- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00283023
Oligodendrocyte Progenitor Cell Culture From Human Brain
October 14, 2020 updated by: Rajavithi Hospital
Phase 1: Oligodendrocyte Progenitor Cell Culture From Human Brain
Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells.
Clinical trials of stem- or progenitor cell transplantation in multiple sclerosis are currently premature.
The researchers developed a protocol for human oligodendrocyte progenitor cell culture from human brain for the treatment of demyelinating disease.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Oligodendrocyte progenitor cell line were cultures and will be transplanted into the patient with Multiple sclerosis.
Study Type
Interventional
Enrollment (Actual)
5
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Bangkok, Thailand, 10400
- Assistant Professor Subsai Kongsaengdao
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 65 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Male or female 20-65 years of age
- Informed consent
- Has elective craniotomy surgery
Exclusion Criteria:
- HIV, hepatitis, and other central nervous system (CNS) infections
- Dementia, Alzheimer disease, and neurodegenerative disease
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: A
Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.
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Oligodendrocyte progenitor cell culture protocol of Rajavithi Hospital will be apply
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Number of oligodendrocyte progenitor cell differentiation
Time Frame: one month
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one month
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Subsai Kongsaengdao, M.D., Division of Neurology, Department of Medicine, Rajavithi Hospital : Thailand
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
December 1, 2007
Primary Completion (Actual)
December 1, 2010
Study Completion (Actual)
December 1, 2010
Study Registration Dates
First Submitted
January 25, 2006
First Submitted That Met QC Criteria
January 26, 2006
First Posted (Estimate)
January 27, 2006
Study Record Updates
Last Update Posted (Actual)
October 19, 2020
Last Update Submitted That Met QC Criteria
October 14, 2020
Last Verified
October 1, 2020
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- RH-CMR-003
- RVH-CMR-003 grant
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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