- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00235027
Improving Safety By Computerizing Outpatient Prescribing
Study Overview
Status
Intervention / Treatment
Detailed Description
Specific Aim 1: Increase routine identification of outpatient adverse drug events (ADEs) through development of a computerized ADE detection monitor.
Specific Aim 2: Use basic computerized outpatient prescribing to reduce preventable ADEs in a diverse array of outpatient settings.
Specific Aim 3: Use advanced decision-support within computerized prescribing to reduce the frequency of preventable ADEs, medication errors, and potential ADEs.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Indiana
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Indianapolis, Indiana, United States
- Regenstrief/Indiana University
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Massachusetts
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Boston, Massachusetts, United States, 02115
- Brigham and Women's Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria: At Brigham & Women's Hospital, clinics utilizing the electronic medical record will be included. At Regenstrief, any clinic that has access to their electronic medical record will be utilized.
- For the impact of basic decision support, clinics were not randomized
- For impact of advanced decision support, clinics were randomized to receive the intervention
Exclusion Criteria:
- Clinics not using electronic medical records
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Adverse Drug Event Monitoring
In this intervention arm, clinicians received medication safety alerts when they prescribed medications in the electronic medical record.
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The intervention in this study is the presentation of medication safety alerts in the electronic medical record to improve patient outcomes and safety.
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No Intervention: Care as Usual
In this arm, clinicians did not receive the medication safety alerts.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Preventable Adverse drug events
Time Frame: 8/5/2004 - 1/5/2005
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Data were electronically collected each time a physician entered a prescription that triggered an alert related to medication safety.
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8/5/2004 - 1/5/2005
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Total adverse drug events, medication errors
Time Frame: 1/15/2001 - 5/15/2001
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1/15/2001 - 5/15/2001
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Collaborators and Investigators
Investigators
- Study Director: Tejal K Gandhi, MD, MPH, Brigham and Women's Hospital
- Principal Investigator: David Bates, MD, Brigham and Women's Hospital
- Study Director: Marc Overhage, MD, Regenstrief Institute, Inc.
Publications and helpful links
General Publications
- Shah NR, Seger AC, Seger DL, Fiskio JM, Kuperman GJ, Blumenfeld B, Recklet EG, Bates DW, Gandhi TK. Improving acceptance of computerized prescribing alerts in ambulatory care. J Am Med Inform Assoc. 2006 Jan-Feb;13(1):5-11. doi: 10.1197/jamia.M1868. Epub 2005 Oct 12.
- Gandhi TK, Seger AC, Overhage JM, Murray MD, Hope C, Fiskio J, Teal E, Bates DW. Outpatient adverse drug events identified by screening electronic health records. J Patient Saf. 2010 Jun;6(2):91-6. doi: 10.1097/PTS.0b013e3181dcae06.
Helpful Links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- RO1 HS 11169
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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