements

  • Concurrent single daily multivitamin allowed
• No other concurrent anticancer therapy
• No concurrent combination antiretroviral therapy for HIV-positive patients
• No other concurrent investigational medications

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Arm I; Patients receive irinotecan IV over 30 minutes followed by 17-N-allylamino-17-demethoxygeldanamycin (17-AAG)* IV over 2 hours on days 1 and 8. Treatment repeats every 21 days for at least 2 courses in the absence of disease progression or unacceptable toxicity. Patients achieving stable or improved disease after course 2 may receive additional courses of treatment.	Drug: irinotecan hydrochloride; Other Names: irinotecan; Campto; Camptosar; U-101440E; CPT-11; Drug: tanespimycin; Other Names: 17-AAG

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Maximum tolerated dose determined by dose-limiting toxicities	21 days

Collaborators and Investigators

• Sponsor: National Cancer Institute (NCI)
• Investigators: Principal Investigator: Archie Tse, Memorial Sloan Kettering Cancer Center

Study record dates

Study Major Dates

• Study Start: May 1, 2005
• Primary Completion (Actual): October 1, 2008

Study Registration Dates

• First Submitted: July 12, 2005
• First Submitted That Met QC Criteria: July 12, 2005
• First Posted (Estimate): July 13, 2005

Study Record Updates

• Last Update Posted (Estimate): June 4, 2013
• Last Update Submitted That Met QC Criteria: June 3, 2013
• Last Verified: June 1, 2013

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Antineoplastic Agents; Topoisomerase Inhibitors; Topoisomerase I Inhibitors; Irinotecan
• Other Study ID Numbers: NCI-2012-01467; U01CA069856 (U.S. NIH Grant/Contract); 05-017; MSKCC-IRB-05017; NCI-7009; CDR0000434501